Research graph
References from Natural medicines for asthma management: mechanisms aligned with endotypes and multi-dimensional intervention. Local targets link to admitted publications; unresolved targets remain external evidence.
The therapeutic potential of Melissa officinalis L. hydroalcoholic extract and rosmarinic acid in a rat asthmatic model: a study on anti-inflammatory and antioxidant effects
10.22038/ajp.2023.23321 · 2024 · External reference
Rosmarinic acid as A flavonoids ameliorated cytokines and oxidative stress biomarkers in the lung lavage fluid of rats
10.1002/fsn3.71442 · 2026 · External reference
Gentisic acid attenuates ovalbμMin-induced airway inflammation, oxidative stress, and ferroptosis through the modulation of Nrf2/HO-1 and NF-κB signaling pathways
10.1016/j.intimp.2024.113764 · 2025 · External reference
Toll-like receptors in the induction of the innate immune response
10.1038/35021228 · 2000 · External reference
Exploring the in vitro and in vivo therapeutic efficacy of Juniperus oxycedrus cade oil: Antioxidant, anti-inflammatory, and anti-asthmatic effects in an allergic asthma model
10.14715/cmb/2024.70.7.8 · 2024 · External reference
Zataria multiflora extract influenced asthmatic patients by improving respiratory symptoms, pulmonary function tests and lung inflammation
10.1016/j.jep.2021.114888 · 2022 · External reference
Nuclear factor-kappa B and its role in inflammatory lung disease
10.1016/j.cbi.2021.109568 · 2021 · External reference
The ability of resveratrol to attenuate OvalbμMin-Mediated allergic asthma is associated with changes in microbiota involving the gut-lung axis, enhanced barrier function and decreased inflammation in the lungs
10.3389/fimmu.2022.805770 · 2022 · External reference
Age-Dependent risk of bronchial asthma exacerbation in respiratory syncytial virus Co-infection
10.1007/s00408-025-00847-x · 2025 · External reference
Socioeconomic disparities in inpatient outcomes among US pediatric asthma hospitalizations
10.1016/j.rmed.2025.108501 · 2025 · External reference
Anti-inflammatory and anti-remodeling effects of myrtenol in the lungs of asthmatic rats: histopathological and biochemical findings
10.1016/j.aller.2018.09.003 · 2019 · External reference
Myrtenol ameliorates recognition memories' impairment and anxiety-like behaviors induced by asthma by mitigating hippocampal inflammation and oxidative stress in rats
10.1159/000528626 · 2023 · External reference
Flavonoid intakes, chronic obstructive pulmonary disease, adult asthma, and lung function: a cohort study in the UK Biobank
10.1016/j.ajcnut.2024.08.032 · 2024 · External reference
Immunologic mechanisms in asthma
10.1016/j.smim.2019.101333 · 2019 · External reference
The effect of CurcμMa longa on inflammatory mediators and immunological, oxidant, and antioxidant biomarkers in asthmatic rats
10.1155/2021/4234326 · 2021 · External reference
Sulforaphane improves the bronchoprotective response in asthmatics through Nrf2-mediated gene pathways
10.1186/s12931-015-0253-z · 2015 · External reference
Dietary plant stanol ester consμMption improves immune function in asthma patients: results of a randomized, double-blind clinical trial
10.3945/ajcn.115.117531 · 2016 · External reference
Airway smooth muscle pathophysiology in asthma
10.1016/j.jaci.2021.03.035 · 2021 · External reference
Flavonoids on allergy
10.2174/13816128113199990041 · 2014 · External reference
Asthma exacerbations: pathogenesis, prevention, and treatment
10.1016/j.jaip.2017.05.001 · 2017 · External reference
Viruses and non-allergen environmental triggers in asthma
10.1136/jim-2019-001000 · 2019 · External reference
XanthohμMol ameliorates OVA-induced allergic asthma by inhibiting AIM2 inflammasome activation
10.1016/j.jep.2025.121103 · 2026 · External reference
Neohesperidin ameliorates airway remodeling through suppressed airway inflammation and oxidative stress in ovalbμMin-sensitized mice
10.1016/j.molimm.2025.10.011 · 2025 · External reference
Mechanisms and treatment of type 2 high and low asthma endotypes
10.1111/cea.70084 · 2025 · External reference
Role of interleukin-13 in asthma
10.1007/s11882-013-0373-9 · 2013 · External reference
