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References from The multifaceted functions of lactate and its translational potentials in cancer. Local targets link to admitted publications; unresolved targets remain external evidence.
Context matters: divergent roles of exercise-induced and tumor-derived lactate in cancer
10.3390/biom15071010 · 2025 · External reference
Foxp3 reprograms T cell metabolism to function in low-glucose, high-lactate environments
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Lactic acid and lactate: revisiting the physiological roles in the tumor microenvironment
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Tumor microenvironment complexity and therapeutic implications at a glance
10.1186/s12964-020-0530-4 · 2020 · External reference
A small-scale test of whether alkalizing diets can reduce the risk of disease as predicted by the warburg hypothesis
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Lactate beyond a waste metabolite: metabolic affairs and signaling in malignancy
10.3389/fonc.2020.00231 · 2020 · External reference
Targeting the warburg effect in cancer: where do we stand?
10.3390/ijms25063142 · 2024 · External reference
New insights on the role of lipid metabolism in the metabolic reprogramming of macrophages
10.3389/fimmu.2019.02993 · 2019 · External reference
Direct assessment of hepatic mitochondrial oxidative and anaplerotic fluxes in humans using dynamic 13C magnetic resonance spectroscopy
10.1038/nm.3415 · 2014 · External reference
Monocarboxylate transporter 1 blockade with AZD3965 inhibits lipid biosynthesis and increases tumour immune cell infiltration
10.1038/s41416-019-0717-x · 2020 · External reference
Understanding the tumor immune microenvironment (TIME) for effective therapy
10.1038/s41591-018-0014-x · 2018 · External reference
LDHA-associated lactic acid production blunts tumor immunosurveillance by T and NK cells
10.1016/j.cmet.2016.08.011 · 2016 · External reference
The science and translation of lactate shuttle theory
10.1016/j.cmet.2018.03.008 · 2018 · External reference
Increased tumor glycolysis characterizes immune resistance to adoptive T cell therapy
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Lactate is a metabolic mediator that shapes immune cell fate and function
10.3389/fphys.2021.688485 · 2021 · External reference
Understanding lactate sensing and signalling
10.1016/j.tem.2022.07.004 · 2022 · External reference
Gpr132 sensing of lactate mediates tumor-macrophage interplay to promote breast cancer metastasis
10.1073/pnas.1614035114 · 2017 · External reference
Lactylation, a novel metabolic reprogramming code: current status and prospects
10.3389/fimmu.2021.688910 · External reference
Dual blockade of Lactate/GPR81 and PD-1/PD-L1 pathways enhances the anti-tumor effects of metformin
10.3390/biom11091373 · External reference
Lactate-lactylation hands between metabolic reprogramming and immunosuppression
10.3390/ijms231911943 · 2022 · External reference
Lactic acid: a narrative review of a promoter of the liver cancer microenvironment
10.21037/jgo-24-368 · External reference
The emerging role of lactate in tumor microenvironment and its clinical relevance
10.1016/j.canlet.2024.216837 · External reference
Metabolic regulation of homologous recombination repair by MRE11 lactylation
10.1016/j.cell.2023.11.022 · External reference
Lactate and lactylation in cancer
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Lactate metabolism and lactylation in kidney diseases: insights into mechanisms and therapeutic opportunities
10.1080/0886022x.2025.2469746 · 2025 · External reference
Targeting epigenetic regulators for cancer therapy: mechanisms and advances in clinical trials
10.1038/s41392-019-0095-0 · 2019 · External reference
Elevated urinary D-lactate levels in patients with diabetes and microalbuminuria
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The multiple roles of LDH in cancer
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Point-of-care coagulation testing for postpartum haemorrhage
10.1016/j.bpa.2022.08.002 · 2022 · External reference
