Research graph
References from Integrating network analysis and machine learning to explore the pharmacological targets and associations of oleanolic acid in lung adenocarcinoma. Local targets link to admitted publications; unresolved targets remain external evidence.
Oleanolic acid conjugated chitosan nanocomplex exerts anti-tumor effects by inhibiting autophagy in lung cancer cells through the signal transducers and activators of transcription 3/B cell lymphoma-2 signaling pathway
10.26402/jpp.2024.3.08 · 2024 · External reference
Omics data analysis reveals common molecular basis of small cell lung cancer and COVID-19
10.1080/07391102.2023.2257803 · 2024 · External reference
Oleanolic acid and its derivatives: biological activities and therapeutic potential in chronic diseases
10.3390/molecules22111915 · 2017 · External reference
TOP2A copy number and TOP2A expression in uterine benign smooth muscle tumours and leiomyosarcoma
10.1136/jclinpath-2015-203561 · 2016 · External reference
Ursolic and oleanolic acids induce mitophagy in A549 human lung cancer cells
10.3390/molecules24193444 · 2019 · External reference
ALOX5AP is an indicator for high CD8 lymphocyte infiltration and “hot” tumor microenvironment in osteosarcoma: a bioinformatic study
10.1007/s10528-023-10374-0 · 2023 · External reference
SRF rearrangements in soft tissue tumors with muscle differentiation
10.3390/biom12111678 · 2022 · External reference
Prognostication of prostate cancer based on TOP2A protein and gene assessment: TOP2A in prostate cancer
10.1186/1479-5876-11-36 · 2013 · External reference
Inhibition of colorectal cancer aggressiveness by oleanolic acid through Nur77 degradation
10.1016/j.phymed.2024.156192 · 2024 · External reference
Rethinking network analysis in ethnopharmacology: a multi-omics and AI roadmap to overcome conceptual and methodological biases
10.3389/fphar.2026.1748478 · 2026 · External reference
A noval prognostic signature of the N7-methylguanosine (m7G)-related miRNA in lung adenocarcinoma
10.1186/s12890-022-02290-7 · 2023 · External reference
Shaping polarization of tumor-associated macrophages in cancer immunotherapy
10.3389/fimmu.2022.888713 · 2022 · External reference
Towards a contactless stress classification using thermal imaging
10.3390/s22030976 · 2022 · External reference
Comprehensive analysis of expression and prognostic value of GATAs in lung cancer
10.7150/jca.52623 · 2021 · External reference
GSVA: gene set variation analysis for microarray and RNA-Seq data
10.1186/1471-2105-14-7 · 2013 · External reference
Inhibition of APOC1 promotes the transformation of M2 into M1 macrophages via the ferroptosis pathway and enhances anti-PD1 immunotherapy in hepatocellular carcinoma based on single-cell RNA sequencing
10.1016/j.redox.2022.102463 · 2022 · External reference
Identify and validate the transcriptomic, functional network, and predictive validity of FBXL19-AS1 in hepatocellular carcinoma
10.3389/fonc.2020.609601 · 2020 · External reference
Oleanolic acid and its derivatives in breast cancer therapy: mechanistic insights, structural modifications, and novel delivery strategies
10.3389/fphar.2026.1755987 · 2026 · External reference
Exploring the underlying mechanism of oleanolic acid treating glioma by transcriptome and molecular docking
10.1016/j.biopha.2022.113586 · 2022 · External reference
Improving bioscience research reporting: the ARRIVE guidelines for reporting animal research
10.1371/journal.pbio.1000412 · 2010 · External reference
TOP2A promotes lung adenocarcinoma cells' malignant progression and predicts poor prognosis in lung adenocarcinoma
10.7150/jca.41415 · 2020 · External reference
The role of pentacyclic triterpenoids in non-small cell lung cancer: the mechanisms of action and therapeutic potential
10.3390/pharmaceutics17010022 · 2024 · External reference
