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References from Extracts from Eryngium heterophyllum Engelm. [Apiaceae] enhance paclitaxel cytotoxicity in A549 lung cancer cells. Local targets link to admitted publications; unresolved targets remain external evidence.
Key genes and molecular mechanisms related to paclitaxel resistance
10.1186/s12935-024-03415-0 · 2024 · External reference
Phytochemical composition and cytotoxic activity of Senecio asirensis hexane fraction using in vitro and in silico approaches
10.1177/1934578x241246418 · 2024 · External reference
A review: uses of gas chromatography-mass spectrometry (GC-MS) technique for analysis of bioactive natural compounds of some plants
10.25258/ijtpr.v9i01.9042 · 2017 · External reference
Cytotoxic activity and chemical composition of the root extract from the Mexican species linum Scabrellum: mechanism of action of the active compound 6-methoxypodophyllotoxin
10.1155/2015/298463 · 2015 · External reference
Lignans from Bursera fagaroides affect in vivo cell behavior by disturbing the tubulin cytoskeleton in zebrafish embryos
10.3390/molecules24010008 · 2019 · External reference
Natural products in drug discovery: advances and opportunities
10.1038/s41573-020-00114-z · 2021 · External reference
Natural medicinal compounds target signal transduction pathways to overcome ABC drug efflux transporter-mediated multidrug resistance in cancer
10.1016/j.drup.2023.101004 · 2023 · External reference
Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
10.3322/caac.21834 · 2024 · External reference
Ethnobotany, biological activities and phytochemical compounds of some species of the genus eryngium (apiaceae) from the central-western region of Mexico
10.3390/molecules28104094 · 2023 · External reference
Cytotoxicity, oxidative stress, cell cycle arrest, and mitochondrial apoptosis after combined treatment of hepatocarcinoma cells with maleic anhydride derivatives and Quercetin
10.1155/2017/2734976 · 2017 · External reference
Selective cytotoxic and antiproliferative effects of extracts from four Mexican medicinal plants in human cancer and non-cancerous cell lines
10.3390/molecules31030549 · 2026 · External reference
GC-MS analysis of bioactive phytochemicals in methanol extract of aerial part and callus of Dipterygium glaucum decne
10.5530/pj.2019.11.167 · 2019 · External reference
Recent advances in elucidating paclitaxel resistance mechanisms in non-small cell lung cancer and strategies to overcome drug resistance
10.2174/0929867326666191016113631 · 2020 · External reference
Fighting multidrug resistance with a fruit extract: anticancer and antibiofilm activities of Acca sellowiana
10.1080/14786419.2019.1624961 · 2021 · External reference
Natural products as alternative choices for P-glycoprotein (P-gp) inhibition
10.3390/molecules22060871 · 2017 · External reference
Potential of natural-based anticancer compounds for P-glycoprotein inhibition
10.2174/1381612825666190112164211 · 2018 · External reference
Overcoming chemotherapy resistance in metastatic cancer: a comprehensive review
10.3390/biomedicines12010183 · 2024 · External reference
Crystal violet assay for determining viability of cultured cells
10.1101/pdb.prot087379 · 2016 · External reference
β-Caryophyllene and β-caryophyllene Oxide—Natural compounds with anticancer and analgesic properties
10.1002/cam4.816 · 2016 · External reference
Falcarindiol from Eryngium heterophyllum engelm. And Eryngium pectinatum C. Presl ex DC.: absolute configuration assignment and evaluation of its antihyperlipidemic activity
10.1080/14786419.2026.2660997 · 2026 · External reference
Contribución al conocimiento del género Eryngium (Apiaceae) en el estado de Michoacán, México
10.21829/abm103.2013.51 · 2013 · External reference
GC-MS analysis of bioactive compounds from the whole plant ethanolic extract of Evolvulus alsinoides (L.) L
10.1007/s13197-013-1079-0 · 2015 · External reference
Unresolved reference
2018 · External reference
Evaluation of cytotoxic activity of cell biomass from Eryngium planum and Lychnis flos-cuculi on melanoma cancer cells
10.3390/molecules29215158 · 2024 · External reference
Insights into molecular mechanisms of chemotherapy resistance in cancer
10.1016/j.tranon.2024.101901 · 2024 · External reference
Synergistic growth inhibitory effects of Eryngium kotschyi extracts with conventional cytotoxic agents: Cisplatin and doxorubicin against human endometrium cancer cells
10.2174/1389201022666210826160307 · 2022 · External reference
Natural products as multidrug resistance modulators in cancer
10.1016/j.ejmech.2019.05.027 · 2019 · External reference
Apiaceae
2020 · External reference
Gas chromatography-mass spectrometry (GC-MS) analysis of bioactive components of Phyllanthus amarus leaves
2012 · External reference
