Research graph
References from Shengji ointment accelerates diabetic foot ulcer wound healing by regulating inflammatory microenvironment. Local targets link to admitted publications; unresolved targets remain external evidence.
Histological and immunohistochemical biomarkers for wound age estimation in human skin: a systematic review
10.7759/cureus.100607 · 2026 · External reference
Skin wound healing: normal macrophage function and macrophage dysfunction in diabetic wounds
10.3390/molecules26164917 · 2021 · External reference
Extraction, isolation and identification of four phenolic compounds from Pleioblastus amarus shoots and their antioxidant and anti-inflammatory properties in vitro
10.1016/j.foodchem.2021.131743 · 2022 · External reference
Diabetic foot ulcers: a review
10.1001/jama.2023.10578 · 2023 · External reference
Pathogenesis and treatment of impaired wound healing in diabetes mellitus: new insights
10.1007/s12325-014-0140-x · 2014 · External reference
Macrophage dysregulation and impaired skin wound healing in diabetes
10.3389/fcell.2020.00528 · 2020 · External reference
Skin aging: mechanistic insights and targeted therapeutic strategies
10.1016/j.jaci.2026.05.015 · 2026 · External reference
13-Methyl-palmatrubine induces apoptosis and cell cycle arrest in A549 cells in vitro and in vivo
10.3892/or.2016.5093 · 2016 · External reference
Neochlorogenic acid ameliorates allergic airway inflammation by suppressing type 2 immunity and upregulating HO-1 expression
10.1016/j.intimp.2024.113867 · 2025 · External reference
STOM promotes retinal angiogenesis in diabetic retinopathy via the ERK1/2/VEGFA pathway
10.1080/02713683.2026.2679145 · 2026 · External reference
Phellodendron amurense extract protects human keratinocytes from PM2.5-induced inflammation via PAR-2 signaling
10.3390/biom11010023 · 2020 · External reference
Diabetic foot ulcers: pathophysiology, immune dysregulation, and emerging therapeutic strategies
10.3390/biomedicines13051076 · 2025 · External reference
Ginsenoside CK inhibits the proliferation of small cell lung cancer cells and induces G2/M cell cycle arrest and apoptosis via the ATM/ATR signaling pathway
10.14744/ejmo.2024.39659 · 2024 · External reference
An AIE-Active polyvinyl alcohol/berberine/hemoadhican smart hydrogel for scarless wound healing with visual pH monitoring
10.1016/j.mtbio.2026.103224 · 2026 · External reference
Treatment of diabetic ulcers with Chuang Ling Ye: systems pharmacology and functional validation reveal the mechanism of angiogenesis and inflammation abatement driven by the PI3K-AKT signaling pathway
10.3389/fphar.2025.1644541 · 2025 · External reference
Streptozotocin-induced diabetic models in mice and rats
10.1002/cpz1.78 · 2021 · External reference
Preliminary research of main components of Dll4/Notch-VEGF signaling pathway under high-glucose stimulation in vitro
10.2147/dmso.s355004 · 2022 · External reference
Notch signal deficiency alleviates hypertrophic scar formation after wound healing through the inhibition of inflammation
10.1016/j.abb.2020.108286 · 2020 · External reference
Tumors vs. chronic wounds: an immune cell's perspective
10.3389/fimmu.2019.02178 · 2019 · External reference
Preparation of berberine micelles and its anti-skin damage in hyperglycemia mice
10.1080/00498254.2026.2683638 · 2026 · External reference
Vascular endothelial growth factor and angiogenesis in the regulation of cutaneous wound repair
10.1089/wound.2013.0517 · 2014 · External reference
Glucocorticoid-mediated induction of caveolin-1 disrupts cytoskeletal organization, inhibits cell migration and re-epithelialization of non-healing wounds
10.1038/s42003-021-02298-5 · 2021 · External reference
Mechanism of Qizhen decoction-mediated maturation of DC cells to activate the IL-12/JAK2/STAT4 pathway to sensitise PD-1 inhibitors in the treatment of colorectal cancer
10.1016/j.jep.2023.117399 · 2024 · External reference
Enhanced delta-notch lateral inhibition model incorporating intracellular notch heterogeneity and tension-dependent rate of delta-notch binding that reproduces sprouting angiogenesis patterns
