Research graph
References from Synaptic mitochondrial dysfunction and Alzheimer’s disease: from molecular mechanisms to therapeutic strategies. Local targets link to admitted publications; unresolved targets remain external evidence.
Molecular nature and physiological role of the mitochondrial calcium uniporter channel
10.1152/ajpcell.00502.2020 · 2021 · External reference
Presenilins are enriched in endoplasmic reticulum membranes associated with mitochondria
10.2353/ajpath.2009.090219 · 2009 · External reference
Molecular tuning of the axonal mitochondrial Ca2+ uniporter ensures metabolic flexibility of neurotransmission
10.1016/j.neuron.2019.11.020 · 2020 · External reference
Oxidative stress: the core pathogenesis and mechanism of Alzheimer's disease
10.1016/j.arr.2022.101619 · 2022 · External reference
Differential modification of the C-terminal tails of different α-tubulins and their importance for microtubule function in vivo
10.7554/elife.87125 · 2023 · External reference
IP3 receptor isoforms differently regulate ER-mitochondrial contacts and local calcium transfer
10.1038/s41467-019-11646-3 · 2019 · External reference
Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter
10.1038/nature10234 · 2011 · External reference
Adaptive regulation of the brain's antioxidant defences by neurons and astrocytes
10.1016/j.freeradbiomed.2016.06.027 · 2016 · External reference
Targeting dynamin-related protein-1 as a potential therapeutic approach for mitochondrial dysfunction in Alzheimer's disease
10.1016/j.bbadis.2023.166798 · 2023 · External reference
Neuronal mitochondrial calcium uniporter (MCU) deficiency is neuroprotective in hyperexcitability by modulation of metabolic pathways and ROS balance
10.1007/s12035-024-04148-x · 2024 · External reference
Presynaptic mitochondrial calcium sequestration influences transmission at mammalian central synapses
10.1523/jneurosci.22-14-05840.2002 · 2002 · External reference
Lysine 27 ubiquitination of the mitochondrial transport protein Miro is dependent on serine 65 of the Parkin ubiquitin ligase
10.1074/jbc.m114.563031 · 2014 · External reference
The vital role of melatonin and its metabolites in the neuroprotection and retardation of brain aging
10.3390/ijms25105122 · 2024 · External reference
DWORF gene therapy improves cardiac calcium handling and mitochondrial function
10.1161/circresaha.125.326550 · 2025 · External reference
Tau impairs neural circuits, dominating amyloid-β effects, in Alzheimer models in vivo
10.1038/s41593-018-0289-8 · 2019 · External reference
Amyloid beta oligomers-induced Ca2+ entry pathways: role of neuronal networks, NMDA receptors and amyloid channel formation
10.3390/biomedicines10051153 · 2022 · External reference
Mitochondrial aspects of synaptic dysfunction in Alzheimer's Disease
10.3233/jad-160726 · 2017 · External reference
Regulation of axonal mitochondrial transport and its impact on synaptic transmission
10.1016/j.neures.2011.02.005 · 2011 · External reference
Vitagenes, dietary antioxidants and neuroprotection in neurodegenerative diseases
10.2741/3250 · 2009 · External reference
Mitochondria and calcium in Alzheimer’s disease: from cell signaling to neuronal cell death
10.1016/j.tins.2020.10.004 · 2021 · External reference
Increased mitochondrial calcium levels associated with neuronal death in a mouse model of Alzheimer’s disease
10.1038/s41467-020-16074-2 · 2020 · External reference
Time-restricted role for dendritic activation of the mTOR-p70S6K pathway in the induction of late-phase long-term potentiation in the CA1
10.1073/pnas.2336098100 · 2003 · External reference
Local mitochondrial replication in the periphery of neurons requires the eEF1A1 protein and thetranslation of nuclear-encoded proteins
10.1016/j.isci.2024.109136 · 2024 · External reference
Distinct effects of cardiac mitochondrial calcium uniporter inactivation via EMRE deletion in the short and long term
10.1016/j.yjmcc.2023.05.007 · 2023 · External reference
Parkinson's disease mutant Miro1 causes mitochondrial dysfunction and dopaminergic neuron loss