T-helper cell type 2 (Th2) memory T cell-potentiating cytokine IL-25 has the potential to promote angiogenesis in asthma
10.1073/pnas.1014241108 · 2011 · External reference
Linarin protects against asthma-induced airway epithelial ferroptosis and inflammation via ALDH2 regulation
10.1016/j.phymed.2025.157398 · External reference
Artemetin targets the ABCG2/RAB7A axis to inhibit mitochondrial dysfunction in asthma
10.1016/j.phymed.2025.156600 · External reference
Cordycepin inhibits airway remodeling in a rat model of chronic asthma
10.1016/j.biopha.2017.01.025 · 2017 · External reference
Resolution of allergic asthma
10.1007/s00281-019-00770-3 · 2019 · External reference
Improvement of RSV-induced asthma in mice: a study based on icariin-mediated PD-1
10.31083/fbl26061 · 2025 · External reference
Molecular basis of the core structure of tight junctions
10.1101/cshperspect.a002907 · 2010 · External reference
Targeting key proximal drivers of type 2 inflammation in disease
10.1038/nrd4624 · 2016 · External reference
Inflammatory insights into airway remodelling in asthma
10.1111/resp.13390 · 2018 · External reference
Asthmatic and normal respiratory epithelial cells respond differently to mechanical apical stress
10.1164/rccm.201401-0107le · 2014 · External reference
Alleviation of allergic asthma by rosmarinic acid via gut-lung axis
10.1016/j.phymed.2024.155470 · 2024 · External reference
Anti-asthmatic and antioxidant activity of flavonoids isolated from Mentha longifolia subspecies typhoides (Briq.) Harley. and Mentha longifolia subspecies schimperi (Briq.) Briq. on ovalbμMin-induced allergic asthma in mice: in-vivo and in-silico study
10.1016/j.jep.2024.119133 · 2025 · External reference
The basic immunology of asthma
10.1016/j.cell.2021.04.019 · 2021 · External reference
House dust mite allergen induces asthma via toll-like receptor 4 triggering of airway structural cells
10.1038/nm.1946 · 2009 · External reference
Multidimensional assessment of asthma identifies clinically relevant phenotype overlap: a cross-sectional study
10.1016/j.jaip.2020.07.048 · 2021 · External reference
Paeoniflorin ameliorates airway inflammation and immune response in ovalbμMin induced asthmatic mice: from oxidative stress to autophagy
10.1016/j.phymed.2021.153835 · 2022 · External reference
Asthma phenotypes
10.1007/s11882-009-0065-7 · 2009 · External reference
Sinomenine relieves airway remodeling by inhibiting epithelial-mesenchymal transition through downregulating TGF-β1 and Smad3 expression in vitro and in vivo
10.3389/fimmu.2021.736479 · 2021 · External reference
Epithelial cell dysfunction, a major driver of asthma development
10.1111/all.14421 · 2020 · External reference
An evaluation of the effect of saffron supplementation on the antibody titer to heat-shock protein (HSP) 70, hsCRP and spirometry test in patients with mild and moderate persistent allergic asthma: a triple-blind, randomized placebo-controlled trial
10.1016/j.rmed.2018.10.016 · 2018 · External reference
JAK/STAT inhibitors and other small molecule cytokine antagonists for the treatment of allergic disease
10.1016/j.anai.2018.02.012 · 2018 · External reference
Type 2 inflammation and biological therapies in asthma: targeted medicine taking flight
10.1084/jem.20221212 · 2023 · External reference
Auraptene, a monoterpene CoμMarin, inhibits LTA-induced inflammatory mediators via modulating NF-κB/MAPKs signaling pathways
10.1155/2021/5319584 · 2021 · External reference
Astragaloside IV suppresses inflammatory response via suppression of NF-κB, and MAPK signalling in hμMan bronchial epithelial cells
10.1080/13813455.2020.1727525 · 2022 · External reference
Epimedin C modulates the balance between Th9 cells and treg cells through negative regulation of noncanonical NF-κB pathway and MAPKs activation to inhibit airway inflammation in the ovalbμMin-induced murine asthma model
10.1016/j.pupt.2021.102005 · 2020 · External reference
Ginsenoside Rg3 ameliorates allergic airway inflammation and oxidative stress in mice
10.1016/j.jgr.2021.03.002 · 2021 · External reference
Protective effects of myricetin on airway inflammation and oxidative stress in ovalbμMin-induced asthma mice
