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References from Role of the cGAS-STING signaling pathway in diabetes mellitus and its complications: from mechanisms to therapeutics. Local targets link to admitted publications; unresolved targets remain external evidence.
Metformin as a multi-target modulator of atherosclerosis: integrated regulation of Nrf2/KLF2, mitochondrial homeostasis, inflammation, ferroptosis, and innate immunity
10.1093/jpp/rgag056 · 2026 · External reference
Rosavin improves insulin resistance and alleviates hepatic and kidney damage via modulating the cGAS-STING pathway and autophagy signaling in HFD/STZ-induced T2DM animals
10.1039/d4md00023d · 2024 · External reference
IFI16 and cGAS cooperate in the activation of STING during DNA sensing in human keratinocytes
10.1038/ncomms14392 · 2017 · External reference
Hyperglycemia-induced STING signaling activation leads to aortic endothelial injury in diabetes
10.1186/s12964-023-01393-w · 2023 · External reference
Macrophage-specific inhibition of the histone demethylase JMJD3 decreases STING and pathologic inflammation in diabetic wound repair
10.1038/s41423-022-00919-5 · 2022 · External reference
cGAS‒STING signaling and function in metabolism and kidney diseases
10.1093/jmcb/mjab066 · 2021 · External reference
DsbA-L prevents obesity-induced inflammation and insulin resistance by suppressing the mtDNA release-activated cGAS-cGAMP-STING pathway
10.1073/pnas.1708744114 · 2017 · External reference
Dysfunctional mitochondria as critical players in the inflammation of autoimmune diseases: potential role in Sjogren's syndrome
10.1016/j.autrev.2021.102867 · 2021 · External reference
Hemostatic state augmented with platelet indices among Sudanese diabetic septic foot
10.1186/s12878-018-0104-5 · 2018 · External reference
cGAS suppresses beta-cell proliferation by a STING-independent but CEBPbeta-dependent mechanism
10.1016/j.metabol.2024.155933 · 2024 · External reference
Targeting the cGAS-STING pathway to modulate immune inflammation in diabetes and cardiovascular complications: mechanisms and therapeutic insights
10.3390/cimb47090750 · 2025 · External reference
Hoxa5 alleviates adipose tissue metabolic distortions in high-fat diet mice associated with a reduction in MERC
10.1186/s12915-024-02047-0 · 2024 · External reference
BRG1 deficiency promotes cardiomyocyte inflammation and apoptosis by activating the cGAS-STING signaling in diabetic cardiomyopathy
10.1007/s10753-024-02058-7 · External reference
Dual-network hydrogel loaded with octreotide promotes diabetic wound healing by inhibiting cGAS-STING pathway
10.1016/j.cej.2025.170675 · External reference
AMPK/SIRT1/PGC-1alpha signaling pathway: molecular mechanisms and targeted strategies from energy homeostasis regulation to disease therapy
10.1111/cns.70657 · External reference
Endoplasmic reticulum stress orchestrates cGAS-STING activation in lipid metabolism-associated disorders
10.1016/j.intimp.2025.115968 · External reference
The central role of endoplasmic reticulum stress in Parkinson's disease and targeted therapeutic strategies
10.1016/j.bcp.2026.118218 · External reference
Mitochondrial damage and activation of the STING pathway lead to renal inflammation and fibrosis
10.1016/j.cmet.2019.08.003 · 2019 · External reference
Celecoxib ameliorates diabetic sarcopenia by inhibiting inflammation, stress response, mitochondrial dysfunction, and subsequent activation of the protein degradation systems
10.3389/fphar.2024.1344276 · 2024 · External reference
Regulation of monocyte activation by PPARalpha through interaction with the cGAS-STING pathway
10.2337/db22-0654 · 2023 · External reference
The mediating role of general self-efficacy in health self-management and psychological stress among older adults in shanghai: a structural equation modeling analysis
10.3390/healthcare13010046 · 2024 · External reference
Innate immune signalling in the adipocyte
10.1093/jb/mvag017 · 2026 · External reference
RBM43 controls PGC1alpha translation and a PGC1alpha-STING signaling axis
10.1016/j.cmet.2025.01.013 · 2025 · External reference
ZBiotics ameliorates T2DM-induced histopathological damage in liver, kidney and adipose tissues by modulating the NOD-like receptor signaling in Wistar rats
