Research graph
References from Hydrogen: a review of the effects and underlying mechanisms in oral diseases. Local targets link to admitted publications; unresolved targets remain external evidence.
Hydrogen gas attenuates toxic metabolites and oxidative stress-mediated signaling to inhibit neurodegeneration and enhance memory in Alzheimer’s disease models
10.3390/ijms26146922 · 2025 · External reference
The role of IL-6 on apical periodontitis: a systematic review
10.1111/iej.12196 · 2014 · External reference
Drinking hydrogen-rich water has additive effects on non-surgical periodontal treatment of improving periodontitis: a pilot study
10.3390/antiox4030513 · 2015 · External reference
Effects of hydrogen rich water and pure water on periodontal inflammatory factor level, oxidative stress level and oral flora: a systematic review and meta-analysis
10.21037/atm-22-4422 · 2022 · External reference
Anti-inflammatory and bacteriostatic effects of hydrogen-rich water on rats with periodontitis
10.1155/jfbc/5917799 · 2024 · External reference
Neutrophils’ contribution to periodontitis and periodontitis-associated cardiovascular diseases
10.3390/ijms242015370 · 2023 · External reference
Assessment of the effects of hydrogen water on human gingival fibroblast cell culture in patients with chronic periodontitis
10.4103/jisp.jisp_546_21 · 2023 · External reference
Local drug delivery systems as novel approach for controlling NETosis in periodontitis
10.3390/pharmaceutics16091175 · 2024 · External reference
Composition of human peri-implantitis and periodontitis lesions
10.1177/0022034514551754 · 2014 · External reference
Gas as medicine: the case for hydrogen gas as a therapeutic agent for critical illness
10.1186/s40635-025-00798-w · 2025 · External reference
Diffusivity signatures characterize trigeminal neuralgia associated with multiple sclerosis
10.1177/1352458515579440 · 2016 · External reference
A study on the protective effect of molecular hydrogen on osteoradionecrosis of the jaw in rats
10.1016/j.ijom.2020.04.011 · 2020 · External reference
Roles of oral microbiota and oral-gut microbial transmission in hypertension
10.1016/j.jare.2022.03.007 · 2023 · External reference
Hydrogen rescues vascular endothelial cells in obstructive sleep apnea-hypopnea syndrome by modulating nitric oxide
10.21037/jtd-2025-1345 · 2025 · External reference
The role of ROS in tumour development and progression
10.1038/s41568-021-00435-0 · 2022 · External reference
Osteoradionecrosis of the jaws--a current overview--part 1: physiopathology and risk and predisposing factors
10.1007/s10006-009-0198-9 · 2010 · External reference
Osteoradionecrosis of the jaws: definition, epidemiology, staging and clinical and radiological findings. A concise review
10.1111/idj.12318 · 2018 · External reference
Molecular hydrogen therapy in respiratory diseases: mechanisms, evidence, and technical considerations
10.1080/26895293.2026.2643533 · 2026 · External reference
The International Classification of Headache Disorders
10.1177/0333102417738202 · 2018 · External reference
Oral surgery and osteoradionecrosis in patients undergoing head and neck radiation therapy: an update of the current literature
10.3390/biomedicines11123339 · 2023 · External reference
Molecular hydrogen attenuates sepsis-induced cardiomyopathy in mice by promoting autophagy
10.1186/s12871-024-02462-4 · 2024 · External reference
Microbial dysbiosis in periodontitis and peri-implantitis: pathogenesis, immune responses, and therapeutic
10.3389/fcimb.2025.1517154 · 2025 · External reference
Radiation therapy and mandibular osteoradionecrosis: state of the art
10.1007/s11912-020-00954-3 · 2020 · External reference
Inflammatory bone loss and signaling pathways in periodontitis: mechanistic insights and emerging therapeutic strategies
10.1038/s41413-025-00478-1 · 2026 · External reference
