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References from Role of ALDH2 in myocardial ischemia-reperfusion injury: using ALDH2 as a potential therapeutic target. Local targets link to admitted publications; unresolved targets remain external evidence.
Lipid peroxidation: production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenal
10.1155/2014/360438 · 2014 · External reference
SNHG3/miR-330-5p/HSD11B1 alleviates myocardial ischemia-reperfusion injury by regulating the ERK/p38 signaling pathway
10.2174/0929866530666230721143705 · 2023 · External reference
Alda-1 modulates the kinetic properties of mitochondrial aldehyde dehydrogenase (ALDH2)
10.1111/febs.13833 · 2016 · External reference
Human aldehyde dehydrogenase genes: alternatively spliced transcriptional variants and their suggested nomenclature
10.1097/fpc.0b013e3283329023 · 2009 · External reference
Lymphocyte communication in myocardial ischemia/reperfusion injury
10.1089/ars.2016.6940 · 2017 · External reference
The pathophysiological role of neutrophil extracellular traps in inflammatory diseases
10.1160/th17-09-0630 · 2018 · External reference
Aldehyde dehydrogenase 2 in cardiac protection: a new therapeutic target?
10.1016/j.tcm.2009.09.003 · 2009 · External reference
ROS and redox signaling in myocardial ischemia-reperfusion injury and cardioprotection
10.1016/j.freeradbiomed.2018.01.024 · 2018 · External reference
Activation of aldehyde dehydrogenase-2 reduces ischemic damage to the heart
10.1126/science.1158554 · 2008 · External reference
Targeting aldehyde dehydrogenase 2: new therapeutic opportunities
10.1152/physrev.00017.2013 · 2014 · External reference
Aldehyde dehydrogenase-2 inhibition blocks remote preconditioning in experimental and human models
10.1007/s00395-013-0343-3 · 2013 · External reference
Overview of the role of alcohol dehydrogenase and aldehyde dehydrogenase and their variants in the genesis of alcohol-related pathology
10.1079/pns2003327 · 2004 · External reference
Evolution of the cytokinin dehydrogenase (CKX) domain
10.1007/s00239-021-10035-z · 2021 · External reference
Ferroptosis: an iron-dependent form of nonapoptotic cell death
10.1016/j.cell.2012.03.042 · 2012 · External reference
The genetics of alcohol metabolism: role of alcohol dehydrogenase and aldehyde dehydrogenase variants
2007 · External reference
Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes
10.1016/0891-5849(91)90192-6 · 1991 · External reference
Ferroptosis as a target for protection against cardiomyopathy
10.1073/pnas.1821022116 · 2019 · External reference
Regulation of the inflammatory response in cardiac repair
10.1161/circresaha.111.243162 · 2012 · External reference
Aldehydic load and aldehyde dehydrogenase 2 profile during the progression of post-myocardial infarction cardiomyopathy: benefits of Alda-1
10.1016/j.ijcard.2014.10.140 · 2015 · External reference
East Asian variant of aldehyde dehydrogenase 2 is related to worse cardioprotective results after coronary artery bypass grafting
10.1093/icvts/ivy204 · 2019 · External reference
Impaired cardiac SIRT1 activity by carbonyl stress contributes to aging-related ischemic intolerance
10.1371/journal.pone.0074050 · 2013 · External reference
ALDH2 mediated ferroptosis regulation in ischemia-reperfusion injury
10.1111/jcmm.71072 · 2026 · External reference
Remote ischaemic preconditioning: underlying mechanisms and clinical application
10.1093/cvr/cvn114 · 2008 · External reference
Molecular basis of cardioprotection: signal transduction in ischemic pre-post-and remote conditioning
10.1161/circresaha.116.305348 · 2015 · External reference
Myocardial ischaemia-reperfusion injury and cardioprotection in perspective
10.1038/s41569-020-0403-y · 2020 · External reference