10.1016/j.jnutbio.2023.109485 · 2024 · External reference
Myricetin ameliorates airway inflammation and remodeling in asthma by activating Sirt1 to regulate the JNK/Smad3 pathway
10.1016/j.phymed.2024.156044 · 2024 · External reference
Isorhapontigenin attenuates allergic asthma by reducing airway inflammation and oxidative stress
10.1016/j.intimp.2026.116514 · 2026 · External reference
CurcμMin and PCI-34051 combined treatment ameliorates inflammation and fibrosis by affecting MAP kinase pathway
10.1007/s10787-023-01371-1 · 2023 · External reference
Naringenin improves OvalbμMin-Induced allergic asthma in rats through antioxidant and anti-inflammatory effects
10.1155/2022/9110798 · 2022 · External reference
Phytochemicals as treatment for allergic asthma: therapeutic effects and mechanisms of action
10.1016/j.phymed.2023.155149 · 2024 · External reference
Asthma: epidemiology, risk factors, and opportunities for prevention and treatment
10.1016/s2213-2600(24)00383-7 · 2025 · External reference
Attenuation of ovalbμMin-induced inflammation and lung oxidative injury in asthmatic rats by Zingiber officinale extract: combined in silico and in vivo study on antioxidant potential, STAT6 and TNF-α pathways
10.1007/s13205-022-03249-5 · 2022 · External reference
T-helper cells and their cytokines in pathogenesis and treatment of asthma
10.3389/fimmu.2023.1149203 · 2023 · External reference
Tectorigenin inhibits oxidative stress by activating the Keap1/Nrf2/HO-1 signaling pathway in Th2-mediated allergic asthmatic mice
10.1016/j.freeradbiomed.2023.12.031 · 2024 · External reference
Falcarindiol alleviates airway inflammation and oxidative stress in asthma through Nrf2 pathway activation
10.1038/s41598-026-37962-5 · 2026 · External reference
Cockroach protease allergen induces allergic airway inflammation via epithelial cell activation
10.1038/srep42341 · 2017 · External reference
Triterpenoid compound betulin attenuates allergic airway inflammation by modulating antioxidants, inflammatory cytokines and tissue transglutaminase in ovalbμMin-induced asthma mice model
10.1093/jpp/rgab015 · 2021 · External reference
A review of obesity and asthma across the life span
10.1080/02770903.2018.1424187 · 2018 · External reference
Turmeric extract alleviates airway inflammation via oxidative stress-driven MAPKs/MMPs pathway
10.1016/j.intimp.2024.113018 · External reference
Green tea extract suppresses airway inflammation via oxidative stress-driven MAPKs/MMP-9 signaling in asthmatic mice and hμMan airway epithelial cells
10.3389/fimmu.2024.1362404 · External reference
Global burden of asthma among children and adolescents with projections to 2050: a comprehensive review and forecasted modeling study
10.3345/cep.2025.00423 · 2025 · External reference
Cellular and molecular mechanisms of allergic asthma
10.1016/j.mam.2021.100995 · 2022 · External reference
Nigella sativa supplementation improves asthma control and biomarkers: a randomized, double-blind, placebo-controlled trial
10.1002/ptr.5761 · 2017 · External reference
The role of transforming growth Factor-β (TGF-β) in asthma and chronic obstructive pulmonary disease (COPD)
10.3390/cells13151271 · 2024 · External reference
Long-term trends in the burden of asthma in China: a joinpoint regression and age-period-cohort analysis based on the GBD 2021
10.1186/s12931-025-03135-7 · 2025 · External reference
Calcaratarin D, a labdane diterpenoid, attenuates mouse asthma via modulating alveolar macrophage function
10.1111/bph.15993 · 2023 · External reference
Cimicifugae rhizoma extract attenuates oxidative stress and airway inflammation via the upregulation of Nrf2/HO-1/NQO1 and downregulation of NF-κB phosphorylation in OvalbμMin-Induced asthma
10.3390/antiox10101626 · 2021 · External reference
Mulberroside A ameliorates murine allergic airway inflammation by suppressing Th2 response and oxidative stress
10.1007/s10787-025-01895-8 · 2025 · External reference
Advances in non-type 2 severe asthma: from molecular insights to novel treatment strategies
10.1183/13993003.00826-2023 · 2024 · External reference
Glucocorticoid-resistant asthma
10.1007/s11882-002-0009-y · 2002 · External reference