Naringenin induces ferroptosis in osteosarcoma cells through the STAT3-MGST2 signaling pathway
10.1016/j.jbo.2024.100657 · 2025 · External reference
Revealing the significance of tissue-resident memory T cells in lung adenocarcinoma through bioinformatic analysis and experimental validation
10.3389/fimmu.2025.1600863 · 2025 · External reference
Genomic features and its potential implication in bone oligometastatic NSCLC
10.1186/s12890-023-02354-2 · 2023 · External reference
Emerging insights of tumor heterogeneity and drug resistance mechanisms in lung cancer targeted therapy
10.1186/s13045-019-0818-2 · 2019 · External reference
Identification of CDK2-Related immune forecast model and ceRNA in lung adenocarcinoma, a pan-cancer analysis
10.3389/fcell.2021.682002 · 2021 · External reference
ARIH1 activates STING-Mediated T-cell activation and sensitizes tumors to immune checkpoint blockade
10.1038/s41467-023-39920-5 · 2023 · External reference
Non-genetic mechanisms of therapeutic resistance in cancer
10.1038/s41568-020-00302-4 · 2020 · External reference
The role of lipoxygenases in pathophysiology; new insights and future perspectives
10.1016/j.redox.2015.08.006 · 2015 · External reference
Study on the expression of TOP2A in hepatocellular carcinoma and its relationship with patient prognosis
10.1186/s12935-021-02439-0 · 2022 · External reference
AutoDock4 and AutoDockTools4: automated docking with selective receptor flexibility
10.1002/jcc.21256 · 2009 · External reference
Robust enumeration of cell subsets from tissue expression profiles
10.1038/nmeth.3337 · 2015 · External reference
Worldwide traceability of antibiotic residues from livestock in wastewater and soil: a systematic review
10.3390/ani12010060 · 2021 · External reference
Ligand docking and binding site analysis with PyMOL and autodock/vina
10.1007/s10822-010-9352-6 · 2010 · External reference
Cytoscape: a software environment for integrated models of biomolecular interaction networks
10.1101/gr.1239303 · 2003 · External reference
NFIC mediates m6A mRNA methylation to orchestrate transcriptional and post-transcriptional regulation to represses malignant phenotype of non-small cell lung cancer cells
10.1186/s12935-024-03414-1 · 2024 · External reference
Comprehensive analysis reveals the potential value of inflammatory response genes in the prognosis, immunity, and drug sensitivity of lung adenocarcinoma
10.1186/s12920-022-01340-7 · 2022 · External reference
Integrated bioinformatics analysis and experimental validation reveal the relationship between ALOX5AP and the prognosis and immune microenvironment in glioma
10.1186/s12920-024-01991-8 · 2024 · External reference
Therapeutic potential of plants and plant derived phytochemicals against acetaminophen-induced liver injury
10.3390/ijms19123776 · 2018 · External reference
Neutrophil extracellular traps-associated modification patterns depict the tumor microenvironment, precision immunotherapy, and prognosis of clear cell renal cell carcinoma
10.3389/fonc.2022.1094248 · 2022 · External reference
Crystal structures of human MGST2 reveal synchronized conformational changes regulating catalysis
10.1038/s41467-021-21924-8 · 2021 · External reference
AutoDock vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading
10.1002/jcc.21334 · 2010 · External reference
Oleanolic acid inhibits M2 macrophage polarization and potentiates anti-PD-1 therapy in hepatocellular carcinoma by targeting miR-130b-3p-PTEN-PI3K-Akt signaling and glycolysis
10.1016/j.phymed.2025.156750 · 2025 · External reference
Altered metabolism in cancer: insights into energy pathways and therapeutic targets
10.1186/s12943-024-02119-3 · 2024 · External reference
Effect of EZH2 on pulmonary artery smooth muscle cell migration in pulmonary hypertension
10.3892/mmr.2020.11768 · 2021 · External reference
Oncogenic role and potential regulatory mechanism of topoisomerase IIα in a pan-cancer analysis