10.1038/s41598-018-27645-1 · 2018 · External reference
Elevated levels of matrix metalloproteinases and chronic wound healing: an updated review of clinical evidence
10.12968/jowc.2016.25.5.277 · 2016 · External reference
Interleukin-23 regulates interleukin-17 expression in wounds, and its inhibition accelerates diabetic wound healing through the alteration of macrophage polarization
10.1096/fj.201700773r · 2018 · External reference
Pilose antler extract promotes angiogenesis and vascular maturation to accelerate wound healing
10.1038/s41598-025-33728-7 · 2025 · External reference
Astragaloside IV promotes cerebral tissue restoration through activating AMPK- mediated microglia polarization in ischemic stroke rats
10.1016/j.jep.2024.118532 · 2024 · External reference
Targeting LKB1-AMPK-SIRT1-induced autophagy and mitophagy pathways improves cerebrovascular homeostasis in APP/PS1 mice
10.1016/j.freeradbiomed.2025.03.045 · 2025 · External reference
Dihydroartemisinin regulates self-renewal of human melanoma-initiating cells by targeting PKM2/LDHA related glycolysis
10.14744/ejmo.2024.70803 · 2024 · External reference
Neuroprotective effect of Da Chuanxiong Formula against cognitive and motor deficits in a rat controlled cortical impact model of traumatic brain injury
10.1016/j.jep.2018.02.004 · 2018 · External reference
A TCM formula comprising Sophorae Flos and Lonicerae Japonicae Flos alters compositions of immune cells and molecules of the STAT3 pathway in melanoma microenvironment
10.1016/j.phrs.2019.02.020 · 2019 · External reference
Effect of Xiongmatang extract on behavioral and TRPV1-CGRP/CGRP-R pathway in rats with migraine
10.3389/fphar.2022.835187 · 2022 · External reference
Multidimensional regulatory mechanisms and targeted therapeutic strategies for inhibited keratinocyte proliferation in diabetic wounds
10.2147/dddt.s598433 · 2026 · External reference
OxInflammatory responses in the wound healing process: a systematic review
10.3390/antiox13070823 · 2024 · External reference
Structural changes, and anti-inflammatory, anti-cancer potential of polysaccharides from multiple processing of Rehmannia glutinosa
10.1016/j.ijbiomac.2022.02.112 · 2022 · External reference
Lonicerin targets EZH2 to alleviate ulcerative colitis by autophagy-mediated NLRP3 inflammasome inactivation
10.1016/j.apsb.2021.03.011 · 2021 · External reference
Guilongwan ameliorates experimental diabetic foot ulcer in rats via the inhibition of delta-like 4/Notch1 signaling in M1 macrophages
10.1002/adbi.202400819 · 2025 · External reference
Co-decoction of Lilii bulbus and Radix Rehmannia Recens and its key bioactive ingredient verbascoside inhibit neuroinflammation and intestinal permeability associated with chronic stress-induced depression via the gut microbiota-brain axis
10.1016/j.phymed.2024.155510 · 2024 · External reference
Etiology, epidemiology, and disparities in the burden of diabetic foot ulcers
10.2337/dci22-0043 · 2023 · External reference
Extraction, structure, pharmacological activities and drug carrier applications of Angelica sinensis polysaccharide
10.1016/j.ijbiomac.2021.05.213 · 2021 · External reference
Exploring the contribution of pro-inflammatory cytokines to impaired wound healing in diabetes
10.3389/fimmu.2023.1216321 · 2023 · External reference
Epidemiology and outcome of diabetic foot ulcers in Nigeria: a systematic review and meta-analysis of 2 decades: 2005 - 2024
10.1007/s44197-025-00509-4 · 2026 · External reference
Epidemiology, pathophysiology, and management of diabetic foot: a comprehensive review
10.1016/j.foot.2026.102225 · 2026 · External reference
Clinically relevant experimental rodent models of diabetic foot ulcer
10.1007/s11010-022-04372-w · 2022 · External reference
Immunology of acute and chronic wound healing
10.3390/biom11050700 · 2021 · External reference
Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: results from the International Diabetes Federation Diabetes Atlas, 9(th) edition
10.1016/j.diabres.2019.107843 · 2019 · External reference
Inhibition of miR-181c-5p rescues diabetes-impaired angiogenesis in ischemia and wound healing
