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References from Targeting pancreatic cancer with natural compounds: molecular mechanisms, preclinical evidence, clinical perspectives, and limitations. Local targets link to admitted publications; unresolved targets remain external evidence.
Integrating cannabis into clinical cancer care
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Structure-antioxidant activity relationships of Luteolin and Catechin
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Quercetin derivatives: drug design, development, and biological activities, a review
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The flavonoid quercetin inhibits pancreatic cancer growth in vitro and in vivo
10.1097/mpa.0b013e318264ccae · 2013 · External reference
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Unresolved reference
External reference
Luteolin inhibits vascular endothelial growth factor-induced angiogenesis; inhibition of endothelial cell survival and proliferation by targeting phosphatidylinositol 3’-kinase activity
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Efficacy and safety of larotrectinib in patients with TRK fusion gastrointestinal cancer
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Antitumor effects of KITC, a new resveratrol derivative, in AsPC-1 and BxPC-3 human pancreatic carcinoma cells
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Evidence-based complementary treatment of pancreatic cancer: a review of adjunct therapies including paricalcitol, hydroxychloroquine, intravenous vitamin C, statins, metformin, curcumin, and aspirin
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Curcumin inhibits tumor growth and angiogenesis in an orthotopic mouse model of human pancreatic cancer
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Genetic mutations associated with cigarette smoking in pancreatic cancer
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Phase II study of calcitriol-enhanced docetaxel in patients with previously untreated metastatic or locally advanced pancreatic cancer
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Phase I dose escalation pharmacokinetic study in healthy volunteers of resveratrol, a potential cancer chemopreventive agent
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Quercetin mediates β-Catenin in pancreatic cancer stem-like cells
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Cannabinoids induce apoptosis of pancreatic tumor cells via endoplasmic reticulum stress-related genes
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The vitamin D analog, MART-10, represses metastasis potential via downregulation of epithelial-mesenchymal transition in pancreatic cancer cells
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FOLFIRINOX or gemcitabine as adjuvant therapy for pancreatic cancer
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Five-year outcomes of FOLFIRINOX vs gemcitabine as adjuvant therapy for pancreatic cancer: a randomized clinical trial
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Quercetin and ferroptosis
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Natural anti-cancer products: insights from herbal medicine
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Cannabinoids inhibit energetic metabolism and induce AMPK-dependent autophagy in pancreatic cancer cells
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Phase II trial of curcumin in patients with advanced pancreatic cancer
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10.1093/annonc/mdp332 · 2010 · External reference
Unresolved reference
External reference
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10.1186/s12885-025-15152-2 · 2025 · External reference
Pharmacologic ascorbate synergizes with gemcitabine in preclinical models of pancreatic cancer
10.1016/j.freeradbiomed.2011.03.007 · 2011 · External reference
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10.1186/s12904-019-0494-6 · 2019 · External reference
A pilot study of paricalcitol plus nanoliposomal irinotecan and 5-FU/LV in advanced pancreatic cancer patients after progression on gemcitabine-based therapy
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10.3390/nu16234085 · 2024 · External reference
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10.1155/2023/4772134 · 2023 · External reference
Chemosensitization of tumors by resveratrol
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10.1200/jco.2013.31.18_suppl.lba4003 · 2013 · External reference
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Resveratrol, a multitargeted agent, can enhance antitumor activity of gemcitabine in vitro and in orthotopic mouse model of human pancreatic cancer
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The therapeutic potential of natural products for treating pancreatic cancer
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The effect of resveratrol and quercetin on epithelial-mesenchymal transition in pancreatic cancer stem cell
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Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease
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10.1002/jcb.25897 · 2017 · External reference
Luteolin decreases invasiveness, deactivates STAT3 signaling, and reverses interleukin-6 induced epithelial-mesenchymal transition and matrix metalloproteinase secretion of pancreatic cancer cells
10.2147/ott.s91511 · 2015 · External reference
Regulation of tumor microenvironment for pancreatic cancer therapy