10.1093/brain/awaf051 · 2025 · External reference
SIRT3 haploinsufficiency aggravates loss of GABAergic interneurons and neuronal network hyperexcitability in an Alzheimer's disease model
10.1523/jneurosci.1446-19.2019 · 2020 · External reference
Tortoise plastron and deer antler gelatin prevents against neuronal mitochondrial dysfunction in vitro: implication for a potential therapy of Alzheimer's disease
10.3389/fphar.2021.690256 · 2021 · External reference
Programming axonal mitochondrial maintenance and bioenergetics in neurodegeneration and regeneration
10.1016/j.neuron.2022.03.015 · 2022 · External reference
The mitochondrial calcium uniporter: balancing tumourigenic and anti-tumourigenic responses
10.1113/jp285515 · 2024 · External reference
A cross-sectional comparison of brain glucose and ketone metabolism in cognitively healthy older adults, mild cognitive impairment and early Alzheimer's disease
10.1016/j.exger.2017.07.004 · 2018 · External reference
Microglia monitor and protect neuronal function through specialized somatic purinergic junctions
10.1126/science.aax6752 · 2020 · External reference
Imaging interorganelle contacts and local calcium dynamics at the ER-mitochondrial interface
10.1016/j.molcel.2010.06.029 · 2010 · External reference
MST1, a novel therapeutic target for Alzheimer's disease, regulates mitochondrial homeostasis by mediating mitochondrial DNA transcription and the PI3K-Akt-ROS pathway
10.1186/s12967-024-05852-x · 2024 · External reference
Alzheimer's disease: combination therapies and clinical trials for combination therapy development
10.1007/s40263-024-01103-1 · 2024 · External reference
Can ketones compensate for deteriorating brain glucose uptake during aging? Implications for the risk and treatment of Alzheimer's disease
10.1111/nyas.12999 · 2016 · External reference
A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter
10.1038/nature10230 · 2011 · External reference
Mitochondrial targeting against Alzheimer's disease: lessons from hibernation
10.3390/cells13010012 · 2023 · External reference
Biological sex and DNA repair deficiency drive Alzheimer's disease via systemic metabolic remodeling and brain mitochondrial dysfunction
10.1007/s00401-020-02152-8 · 2020 · External reference
Mitochondria at the neuronal presynapse in health and disease
10.1038/nrn.2017.170 · 2018 · External reference
Long-term potentiation requires a rapid burst of dendritic mitochondrial fission during induction
10.1016/j.neuron.2018.09.025 · 2018 · External reference
3D neuronal mitochondrial morphology in axons, dendrites, and somata of the aging mouse hippocampus
10.1016/j.celrep.2021.109509 · 2021 · External reference
Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer's disease
10.1038/s41593-018-0332-9 · 2019 · External reference
Cell-type-specific profiling of brain mitochondria reveals functional and molecular diversity
10.1038/s41593-019-0479-z · 2019 · External reference
Biogenetic and morphofunctional heterogeneity of mitochondria: the case of synaptic mitochondria
10.1515/revneuro-2016-0077 · 2017 · External reference
Mitochondrial adaptor TRAK2 activates and functionally links opposing kinesin and dynein motors
10.1038/s41467-021-24862-7 · 2021 · External reference
Mitochondrial dynamics in neuronal injury, development and plasticity
10.1242/jcs.171017 · 2017 · External reference
Deletion of a neuronal Drp1 activator protects against cerebral ischemia
10.1523/jneurosci.1926-19.2020 · 2020 · External reference
Alzheimer's disease: from firing instability to homeostasis network collapse
10.1016/j.neuron.2017.11.028 · 2018 · External reference
Microglial large extracellular vesicles propagate early synaptic dysfunction in Alzheimer's disease
10.1093/brain/awac083 · 2022 · External reference
The prevalence of lewy body pathology across nine international community-based cohorts
10.1093/brain/awag112 · 2026 · External reference
Mitochondrial dysfunction and Purkinje cell loss in autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS)
