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References from Alismatis Rhizoma prevents AβO-induced neuronal cell death and synaptic loss in Alzheimer’s disease models. Local targets link to admitted publications; unresolved targets remain external evidence.
Amyloid-beta and Tau in Alzheimer's disease: pathogenesis, mechanisms, and interplay
10.1038/s41419-025-08186-8 · 2026 · External reference
Amyloid beta in Alzheimer’s disease: mechanisms, biomarker potential, and therapeutic targets
10.1002/cns.70688 · 2025 · External reference
The role of CREB and BDNF in neurobiology and treatment of Alzheimer’s disease
10.1016/j.lfs.2020.118020 · 2020 · External reference
Brain-derived neurotrophic factor and its clinical implications
10.5114/aoms.2015.56342 · 2015 · External reference
Molecular sabotage of hippocampal synaptic plasticity by amyloid-beta in Alzheimer's disease: a narrative review
10.1177/25424823261415807 · 2026 · External reference
Comprehensive review on Alzheimer’s disease: causes and treatment
10.3390/molecules25245789 · 2020 · External reference
5-Hydroxytryptophan reduces levodopa-induced dyskinesia via regulating AKT/mTOR/S6K and CREB/DeltaFosB signals in a mouse model of Parkinson's disease
10.4062/biomolther.2022.141 · 2023 · External reference
Retrograde BDNF to TrkB signaling promotes synapse elimination in the developing cerebellum
10.1038/s41467-017-00260-w · 2017 · External reference
GSK3beta inhibition promotes synaptogenesis in Drosophila and mammalian neurons
10.1371/journal.pone.0118475 · 2015 · External reference
Anti-inflammatory activities and effect of rhizoma Alismatis on immune system
1991 · External reference
Hypolipidemic effects of Alismatis rhizome on lipid profile in mice fed high-fat diet
10.15537/1658-3175.5336 · 2011 · External reference
Petasites japonicus leaf extract inhibits Alzheimer’s-like pathology through suppression of neuroinflammation
10.1039/d2fo01989b · 2022 · External reference
Memantine rescues transient cognitive impairment caused by high-molecular-weight abeta oligomers but not the persistent impairment induced by low-molecular-weight oligomers
10.1523/jneurosci.0482-13.2013 · 2013 · External reference
Reversal of multidrug resistance in cancer cells by Rhizoma Alismatis extract
10.1016/j.phymed.2006.03.004 · 2007 · External reference
Brain-derived neurotrophic factor in Alzheimer’s disease and its pharmaceutical potential
10.1186/s40035-022-00279-0 · 2022 · External reference
CREB DNA binding activity is inhibited by glycogen synthase kinase-3 beta and facilitated by lithium
10.1046/j.1471-4159.2001.00495.x · 2001 · External reference
PI3K/AKT signaling pathway: molecular mechanisms and therapeutic potential in depression
10.1016/j.phrs.2024.107300 · 2024 · External reference
The impact of real-world evidence in implementing and optimizing Alzheimer’s disease care
10.1016/j.medj.2025.100695 · 2025 · External reference
Glycogen synthase kinase-3 inhibition is integral to long-term potentiation
10.1111/j.1460-9568.2006.05245.x · 2007 · External reference
GSK3 inhibitors show benefits in an Alzheimer's disease (AD) model of neurodegeneration but adverse effects in control animals
10.1016/j.nbd.2008.10.007 · 2009 · External reference
Effects of small molecules on neurogenesis: neuronal proliferation and differentiation
10.1016/j.apsb.2023.10.007 · 2024 · External reference
Trichosanthis Semen exerts neuroprotective effects in Alzheimer’s disease models by inhibiting amyloid-beta accumulation and regulating the Akt and ERK signaling pathways
10.3233/jad-231124 · 2024 · External reference
NXP031 restores memory function by dual effects degrading Abeta accumulation and facilitating antioxidant pathway in Alzheimer’s disease models
10.1016/j.freeradbiomed.2024.11.008 · 2025 · External reference
Donepezil inhibits the amyloid-beta oligomer-induced microglial activation in vitro and in vivo
