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References from Novel PE‐DT-fusion toxin enhances internalization and target-dependently restores the cytotoxicity of recombinant immunotoxins. Local targets link to admitted publications; unresolved targets remain external evidence.
CAT-8015: a second-generation pseudomonas exotoxin A-based immunotherapy targeting CD22-expressing hematologic malignancies
10.1158/1078-0432.ccr-08-1456 · 2009 · External reference
Advances in anticancer immunotoxin therapy
10.1634/theoncologist.2014-0358 · 2015 · External reference
Immunotoxin: a new tool for cancer therapy
10.1177/1010428317692226 · 2017 · External reference
Reduced cytotoxicity by mutation of lysine 590 of pseudomonas exotoxin can be restored in an optimized, lysine-free immunotoxin
10.1093/immadv/ltac007 · 2022 · External reference
Essential role for bim in mediating the apoptotic and antitumor activities of immunotoxins
10.1038/onc.2017.111 · 2017 · External reference
Syndecans: multifunctional cell-surface co-receptors
10.1042/bj3270001 · 1997 · External reference
Anti-mesothelin recombinant immunotoxin therapy for colorectal cancer
10.1016/j.clcc.2019.06.006 · 2019 · External reference
Factors affecting endotoxin removal from recombinant therapeutic proteins by anion exchange chromatography
10.1016/j.pep.2008.10.006 · 2009 · External reference
Targeting negative surface charges of cancer cells by multifunctional nanoprobes
10.7150/thno.16358 · 2016 · External reference
Does fusion of domains from unrelated proteins affect their folding pathways and the structural changes involved in their function? A case study with the diphtheria toxin T domain
10.1093/protein/15.5.383 · 2002 · External reference
The crystal structure of diphtheria toxin
10.1038/357216a0 · 1992 · External reference
Mesothelin antigen density influences anti-mesothelin chimeric antigen receptor T cell cytotoxicity
10.1016/j.jcyt.2024.01.011 · 2024 · External reference
Harnessing the potential of CAR-T cell therapy: progress, challenges, and future directions in hematological and solid tumor treatments
10.1186/s12967-023-04292-3 · 2023 · External reference
Diphtheria toxin forms transmembrane channels in planar lipid bilayers
10.1073/pnas.78.1.172 · 1981 · External reference
Receptor-mediated internalization and degradation of diphtheria toxin by monkey kidney cells
10.1016/s0021-9258(19)86490-6 · 1979 · External reference
Differential cellular internalization of anti-CD19 and -CD22 immunotoxins results in different cytotoxic activity
10.1158/0008-5472.can-08-0461 · 2008 · External reference
10.1016/b978-0-12-809199-9.00003-3
10.1016/b978-0-12-809199-9.00003-3 · 2017 · External reference
Engineered Anti-GPC3 immunotoxin, HN3-ABD-T20, produces regression in mouse liver cancer xenografts through prolonged serum retention
10.1002/hep.30949 · 2020 · External reference
10.1007/978-1-62703-637-5_13
10.1007/978-1-62703-637-5_13 · 2013 · External reference
Immunotoxin targeting glypican-3 regresses liver cancer via dual inhibition of wnt signalling and protein synthesis
10.1038/ncomms7536 · 2015 · External reference
Triton X-114 and amine-based wash strategy reduces lipopolysaccharides to FDA limit and achieves purer, more potent recombinant immunotoxin
10.1021/acs.bioconjchem.1c00013 · 2021 · External reference
Role of acidic residues in helices TH8-TH9 in membrane interactions of the diphtheria toxin T domain
10.3390/toxins7041303 · 2015 · External reference
Considerations for the design of antibody-based therapeutics
10.1016/j.xphs.2019.05.031 · 2020 · External reference
Pathways and mechanisms of endocytic recycling
10.1038/nrm2755 · 2009 · External reference
Anti-CD22–chimeric antigen receptors targeting B-cell precursor acute lymphoblastic leukemia
10.1182/blood-2012-06-438002 · 2013 · External reference