10.1038/s41598-022-15205-7 · 2022 · External reference
The role of TOP2A in immunotherapy and vasculogenic mimicry in non-small cell lung cancer and its potential mechanism
10.1038/s41598-023-38117-6 · 2023 · External reference
Expression and potential molecular mechanism of TOP2A in metastasis of non-small cell lung cancer
10.1038/s41598-024-63055-2 · 2024 · External reference
Ferroptosis-related APOE, BCL3 and ALOX5AP gene polymorphisms are associated with the risk of thyroid cancer
10.2147/pgpm.s352225 · 2022 · External reference
Single cell-RNA sequencing reveal TOP2A as a key driver of hepatocellular carcinoma progression
10.1038/s41598-025-16785-w · 2025 · External reference
ALOX5AP predicts poor prognosis by enhancing M2 macrophages polarization and immunosuppression in serous ovarian cancer microenvironment
10.3389/fonc.2021.675104 · 2021 · External reference
clusterProfiler: an R package for comparing biological themes among gene clusters
10.1089/omi.2011.0118 · 2012 · External reference
Oleanolic acid and its derivatives: new inhibitor of protein tyrosine phosphatase 1B with cellular activities
10.1016/j.bmc.2008.07.080 · 2008 · External reference
Antihypertensive activity of oleanolic acid is mediated via downregulation of secretory phospholipase A2 and fatty acid synthase in spontaneously hypertensive rats
10.3892/ijmm.2020.4744 · 2020 · External reference
A fast multi-locus ridge regression algorithm for high-dimensional genome-wide association studies
10.3389/fgene.2021.649196 · 2021 · External reference
Oleanolic acid suppresses the proliferation of lung carcinoma cells by miR-122/Cyclin G1/MEF2D axis
10.1007/s11010-014-2228-7 · 2015 · External reference
ZMIZ2 promotes the development of triple-receptor negative breast cancer
10.1186/s12935-021-02393-x · 2022 · External reference
AutoDock4 and AutoDockTools4: automated docking with selective receptor flexibility
10.1002/jcc.21256 · ExternalCitation · doi-reference
AutoDock vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading
10.1002/jcc.21334 · ExternalCitation · doi-reference
ALOX5AP is an indicator for high CD8 lymphocyte infiltration and “hot” tumor microenvironment in osteosarcoma: a bioinformatic study
10.1007/s10528-023-10374-0 · ExternalCitation · doi-reference
Ligand docking and binding site analysis with PyMOL and autodock/vina
10.1007/s10822-010-9352-6 · ExternalCitation · doi-reference
Oleanolic acid suppresses the proliferation of lung carcinoma cells by miR-122/Cyclin G1/MEF2D axis
10.1007/s11010-014-2228-7 · ExternalCitation · doi-reference
Exploring the underlying mechanism of oleanolic acid treating glioma by transcriptome and molecular docking
10.1016/j.biopha.2022.113586 · ExternalCitation · doi-reference
Oleanolic acid and its derivatives: new inhibitor of protein tyrosine phosphatase 1B with cellular activities
10.1016/j.bmc.2008.07.080 · ExternalCitation · doi-reference
Naringenin induces ferroptosis in osteosarcoma cells through the STAT3-MGST2 signaling pathway
10.1016/j.jbo.2024.100657 · ExternalCitation · doi-reference
Inhibition of colorectal cancer aggressiveness by oleanolic acid through Nur77 degradation
10.1016/j.phymed.2024.156192 · ExternalCitation · doi-reference
Oleanolic acid inhibits M2 macrophage polarization and potentiates anti-PD-1 therapy in hepatocellular carcinoma by targeting miR-130b-3p-PTEN-PI3K-Akt signaling and glycolysis
10.1016/j.phymed.2025.156750 · ExternalCitation · doi-reference
The role of lipoxygenases in pathophysiology; new insights and future perspectives
10.1016/j.redox.2015.08.006 · ExternalCitation · doi-reference
Inhibition of APOC1 promotes the transformation of M2 into M1 macrophages via the ferroptosis pathway and enhances anti-PD1 immunotherapy in hepatocellular carcinoma based on single-cell RNA sequencing