Trigeminal neuralgia secondary to multiple sclerosis: from the clinical picture to the treatment options
10.1186/s10194-019-0969-0 · 2019 · External reference
The effectiveness of curcumin in treating oral mucositis related to radiation and chemotherapy: a systematic review
10.3390/antiox13101160 · 2024 · External reference
Hyperbaric hydrogen therapy a possible treatment for cancer
10.1126/science.1166304 · 1975 · External reference
The contribution of the hypoxia inducible factor-1α axis to periodontitis
10.1177/00220345261426978 · 2026 · External reference
Organophosphorus compounds and MAPK signaling pathways
10.3390/ijms21124258 · 2020 · External reference
Harnessing polysialic acid (PSA)-embedded exudate-absorbing hydrogel for on-demand trigeminal neuralgia treatment
10.1016/j.ijbiomac.2024.138035 · 2025 · External reference
Evidence-based review and clinical practice recommendations for the diagnosis and management of common oral mucosal lesions
10.5493/wjem.v16.i1.115535 · 2026 · External reference
DNA damage by lipid peroxidation products: implications in cancer, inflammation and autoimmunity
10.3934/genet.2017.2.103 · 2021 · External reference
Shotgun metagenomics identifies in a cross-sectional setting improved plaque microbiome biomarkers for peri-implant diseases
10.1111/jcpe.14121 · 2025 · External reference
Plant-derived natural products targeting ion channels for pain
10.1016/j.ynpai.2023.100128 · 2023 · External reference
Hydrogen suppresses oxidative stress by inhibiting the p38 MAPK signaling pathway in preeclampsia
10.17219/acem/154623 · 2023 · External reference
ROS-Induced gingival fibroblast senescence: implications in exacerbating inflammatory responses in periodontal disease
10.1007/s10753-024-02014-5 · 2024 · External reference
Oxidative stress and antioxidant pathways in the pathogenesis of periodontitis and peri-implantitis: mechanistic insights and therapeutic potentials
10.3389/froh.2026.1814823 · 2026 · External reference
Trigeminal neuralgia (part I): revisiting the clinical phenotype
10.1177/0333102415611405 · 2016 · External reference
Long-term consumption of hydrogen-rich water provides hepatoprotection by improving mitochondrial biology and quality control in chronically stressed mice
10.1371/journal.pone.0317080 · 2025 · External reference
Clinical use and treatment mechanism of molecular hydrogen in the treatment of various kidney diseases including diabetic kidney disease
10.3390/biomedicines11102817 · 2023 · External reference
Oral microbiome, periodontal disease and systemic bone-related diseases in the era of homeostatic medicine
10.1016/j.jare.2024.08.019 · 2025 · External reference
Induced experimental peri-implantitis and periodontitis: what are the differences in the inflammatory response?
10.1563/aaid-joi-d-19-00362 · 2021 · External reference
Effectiveness and safety of hydrogen inhalation therapy as an additional treatment for hypertension in real-world practice: a retrospective, observational study in China
10.3389/fcvm.2024.1391282 · 2024 · External reference
Role of TRPM2 in oxidative stress–mediated bone loss in periodontitis
10.1177/00220345251329330 · 2025 · External reference
Hydrogen-generating nanomodulators for metabolic repair and functional recovery in ovarian tissue transplantation
10.1186/s12951-026-04024-x · 2026 · External reference
Silicon nanoparticles for oral administration of molecular hydrogen
10.1016/j.ijpharm.2022.122371 · 2022 · External reference
Hydrogen-rich water attenuates experimental periodontitis in a rat model
10.1111/j.1600-051x.2011.01801.x · 2011 · External reference
Inhibition of streptococcal biofilm by hydrogen water
10.1016/j.jdent.2017.01.004 · 2017 · External reference
Microbial profiling of peri-implantitis compared to the periodontal microbiota in health and disease using 16S rRNA sequencing
10.5051/jpis.2202080104 · 2023 · External reference