10.1073/pnas.1113166109 · 2012 · External reference
Proteomic profiling of neuronal mitochondria reveals modulators of synaptic architecture
10.1186/s13024-017-0221-9 · 2017 · External reference
The pleiotropic neuroprotective effects of resveratrol in cognitive decline and Alzheimer's disease pathology: from antioxidant to epigenetic therapy
10.1016/j.arr.2021.101271 · 2021 · External reference
Novel small molecular compound 2JY-OBZ4 alleviates AD pathology in cell models via regulating multiple targets
10.18632/aging.204336 · 2022 · External reference
Ablation of ferroptosis regulator glutathione peroxidase 4 in forebrain neurons promotes cognitive impairment and neurodegeneration
10.1016/j.redox.2017.01.021 · 2017 · External reference
Ceftriaxone treatment preserves cortical inhibitory interneuron function via transient salvage of GLT-1 in a rat traumatic brain injury model
10.1093/cercor/bhy328 · 2019 · External reference
The effect of mitochondrial calcium uniporter and cyclophilin D knockout on resistance of brain mitochondria to Ca2+-induced damage
10.1016/j.jbc.2021.100669 · 2021 · External reference
β-amyloid and tau drive early Alzheimer's disease decline while glucose hypometabolism drives late decline
10.1038/s42003-020-1079-x · 2020 · External reference
Synaptic energy use and supply
10.1016/j.neuron.2012.08.019 · 2012 · External reference
Amyloid β oligomers suppress excitatory transmitter release via presynaptic depletion of phosphatidylinositol-4,5-bisphosphate
10.1038/s41467-019-09114-z · 2019 · External reference
Protective effects of luteolin against amyloid beta-induced oxidative stress and mitochondrial impairments through peroxisome proliferator-activated receptor γ-dependent mechanism in Alzheimer's disease
10.1016/j.redox.2023.102848 · 2023 · External reference
Urolithin A improves Alzheimer's disease cognition and restores mitophagy and lysosomal functions
10.1002/alz.13847 · 2024 · External reference
ROCK1 activation-mediated mitochondrial translocation of Drp1 and cofilin are required for arnidiol-induced mitochondrial fission and apoptosis
10.1186/s13046-020-01545-7 · 2020 · External reference
Synaptic vesicle exocytosis in hippocampal synaptosomes correlates directly with total mitochondrial volume
10.1007/s12031-012-9848-8 · 2013 · External reference
Impaired mitochondrial calcium efflux contributes to disease progression in models of Alzheimer's disease
10.1038/s41467-019-11813-6 · 2019 · External reference
Reactive oxygen species, toxicity, oxidative stress, and antioxidants: chronic diseases and aging
10.1007/s00204-023-03562-9 · 2023 · External reference
Fragmented mitochondria released from microglia trigger A1 astrocytic response and propagate inflammatory neurodegeneration
10.1038/s41593-019-0486-0 · 2019 · External reference
The causal role of lipoxidative damage in mitochondrial bioenergetic dysfunction linked to Alzheimer's disease pathology
10.3390/life11050388 · 2021 · External reference
Presynaptic mitochondrial volume and packing density scale with presynaptic power demand
10.1523/jneurosci.1236-21.2021 · 2022 · External reference
Hippocampal phosphorylated tau induced cognitive decline, dendritic spine loss and mitochondrial abnormalities in a mouse model of Alzheimer's disease
10.1093/hmg/ddx381 · 2018 · External reference
Astaxanthin protection against neuronal excitotoxicity via glutamate receptor inhibition and improvement of mitochondrial function
10.3390/md20100645 · 2022 · External reference
Building the neuronal microtubule cytoskeleton
10.1016/j.neuron.2015.05.046 · 2015 · External reference
A ketone ester diet exhibits anxiolytic and cognition-sparing properties, and lessens amyloid and tau pathologies in a mouse model of Alzheimer's disease
10.1016/j.neurobiolaging.2012.11.023 · 2013 · External reference
Mitophagy and Alzheimer's disease: cellular and molecular mechanisms
10.1016/j.tins.2017.01.002 · 2017 · External reference
Alzheimer disease
10.1038/s41572-021-00269-y · 2021 · External reference