Lactate modulates CD4(+) T-cell polarization and induces an immunosuppressive environment, which sustains prostate carcinoma progression via TLR8/miR21 axis
10.1038/s41388-019-0688-7 · 2019 · External reference
Lactate in the regulation of tumor microenvironment and therapeutic approaches
10.3389/fonc.2019.01143 · 2019 · External reference
Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis
10.1073/pnas.0709747104 · 2007 · External reference
Antitumor activity of 7-aminocarboxycoumarin derivatives, a new class of potent inhibitors of lactate influx but not efflux
10.1158/1535-7163.mct-13-0653 · 2014 · External reference
Development of a novel lactate dehydrogenase A inhibitor with potent antitumor activity and immune activation
10.1111/cas.15468 · 2022 · External reference
Gluconeogenesis and hepatic glycogenolysis during exercise at the lactate threshold
10.1152/japplphysiol.01202.2012 · 2013 · External reference
D-lactic acidosis - case report and review of the literature
10.1055/s-0042-117647 · 2017 · External reference
Identification of SIRT3 as an eraser of H4K16la
10.1016/j.isci.2023.107757 · 2023 · External reference
Emerging roles of lactate in acute and chronic inflammation
10.1186/s12964-024-01624-8 · 2024 · External reference
Lactate metabolism and lactylation in cancer: from pathogenesis to therapeutic advances
10.1038/s41392-026-02672-x · 2026 · External reference
100 years of the Warburg effect: a cancer metabolism endeavor
10.1016/j.cell.2024.06.026 · 2024 · External reference
Tumor cell-derived lactate induces TAZ-dependent upregulation of PD-L1 through GPR81 in human lung cancer cells
10.1038/onc.2017.188 · 2017 · External reference
Reciprocal metabolic reprogramming through lactate shuttle coordinately influences tumor-stroma interplay
10.1158/0008-5472.can-12-1949 · 2012 · External reference
The CD28 signaling pathway regulates glucose metabolism
10.1016/s1074-7613(02)00323-0 · 2002 · External reference
Oncometabolites drive tumorigenesis by enhancing protein acylation: from chromosomal remodelling to nonhistone modification
10.1186/s13046-022-02338-w · 2022 · External reference
Non-enzymatic lysine lactoylation of glycolytic enzymes
10.1016/j.chembiol.2019.11.005 · 2020 · External reference
Tumor microenvironment: lactic acid promotes tumor development
10.1155/2022/3119375 · 2022 · External reference
The tumor metabolic microenvironment: lessons from lactate
10.1158/0008-5472.can-18-3726 · 2019 · External reference
Molecular PET imaging: unlocking the secrets of cancer metabolism
10.1016/j.bcp.2025.117202 · 2025 · External reference
Glutamine metabolism in cancers: targeting the oxidative homeostasis
10.3389/fonc.2022.994672 · 2022 · External reference
Post-translational protein lactylation modification in health and diseases: a double-edged sword
10.1186/s12967-023-04842-9 · 2024 · External reference
Tumor-derived lactic acid modulates dendritic cell activation and antigen expression
10.1182/blood-2005-05-1795 · 2006 · External reference
Exploring lactylation and cancer biology: insights from pathogenesis to clinical applications
10.3389/fcell.2025.1598232 · 2025 · External reference
Glycolytic metabolism is essential for CCR7 oligomerization and dendritic cell migration
10.1038/s41467-018-04804-6 · 2018 · External reference
Cellular uptake of MCT1 inhibitors AR-C155858 and AZD3965 and their effects on MCT-mediated transport of L-Lactate in murine 4T1 breast tumor cancer cells
10.1208/s12248-018-0279-5 · 2019 · External reference
A phase I dose-escalation study of AZD3965, an oral monocarboxylate transporter 1 inhibitor, in patients with advanced cancer
10.1158/1078-0432.ccr-22-2263 · 2023 · External reference
d-lactate modulates M2 tumor-associated macrophages and remodels immunosuppressive tumor microenvironment for hepatocellular carcinoma
10.1126/sciadv.adg2697 · 2023 · External reference
Lactate and lactylation: dual regulators of T-Cell-Mediated tumor immunity and immunotherapy
10.3390/biom14121646 · 2024 · External reference
Oxamate, an LDHA inhibitor, inhibits stemness, including EMT and high DNA repair ability, induces senescence, and exhibits radiosensitizing effects in glioblastoma cells