10.1016/j.redox.2022.102463 · ExternalCitation · doi-reference
Robust enumeration of cell subsets from tissue expression profiles
10.1038/nmeth.3337 · ExternalCitation · doi-reference
Crystal structures of human MGST2 reveal synchronized conformational changes regulating catalysis
10.1038/s41467-021-21924-8 · ExternalCitation · doi-reference
ARIH1 activates STING-Mediated T-cell activation and sensitizes tumors to immune checkpoint blockade
10.1038/s41467-023-39920-5 · ExternalCitation · doi-reference
Non-genetic mechanisms of therapeutic resistance in cancer
10.1038/s41568-020-00302-4 · ExternalCitation · doi-reference
Oncogenic role and potential regulatory mechanism of topoisomerase IIα in a pan-cancer analysis
10.1038/s41598-022-15205-7 · ExternalCitation · doi-reference
The role of TOP2A in immunotherapy and vasculogenic mimicry in non-small cell lung cancer and its potential mechanism
10.1038/s41598-023-38117-6 · ExternalCitation · doi-reference
Expression and potential molecular mechanism of TOP2A in metastasis of non-small cell lung cancer
10.1038/s41598-024-63055-2 · ExternalCitation · doi-reference
Single cell-RNA sequencing reveal TOP2A as a key driver of hepatocellular carcinoma progression
10.1038/s41598-025-16785-w · ExternalCitation · doi-reference
Omics data analysis reveals common molecular basis of small cell lung cancer and COVID-19
10.1080/07391102.2023.2257803 · ExternalCitation · doi-reference
clusterProfiler: an R package for comparing biological themes among gene clusters
10.1089/omi.2011.0118 · ExternalCitation · doi-reference
Cytoscape: a software environment for integrated models of biomolecular interaction networks
10.1101/gr.1239303 · ExternalCitation · doi-reference
TOP2A copy number and TOP2A expression in uterine benign smooth muscle tumours and leiomyosarcoma
10.1136/jclinpath-2015-203561 · ExternalCitation · doi-reference
GSVA: gene set variation analysis for microarray and RNA-Seq data
10.1186/1471-2105-14-7 · ExternalCitation · doi-reference
Prognostication of prostate cancer based on TOP2A protein and gene assessment: TOP2A in prostate cancer
10.1186/1479-5876-11-36 · ExternalCitation · doi-reference
A noval prognostic signature of the N7-methylguanosine (m7G)-related miRNA in lung adenocarcinoma
10.1186/s12890-022-02290-7 · ExternalCitation · doi-reference
Genomic features and its potential implication in bone oligometastatic NSCLC
10.1186/s12890-023-02354-2 · ExternalCitation · doi-reference
Comprehensive analysis reveals the potential value of inflammatory response genes in the prognosis, immunity, and drug sensitivity of lung adenocarcinoma
10.1186/s12920-022-01340-7 · ExternalCitation · doi-reference
Integrated bioinformatics analysis and experimental validation reveal the relationship between ALOX5AP and the prognosis and immune microenvironment in glioma
10.1186/s12920-024-01991-8 · ExternalCitation · doi-reference
ZMIZ2 promotes the development of triple-receptor negative breast cancer
10.1186/s12935-021-02393-x · ExternalCitation · doi-reference
Study on the expression of TOP2A in hepatocellular carcinoma and its relationship with patient prognosis
10.1186/s12935-021-02439-0 · ExternalCitation · doi-reference
NFIC mediates m6A mRNA methylation to orchestrate transcriptional and post-transcriptional regulation to represses malignant phenotype of non-small cell lung cancer cells
10.1186/s12935-024-03414-1 · ExternalCitation · doi-reference
Altered metabolism in cancer: insights into energy pathways and therapeutic targets
10.1186/s12943-024-02119-3 · ExternalCitation · doi-reference
Emerging insights of tumor heterogeneity and drug resistance mechanisms in lung cancer targeted therapy
10.1186/s13045-019-0818-2 · ExternalCitation · doi-reference
Improving bioscience research reporting: the ARRIVE guidelines for reporting animal research
10.1371/journal.pbio.1000412 · ExternalCitation · doi-reference
