Research graph
References from Andrographolide inhibits STAT1 expression and desensitizes interferon γ-induced priming in macrophage cells. Local targets link to admitted publications; unresolved targets remain external evidence.
An insight into the pharmacological and analytical potential of andrographolide
10.1111/fcp.12757 · 2022 · External reference
Andrographis paniculata: a review of pharmacological activities and clinical effects
2011 · External reference
REST negatively and ISGF3 positively regulate the human STAT1 gene in melanoma
10.1158/1535-7163.mct-12-0923 · 2013 · External reference
The good and the bad: monocytes' and Macrophages' diverse functions in inflammation
10.3390/cells11121979 · 2022 · External reference
Sensors of the innate immune system: their mode of action
10.1038/nrrheum.2009.136 · 2009 · External reference
Effects of IFN-γ on intracellular trafficking and activity of macrophage NADPH oxidase flavocytochrome b558
10.1189/jlb.0512244 · 2012 · External reference
Molecular basis of interferon-gamma and lipopolysaccharide enhancement of phagocyte respiratory burst capability. Studies on the gene expression of several NADPH oxidase components
10.1016/s0021-9258(17)30495-7 · 1990 · External reference
Innate immune responses to danger signals in systemic inflammatory response syndrome and sepsis
10.1111/j.1365-3083.2009.02255.x · 2009 · External reference
Dysregulated type I interferon and inflammatory monocyte-macrophage responses cause lethal pneumonia in SARS-CoV-Infected mice
10.1016/j.chom.2016.01.007 · 2016 · External reference
Macrophages in cardiovascular diseases: molecular mechanisms and therapeutic targets
10.1038/s41392-024-01840-1 · 2024 · External reference
IFNβ-dependent increases in STAT1, STAT2, and IRF9 mediate resistance to viruses and DNA damage
10.1038/emboj.2013.203 · 2013 · External reference
The selective RNA polymerase I inhibitor CX-5461 mitigates neointimal remodeling in a modified model of rat aortic transplantation
10.1097/tp.0000000000002372 · 2018 · External reference
Identification of a distinct cluster of GDF15(high) macrophages induced by in vitro differentiation exhibiting anti-inflammatory activities
10.3389/fimmu.2024.1309739 · 2024 · External reference
Targeting interferon-γ in hyperinflammation: opportunities and challenges
10.1038/s41584-021-00694-z · 2021 · External reference
Andrographolide inhibits influenza A virus-induced inflammation in a murine model through NF-κB and JAK-STAT signaling pathway
10.1016/j.micinf.2017.08.009 · 2017 · External reference
Type I interferons: expression and signalization
10.1007/s000180050240 · 1998 · External reference
The cGAS-STING pathway drives type I IFN immunopathology in COVID-19
10.1038/s41586-022-04421-w · 2022 · External reference
Regulation of IFNβ expression: focusing on the role of its promoter and transcription regulators
10.3389/fmicb.2023.1158777 · 2023 · External reference
Functional crosstalk between type I and II interferon through the regulated expression of STAT1
10.1371/journal.pbio.1000361 · 2010 · External reference
Macrophages in intestinal homeostasis and inflammatory bowel disease
10.1038/s41575-023-00769-0 · 2023 · External reference
Type I interferon gene induction by the interferon regulatory factor family of transcription factors
10.1016/j.immuni.2006.08.009 · 2006 · External reference
Sensitization of IFN-Gamma Jak-STAT signaling during macrophage activation
10.1038/ni828 · 2002 · External reference
Regulation of interferon and toll-like receptor signaling during macrophage activation by opposing feedforward and feedback inhibition mechanisms
10.1111/j.1600-065x.2008.00707.x · 2008 · External reference
IFNγ: signalling, epigenetics and roles in immunity, metabolism, disease and cancer immunotherapy
10.1038/s41577-018-0029-z · 2018 · External reference
Regulation of type I interferon responses
10.1038/nri3581 · 2014 · External reference
Lipopolysaccharide-induced expression of interferon-beta mediates the timing of inducible nitric-oxide synthase induction in RAW 264.7 macrophages