Renoprotective and neuroprotective effects of enteric hydrogen generation from Si-based agent
10.1038/s41598-020-62755-9 · 2020 · External reference
Magnesium particles coated with mesoporous nanoshells as sustainable therapeutic-hydrogen suppliers to scavenge continuously generated hydroxyl radicals in long term
10.1002/ppsc.201800424 · 2019 · External reference
Therapeutic potential of hydrogen as a radioprotective agent for the prevention of radiation dermatitis
10.3390/antiox13121475 · 2024 · External reference
The protective role of molecular hydrogen in ischemia/reperfusion injury
10.3390/ijms25147884 · 2024 · External reference
Hydrogen-rich water attenuates radiation-induced oral mucositis in mice via antioxidant and gut microbiota-stabilizing effects: a longitudinal study
10.1080/29933935.2025.2595392 · 2025 · External reference
Antibacterial activity of hydrogen-rich water against oral bacteria
10.11620/ijob.2013.38.2.081 · 2013 · External reference
Antibacterial effect of electrolyzed water on oral bacteria
2006 · External reference
Periodontal pathogens: a crucial link between periodontal diseases and oral cancer
10.3389/fmicb.2022.919633 · 2022 · External reference
Hydrogen attenuates postoperative pain through Trx1/ASK1/MMP9 signaling pathway
10.1186/s12974-022-02670-0 · 2023 · External reference
Hydrogen promoted mitochondrial autophagy and alleviated CIH-induced vascular endothelial cell senescence by regulating oxidative stress
10.1016/j.ejphar.2025.178078 · 2025 · External reference
Delivery of molecular hydrogen for precision immunomodulation: mechanisms, detection methods, and applications
10.1002/advs.202500283 · 2025 · External reference
In vivo microelectrode monitoring of real-time hydrogen concentration in different tissues of rats after inhaling hydrogen gas
10.4103/2045-9912.330694 · 2022 · External reference
Research progress on the therapeutic roles and mechanisms of hydrogen-rich water in periodontitis
10.12016/j.issn.2096-1456.202440004 · 2025 · External reference
Effects of hydrogen-rich water on cariogenic bacteria
10.4103/ijdr.ijdr_948_22 · 2023 · External reference
Trigeminal neuralgia--a prospective systematic study of clinical characteristics in 158 patients
10.1111/head.12441 · 2014 · External reference
Hydrogen gas inhalation improved intestinal microbiota in ulcerative colitis: a randomised double-blind placebo-controlled trial
10.3390/biomedicines13081799 · 2025 · External reference
Hydrogen-releasing magnesium hydrogel mitigates post laminectomy epidural fibrosis through inhibition of neutrophil extracellular traps
10.1016/j.actbio.2024.09.006 · 2024 · External reference
Precision redox: the key for antioxidant pharmacology
10.1089/ars.2020.8212 · 2021 · External reference
Molecular hydrogen protects against sepsis-induced cardiomyopathy through improving Golgi stress-mediated autophagy, inflammation and apoptosis
10.1111/bph.70132 · 2025 · External reference
The potential role of reactive oxygen species produced by low-density neutrophils in periodontitis
10.1055/s-0044-1782211 · 2024 · External reference
Amelioration of nerve demyelination by hydrogen-producing silicon-based agent in neuropathic pain rats
10.1016/j.intimp.2023.110033 · 2023 · External reference
Hydrogen repairs LPS-induced endothelial progenitor cells injury via PI3K/AKT/eNOS pathway
10.3389/fphar.2022.894812 · 2022 · External reference
Preconditioning effect of hydrogen gas on traumatic brain injury
10.1177/08977151261432145 · 2026 · External reference
Assessment of antibacterial effect of hydrogen water on plaque from patients with chronic periodontitis
10.4103/jisp.jisp_317_20 · 2021 · External reference
Cytokines in gingivitis and periodontitis: from pathogenesis to therapeutic targets
10.3389/fimmu.2024.1435054 · 2024 · External reference
The role of oxidative stress in the relationship between periodontitis and Alzheimer’s disease: a review of the literature