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Luteolin, a flavonoid, as an anticancer agent: a review
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The effect of quercetin on inflammatory factors and clinical symptoms in women with rheumatoid arthritis: a double-blind, randomized controlled trial
10.1080/07315724.2016.1140093 · 2017 · External reference
Nimbolide: a potential phytochemical agent in multimodal pancreatic cancer therapies
10.2174/0113895575293138240527061556 · 2025 · External reference
Flavonoid apigenin modified gene expression associated with inflammation and cancer and induced apoptosis in human pancreatic cancer cells through inhibition of GSK-3β/NF-κB signaling cascade
10.1002/mnfr.201300307 · 2013 · External reference
Interactions between dietary flavonoids apigenin or luteolin and chemotherapeutic drugs to potentiate anti-proliferative effect on human pancreatic cancer cells, in vitro
10.1016/j.fct.2013.07.036 · 2013 · External reference
Luteolin and gemcitabine protect against pancreatic cancer in an orthotopic mouse model
10.1097/mpa.0000000000000215 · 2015 · External reference
Unresolved reference
External reference
A phase I/II study of gemcitabine-based chemotherapy plus curcumin for patients with gemcitabine-resistant pancreatic cancer
10.1007/s00280-010-1470-2 · 2011 · External reference
A phase I study investigating the safety and pharmacokinetics of highly bioavailable curcumin (Theracurmin) in cancer patients
10.1007/s00280-013-2151-8 · 2013 · External reference
The antitumor activities of flavonoids
2005 · External reference
DPYD, down-regulated by the potentially chemopreventive agent luteolin, interacts with STAT3 in pancreatic cancer
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Vitamin D analogues up-regulate p21 and p27 during growth inhibition of pancreatic cancer cell lines
10.1038/bjc.1997.479 · 1997 · External reference
Pain as a predictor of outcome in patients with operable pancreatic carcinoma
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10.1200/jco.19.00946 · 2019 · External reference
Clinical usefulness of carbohydrate antigen 19-9 as a screening test for pancreatic cancer in an asymptomatic population
10.1111/j.1440-1746.2004.03219.x · 2004 · External reference
Quercetin sensitizes pancreatic cancer cells to TRAIL-induced apoptosis through JNK-mediated cFLIP turnover
10.1016/j.biocel.2016.07.033 · 2016 · External reference
Vitamin C suppresses pancreatic carcinogenesis through the inhibition of both glucose metabolism and wnt signaling
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Overall survival results from the POLO trial: a phase III study of active maintenance olaparib versus placebo for germline BRCA-mutated metastatic pancreatic cancer
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Evidence for activation of mutated p53 by apigenin in human pancreatic cancer
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The role of resveratrol in cancer therapy
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Nimbolide reduces CD44 positive cell population and induces mitochondrial apoptosis in pancreatic cancer cells
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Steady-state pharmacokinetics and tolerability of trans-resveratrol 2000 mg twice daily with food, quercetin and alcohol (ethanol) in healthy human subjects
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Quercetin facilitates cell death and chemosensitivity through RAGE/PI3K/AKT/mTOR axis in human pancreatic cancer cells
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Nuclear factor-kappaB and IkappaB kinase are constitutively active in human pancreatic cells, and their down-regulation by curcumin (diferuloylmethane) is associated with the suppression of proliferation and the induction of apoptosis
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The dietary compound luteolin inhibits pancreatic cancer growth by targeting BCL-2
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Unresolved reference
External reference
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Apigenin down-regulates the hypoxia response genes: HIF-1α, GLUT-1, and VEGF in human pancreatic cancer cells
10.1016/j.jss.2010.10.041 · 2011 · External reference
Phase I evaluation of intravenous ascorbic acid in combination with gemcitabine and erlotinib in patients with metastatic pancreatic cancer
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Quercetin alleviates kainic acid-induced seizure by inhibiting the Nrf2-mediated ferroptosis pathway
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Curcumin sensitizes pancreatic cancer cells to gemcitabine by attenuating PRC2 subunit EZH2, and the lncRNA PVT1 expression
10.1093/carcin/bgx065 · 2017 · External reference
Quercetin inhibits epithelial-mesenchymal transition, decreases invasiveness and metastasis, and reverses IL-6 induced epithelial-mesenchymal transition, expression of MMP by inhibiting STAT3 signaling in pancreatic cancer cells
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Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH
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Chemoresistance in pancreatic cancer
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Curcumin induces apoptosis in pancreatic cancer cells through the induction of forkhead box O1 and inhibition of the PI3K/Akt pathway
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2014 · External reference
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