Molecular mechanisms of dendrite stability
10.1038/nrn3486 · 2013 · External reference
Mitochondria-associated membranes as hubs for neurodegeneration
10.1007/s00401-015-1528-7 · 2016 · External reference
Organelle-specific sensors for monitoring Ca2+ dynamics in neurons
10.3389/fnsyn.2016.00029 · 2016 · External reference
Emerging roles of mitochondria in synaptic transmission and neurodegeneration
10.1016/j.cophys.2018.03.009 · 2018 · External reference
Energy matters: presynaptic metabolism and the maintenance of synaptic transmission
10.1038/s41583-021-00535-8 · 2022 · External reference
The importance of dendritic mitochondria in the morphogenesis and plasticity of spines and synapses
10.1016/j.cell.2004.11.003 · 2004 · External reference
Transient assembly of F-actin on the outer mitochondrial membrane contributes to mitochondrial fission
10.1083/jcb.201404050 · 2015 · External reference
Myosin light chain kinase facilitates endocytosis of synaptic vesicles at hippocampal boutons
10.1111/jnc.13635 · 2016 · External reference
The cross-talk of energy sensing and mitochondrial anchoring sustains synaptic efficacy by maintaining presynaptic metabolism
10.1038/s42255-020-00289-0 · 2020 · External reference
Mitochondrial support and local translation of mitochondrial proteins in synaptic plasticity and function
10.14670/hh-18-345 · 2021 · External reference
ApoE4 (Δ272-299) induces mitochondrial-associated membrane formation and mitochondrial impairment by enhancing GRP75-modulated mitochondrial calcium overload in neuron
10.1186/s13578-021-00563-y · 2021 · External reference
Clinical evidence of hyperbaric oxygen therapy for Alzheimer's disease: a systematic review and meta-analysis of randomized controlled trials
10.3389/fnagi.2024.1360148 · 2024 · External reference
MICU1 serves as a molecular gatekeeper to prevent in vivo mitochondrial calcium overload
10.1016/j.celrep.2016.07.011 · 2016 · External reference
Miro proteins coordinate microtubule- and actin-dependent mitochondrial transport and distribution
10.15252/embj.201696380 · 2018 · External reference
Loss of neuronal Miro1 disrupts mitophagy and induces hyperactivation of the integrated stress response
10.15252/embj.2018100715 · 2021 · External reference
Mitochondrial transport in neurons and evidence for its involvement in acute neurological disorders
10.3389/fnins.2023.1268883 · 2023 · External reference
Presenilins and mitochondria-an intriguing link: mini-review
10.3389/fnins.2023.1249815 · 2023 · External reference
Mitochondria-targeted antioxidants protect against amyloid-beta toxicity in Alzheimer's disease neurons
10.3233/jad-2010-100564 · 2010 · External reference
Endoplasmic reticulum-mitochondria signaling in neurons and neurodegenerative diseases
10.1242/jcs.248534 · 2022 · External reference
Pharmacological inhibition of the mitochondrial Ca2+ uniporter: relevance for pathophysiology and human therapy
10.1016/j.yjmcc.2020.09.014 · 2021 · External reference
Mitophagy in Alzheimer's disease: molecular defects and therapeutic approaches
10.1038/s41380-022-01631-6 · 2023 · External reference
Hallmarks of brain aging: adaptive and pathological modification by metabolic states
10.1016/j.cmet.2018.05.011 · 2018 · External reference
Mitostasis in neurons: maintaining mitochondria in an extended cellular architecture
10.1016/j.neuron.2017.09.055 · 2017 · External reference
Long-term potentiation in cultured hippocampal neurons
10.1016/j.semcdb.2011.07.017 · 2011 · External reference
Toward common treatment strategies: convergent proteinopathies and mitochondrial dysfunction in Alzheimer's and Parkinson's diseases
10.3389/fnins.2026.1846384 · 2026 · External reference
Premature synaptic mitochondrial dysfunction in the hippocampus during aging contributes to memory loss
10.1016/j.redox.2020.101558 · 2020 · External reference
Mitochondria-targeting by small molecules against Alzheimer's disease: a mechanistic perspective
10.1016/j.bbadis.2024.167617 · 2025 · External reference