10.3390/jpm15080384 · 2025 · External reference
The role of oral microbiome in respiratory health and diseases
10.1016/j.rmed.2021.106475 · 2021 · External reference
Single-cell atlas of human gingiva unveils a NETs-related neutrophil subpopulation regulating periodontal immunity
10.1016/j.jare.2024.07.028 · 2025 · External reference
Antitumor activity of protons and molecular hydrogen: underlying mechanisms
10.3390/cancers13040893 · 2021 · External reference
Molecular hydrogen suppresses Porphyromonas gingivalis lipopolysaccharide-induced increases in interleukin-1 alpha and interleukin-6 secretion in human gingival cells
10.1007/s11010-021-04262-7 · 2022 · External reference
Streptococcus mutans and cariogenic biofilms: mechanisms, disruption strategies, and future therapeutic directions
10.1111/apm.70093 · 2025 · External reference
Hydrogen gas mitigates acute hypoxia-induced oxidative and inflammatory brain injuries in medaka (Oryzias latipes)
10.3390/antiox14091130 · 2025 · External reference
The oral microbiome: role of key organisms and complex networks in oral health and disease
10.1111/prd.12393 · 2021 · External reference
Essential review points on the retrospective study of osteoradionecrosis in the jaws
10.5125/jkaoms.2020.46.3.208 · 2020 · External reference
Role of oxidative stress in the relationship between periodontitis and systemic diseases
10.3389/fphys.2023.1210449 · 2023 · External reference
Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death
10.1038/nature15514 · 2015 · External reference
Pharmacokinetics of hydrogen during hydrogen-saturated saline infusion in pigs
10.3390/biomedicines13010234 · 2025 · External reference
A white patch on the tongue
10.1136/bmj-2022-070027.r0 · 2022 · External reference
Comparative evaluation of antibacterial effects of hydrogen water and chlorhexidine mouthwash on Porphyromonas gingivalis and fusobacterium nucle
2023 · External reference
Oxidative stress and metabolic dysfunction in oral lichen planus pathogenesis
10.1080/19768354.2026.2648907 · 2026 · External reference
Hydrogen-rich water intake accelerates oral palatal wound healing via activation of the Nrf2/Antioxidant defense pathways in a rat model
10.1155/2016/5679040 · 2016 · External reference
Core–shell microspheres enabling sustained hydrogen release and peroxidase-like catalytic activity for periodontitis therapy
10.1002/adhm.202504793 · 2026 · External reference
Hydrogen, a novel therapeutic molecule, regulates oxidative stress, inflammation, and apoptosis
10.3389/fphys.2021.789507 · 2021 · External reference
Analysis of IL-6, IL-10 and NF-κB gene polymorphisms in aggressive and chronic periodontitis
10.21101/cejph.a4656 · 2017 · External reference
Effects of hydrogen-rich water on aging periodontal tissues in rats
10.1038/srep05534 · 2014 · External reference
Recurrent aphthous stomatitis: etiology, morphology, pathogenesis, and contemporary treatment methods
2025 · External reference
Neutrophils in the periodontium: interactions with pathogens and roles in tissue homeostasis and inflammation
10.1111/imr.13152 · 2022 · External reference
In situ nanoreactor for photosynthesizing H(2) gas to mitigate oxidative stress in tissue inflammation
10.1021/jacs.7b07492 · 2017 · External reference
An in situ depot for continuous evolution of gaseous H(2) mediated by a magnesium passivation/activation cycle for treating osteoarthritis
10.1002/anie.201806159 · 2018 · External reference
Hydrogen: a novel treatment strategy in kidney disease
10.1159/000520981 · 2022 · External reference
Glucosyltransferase-modulated Streptococcus mutans adhesion to different surfaces involved in biofilm formation by atomic force microscopy
10.1111/1348-0421.13025 · 2022 · External reference
Alterations and correlations in dental plaque microbial communities and metabolome characteristics in patients with caries, periodontitis, and comorbid diseases