Evolving therapies for myocardial ischemia/reperfusion injury
10.1016/j.jacc.2015.02.032 · 2015 · External reference
East Asian variant aldehyde dehydrogenase type 2 genotype exacerbates ischemia/reperfusion injury with ST-elevation myocardial infarction in men: possible sex differences
10.1007/s00380-021-01907-x · 2022 · External reference
Baicalin protects H9c2 cardiomyocytes against hypoxia/reoxygenation-induced apoptosis and oxidative stress through activation of mitochondrial aldehyde dehydrogenase 2
10.1111/1440-1681.12876 · 2018 · External reference
Sex differences in the phosphorylation of mitochondrial proteins result in reduced production of reactive oxygen species and cardioprotection in females
10.1161/circresaha.109.213645 · 2010 · External reference
p55γ degrades RIP3 via MG53 to suppress ischaemia-induced myocardial necroptosis and mediates cardioprotection of preconditioning
10.1093/cvr/cvad123 · 2023 · External reference
Aldehyde dehydrogenase 2 rs671 G/A and a/A genotypes are associated with the risk of acute myocardial infarction
10.2147/ijgm.s475756 · 2024 · External reference
Matrix-dependent mechanism of neutrophil-mediated release and activation of matrix metalloproteinase 9 in myocardial ischemia/reperfusion
10.1161/01.cir.103.17.2181 · 2001 · External reference
Deubiquitinase OTUD5 as a novel protector against 4-HNE-Triggered ferroptosis in myocardial ischemia/reperfusion injury
10.1002/advs.202301852 · 2023 · External reference
Declines in mitochondrial respiration during cardiac reperfusion: age-dependent inactivation of alpha-ketoglutarate dehydrogenase
10.1073/pnas.96.12.6689 · 1999 · External reference
Aldehyde dehydrogenase 2 (ALDH2) rescues myocardial ischaemia/reperfusion injury: role of autophagy paradox and toxic aldehyde
10.1093/eurheartj/ehq253 · 2011 · External reference
Impaired autophagosome clearance contributes to cardiomyocyte death in ischemia/reperfusion injury
10.1161/circulationaha.111.041814 · 2012 · External reference
Impaired ALDH2 activity decreases the mitochondrial respiration in H9C2 cardiomyocytes
10.1016/j.cellsig.2015.11.006 · 2016 · External reference
Distinct roles of autophagy in the heart during ischemia and reperfusion: roles of AMP-activated protein kinase and beclin 1 in mediating autophagy
10.1161/01.res.0000261924.76669.36 · 2007 · External reference
Mechanisms underlying acute protection from cardiac ischemia-reperfusion injury
10.1152/physrev.00024.2007 · 2008 · External reference
4-Hydroxy-2-nonenal-mediated impairment of intracellular proteolysis during oxidative stress. Identification of proteasomes as target molecules
10.1074/jbc.274.34.23787 · 1999 · External reference
Diabetic aldehyde dehydrogenase 2 mutant (ALDH2*2) mice are more susceptible to cardiac ischemic-reperfusion injury due to 4-Hydroxy-2-Nonenal induced coronary endothelial cell damage
10.1161/jaha.121.021140 · 2021 · External reference
Neutrophil extracellular traps in immunity and disease
10.1038/nri.2017.105 · 2018 · External reference
Alda-1 is an agonist and chemical chaperone for the common human aldehyde dehydrogenase 2 variant
10.1038/nsmb.1737 · 2010 · External reference
Molecular mechanisms of alcohol-mediated carcinogenesis
10.1038/nrc2191 · 2007 · External reference
Targeting E3 ubiquitin ligase Hrd1 prevents myocardial ischemia-reperfusion injury through enhancing ALDH2 enzymatic activity
10.1161/circulationaha.125.074399 · 2026 · External reference
Myocardial substrate metabolism in the normal and failing heart
10.1152/physrev.00006.2004 · 2005 · External reference
Aldehyde dehydrogenase 2 gene is a risk factor for myocardial infarction in Japanese men
10.1291/hypres.25.677 · 2002 · External reference
Fourth universal definition of myocardial infarction (2018)