10.1016/j.neuro.2013.10.004 · 2014 · External reference
Dietary regulation of PI3K/AKT/GSK-3beta pathway in Alzheimer’s disease
10.1186/alzrt265 · 2014 · External reference
Glycogen synthase kinase-3 signaling in Alzheimer’s disease
10.1016/j.bbamcr.2020.118664 · 2020 · External reference
Amyloid-beta oligomers regulate the properties of human neural stem cells through GSK-3beta signaling
10.1038/emm.2013.125 · 2013 · External reference
Trichosanthis Semen suppresses lipopolysaccharide-induced neuroinflammation by regulating the NF-kappaB signaling pathway and HO-1 expression in microglia
10.3390/toxins13120898 · 2021 · External reference
Dimethysiloxane polymer for the effective transdermal delivery of donepezil in Alzheimer's disease treatment
10.1039/d4bm01368a · 2025 · External reference
Study on the hypoglycemic activities and metabolism of alcohol extract of Alismatis Rhizoma
10.1016/j.fitote.2012.05.009 · 2012 · External reference
The role of brain derived neurotrophic factor in central nervous system
10.3389/fnagi.2022.986443 · 2022 · External reference
Monitoring synaptic pathology in Alzheimer's disease through fluid and PET imaging biomarkers: a comprehensive review and future perspectives
10.1038/s41380-023-02376-6 · 2024 · External reference
Updates in Alzheimer's disease: from basic research to diagnosis and therapies
10.1186/s40035-024-00432-x · 2024 · External reference
Adult-born neurons immature during learning are necessary for remote memory reconsolidation in rats
10.1038/s41467-021-22069-4 · 2021 · External reference
Differential contribution of TrkB and p75(NTR) to BDNF-dependent self-renewal, proliferation, and differentiation of adult neural stem cells
10.3389/fnmol.2023.1271820 · 2023 · External reference
Brain-derived neurotrophic factor: a key molecule for memory in the healthy and the pathological brain
10.3389/fncel.2019.00363 · 2019 · External reference
Unresolved reference
2011 · External reference
Non-fibrillar oligomeric amyloid-beta within synapses
10.3233/jad-160007 · 2016 · External reference
Enhanced synaptic plasticity in newly generated granule cells of the adult hippocampus
10.1038/nature02553 · 2004 · External reference
PI3K/Akt/GSK3beta induced CREB activation ameliorates arsenic mediated alterations in NMDA receptors and associated signaling in rat hippocampus: neuroprotective role of curcumin
10.1016/j.neuro.2018.04.018 · 2018 · External reference
Synapse vulnerability and resilience underlying Alzheimer’s disease
10.1016/j.ebiom.2025.105557 · 2025 · External reference
Traditional uses, phytochemistry, pharmacology, toxicology and quality control of Alisma orientale (Sam.) Juzep: a review
10.1016/j.jep.2014.10.061 · 2014 · External reference
Oligomeric Abeta-induced synaptic dysfunction in Alzheimer’s disease
10.1186/1750-1326-9-48 · 2014 · External reference
TrkB/BDNF signaling pathway and its small molecular agonists in CNS injury
10.1016/j.lfs.2023.122282 · 2024 · External reference
Caspases in Alzheimer’s disease: mechanism of activation, role, and potential treatment
10.1007/s12035-023-03847-1 · 2024 · External reference
Brain-derived neurotrophic factor induces long-term potentiation in intact adult hippocampus: requirement for ERK activation coupled to CREB and upregulation of Arc synthesis
10.1523/jneurosci.22-05-01532.2002 · 2002 · External reference
Promotion of neuroinflammation by the glymphatic system: a new insight into ethanol extracts from Alisma orientale in alleviating obesity-associated cognitive impairment
10.1016/j.phymed.2023.155147 · 2024 · External reference
Human tau accumulation promotes glycogen synthase kinase-3beta acetylation and thus upregulates the kinase: a vicious cycle in Alzheimer neurodegeneration
10.1016/j.ebiom.2022.103970 · 2022 · External reference
Mechanisms of abnormal adult hippocampal neurogenesis in Alzheimer's disease
10.3389/fnins.2023.1125376 · 2023 · External reference