10.3390/ijms26125710 · 2025 · External reference
The oncogenic and clinical implications of lactate induced immunosuppression in the tumour microenvironment
10.1016/j.canlet.2020.12.021 · 2021 · External reference
Lactylation in cancer: mechanisms in tumour biology and therapeutic potentials
10.1002/ctm2.70070 · 2024 · External reference
Lactate and lactylation in gastrointestinal cancer: current progress and perspectives
10.3892/or.2024.8839 · 2025 · External reference
Development of a potent and selective G2A (GPR132) agonist
10.1021/acs.jmedchem.3c02164 · 2024 · External reference
Dux activates metabolism-lactylation-MET network during early iPSC reprogramming with Brg1 as the histone lactylation reader
10.1093/nar/gkae183 · External reference
Lactylation: the novel histone modification influence on gene expression, protein function, and disease
10.1186/s13148-024-01682-2 · External reference
Targeting mTOR for cancer therapy
10.1186/s13045-019-0754-1 · 2019 · External reference
Lactate: a metabolic driver in the tumour landscape
10.1016/j.tibs.2018.10.011 · 2019 · External reference
10.1016/j.csbj.2021.08.013 · 2021 · Admitted local publication
From metabolic byproduct to immune modulator: the role of lactate in tumor immune escape
10.3389/fimmu.2024.1492050 · 2024 · External reference
SIRT3-dependent delactylation of cyclin E2 prevents hepatocellular carcinoma growth
10.15252/embr.202256052 · 2023 · External reference
Unlocking the multifaceted molecular functions and diverse disease implications of lactylation
10.1111/brv.13135 · 2025 · External reference
Auto-Kla: a novel web server to discriminate lysine lactylation sites using automated machine learning
10.1093/bib/bbad070 · 2023 · External reference
Calcium carbonate nanoparticles stimulate cancer cell reprogramming to suppress tumor growth and invasion in an organ-on-a-chip system
10.1038/s41598-021-88687-6 · 2021 · External reference
Programmed cell death-1 (PD-1) checkpoint blockade in combination with a mammalian target of rapamycin inhibitor restrains hepatocellular carcinoma growth induced by hepatoma cell-intrinsic PD-1
10.1002/hep.29360 · 2017 · External reference
Aerobic glycolysis controls myeloid-derived suppressor cells and tumor immunity via a specific CEBPB isoform in triple-negative breast cancer
10.1016/j.cmet.2018.04.022 · 2018 · External reference
Lactate metabolism in human health and disease
10.1038/s41392-022-01151-3 · 2022 · External reference
Lactate-responsive gene editing to synergistically enhance macrophage-mediated cancer immunotherapy
10.1002/smll.202301519 · 2023 · External reference
Advances in the interaction of glycolytic reprogramming with lactylation
10.1016/j.biopha.2024.116982 · External reference
Understanding the warburg effect in cancer
10.1101/cshperspect.a041532 · External reference
L- and D-Lactate: unveiling their hidden functions in disease and health
10.1186/s12964-025-02132-z · 2025 · External reference
2-Deoxy-D-glucose-induced cytotoxicity and radiosensitization in tumor cells is mediated via disruptions in thiol metabolism
2003 · External reference
Lactate: a rising star in tumors and inflammation
10.3389/fimmu.2024.1496390 · External reference
Activation of GPR81 by lactate drives tumour-induced cachexia
10.1038/s42255-024-01011-0 · External reference
Energy metabolism in health and diseases
10.1038/s41392-025-02141-x · 2025 · External reference
Lactate: a key regulator of the immune response
10.1016/j.immuni.2025.02.008 · 2025 · External reference
Downregulation of MCT4 for lactate exchange promotes the cytotoxicity of NK cells in breast carcinoma
10.1002/cam4.1713 · 2018 · External reference
Burkitt lymphoma and lactic acidosis: a case report and review of the literature
10.14814/phy2.14737 · 2021 · External reference
Lactylation: the emerging frontier in post-translational modification
10.3389/fgene.2024.1423213 · 2024 · External reference
DeepKla: an attention mechanism-based deep neural network for protein lysine lactylation site prediction
10.1002/imt2.11 · 2022 · External reference
Burning lactic acid: a road to revitalizing antitumor immunity
10.1007/s11684-025-1126-6 · 2025 · External reference