Ferroptosis-related APOE, BCL3 and ALOX5AP gene polymorphisms are associated with the risk of thyroid cancer
10.2147/pgpm.s352225 · ExternalCitation · doi-reference
Oleanolic acid conjugated chitosan nanocomplex exerts anti-tumor effects by inhibiting autophagy in lung cancer cells through the signal transducers and activators of transcription 3/B cell lymphoma-2 signaling pathway
10.26402/jpp.2024.3.08 · ExternalCitation · doi-reference
Identification of CDK2-Related immune forecast model and ceRNA in lung adenocarcinoma, a pan-cancer analysis
10.3389/fcell.2021.682002 · ExternalCitation · doi-reference
A fast multi-locus ridge regression algorithm for high-dimensional genome-wide association studies
10.3389/fgene.2021.649196 · ExternalCitation · doi-reference
Shaping polarization of tumor-associated macrophages in cancer immunotherapy
10.3389/fimmu.2022.888713 · ExternalCitation · doi-reference
Revealing the significance of tissue-resident memory T cells in lung adenocarcinoma through bioinformatic analysis and experimental validation
10.3389/fimmu.2025.1600863 · ExternalCitation · doi-reference
Identify and validate the transcriptomic, functional network, and predictive validity of FBXL19-AS1 in hepatocellular carcinoma
10.3389/fonc.2020.609601 · ExternalCitation · doi-reference
ALOX5AP predicts poor prognosis by enhancing M2 macrophages polarization and immunosuppression in serous ovarian cancer microenvironment
10.3389/fonc.2021.675104 · ExternalCitation · doi-reference
Neutrophil extracellular traps-associated modification patterns depict the tumor microenvironment, precision immunotherapy, and prognosis of clear cell renal cell carcinoma
10.3389/fonc.2022.1094248 · ExternalCitation · doi-reference
Rethinking network analysis in ethnopharmacology: a multi-omics and AI roadmap to overcome conceptual and methodological biases
10.3389/fphar.2026.1748478 · ExternalCitation · doi-reference
Oleanolic acid and its derivatives in breast cancer therapy: mechanistic insights, structural modifications, and novel delivery strategies
10.3389/fphar.2026.1755987 · ExternalCitation · doi-reference
Worldwide traceability of antibiotic residues from livestock in wastewater and soil: a systematic review
10.3390/ani12010060 · ExternalCitation · doi-reference
SRF rearrangements in soft tissue tumors with muscle differentiation
10.3390/biom12111678 · ExternalCitation · doi-reference
Therapeutic potential of plants and plant derived phytochemicals against acetaminophen-induced liver injury
10.3390/ijms19123776 · ExternalCitation · doi-reference
Oleanolic acid and its derivatives: biological activities and therapeutic potential in chronic diseases
10.3390/molecules22111915 · ExternalCitation · doi-reference
Ursolic and oleanolic acids induce mitophagy in A549 human lung cancer cells
10.3390/molecules24193444 · ExternalCitation · doi-reference
The role of pentacyclic triterpenoids in non-small cell lung cancer: the mechanisms of action and therapeutic potential
10.3390/pharmaceutics17010022 · ExternalCitation · doi-reference
Towards a contactless stress classification using thermal imaging
10.3390/s22030976 · ExternalCitation · doi-reference
Antihypertensive activity of oleanolic acid is mediated via downregulation of secretory phospholipase A2 and fatty acid synthase in spontaneously hypertensive rats
10.3892/ijmm.2020.4744 · ExternalCitation · doi-reference
Effect of EZH2 on pulmonary artery smooth muscle cell migration in pulmonary hypertension
10.3892/mmr.2020.11768 · ExternalCitation · doi-reference
TOP2A promotes lung adenocarcinoma cells' malignant progression and predicts poor prognosis in lung adenocarcinoma
10.7150/jca.41415 · ExternalCitation · doi-reference
Comprehensive analysis of expression and prognostic value of GATAs in lung cancer
10.7150/jca.52623 · ExternalCitation · doi-reference
