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References from Polysaccharides from the root tubers of Curcuma wenyujin ameliorate cholestatic liver injury associated with remodeling gut microbiota and restoring bile acid homeostasis. Local targets link to admitted publications; unresolved targets remain external evidence.
Bile acids induce inflammatory genes in hepatocytes: a novel mechanism of inflammation during obstructive cholestasis
10.1016/j.ajpath.2010.11.026 · 2011 · External reference
Cholangiocyte pathobiology
10.1038/s41575-019-0125-y · 2019 · External reference
The interaction between bacteria and bile
10.1016/j.femsre.2004.09.003 · 2005 · External reference
UDCA, NorUDCA, and TUDCA in liver diseases: a review of their mechanisms of action and clinical applications
10.1007/164_2019_241 · 2019 · External reference
Disruption of bile acid metabolism in the gut–liver axis predisposes mice to inflammatory bowel disease
10.1002/mco2.70429 · 2025 · External reference
EASL clinical practice guidelines: management of cholestatic liver diseases
10.1016/j.jhep.2009.04.009 · 2009 · External reference
Bile acid metabolism and signalling in liver disease
10.1016/j.jhep.2024.09.032 · 2025 · External reference
Enteronephrohepatic circulation of bile acids and therapeutic potential of systemic bile acid transporter inhibitors
10.1016/j.jhep.2025.05.009 · 2025 · External reference
Neutrophils aggravate acute liver injury during obstructive cholestasis in bile duct-ligated mice
10.1053/jhep.2003.50341 · 2003 · External reference
JiaGaSongTang improves chronic cholestasis via enhancing FXR-Mediated bile acid metabolism
10.1016/j.phymed.2024.155347 · 2024 · External reference
Cholestatic liver diseases: a primer for generalists and subspecialists
10.1016/j.mayocp.2020.01.015 · 2020 · External reference
Blockade of neutrophil extracellular trap components ameliorates cholestatic liver disease in Mdr2 (Abcb4) knockout mice
10.1016/j.jaut.2024.103229 · 2024 · External reference
Exploring the associations of gut microbiota with inflammatory and the early hematoma expansion in intracerebral hemorrhage: from change to potential therapeutic objectives
10.3389/fcimb.2025.1462562 · 2025 · External reference
The gut microbial influence on cholestatic liver disease
10.1111/liv.14153 · 2019 · External reference
The combination of curcumae radix and Syzygium aromaticum extracts mitigates benign prostatic hyperplasia through anti-proliferative and anti-inflammatory effects
10.5534/wjmh.240071 · 2025 · External reference
Protective effect of herbal medicine huangqi decoction against chronic cholestatic liver injury by inhibiting bile acid-stimulated inflammation in DDC-Induced mice
10.1016/j.phymed.2019.152948 · 2019 · External reference
Review of the traditional uses, phytochemistry, and pharmacology of Curcuma wenyujin Y. H. Chen et C. Ling
10.1016/j.jep.2020.113689 · 2021 · External reference
The effect of acetyl structure optimization of spruce (picea abies.) mannan on promoting enzymatic hydrolysis
10.1016/j.ijbiomac.2025.143098 · 2025 · External reference
Dendrobium polysaccharides ameliorate alcohol-induced liver injury by inhibiting the pathogenic ER stress-sphingolipid axis
10.1016/j.phymed.2026.157863 · 2026 · External reference
Gut microbiota and bile acids: metabolic interactions and impacts on diabetic kidney disease
10.1016/j.crmicr.2024.100315 · 2024 · External reference
Targeting SIRT1/AMPK/Nrf2/NF-кB by sitagliptin protects against oxidative stress-mediated ER stress and inflammation during ANIT-Induced cholestatic liver injury
10.1016/j.tox.2024.153889 · 2024 · External reference
A placebo-controlled trial of obeticholic acid in primary biliary cholangitis
10.1056/nejmoa1509840 · 2016 · External reference
Bifidobacterium and lactobacillus improve inflammatory bowel disease in zebrafish of different ages by regulating the intestinal mucosal barrier and microbiota
10.1016/j.lfs.2023.121699 · 2023 · External reference
Peptidoglycan isolated from the fruit of Lycium barbarum alleviates liver fibrosis in mice by regulating the TGF-β/Smad7 signaling and gut microbiota
10.1038/s41401-024-01454-x · 2025 · External reference
Extraction, purification, structural elucidation, and immunomodulatory activity of Bletilla striata polysaccharides via the NF-κB signaling pathway
10.3389/fimmu.2026.1749545 · 2026 · External reference
6α-Ethyl-Chenodeoxycholic acid (6-ECDCA), a potent and selective FXR agonist endowed with anticholestatic activity
10.1021/jm025529g · 2002 · External reference
The preparation and structure analysis methods of natural polysaccharides of plants and fungi: a review of recent development
10.3390/molecules24173122 · 2019 · External reference
Bile salt hydrolase catalyses formation of amine-conjugated bile acids
10.1038/s41586-023-06990-w · 2024 · External reference
Resistance of rat hepatocytes against bile acid-induced apoptosis in cholestatic liver injury is due to nuclear factor-kappa B activation
10.1016/s0168-8278(03)00214-9 · 2003 · External reference
Bioactivities, isolation and purification methods of polysaccharides from natural products: a review
10.1016/j.ijbiomac.2016.06.100 · 2016 · External reference
Crosstalk between bile acid-activated receptors and microbiome in entero-hepatic inflammation
10.1016/j.molmed.2021.12.006 · 2022 · External reference
Mitochondrial dysfunction-mediated hepatocyte senescence is involved in cholestatic liver injury
10.1016/j.freeradbiomed.2025.08.006 · 2025 · External reference
Gut microbiota-mediated therapeutic mechanisms of Dendrobium officinale polysaccharide: a review
10.1016/j.ijbiomac.2026.151361 · 2026 · External reference
Rapid discrimination and screening of volatile markers for varietal recognition of curcumae radix using ATR-FTIR and HS-GC-MS combined with chemometrics
10.1016/j.jep.2021.114422 · 2021 · External reference
Huangqi decoction alleviates alpha-naphthylisothiocyanate induced intrahepatic cholestasis by reversing disordered bile acid and glutathione homeostasis in mice
10.3389/fphar.2017.00938 · 2017 · External reference
Protective effect of astragalus polysaccharides against sodium fluoride-induced liver injury: a comprehensive study based on network pharmacology, metabolomics, and transcriptomics
10.1016/j.ecoenv.2025.118975 · 2025 · External reference
Extraction, purification, structure, modification, and biological activity of traditional Chinese medicine polysaccharides: a review
10.3389/fnut.2022.1005181 · 2022 · External reference
Yu dan tong formula inhibits NLRP3 inflammasome activation by suppressing Ca2+ influx in treating cholestatic liver disease
10.1016/j.phymed.2026.157947 · 2026 · External reference
Discovery of bioactive microbial gene products in inflammatory bowel disease
10.1038/s41586-022-04648-7 · 2022 · External reference
Mulberry water extract alleviates osteoarthritis via lactobacillus johnsonii-dependent bile acid restoration
10.1016/j.phymed.2025.157679 · 2026 · External reference
Adaptive changes in hepatobiliary transporter expression in primary biliary cirrhosis
10.1016/s0168-8278(03)00096-5 · 2003 · External reference
Identification of Yinchenwuling Fang's active components and hepatoprotective effects against cholestatic liver damage induced by alpha-naphthyl isothiocyanate in mice
10.1016/j.jchromb.2022.123570 · 2023 · External reference