10.1186/s13098-025-01600-3 · 2025 · External reference
Electroacupuncture protects gastric Cajal cells by reducing macrophage pyroptosis in diabetic gastroparesis
10.4239/wjd.v17.i2.114252 · 2026 · External reference
STING activation promotes inflammatory response and delays skin wound healing in diabetic mice
10.1016/j.bbrc.2022.04.085 · 2022 · External reference
PCSK9 causes inflammation and cGAS/STING pathway activation in diabetic nephropathy
10.1096/fj.202300342rrr · 2023 · External reference
Amlexanox alleviates renal inflammation and fibrosis by inhibiting cGAS/STING/TBK1 and TGF-beta1/Smad signaling
10.1016/j.ejphar.2025.178266 · 2025 · External reference
A novel GPR84 antagonist attenuates diabetic lung injury by inhibiting pyroptosis via the cGAS-STING pathway in pulmonary vascular endothelial cells
10.1016/j.intimp.2025.115190 · 2025 · External reference
Nuclear envelope integrity in health and disease: consequences on genome instability and inflammation
10.3390/ijms22147281 · 2021 · External reference
STING facilitates the development of radiation-induced lung injury via regulating the PERK/eIF2alpha pathway
10.21037/tlcr-24-649 · 2024 · External reference
cGAMP promotes inner blood-retinal barrier breakdown through P2RX7-mediated transportation into microglia
10.1186/s12974-025-03391-w · 2025 · External reference
High glucose-induced STING activation inhibits diabetic wound healing through promoting M1 polarization of macrophages
10.1038/s41420-023-01425-x · 2023 · External reference
Molecular mechanisms and multi-target therapeutic strategies of diabetic nephropathy: from pathogenesis to precision interventions
10.3389/fphar.2025.1729941 · 2025 · External reference
The dual role of cell death in skeletal muscle homeostasis and disease: mechanisms and therapeutic targeting
10.1016/j.ejphar.2026.179208 · 2026 · External reference
Fibroblast growth factor-inducible 14 accelerates pulmonary fibrosis by inducing fibroblast senescence in mice
10.1007/s00018-026-06161-w · 2026 · External reference
Qihuang Yishen formula attenuates renal tubular injury by modulating inflammation via the cGAS/STING pathway in diabetic kidney disease
10.1016/j.phymed.2025.157399 · 2025 · External reference
Interrupting a mitochondrial DNA-driven innate immune circuit attenuates hepatic tissue remodeling and fibrotic architecture in experimental steatohepatitis
10.1016/j.tice.2026.103733 · 2026 · External reference
First evidence for STING SNP R293Q being protective regarding obesity-associated cardiovascular disease in age-advanced subjects - a cohort study
10.1186/s12979-020-00176-y · 2020 · External reference
Triple tumor microenvironment-responsive ferroptosis pathways induced by manganese-based imageable nanoenzymes for enhanced breast cancer theranostics
10.1002/smtd.202300230 · 2023 · External reference
The cGAS-STING pathway: a therapeutic target in diabetes and its complications
10.1093/burnst/tkad050 · External reference
Glucagon-like peptide-1 receptor agonists rescued diabetic vascular endothelial damage through suppression of aberrant STING signaling
10.1016/j.apsb.2024.03.011 · External reference
Microglial cGAS deletion preserves intercellular communication and alleviates amyloid-beta-induced pathogenesis of Alzheimer's disease
10.1002/advs.202410910 · 2025 · External reference
The selective STING inhibitor H-151 preserves myocardial function and ameliorates cardiac fibrosis in murine myocardial infarction
10.1016/j.intimp.2022.108658 · 2022 · External reference
Apoptotic vesicle membrane-mediated targeted endothelial mitochondrial transplantation-clearance therapy for diabetic wound healing
10.34133/research.1042 · 2026 · External reference
Elevation of ISG15 promotes diabetic kidney disease by modulating renal tubular epithelial cell pyroptosis
10.1002/ctm2.70337 · External reference
IL-37 ameliorates myocardial fibrosis by regulating mtDNA-enriched vesicle release in diabetic cardiomyopathy mice
10.1186/s12967-024-05250-3 · 2024 · External reference
Endurance exercise remodels skeletal muscle by suppressing Ythdf1-mediated myostatin expression
10.1038/s41419-025-07379-5 · External reference
Endoplasmic reticulum stress and unfolded protein response: roles in skeletal muscle atrophy
10.1016/j.bcp.2025.116799 · 2025 · External reference