10.1186/s12903-023-03785-3 · 2024 · External reference
Orally administered silicon hydrogen nanomaterials as target therapy to treat intestinal diseases
10.1021/acsnano.3c06551 · 2023 · External reference
Potent anti-inflammatory responses: role of hydrogen in IL-1α dominated early phase systemic inflammation
10.3389/fphar.2023.1138762 · 2023 · External reference
Molecular hydrogen: an emerging therapeutic medical gas for brain disorders
10.1007/s12035-022-03175-w · 2022 · External reference
ROS-Scavenging hydrogen nanotherapy simultaneously targets inflammation and pain in rheumatoid arthritis
10.1016/j.mtbio.2025.102068 · 2025 · External reference
Hydrogen-rich water achieves cytoprotection from oxidative stress injury in human gingival fibroblasts in culture or 3D-tissue equivalents, and wound-healing promotion, together with ROS-scavenging and relief from glutathione diminishment
10.1007/s13577-016-0150-x · 2016 · External reference
Magnesium-based micromotors as hydrogen generators for precise rheumatoid arthritis therapy
10.1021/acs.nanolett.0c04438 · 2021 · External reference
H2-driven autonomous pore-forming hydrogel promotes rapid vascularization for dry socket healing
10.1016/j.biomaterials.2026.124191 · 2026 · External reference
The role of reactive oxygen species (ROS) in periodontitis: a potential therapeutic target
10.1002/iid3.70301 · 2025 · External reference
Functional roles of p38 mitogen-activated protein kinase in macrophage-mediated inflammatory responses
10.1155/2014/352371 · 2014 · External reference
Ferroptosis of macrophages facilitates bone loss in apical periodontitis via NRF2/FSP1/ROS pathway
10.1016/j.freeradbiomed.2023.08.020 · 2023 · External reference
Hydrogen-rich water for the treatment of experimental peri-implantitis
2023 · External reference
Preventive effects of drinking hydrogen-rich water on gingival oxidative stress and alveolar bone resorption in rats fed a high-fat diet
10.3390/nu9010064 · 2017 · External reference
Hydrogen-rich electrolyzed water is a useful mouthwash due to its biofilm-control properties: an in vitro and in vivo study
10.12701/jyms.2025.42.34 · 2025 · External reference
Sequential hydrogen-release implant for promoting the soft tissue integration through immunomodulatory and pro-remodeling coupling
10.1016/j.bioactmat.2025.11.018 · 2026 · External reference
UBE2C regulates the KEAP1/NRF2 signaling pathway to promote the growth of gastric cancer by inhibiting autophagy
10.1016/j.ijbiomac.2024.134011 · 2024 · External reference
Chronic hydrogen-rich saline treatment attenuates vascular dysfunction in spontaneous hypertensive rats
10.1016/j.bcp.2012.01.031 · 2012 · External reference
Lactulose ameliorates cerebral ischemia-reperfusion injury in rats by inducing hydrogen by activating Nrf2 expression
10.1016/j.freeradbiomed.2013.08.004 · 2013 · External reference
Therapeutic ionizing radiation induced bone loss: a review of in vivo and in vitro findings
10.1080/03008207.2018.1439482 · 2018 · External reference
Reactive oxygen species enlightened therapeutic strategy for oral and maxillofacial diseases-art of destruction and reconstruction
10.3390/biomedicines10112905 · 2022 · External reference
Oxidative damage pathways in relation to normal tissue injury
10.1259/bjr/18237646 · 2007 · External reference
Local generation of hydrogen for enhanced photothermal therapy
10.1038/s41467-018-06630-2 · 2018 · External reference
Periodontitis-level butyrate-induced ferroptosis in periodontal ligament fibroblasts by activation of ferritinophagy
10.1038/s41420-020-00356-1 · 2020 · External reference
Prospects of molecular hydrogen in cancer prevention and treatment
10.1007/s00432-024-05685-7 · 2024 · External reference
Accurate in vivo real-time determination of the hydrogen concentration in different tissues of mice after hydrogen inhalation
10.1016/j.heliyon.2022.e10778 · 2022 · External reference