Natural products as sources of new drugs over the nearly four decades from 01/1981 to 09/2019
10.1021/acs.jnatprod.9b01285 · 2020 · External reference
Mechanisms of taxol resistance related to microtubules
10.1038/sj.onc.1206934 · 2003 · External reference
Potential strategies for overcoming drug resistance pathways using propolis and its polyphenolic/flavonoid compounds in combination with chemotherapy and radiotherapy
10.3390/nu16213741 · 2024 · External reference
Emodin enhances cisplatin sensitivity in non-small cell lung cancer through pgp downregulation
10.3892/ol.2021.12491 · 2021 · External reference
Eryngium species as a potential ally for treating metabolic syndrome and diabetes
10.3389/fnut.2022.878306 · 2022 · External reference
Utilization of redox modulating small molecules that selectively act as pro-oxidants in cancer cells to open a therapeutic window for improving cancer therapy
10.1016/j.redox.2021.101864 · 2021 · External reference
GC-MS (gas chromatography and mass spectroscopy) analysis of methanol leaf extract of Rhododendron arboreum sm. Of district sirmaur, Himachal Pradesh
10.22270/jddt.v13i1.5908 · 2023 · External reference
Paclitaxel for non-small cell lung cancer
10.1517/14656566.5.8.1771 · 2004 · External reference
The redox paradox: cancer’s double-edged sword for malignancy and therapy
10.3390/antiox14101187 · 2025 · External reference
Antioxidant and anti-inflammatory mechanisms of lipophilic fractions from Polyscias fruticosa leaves based on network pharmacology, in silico, and in vitro approaches
10.3390/foods12193643 · 2023 · External reference
The connection between the toxicity of anthracyclines and their ability to modulate the P-glycoprotein-mediated transport in A549, HepG2, and MCF-7 cells
10.1155/2014/819548 · 2014 · External reference
Phase III randomised trial comparing paclitaxel/carboplatin with paclitaxel/cisplatin in patients with advanced non-small-cell lung cancer: a cooperative multinational trial
10.1093/annonc/mdf332 · 2002 · External reference
Nanoparticles attenuate P-glycoprotein/MDR1 function in A549 human alveolar epithelial cells
10.1016/j.ejpb.2010.11.009 · 2011 · External reference
Achillin increases chemosensitivity to paclitaxel, overcoming resistance and enhancing apoptosis in human hepatocellular carcinoma cell line resistant to paclitaxel (Hep3B/PTX)
10.3390/pharmaceutics11100512 · 2019 · External reference
Natural compounds and derivatives as modulators of multidrug resistance and their mechanisms of action: recent studies in vitro, in vivo and in silico
10.1007/s42452-024-06239-9 · 2024 · External reference
Polyphenolic content and antioxidant activity of leaves of Urtica simensis grown in Ethiopia
10.52292/j.laar.2017.295 · 2017 · External reference
Natural products for enhancing the sensitivity or decreasing the adverse effects of anticancer drugs through regulating the redox balance
10.1186/s13020-024-00982-2 · 2024 · External reference
Efficacy and safety of nab-paclitaxel plus platinum in non-small cell lung cancer: a meta-analysis
10.3389/fmed.2023.1139248 · 2023 · External reference
Evaluación del contenido de polifenoles totales y la capacidad antioxidante de los extractos etanólicos de los frutos de aguaymanto (Physalis peruviana L.) de diferentes lugares del Perú
10.37761/rsqp.v82i3.58 · 2016 · External reference
Lung cancer
10.1016/s0140-6736(21)00312-3 · 2021 · External reference
An ethyl acetate extract of Eryngium carlinae inflorescences attenuates oxidative stress and inflammation in the liver of streptozotocin-induced diabetic rats
10.3390/antiox12061235 · 2023 · External reference
Phytochemical analysis and in-vitro biological activities of three wild eryngium species: E. beecheyanum, E. heterophyllum, and E. mexiae
10.3390/molecules30214250 · 2025 · External reference
Checklist of the native vascular plants of Mexico
10.1016/j.rmb.2016.06.017 · 2016 · External reference
Phytochemical analysis, antioxidant, antibacterial and cytotoxic activity of different plant organs of Eryngium serbicum L
10.1016/j.indcrop.2018.02.031 · 2018 · External reference
Phytochemical constituents and pharmacological activities of eryngium L. (apiaceae)
10.2174/2210290601203010099 · 2012 · External reference
Molecular mechanism of palmitic acid and its derivatives in tumor progression
10.3389/fonc.2023.1224125 · 2023 · External reference
Microtubule nucleation: gamma-Tubulin and beyond
10.1242/jcs.03226 · 2006 · External reference
Cytotoxic effects of Eryngium kotschyi and Eryngium maritimum on Hep2, HepG2, vero and U138 MG cell lines
10.3109/13880209.2013.803208 · 2013 · External reference
Global burden of lung cancer in 2022 and projections to 2050: incidence and mortality estimates from GLOBOCAN
10.1016/j.canep.2024.102693 · 2024 · External reference
Natural products reverse cancer multidrug resistance
10.3389/fphar.2024.1348076 · 2024 · External reference