10.2337/db24-0867 · 2026 · External reference
Shengji ointment combined with bromelain promotes granulation of exposed tendons in diabetic foot ulcers: a multicenter, randomized, positive-controlled clinical trial
10.1016/j.heliyon.2024.e39716 · 2024 · External reference
Dandelion-derived vesicles-laden hydrogel dressings capable of neutralizing Staphylococcus aureus exotoxins for the care of invasive wounds
10.1016/j.jconrel.2024.02.045 · 2024 · External reference
Network pharmacology-based investigation on therapeutic mechanisms of the Angelica dahurica radix and ligusticum chuanxiong rhizoma herb pair for anti-migraine effect
10.3390/plants11172196 · 2022 · External reference
Neochlorogenic acid attenuates endothelial injury in diabetic ApoE(-/-) mice by suppressing NF-κB mediated NLRP3 inflammasome activation
10.1039/d6fo00170j · 2026 · External reference
Asperosaponin VI promotes angiogenesis and accelerates wound healing in rats via up-regulating HIF-1α/VEGF signaling
10.1038/aps.2017.161 · 2018 · External reference
Xueshuantong injection alleviates cerebral microcirculation disorder in middle cerebral artery occlusion/reperfusion rats by suppressing inflammation via JNK mediated JAK2/STAT3 and NF-κB signaling pathways
10.1016/j.jep.2022.115592 · 2022 · External reference
Therapeutic potential of traditional Chinese medicine and mechanisms for the treatment of type 2 diabetes mellitus
10.1186/s13020-025-01222-x · 2025 · External reference
Rehmannia glutinosa polysaccharides: a review on structural features, pharmacological potential, and advanced delivery systems
10.3389/fnut.2026.1772902 · 2026 · External reference
Angelica sinensis in China-A review of botanical profile, ethnopharmacology, phytochemistry and chemical analysis
10.1016/j.jep.2016.05.023 · 2016 · External reference
VEGF-A, PDGF-BB and HB-EGF engineered for promiscuous super affinity to the extracellular matrix improve wound healing in a model of type 1 diabetes
10.1038/s41536-021-00189-1 · 2021 · External reference
Macrophage-mediated inflammation in diabetic wound repair
10.1016/j.semcdb.2021.06.013 · 2021 · External reference
13-Methyl-palmatrubine shows an anti-tumor role in non-small cell lung cancer via shifting M2 to M1 polarization of tumor macrophages
10.1016/j.intimp.2021.108468 · 2022 · External reference
Gastroprotective action of the extract of Corydalis yanhusuo in Helicobacter pylori infection and its bioactive component, dehydrocorydaline
10.1016/j.jep.2023.116173 · 2023 · External reference
Anti-inflammatory activity of Pogostemon cablin: bioactive components and their modulation of MAPK and NF-κB signaling pathway
10.1016/j.bioorg.2025.108516 · 2025 · External reference
Protein tyrosine phosphatase 1B impairs diabetic wound healing through vascular endothelial growth factor receptor 2 dephosphorylation
10.1161/atvbaha.114.304705 · 2015 · External reference
Simultaneous quantification of nine new furanocoumarins in Angelicae Dahuricae Radix using ultra-fast liquid chromatography with tandem mass spectrometry
10.3390/molecules22020322 · 2017 · External reference
Endothelial KLF15/VASN axis inhibits angiogenesis via activation of Notch1 signaling
10.1161/circresaha.124.325494 · 2025 · External reference
Cryptochlorogenic acid attenuates LPS-induced inflammatory response and oxidative stress via upregulation of the Nrf2/HO-1 signaling pathway in RAW 264.7 macrophages
10.1016/j.intimp.2020.106436 · 2020 · External reference
The Angelica dahurica: a review of traditional uses, phytochemistry and pharmacology
10.3389/fphar.2022.896637 · 2022 · External reference
Triggering of a Dll4-Notch1 loop impairs wound healing in diabetes
10.1073/pnas.1900351116 · 2019 · External reference
Traditional Chinese medicine compounds containing Lonicera japonica, Chrysanthemum morifolium, and Siraitia grosvenorii inhibits the growth of Streptococcus mutans
10.1155/2022/5802343 · 2022 · External reference
Roxadustat promotes angiogenesis through HIF-1α/VEGF/VEGFR2 signaling and accelerates cutaneous wound healing in diabetic rats
10.1111/wrr.12708 · 2019 · External reference