Mesothelin-targeted Thorium-227 conjugate (MSLN-TTC): preclinical evaluation of a new targeted alpha therapy for mesothelin-positive cancers
10.1158/1078-0432.ccr-18-3476 · 2019 · External reference
Mesothelin-targeted recombinant immunotoxins for solid tumors
10.3390/biom10070973 · 2020 · External reference
Immunotoxin screening system: a rapid and direct approach to obtain functional antibodies with internalization capacities
10.3390/toxins12100658 · 2020 · External reference
A recombinant immunotoxin targeting CD22 with low immunogenicity, low nonspecific toxicity, and high antitumor activity in mice
10.1097/cji.0b013e3181cd1164 · 2010 · External reference
Combining the antimesothelin immunotoxin SS1P with the BH3-mimetic ABT-737 induces cell death in SS1P-resistant pancreatic cancer cells
10.1097/cji.0000000000000010 · 2014 · External reference
Methylation-associated partial down-regulation of mesothelin causes resistance to anti-mesothelin immunotoxins in a pancreatic cancer cell line
10.1371/journal.pone.0122462 · 2015 · External reference
High throughput cytotoxicity screening of anti-HER2 immunotoxins conjugated with antibody fragments from phage-displayed synthetic antibody libraries
10.1038/srep31878 · 2016 · External reference
Functional domains of pseudomonas exotoxin identified by deletion analysis of the gene expressed in E. coli
10.1016/0092-8674(87)90363-1 · 1987 · External reference
The KDEL retrieval system is exploited by pseudomonas exotoxin A, but not by Shiga-like toxin-1, during retrograde transport from the golgi complex to the endoplasmic reticulum
10.1242/jcs.112.4.467 · 1999 · External reference
Hairy cell leukemia: present and future directions
10.1080/10428194.2019.1608536 · 2019 · External reference
Recombinant immunotoxins containing truncated bacterial toxins for the treatment of hematologic malignancies
10.2165/00063030-200923010-00001 · 2009 · External reference
Importance of the glutamate residue of KDEL in increasing the cytotoxicity of pseudomonas exotoxin derivatives and for increased binding to the KDEL receptor
10.1042/bj3070029 · 1995 · External reference
Phase I trial of recombinant immunotoxin RFB4(dsFv)-PE38 (BL22) in patients with B-cell malignancies
10.1200/jco.2005.11.437 · 2005 · External reference
Conformational switching, refolding and membrane insertion of the diphtheria toxin translocation domain
10.1016/bs.mie.2020.12.016 · 2021 · External reference
Favorable therapeutic response after anti-Mesothelin antibody-drug conjugate treatment requires high expression of Mesothelin in tumor cells
10.1007/s00404-020-05734-9 · 2020 · External reference
Quantitative molecular profiling of biomarkers for pancreatic cancer with functionalized quantum dots
10.1016/j.nano.2012.01.005 · 2012 · External reference
Strategies to mitigate the on- and off-target toxicities of recombinant immunotoxins: an antibody engineering perspective
10.1093/abt/tbac014 · 2022 · External reference
Combinatorial efficacy and toxicity of an engineered toxin body MT-3724 with gemcitabine and oxaliplatin in relapsed or refractory diffuse large B cell lymphoma
10.1080/07357907.2022.2162073 · 2023 · External reference
Protein kinase inhibitor H89 enhances the activity of pseudomonas exotoxin A–Based immunotoxins
10.1158/1535-7163.mct-15-0828 · 2016 · External reference
Multiple myeloma long-term survivors exhibit sustained immune alterations decades after first-line therapy
10.1038/s41467-024-54543-0 · 2024 · External reference
Pseudomonas exotoxin A: optimized by evolution for effective killing
10.3389/fmicb.2015.00963 · 2015 · External reference
Receptor crosslinking: a general method to trigger internalization and lysosomal targeting of therapeutic receptor:ligand complexes
10.1038/mt.2015.178 · 2015 · External reference
New insights on pseudomonas aeruginosa exotoxin A-based immunotoxins in targeted cancer therapeutic delivery