Partial inhibition of complex I restores mitochondrial morphology and mitochondria-ER communication in hippocampus of APP/PS1 mice
10.3390/cells12081111 · 2023 · External reference
TG2 promotes amyloid beta aggregates: impact on ER-mitochondria crosstalk, calcium homeostasis and synaptic function in Alzheimer's disease
10.1016/j.biopha.2023.114596 · 2023 · External reference
NOX4 promotes ferroptosis of astrocytes by oxidative stress-induced lipid peroxidation via the impairment of mitochondrial metabolism in Alzheimer's diseases
10.1016/j.redox.2021.101947 · 2021 · External reference
The role of mitochondrially derived ATP in synaptic vesicle recycling
10.1074/jbc.m115.656405 · 2015 · External reference
MICU1 and MICU2 finely tune the mitochondrial Ca2+ uniporter by exerting opposite effects on MCU activity
10.1016/j.molcel.2014.01.013 · 2014 · External reference
The interaction of mitochondrial biogenesis and fission/fusion mediated by PGC-1α regulates rotenone-induced dopaminergic neurotoxicity
10.1007/s12035-016-9944-9 · 2017 · External reference
Central and peripheral metabolic defects contribute to the pathogenesis of Alzheimer's disease: targeting mitochondria for diagnosis and prevention
10.1089/ars.2019.7763 · 2020 · External reference
An energetic view of stress: focus on mitochondria
10.1016/j.yfrne.2018.01.001 · 2018 · External reference
Presenilin-2 and calcium handling: molecules, organelles, cells and brain networks
10.3390/cells9102166 · 2020 · External reference
Are mitophagy enhancers therapeutic targets for Alzheimer's disease?
10.1016/j.biopha.2022.112918 · 2022 · External reference
Mitochondria in aging and Alzheimer's disease: focus on mitophagy
10.1177/10738584221139761 · 2024 · External reference
Impact of diet and exercise on mitochondrial quality and mitophagy in Alzheimer's disease
10.1016/j.arr.2025.102734 · 2025 · External reference
Pleiotropic mitochondria: the influence of mitochondria on neuronal development and disease
10.1523/jneurosci.1157-19.2019 · 2019 · External reference
Microglia-mediated synapse loss in Alzheimer's disease
10.1523/jneurosci.1136-17.2017 · 2018 · External reference
Spatially stable mitochondrial compartments fuel local translation during plasticity
10.1016/j.cell.2018.12.013 · 2019 · External reference
Are mitochondria critical in the pathogenesis of Alzheimer's disease?
10.1016/j.brainresrev.2005.03.004 · 2005 · External reference
Amyloid beta and phosphorylated tau-induced defective autophagy and mitophagy in Alzheimer's disease
10.3390/cells8050488 · 2019 · External reference
Chrononutrition and energy balance: how meal timing and circadian rhythms shape weight regulation and metabolic health
10.3390/nu17132135 · 2025 · External reference
Mitochondria as sensors and regulators of calcium signalling
10.1038/nrm3412 · 2012 · External reference
Proteomic profiling of mitochondrial-derived vesicles in brain reveals enrichment of respiratory complex sub-assemblies and small TIM chaperones
10.1021/acs.jproteome.0c00506 · 2021 · External reference
Mitochondrial fission controls astrocyte morphogenesis and organization in the cortex
10.1083/jcb.202410130 · 2025 · External reference
Susceptibility to cellular stress in PS1 mutant N2a cells is associated with mitochondrial defects and altered calcium homeostasis
10.1038/s41598-020-63254-7 · 2012 · External reference
Loss of mitochondrial Ca2+ uptake protein 3 impairs skeletal muscle calcium handling and exercise capacity
10.1113/jp284894 · 2024 · External reference
Glutamate excitotoxicity and Ca2+-regulation of respiration: role of the Ca2+ activated mitochondrial transporters (CaMCs)
10.1016/j.bbabio.2016.04.003 · 2016 · External reference
Transmission electron microscopy study of mitochondria in aging brain synapses
10.3390/antiox8060171 · 2019 · External reference
Metformin use is associated with slowed cognitive decline and reduced incident dementia in older adults with type 2 diabetes: the Sydney memory and ageing study
10.2337/dc20-0892 · 2020 · External reference