Lactate and lactylation: metabolic architects of tumor progression and metastasis
10.1007/s13402-026-01182-w · 2026 · External reference
Lactate-dependent regulation of immune responses by dendritic cells and macrophages
10.3389/fimmu.2021.691134 · 2021 · External reference
Role of lactate in inflammatory processes: friend or foe
10.3389/fimmu.2021.808799 · 2021 · External reference
Innate lymphoid cells and tumor-derived lactic acid: novel contenders in an enduring game
10.3389/fimmu.2023.1236301 · 2023 · External reference
Tumor lactic acidosis suppresses CTL function by inhibition of p38 and JNK/c-Jun activation
10.1002/ijc.26410 · 2012 · External reference
Class I histone deacetylases (HDAC1-3) are histone lysine delactylases
10.1126/sciadv.abi6696 · 2022 · External reference
mTOR signalling and cellular metabolism are mutual determinants in cancer
10.1038/s41568-018-0074-8 · 2018 · External reference
Metabolic symbiosis in cancer: refocusing the warburg lens
10.1002/mc.21863 · 2013 · External reference
Lactate controls cancer stemness and plasticity through epigenetic regulation
10.1016/j.cmet.2025.01.002 · 2025 · External reference
The TRIM33 bromodomain recognizes histone lysine lactylation
10.1021/acschembio.4c00248 · 2024 · External reference
Cancer immunotherapy via dendritic cells
10.1038/nrc3258 · 2012 · External reference
Demethylzeylasteral targets lactate by inhibiting histone lactylation to suppress the tumorigenicity of liver cancer stem cells
10.1016/j.phrs.2022.106270 · 2022 · External reference
Metabolism of dendritic cells in tumor microenvironment: for immunotherapy
10.3389/fimmu.2021.613492 · 2021 · External reference
Estimation of glucose-alanine-lactate-glutamine cycles in postabsorptive humans: role of skeletal muscle
10.1152/ajpendo.1995.269.3.e443 · 1995 · External reference
Lactate buildup at the site of chronic inflammation promotes disease by inducing CD4(+) T cell metabolic rewiring
10.1016/j.cmet.2019.10.004 · 2019 · External reference
Lactic acid promotes metastatic niche formation in bone metastasis of colorectal cancer
10.1186/s12964-020-00667-x · 2021 · External reference
Inhibition of LDH-A by oxamate enhances the efficacy of Anti-PD-1 treatment in an NSCLC humanized mouse model
10.3389/fonc.2021.632364 · 2021 · External reference
Histone lactylation regulates cancer progression by reshaping the tumor microenvironment
10.3389/fimmu.2023.1284344 · 2023 · External reference
Lactate limits T cell proliferation via the NAD(H) redox state
10.1016/j.celrep.2020.108500 · 2020 · External reference
Lactate: the ugly duckling of energy metabolism
10.1038/s42255-020-0243-4 · 2020 · External reference
A chemical reporter strategy to probe glycoprotein fucosylation
10.1021/ja064619y · 2006 · External reference
Lactate induces pro-tumor reprogramming in intratumoral plasmacytoid dendritic cells
10.3389/fimmu.2019.01878 · 2019 · External reference
Restricting glycolysis preserves T cell effector functions and augments checkpoint therapy
10.1016/j.celrep.2019.08.068 · 2019 · External reference
Systematic review of Gossypol/AT-101 in cancer clinical trials
10.3390/ph15020144 · 2022 · External reference
Bicarbonate increases tumor pH and inhibits spontaneous metastases
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Lactate contribution to the tumor microenvironment: mechanisms, effects on immune cells and therapeutic relevance
10.3389/fimmu.2016.00052 · 2016 · External reference
Lactate in skin homeostasis: metabolism, skin barrier, and immunomodulation
10.3389/fimmu.2025.1510559 · 2025 · External reference
Role of LDH in tumor glycolysis: regulation of LDHA by small molecules for cancer therapeutics
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Gossypol and semisynthetic derivatives: chemistry, bioactivities, and mechanism of actions
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Quantitative determinants of aerobic glycolysis identify flux through the enzyme GAPDH as a limiting step
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The small-molecule compound AC-73 targeting CD147 inhibits leukemic cell proliferation, induces autophagy and increases the chemotherapeutic sensitivity of acute myeloid leukemia cells