The cGAS-STING signaling pathway: a central regulator and novel therapeutic target in skeletal muscle pathophysiology
10.1016/j.bcp.2026.117854 · 2026 · External reference
IFI16 is required for DNA sensing in human macrophages by promoting production and function of cGAMP
10.1038/ncomms14391 · 2017 · External reference
STING induces ZBP1-mediated necroptosis independently of TNFR1 and FADD
10.1038/s41586-025-09536-4 · 2025 · External reference
Role of cGAS/STING pathway in aging and sexual dimorphism in diabetic kidney disease
10.1172/jci.insight.174126 · 2024 · External reference
Micronuclei, inflammation and auto-immune disease
10.1016/j.mrrev.2020.108335 · 2020 · External reference
DNA sensors in metabolic and cardiovascular diseases: molecular mechanisms and therapeutic prospects
10.1111/imr.13382 · 2025 · External reference
Macrophage PTP1B regulates mitochondrial dynamics via the JAK2/STAT3-OPA1 axis and activates the cGAS/STING signaling pathway
10.3389/fimmu.2025.1644289 · 2025 · External reference
TGR5 supresses cGAS/STING pathway by inhibiting GRP75-mediated endoplasmic reticulum-mitochondrial coupling in diabetic retinopathy
10.1038/s41419-023-06111-5 · 2023 · External reference
PLAGL1 overexpression induces cytoplasmic DNA accumulation that triggers cGAS/STING activation
10.1111/jcmm.70130 · External reference
DNA damage-induced AIM2 pyroptosis in high glucose-induced proximal tubular epithelial cell
10.3389/fcell.2024.1457369 · External reference
PLAGL1 overexpression exacerbates type 1 diabetes by inducing beta-cell apoptosis via oxidative stress-dependent dual DNA damage and cGAS/STING pathway activation
10.1111/jdi.70204 · External reference
Mechanisms of impaired skeletal muscle regeneration and therapeutic approaches in aging and chronic disease
10.3390/ph19071091 · External reference
TET2 germline variants promote kidney disease by impairing DNA repair and activating cytosolic nucleotide sensors
10.1038/s41467-024-53798-x · 2024 · External reference
Activated cGAS/STING signaling elicits endothelial cell senescence in early diabetic retinopathy
10.1172/jci.insight.168945 · 2023 · External reference
Mechanisms and therapeutic potential of the cGAS-STING signaling pathway in macrophage activation and polarization
10.1016/j.bcp.2026.118031 · 2026 · External reference
Metrnl ameliorates diabetic cardiomyopathy via inactivation of cGAS/STING signaling dependent on LKB1/AMPK/ULK1-mediated autophagy
10.1016/j.jare.2022.10.014 · 2023 · External reference
Jiangtang Tiaozhi formula relieves HFD-induced obesity related type 2 diabetes by inhibiting the cGAS-STING pathway
10.1111/jcmm.70882 · 2025 · External reference
Lipotoxicity-induced mtDNA release promotes diabetic cardiomyopathy by activating the cGAS-STING pathway in obesity-related diabetes
10.1007/s10565-021-09692-z · External reference
Orphan nuclear receptor 4 A1 involvement in transforming growth factor beta1-induced myocardial fibrosis in diabetic mice
10.26402/jpp.2023.6.04 · External reference
Loss of hepatic DRP1 exacerbates alcoholic hepatitis by inducing megamitochondria and mitochondrial maladaptation
10.1002/hep.32604 · External reference
Beneficial effects of different types of exercise on diabetic cardiomyopathy
10.3390/biom15091223 · 2025 · External reference
Cortistatin antagonizes Piezo1-STING axis and facilitates mitochondrial homeostasis of keratinocytes by attenuating AGEs accumulation in diabetic ulcers
10.1038/s41418-026-01699-5 · 2026 · External reference
STING-IRF3 triggers endothelial inflammation in response to free fatty acid-induced mitochondrial damage in diet-induced obesity
10.1161/atvbaha.117.309017 · 2017 · External reference
Impairment of mitochondrial quality control exacerbates diabetes-related atrial fibrillation by cGAS-STING signaling pathway and cardiomyocyte-macrophage crosstalk
10.7150/thno.124140 · 2026 · External reference
Activation of stimulator of IFN genes (STING) causes proteinuria and contributes to glomerular diseases
10.1681/asn.2021101286 · 2022 · External reference
Protein kinase TBK1/IKKepsilon inhibitor Amlexanox improves cardiac function after acute myocardial infarction in rats
10.23736/s0031-0808.20.03937-3 · 2023 · External reference
Implications of the cGAS-STING pathway in diabetes: risk factors and therapeutic strategies