Alzheimer's Aβ assembly binds sodium pump and blocks endothelial NOS activity via ROS-PKC pathway in brain vascular endothelial cells
10.1016/j.isci.2021.102936 · 2021 · External reference
Mechanisms and roles of mitochondrial localisation and dynamics in neuronal function
10.1042/ns20200008 · 2020 · External reference
Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory
10.1038/nm1782 · 2008 · External reference
Mitochondrial dysfunction as a driver of cognitive impairment in Alzheimer's disease
10.3390/ijms22094850 · 2021 · External reference
Ginsenoside RK1 improves cognitive impairments and pathological changes in Alzheimer's disease via stimulation of the AMPK/Nrf2 signaling pathway
10.1016/j.phymed.2023.155168 · 2024 · External reference
Neurovascular coupling in the dentate gyrus regulates adult hippocampal neurogenesis
10.1016/j.neuron.2019.05.045 · 2019 · External reference
The mitochondrial voltage-dependent anion channel 1, Ca2+ transport, apoptosis, and their regulation
10.3389/fonc.2017.00060 · 2017 · External reference
Hyperglycemia in a type 1 diabetes mellitus model causes a shift in mitochondria coupled-glucose phosphorylation and redox metabolism in rat brain
10.1016/j.freeradbiomed.2020.09.017 · 2020 · External reference
Parkin and PINK1 mitigate STING-induced inflammation
10.1038/s41586-018-0448-9 · 2018 · External reference
Mitochondrial support of persistent presynaptic vesicle mobilization with age-dependent synaptic growth after LTP
10.7554/elife.15275 · 2016 · External reference
Alterations in synaptic function and plasticity in Huntington disease
10.1111/jnc.14723 · 2019 · External reference
Repairing mitochondrial dysfunction in disease
10.1146/annurev-pharmtox-010716-104908 · 2018 · External reference
Reconstitution of mitochondria derived vesicle formation demonstrates selective enrichment of oxidized cargo
10.1371/journal.pone.0052830 · 2012 · External reference
The intersection of amyloid beta and tau at synapses in Alzheimer's disease
10.1016/j.neuron.2014.05.004 · 2014 · External reference
Partial inhibition of mitochondrial complex I ameliorates Alzheimer's disease pathology and cognition in APP/PS1 female mice
10.1038/s42003-020-01584-y · 2021 · External reference
Inhibition of DRP1-dependent mitochondrial fission by Mdivi-1 alleviates atherosclerosis through the modulation of M1 polarization
10.1186/s12967-023-04270-9 · 2023 · External reference
The molecular machinery of neurotransmitter release (Nobel lecture)
10.1002/anie.201406359 · 2014 · External reference
Motile axonal mitochondria contribute to the variability of presynaptic strength
10.1016/j.celrep.2013.06.040 · 2013 · External reference
Dysfunctional mitochondrial bioenergetics and synaptic degeneration in alzheimer disease
10.5213/inj.1938036.018 · 2019 · External reference
GLP-1RA and SGLT2i medications for type 2 diabetes and alzheimer disease and related dementias
10.1001/jamaneurol.2025.0353 · 2025 · External reference
Synaptic mitochondria: an early target of Amyloid-β and Tau in Alzheimer's disease
10.3233/jad-215139 · 2021 · External reference
Pathologically phosphorylated tau at S396/404 (PHF-1) is accumulated inside of hippocampal synaptic mitochondria of aged wild-type mice
10.1038/s41598-021-83910-w · 2021 · External reference
Identification of altered metabolic pathways in plasma and CSF in mild cognitive impairment and Alzheimer's disease using metabolomics
10.1371/journal.pone.0063644 · 2013 · External reference
Mitofusin 2 in macrophages links mitochondrial ROS production, cytokine release, phagocytosis, autophagy, and bactericidal activity
10.1016/j.celrep.2020.108079 · 2020 · External reference
Miro1-dependent mitochondrial positioning drives the rescaling of presynaptic Ca2+ signals during homeostatic plasticity
10.15252/embr.201642710 · 2017 · External reference
Accumulation of amyloid precursor protein C-terminal fragments triggers mitochondrial structure, function, and mitophagy defects in Alzheimer's disease models and human brains
10.1007/s00401-020-02234-7 · 2021 · External reference