10.1074/jbc.m106639200 · 2001 · External reference
Andrographis paniculata (Burm.f.) nees and its major constituent andrographolide as potential antiviral agents
10.1016/j.jep.2021.113954 · 2021 · External reference
Protein kinase calpha is involved in interferon regulatory factor 3 activation and type I interferon-beta synthesis
10.1074/jbc.m700421200 · 2007 · External reference
Central role for type I interferons and Tyk2 in lipopolysaccharide-induced endotoxin shock
10.1038/ni910 · 2003 · External reference
Type I interferon signaling in hematopoietic cells is required for survival in mouse polymicrobial sepsis by regulating CXCL10
10.1084/jem.20091959 · 2010 · External reference
Interferon alpha and beta receptor 1 knockout in human embryonic kidney 293 cells enhances the production efficiency of proteins or adenoviral vectors related to type I interferons
10.3389/fbioe.2023.1192291 · 2023 · External reference
Andrographis paniculata (Burm.f.) nees: traditional uses, phytochemistry, pharmacological properties and quality control/quality assurance
10.1016/j.jep.2021.114054 · 2021 · External reference
Differential effects of forskolin and phobol 12-myristate-13-acetate on the c-fos and c-jun mRNA expression in rat C6 glioma cells
10.1016/s1016-8478(23)17056-7 · 2001 · External reference
Modulation of type I interferon signaling by natural products in the treatment of immune-related diseases
10.1016/s1875-5364(23)60381-4 · 2023 · External reference
Small molecule SIRT1 activators counteract oxidative stress-induced inflammasome activation and nucleolar stress in retinal degeneration
10.1016/j.intimp.2024.113167 · 2024 · External reference
Protein kinase C in the immune system: from signalling to chromatin regulation
10.1111/imm.12510 · 2015 · External reference
The type I interferons: basic concepts and clinical relevance in immune-mediated inflammatory diseases
10.1016/j.gene.2015.09.058 · 2016 · External reference
Andrographolide prevents necroptosis by suppressing the generation of reactive oxygen species
10.3724/abbs.2025077 · 2025 · External reference
Immune cartography of macrophage activation syndrome in the COVID-19 era
10.1038/s41584-020-00571-1 · 2021 · External reference
Type I interferons in infectious disease
10.1038/nri3787 · 2015 · External reference
Spatiotemporal proteomic profiling of the pro-inflammatory response to lipopolysaccharide in the THP-1 human leukaemia cell line
10.1038/s41467-021-26000-9 · 2021 · External reference
Interferon-gamma: an overview of signals, mechanisms and functions
10.1189/jlb.0603252 · 2004 · External reference
Signal integration between IFNgamma and TLR signalling pathways in macrophages
10.1016/j.imbio.2006.05.007 · 2006 · External reference
The therapeutic potential of andrographolide and its derivatives in inflammatory diseases
10.1002/prp2.70161 · 2025 · External reference
An essential role for IFN-β in the induction of IFN-stimulated gene expression by LPS in macrophages
10.1189/jlb.2a0414-191r · 2014 · External reference
Potential anti-inflammatory effects of hesperidin from the genus citrus
10.2174/0929867324666170718104412 · 2018 · External reference
Andrographolide and deoxyandrographolide inhibit protease and IFN-antagonist activities of foot-and-mouth disease virus 3C(pro)
10.3390/ani12151995 · 2022 · External reference
Contribution of interferon-beta to the murine macrophage response to the toll-like receptor 4 agonist, lipopolysaccharide
10.1074/jbc.m604958200 · 2006 · External reference
The multifaceted life of macrophages in white adipose tissue: immune shift couples with metabolic switch
10.1111/imr.13338 · 2024 · External reference
Andrographolide attenuates inflammation by inhibition of NF-kappa B activation through covalent modification of reduced cysteine 62 of p50
10.4049/jimmunol.173.6.4207 · 2004 · External reference
Distal regulatory element of the STAT1 gene potentially mediates positive feedback control of STAT1 expression
10.1111/gtc.12316 · 2016 · External reference