10.4155/tde-2022-0055 · 2023 · External reference
Paclitaxel synergizes with exposure time adjusted CD22-targeting immunotoxins against B-cell malignancies
10.18632/oncotarget.16141 · 2017 · External reference
Domain II of pseudomonas exotoxin is critical for efficacy of bolus doses in a xenograft model of acute lymphoblastic leukemia
10.3390/toxins1050210 · 2018 · External reference
Mechanism of diphtheria toxin catalytic domain delivery to the eukaryotic cell cytosol and the cellular factors that directly participate in the process
10.3390/toxins3030294 · 2011 · External reference
A new optimized version of a colorectal cancer-targeted immunotoxin based on a non-immunogenic variant of the ribotoxin α-Sarcin
10.3390/cancers15041114 · 2023 · External reference
CD22 is a recycling receptor that can shuttle cargo between the cell surface and endosomal compartments of B cells
10.4049/jimmunol.1003005 · 2011 · External reference
Lysine acetylation regulates the interaction between proteins and membranes
10.1038/s41467-021-26657-2 · 2021 · External reference
10.1007/978-1-61779-974-7_35
10.1007/978-1-61779-974-7_35 · 2012 · External reference
Unresolved reference
2004 · External reference
Immunotoxin therapy of cancer
10.1038/nrc1891 · 2006 · External reference
Immunotoxin treatment of cancer
10.1146/annurev.med.58.070605.115320 · 2007 · External reference
Large B-cell lymphoma imprints a dysfunctional immune phenotype that persists years after treatment
10.1182/blood.2024027877 · 2025 · External reference
Tagraxofusp in blastic plasmacytoid dendritic-cell neoplasm
10.1056/nejmoa1815105 · 2019 · External reference
The use of 7-amino actinomycin D in identifying apoptosis: simplicity of use and broad spectrum of application compared with other techniques
10.1182/blood.v87.6.2244.bloodjournal8762244 · 1996 · External reference
Convergent potency of internalized gelonin immunotoxins across varied cell lines, antigens, and targeting moieties
10.1074/jbc.m110.186973 · 2011 · External reference
Modulation of target antigen density improves CAR T-cell functionality and persistence
10.1158/1078-0432.ccr-18-3784 · 2019 · External reference
Uptake of diphtheria toxin and its fragment A moiety by mammalian cells in culture
10.1128/iai.14.3.742-751.1976 · 1976 · External reference
A new age of precision gene therapy
10.1016/s0140-6736(23)01952-9 · 2023 · External reference
A modeling analysis of the effects of molecular size and binding affinity on tumor targeting
10.1158/1535-7163.mct-09-0195 · 2009 · External reference
Interaction of poly-l-lysine coating and heparan sulfate proteoglycan on magnetic nanoparticle uptake by tumor cells
10.2147/ijn.s156029 · 2018 · External reference
Immunotoxins for leukemia
10.1182/blood-2014-01-492256 · 2014 · External reference
Phase 1 study of the anti-CD22 immunotoxin moxetumomab pasudotox for childhood acute lymphoblastic leukemia
10.1182/blood-2017-02-749101 · 2017 · External reference
A protease-resistant immunotoxin against CD22 with greatly increased activity against CLL and diminished animal toxicity
10.1182/blood-2008-08-173195 · 2009 · External reference
A recombinant immunotoxin against the tumor-associated antigen mesothelin reengineered for high activity, low off-target toxicity, and reduced antigenicity
10.1158/1535-7163.mct-12-0336 · 2013 · External reference
Evading the proteasome: absence of lysine residues contributes to pertussis toxin activity by evasion of proteasome degradation
10.1128/iai.02011-06 · 2007 · External reference
Syndecan-1 is critical in ARF6-Dependent macropinocytosis driven by KRAS mutation in the pathophysiology of multiple myeloma
10.1182/blood-2019-127454 · 2019 · External reference
Mechanism of insertion of diphtheria toxin: peptide entry and pore size determinations
10.1073/pnas.81.11.3341 · 1984 · External reference