10.1016/j.ijbiomac.2024.134210 · 2024 · External reference
NAD metabolism modulates inflammation and mitochondria function in diabetic kidney disease
10.1016/j.jbc.2023.104975 · 2023 · External reference
Application of dental pulp stem cell-derived intracellular vesicles for diabetic wound healing
10.2337/db24-0686 · 2025 · External reference
Experimental type 2 diabetes and lipotoxicity-associated neuroinflammation involve mitochondrial DNA-mediated cGAS/STING axis: implication of Type-1 interferon response in cognitive impairment
10.1007/s12035-024-03933-y · 2024 · External reference
Network of cell death in myocardial ischemia-reperfusion injury: mechanisms and targeted therapeutic strategies
10.1016/j.bcp.2026.117999 · External reference
The myocardial ischemic cascade network and multi-target synergistic interventions: from molecular mechanisms to therapeutic innovations
10.1016/j.bcp.2026.117704 · External reference
Aberrant STING signalling promotes endothelial dysfunction and neurovascular injury in diabetic retinopathy
10.1007/s00125-025-06628-8 · 2026 · External reference
Tao Hong Si Wu decoction attenuates myocardial injury in diabetic mice by regulating the cGAS/STING/NLRP3 axis
10.1007/s13205-025-04516-x · 2025 · External reference
DDX41 is required for cGAS-STING activation against DNA virus infection
10.1016/j.celrep.2022.110856 · 2022 · External reference
LARP7 contributes to glucose-induced cardiac dysfunction, apoptosis and fibrosis by inhibiting the degradation of STING
10.31083/j.fbl2907274 · 2024 · External reference
Diabetes mellitus-driven pulmonary injury: multidimensional mechanisms linking metabolic dysregulation to gut-lung axis and promising therapies
10.3389/fphar.2025.1689522 · External reference
Fenofibrate inhibits activation of cGAS-STING pathway by alleviating mitochondrial damage to attenuate inflammatory response in diabetic dry eye
10.1016/j.freeradbiomed.2025.05.383 · External reference
Tectorigenin alleviates diabetic lung injury by restoring gut microbiota and metabolic homeostasis
10.1016/j.bcp.2025.117545 · 2026 · External reference
Exploring the pathogenesis of MAFLD from an immunological perspective: from the perspective of the cGAS/STING/NF-kappaB signaling pathway
10.3389/fimmu.2025.1674018 · 2025 · External reference
METTL3-Mediated N 6 -Methyladenosine mRNA modification and cGAS-STING pathway activity in kidney fibrosis
10.1681/asn.0000000000000428 · 2024 · External reference
Copper induces cell death by targeting lipoylated TCA cycle proteins
10.1126/science.abf0529 · 2022 · External reference
Synthetic enforcement of STING signaling in cancer cells appropriates the immune microenvironment for checkpoint inhibitor therapy
10.1126/sciadv.add8564 · 2023 · External reference
Homoplantaginin alleviates high glucose-induced vascular endothelial senescence by inhibiting mtDNA-cGAS-STING pathway via blunting DRP1-mitochondrial fission-VDAC1 axis
10.1096/fj.202401299rr · External reference
Metformin normalizes mitochondrial function to delay astrocyte senescence in a mouse model of Parkinson's disease through Mfn2-cGAS signaling
10.1186/s12974-024-03072-0 · External reference
AhR deficiency exacerbates inflammation in diabetic wounds via impaired mitophagy and cGAS-STING-NLRP3 activation: therapeutic potential of hydrogels loaded with FICZ
10.1016/j.mtbio.2025.102119 · External reference
FXR suppress Muller cell activation by regulating cGAS/STING pathway in diabetic retinopathy
10.1111/febs.17421 · External reference
The central role of the AMPK/SIRT1/PGC-1alpha signaling axis in skeletal muscle physiology and pathology and its targeted therapeutic strategies
10.3390/ph19071056 · External reference
Luteolin ameliorates diabetic retinopathy through activation of the Nrf2/Keap1 and SIRT3/AMPK antioxidant axes and suppression of cGAS-STING and Wnt/beta-catenin pathways in experimental rats
10.1007/s13105-026-01170-6 · External reference
The role and mechanisms of the cGAS-STING signaling pathway in age-related pathophysiological processes: challenges and therapeutic strategies
10.1016/j.bcp.2026.118317 · 2026 · External reference
Ubiquitin specific protease 38 aggravates pathological cardiac remodeling by stabilizing phospho-TBK1
10.7150/ijbs.85562 · 2024 · External reference