10.1016/j.jacc.2018.08.1038 · 2018 · External reference
European society of cardiology: cardiovascular disease statistics 2019
10.1093/eurheartj/ehz859 · 2020 · External reference
Role of iron in carcinogenesis: cancer as a ferrotoxic disease
10.1111/j.1349-7006.2008.01001.x · 2009 · External reference
Heart disease and stroke Statistics-2023 update: a report from the American heart association
10.1161/cir.0000000000001123 · 2023 · External reference
4-Hydroxy-2-nonenal: a product and mediator of oxidative stress
10.1016/s0163-7827(03)00014-6 · 2003 · External reference
Analysis and update of the human aldehyde dehydrogenase (ALDH) gene family
10.1186/1479-7364-2-2-138 · 2005 · External reference
Effect of remote ischemic conditioning on infarct size in patients with anterior ST-elevation myocardial infarction
10.1016/j.ahj.2016.08.004 · 2016 · External reference
Involvement of neutrophils in the pathogenesis of lethal myocardial reperfusion injury
10.1016/j.cardiores.2003.10.011 · 2004 · External reference
Heart disease and stroke Statistics-2021 update: a report from the American heart association
10.1161/cir.0000000000000950 · 2021 · External reference
Mitochondrial PKC-ε deficiency promotes I/R-mediated myocardial injury via GSK3β-dependent mitochondrial permeability transition pore opening
10.1111/jcmm.13121 · 2017 · External reference
Histone lactylation boosts reparative gene activation post-myocardial infarction
10.1161/circresaha.122.320488 · 2022 · External reference
Regulated cell death in myocardial ischemia-reperfusion injury
10.1016/j.tem.2023.10.010 · 2024 · External reference
Regulation of ferroptotic cancer cell death by GPX4
10.1016/j.cell.2013.12.010 · 2014 · External reference
Myocardial reperfusion injury exacerbation due to ALDH2 deficiency is mediated by neutrophil extracellular traps and prevented by leukotriene C4 inhibition
10.1093/eurheartj/ehae205 · 2024 · External reference
Molecular abnormality of an inactive aldehyde dehydrogenase variant commonly found in orientals
10.1073/pnas.81.1.258 · 1984 · External reference
Remote ischemic postconditioning protects the heart by upregulating ALDH2 expression levels through the PI3K/Akt signaling pathway
10.3892/mmr.2014.2156 · 2014 · External reference
4-Hydroxy-2-Nonenal promotes cardiomyocyte necroptosis via stabilizing receptor-interacting Serine/threonine-protein kinase 1
10.3389/fcell.2021.721795 · 2021 · External reference
Autophagy in ALDH2-elicited cardioprotection against ischemic heart disease: slayer or savior?
10.4161/auto.6.8.13652 · 2010 · External reference
Effect of mitochondrial aldehyde dehydrogenase-2 genotype on cardioprotection in patients with congenital heart disease
10.1093/eurheartj/ehs061 · 2012 · External reference
Remote ischemic postconditioning alleviates myocardial ischemia/reperfusion injury by up-regulating ALDH2
10.26355/eurrev_201810_16061 · 2018 · External reference
Aldehyde dehydrogenase 2 preserves mitochondrial morphology and attenuates hypoxia/reoxygenation-induced cardiomyocyte injury
10.5847/wjem.j.1920-8642.2020.04.007 · 2020 · External reference
A comparative study: cardioprotective effects of high-intensity interval training Versus ischaemic preconditioning in rat myocardial ischaemia-reperfusion
10.3390/life14030310 · 2024 · External reference
Identification of an MGST2 gene and analysis of its function in antioxidant processes in apis cerana cerana
10.1002/arch.21770 · 2021 · External reference
Design, synthesis, and protective effect evaluation on myocardial ischemia of new triazole aldehyde dehydrogenase 2 activators
10.1021/acsmedchemlett.5c00291 · 2025 · External reference
The role of oxidants and free radicals in reperfusion injury
10.1016/j.cardiores.2006.02.025 · 2006 · External reference