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The pyruvate dehydrogenase complex at the epigenetic crossroads of acetylation and lactylation
10.1016/j.ymgme.2024.108540 · 2024 · External reference
Lactate/GPR81 recruits regulatory T cells by modulating CX3CL1 to promote immune resistance in a highly glycolytic gastric cancer
10.1080/2162402x.2024.2320951 · 2024 · External reference
Role of proton-coupled monocarboxylate transporters in cancer: from metabolic crosstalk to therapeutic potential
10.3389/fcell.2020.00651 · 2020 · External reference
A bioorthogonal chemical reporter for the detection and identification of protein lactylation
10.1039/d2sc00918h · 2022 · External reference
Discovery of the first lactate dehydrogenase proteolysis targeting chimera degrader for the treatment of pancreatic cancer
10.1021/acs.jmedchem.2c01505 · 2023 · External reference
Lactylation: linking the warburg effect to DNA damage repair
10.1016/j.cmet.2024.06.015 · 2024 · External reference
Impact of glycolysis enzymes and metabolites in regulating DNA damage repair in tumorigenesis and therapy
10.1186/s12964-025-02047-9 · 2025 · External reference
Cancer cachexia: molecular basis and therapeutic advances
10.1038/s41392-025-02331-7 · 2026 · External reference
Unveiling the veil of lactate in tumor-associated macrophages: a successful strategy for immunometabolic therapy
10.3389/fimmu.2023.1208870 · 2023 · External reference
Lactate kinetics in human tissues at rest and during exercise
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Quantification of lactoyl-CoA (lactyl-CoA) by liquid chromatography mass spectrometry in mammalian cells and tissues
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The Warburg effect: essential part of metabolic reprogramming and central contributor to cancer progression
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Modern perspective of lactate metabolism
10.33549/physiolres.935331 · 2024 · External reference
Meaning and significance of Alkalization therapy for cancer
10.3389/fonc.2022.920843 · 2022 · External reference
The tumor microenvironment in hematologic malignancies: immune evasion, metabolic reprogramming, and therapeutic resistance
10.1097/bs9.0000000000000270 · 2026 · External reference
Cyclic immonium ion of lactyllysine reveals widespread lactylation in the human proteome
10.1038/s41592-022-01523-1 · 2022 · External reference
Lactylation and human disease
10.1017/erm.2025.3 · 2025 · External reference
Lactic acid and an acidic tumor microenvironment suppress anticancer immunity
10.3390/ijms21218363 · 2020 · External reference
Novel strategies to improve tumour therapy by targeting the proteins MCT1, MCT4 and LAT1
10.1016/j.ejmech.2021.113806 · External reference
Lactate in the tumour microenvironment: from immune modulation to therapy
10.1016/j.ebiom.2021.103627 · External reference
Lactate-induced protein lactylation: a bridge between epigenetics and metabolic reprogramming in cancer
10.1111/cpr.13478 · 2023 · External reference
Comprehensive multiscale analysis of lactate metabolic dynamics in vitro and in vivo using highly responsive biosensors
10.1038/s41596-023-00948-y · External reference
The relationship and clinical significance of lactylation modification in digestive system tumors
10.1186/s12935-024-03429-8 · External reference
Ubiquitous protein lactylation in health and diseases
10.1186/s11658-024-00541-5 · External reference
Lactate-induced protein lactylation in cancer: functions, biomarkers and immunotherapy strategies
10.3389/fimmu.2024.1513047 · External reference
Synthesis of cytochrome C oxidase 2: a p53-dependent metabolic regulator that promotes respiratory function and protects glioma and colon cancer cells from hypoxia-induced cell death
10.1038/onc.2011.530 · 2012 · External reference
Dendritic cells in cancer immunology and immunotherapy
10.1038/s41577-019-0210-z · 2020 · External reference
Metabolite transporters as regulators of immunity
10.3390/metabo10100418 · 2020 · External reference
Lactate dehydrogenases amplify reactive oxygen species in cancer cells in response to oxidative stimuli