Microglial mechanisms drive amyloid-β clearance in immunized patients with Alzheimer's disease
10.1038/s41591-025-03574-1 · 2025 · External reference
TRAK/milton motor-adaptor proteins steer mitochondrial trafficking to axons and dendrites
10.1016/j.neuron.2012.11.027 · 2013 · External reference
Synaptic mitochondria: a brain mitochondria cluster with a specific proteome
10.1016/j.jprot.2015.03.005 · 2015 · External reference
Damaged mitochondria coincide with presynaptic vesicle loss and abnormalities in Alzheimer'S disease brain
10.1186/s40478-023-01552-7 · 2023 · External reference
Neuronal ABCA7 deficiency aggravates mitochondrial dysfunction and neurodegeneration in Alzheimer's disease
10.1002/alz.70112 · 2025 · External reference
Mitochondrial dysfunction in Alzheimer's disease: a key frontier for future targeted therapies
10.3389/fimmu.2024.1484373 · 2025 · External reference
A selective and cell-permeable mitochondrial calcium uniporter (MCU) inhibitor preserves mitochondrial bioenergetics after hypoxia/reoxygenation injury
10.1021/acscentsci.8b00773 · 2019 · External reference
Upregulation of Wnt2b exerts neuroprotective effect by alleviating mitochondrial dysfunction in Alzheimer's disease
10.1111/cns.14139 · 2023 · External reference
The mitochondrial calcium uniporter inhibitor Ru265 increases neuronal excitability and reduces neurotransmission via off-target effects
10.1111/bph.16425 · 2024 · External reference
Intersectin-1 enhances calcium-dependent replenishment of the readily releasable pool of synaptic vesicles during development
10.1113/jp286462 · 2025 · External reference
Role of mitochondria transmission in ischemic stroke: friend or foe?
10.1016/j.redox.2025.103868 · 2025 · External reference
Myricetin restores Aβ-induced mitochondrial impairments in N2a-SW cells
10.1021/acschemneuro.1c00591 · 2022 · External reference
Hyperbaric oxygen therapy ameliorates Alzheimer's disease pathology by restoration of mitophagy and suppressing neuroinflammation in 5xFAD mice
10.1016/j.expneurol.2025.115534 · 2026 · External reference
PGC-1a mediated mitochondrial biogenesis promotes recovery and survival of neuronal cells from cellular degeneration
10.1038/s41420-024-01953-0 · 2024 · External reference
ROCK1 induces dopaminergic nerve cell apoptosis via the activation of Drp1-mediated aberrant mitochondrial fission in Parkinson's disease
10.1038/s12276-019-0318-z · 2019 · External reference
Nano-brake halts mitochondrial dysfunction Cascade to alleviate neuropathology and rescue alzheimer's cognitive deficits
10.1002/advs.202204596 · 2023 · External reference
UQCRC1 is a key pathogenic determinant and potential therapeutic target for cognitive impairment in Alzheimer's disease
10.1007/s12035-025-05171-2 · 2025 · External reference
VMP1 attenuates ferroptosis and mitochondrial dysfunction in nucleus pulposus cells through the PINK1/Parkin-mediated mitophagy pathway
10.1186/s13018-025-06033-2 · 2025 · External reference
Danggui-Shaoyao-San can ameliorate Alzheimer's disease by inhibiting hippocampal neuron apoptosis: findings from serum pharmacology
10.2147/dddt.s490900 · 2025 · External reference
Elamipretide (SS-31) improves mitochondrial dysfunction, synaptic and memory impairment induced by lipopolysaccharide in mice
10.1186/s12974-019-1627-9 · 2019 · External reference
FGF21 restores metabolic function in Alzheimer's disease via activation of PI3K/Akt signaling
10.1080/01616412.2025.2521721 · 2026 · External reference
Downregulation of ATP6V1A involved in Alzheimer's disease via synaptic vesicle cycle, phagosome, and oxidative phosphorylation
10.1155/2021/5555634 · 2021 · External reference
Loganin alleviated cognitive impairment in 3×Tg-AD mice through promoting mitophagy mediated by optineurin
10.1016/j.jep.2023.116455 · 2023 · External reference
Cornuside alleviates cognitive impairments induced by Aβ1-42 through attenuating NLRP3-mediated neurotoxicity by promoting mitophagy
10.1186/s13195-025-01695-w · 2025 · External reference