Decreased MFN2 activates the cGAS-STING pathway in diabetic myocardial ischaemia-reperfusion by triggering the release of mitochondrial DNA
10.1186/s12964-023-01216-y · 2023 · External reference
Sesamin ameliorates high-fat diet-induced inflammation and metabolic dysfunction in pregnant uterine smooth muscle via cGAS-STING inhibition
10.1016/j.phymed.2026.158182 · 2026 · External reference
The role of Piezo1 in skeletal muscle physiology and pathology: from mechanosensing to precision therapy
10.1016/j.bcp.2026.118219 · 2026 · External reference
Mitochondrial damage and activation of the cytosolic DNA sensor cGAS-STING pathway lead to cardiac pyroptosis and hypertrophy in diabetic cardiomyopathy mice
10.1038/s41420-022-01046-w · 2022 · External reference
Oxygen-boosted nanodrug for amplified ferroptosis-photodynamic immunotherapy together with PD-1 checkpoint blockade against triple-negative breast cancer
10.1016/j.colsurfb.2025.114963 · 2025 · External reference
The dual pathological roles and targeted therapy of PGE(2): from receptor signaling networks to disease microenvironment modulation
10.3389/fphar.2026.1810417 · 2026 · External reference
Targeted inhibition of macrophage STING signaling alleviates inflammatory injury and ventricular remodeling in acute myocardial infarction
10.1016/j.apsb.2025.06.014 · 2025 · External reference
Excess glucose alone depress young mesenchymal stromal/stem cell osteogenesis and mitochondria activity within hours/days via NAD(+)/SIRT1 axis
10.1186/s12929-024-01039-0 · 2024 · External reference
RIPK3 deficiency ameliorates diabetic sarcopenia through proteostasis regulation by suppressing inflammatory signaling and cellular stress pathways
10.1016/j.bcp.2025.117627 · 2026 · External reference
Polysaccharide-engineered mitochondria reprogram macrophages to resolve diabetic wound inflammation and promote repair
10.1016/j.bioactmat.2026.04.009 · 2026 · External reference
Palmitic acid dysregulates the Hippo-YAP pathway and inhibits angiogenesis by inducing mitochondrial damage and activating the cytosolic DNA sensor cGAS-STING-IRF3 signaling mechanism
10.1074/jbc.m117.804005 · 2017 · External reference
Targeting the TFAM-cGAS-STING axis: a mitochondrial-inflammatory link in the pathogenesis and treatment of diabetic kidney disease
10.1007/s11255-025-04651-7 · 2026 · External reference
cGAS-STING activation contributes to podocyte injury in diabetic kidney disease
10.1016/j.isci.2022.105145 · 2022 · External reference
AMPK directly phosphorylates TBK1 to integrate glucose sensing into innate immunity
10.1016/j.molcel.2022.10.026 · 2022 · External reference
Leptin attenuates diabetic cardiomyopathy-induced cardiac remodeling via regulating cGAS/STING signaling and Opa1-mediated mitochondrial fusion
10.1016/j.cellsig.2025.111805 · External reference
U-shaped association between plasma cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) levels and myocardial infarction
10.1186/s12872-025-04543-9 · External reference
Isorhamnetin attenuates diabetic kidney disease by modulating mitochondrial homeostasis and suppressing cGAS-STING axis-dependent NLRP3 inflammasome activation
10.4103/apjtb.apjtb_58_26 · 2026 · External reference
GRP75 regulates mitochondrial-supercomplex turnover to modulate insulin sensitivity
10.2337/db21-0173 · External reference
The TBK1/IKKepsilon inhibitor amlexanox improves dyslipidemia and prevents atherosclerosis
10.1172/jci.insight.155552 · External reference
Circulating cell-free mtDNA release is associated with the activation of cGAS-STING pathway and inflammation in mitochondrial diseases
10.1007/s00415-022-11146-3 · External reference
Spermidine alleviates diabetic periodontitis by reversing human periodontal ligament stem cell senescence via mitophagy
10.1016/j.freeradbiomed.2024.12.016 · 2025 · External reference
Cardiomyocyte-derived USP20 attenuates diabetic cardiomyopathy by facilitating the degradation of STING and mitigating STING-mediated inflammation
10.1096/fj.202503913r · 2026 · External reference
CerS6 links ceramide metabolism to innate immune responses in diabetic kidney disease
10.1038/s41467-025-56891-x · 2025 · External reference
Salvianolic acid A prevents UV-induced skin damage by inhibiting the cGAS-STING pathway
10.1016/j.intimp.2024.111971 · 2024 · External reference