10.1038/s41392-021-00595-3 · 2021 · External reference
Microbiotic nanomedicine for tumor-specific chemotherapy-synergized innate/adaptive antitumor immunity
10.1016/j.nantod.2022.101377 · 2022 · External reference
The emerging era of lactate: a rising star in cellular signaling and its regulatory mechanisms
10.1002/jcb.30458 · External reference
Interplay between metabolic reprogramming and post-translational modifications: from glycolysis to lactylation
10.3389/fimmu.2023.1211221 · External reference
A phase II study of the orally administered negative enantiomer of gossypol (AT-101), a BH3 mimetic, in patients with advanced adrenal cortical carcinoma
10.1007/s10637-019-00797-1 · 2019 · External reference
CircXRN2 suppresses tumor progression driven by histone lactylation through activating the Hippo pathway in human bladder cancer
10.1186/s12943-023-01856-1 · 2023 · External reference
KAT8-catalyzed lactylation promotes eEF1A2-mediated protein synthesis and colorectal carcinogenesis
10.1073/pnas.2314128121 · 2024 · External reference
Synergistically suppressive effects on colorectal cancer cells by combination of mTOR inhibitor and glycolysis inhibitor, Oxamate
2018 · External reference
Synergistic effect of targeting mTOR by rapamycin and depleting ATP by inhibition of glycolysis in lymphoma and leukemia cells
10.1038/sj.leu.2403968 · 2005 · External reference
Royal jelly acid suppresses hepatocellular carcinoma tumorigenicity by inhibiting H3 histone lactylation at H3K9la and H3K14la sites
10.1016/j.phymed.2023.154940 · 2023 · External reference
Lactate and lactylation in macrophage metabolic reprogramming: current progress and outstanding issues
10.3389/fimmu.2024.1395786 · 2024 · External reference
Lactate-modulated immunosuppression of myeloid-derived suppressor cells contributes to the radioresistance of pancreatic cancer
10.1158/2326-6066.cir-20-0111 · 2020 · External reference
Lactate promotes macrophage HMGB1 lactylation, acetylation, and exosomal release in polymicrobial sepsis
10.1038/s41418-021-00841-9 · 2022 · External reference
Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma
10.1038/s42255-022-00710-w · 2023 · External reference
The role of nonhistone lactylation in disease
10.1016/j.heliyon.2024.e36296 · External reference
Histone lactylation: from tumor lactate metabolism to epigenetic regulation
10.7150/ijbs.91492 · External reference
Roles of G protein-coupled receptors in inflammatory bowel disease
10.3748/wjg.v26.i12.1242 · 2020 · External reference
Metabolic regulation of gene expression by histone lactylation
10.1038/s41586-019-1678-1 · 2019 · External reference
The role of glycolysis and lactate in the induction of tumor-associated macrophages immunosuppressive phenotype
10.1016/j.intimp.2022.108994 · 2022 · External reference
Lactate's impact on immune cells in sepsis: unraveling the complex interplay
10.3389/fimmu.2024.1483400 · External reference
A rising star involved in tumour immunity: lactylation
10.1111/jcmm.70146 · External reference
Histone lactylation bridges metabolic reprogramming and epigenetic rewiring in driving carcinogenesis: oncometabolite fuels oncogenic transcription
10.1002/ctm2.1614 · External reference
Lactylation in health and disease: physiological or pathological?
10.7150/thno.105353 · 2025 · External reference
ACAT1-Mediated ME2 acetylation drives chemoresistance in ovarian cancer by linking glutaminolysis to lactate production
10.1002/advs.202416467 · 2025 · External reference
Lactic acid in macrophage polarization: the significant role in inflammation and cancer
10.1080/08830185.2021.1955876 · 2022 · External reference
Mutant KRAS-activated circATXN7 fosters tumor immunoescape by sensitizing tumor-specific T cells to activation-induced cell death
10.1038/s41467-024-44779-1 · 2024 · External reference
Potential of lactylation as a therapeutic target in cancer treatment
10.3892/mmr.2025.13456 · 2025 · External reference
Alanyl-tRNA synthetase, AARS1, is a lactate sensor and lactyltransferase that lactylates p53 and contributes to tumorigenesis
10.1016/j.cell.2024.04.002 · 2024 · External reference