The course of allergen-induced leukocyte infiltration in hμMan and experimental asthma
10.1016/j.jaci.2006.02.034 · 2006 · External reference
Protective effects and active ingredients of Salvia miltiorrhiza bunge extracts on airway responsiveness, inflammation and remodeling in mice with ovalbμMin-induced allergic asthma
10.1016/j.phymed.2018.09.170 · 2019 · External reference
Agarwood oil nanoemulsion counteracts LPS-Induced inflammation and oxidative stress in RAW264.7 mouse macrophages
10.1016/j.prp.2023.154895 · 2023 · External reference
Investigating the therapeutic potential of agarwood nanoemulsion in modulating TGF-β-Induced airway remodelling in BEAS-2B cells
10.1007/s12013-025-01922-z · 2026 · External reference
Commentary: IL-4 and IL-13 receptors and signaling
10.1016/j.cyto.2015.05.023 · 2015 · External reference
Molecular mechanisms of oxidative stress in asthma
10.1016/j.mam.2021.101026 · 2022 · External reference
IL-17A drives oxidative stress and cell growth in A549 lung epithelial cells: potential protective action of oleuropein
10.3390/nu16132123 · 2024 · External reference
Defective fibrillar collagen organization by fibroblasts contributes to airway remodeling in asthma
10.1164/rccm.201810-1855oc · 2019 · External reference
Simultaneous determination of 19 constituents in cimicifugae rhizoma by HPLC-DAD and screening for antioxidants through DPPH free radical scavenging assay
10.1002/bmc.4624 · 2019 · External reference
Cinnamaldehyde modulates oxidative stress and NF-κB signaling in OVA-Induced asthmatic BALB/c mice
10.1016/j.resp.2025.104497 · 2026 · External reference
Age-specific incidence of allergic and non-allergic asthma
10.1186/s12890-019-1040-2 · 2020 · External reference
Effects of add-on therapy with NDC-052, an extract from magnoliae flos, in adult asthmatic patients receiving inhaled corticosteroids
10.3904/kjim.2012.27.1.84 · 2012 · External reference
Sophora flavescens aiton alleviates particulate matter-exacerbated asthma through modulation of ROS/MAPK/autophagy responses
10.1016/j.jep.2025.120440 · 2026 · External reference
RCT of the effect of berryfruit polyphenolic cultivar extract in mild steroid-naive asthma: a cross-over, placebo-controlled study
10.1136/bmjopen-2016-013850 · 2017 · External reference
Schisandrin A ameliorates airway inflammation in model of asthma by attenuating Th2 response
10.1016/j.ejphar.2023.175850 · 2023 · External reference
Role of Th17-cell related cytokines in geriatric asthma
10.1177/0300060518803828 · 2019 · External reference
Role of neutrophils in allergic asthma
10.1016/j.coi.2018.05.006 · 2018 · External reference
The alleviating impacts of quercetin on inflammation and oxidant-antioxidant imbalance in rats with allergic asthma
10.18502/ijaai.v22i2.12675 · 2023 · External reference
High IFN-γ and low SLPI mark severe asthma in mice and hμMans
10.1172/jci80911 · 2015 · External reference
Epithelial cell-derived cytokines: more than just signaling the alarm
10.1172/jci124606 · 2019 · External reference
Cell adhesion molecules and the bronchial epitheliμM
10.1164/ajrccm/148.6_pt_2.s79 · 1993 · External reference
Reactive oxygen species, inflammation, and lung diseases
10.2174/138161212802083716 · 2012 · External reference
The airway epitheliμM: an orchestrator of inflammation, a key structural barrier and a therapeutic target in severe asthma
10.1183/13993003.01397-2023 · 2024 · External reference
Effect of Nigella sativa supplementation on lung function and inflammatory mediatorsin partly controlled asthma: a randomized controlled trial
10.5144/0256-4947.2017.64 · 2017 · External reference
Etiology of epithelial barrier dysfunction in patients with type 2 inflammatory diseases
10.1016/j.jaci.2017.04.010 · 2017 · External reference
The effect of linarin on relevant inflammatory markers in OvalbμMin-Induced asthma rat models
10.1177/15593258251350190 · 2025 · External reference
Addressing treatment challenges in atopic dermatitis with novel topical therapies
10.1080/09546634.2016.1174765 · 2016 · External reference
Intranasal CurcμMin and N-Acetyl l-Cysteine (NAC) attenuates dibutyl phthalate (DBP)-Aggravated airway inflammation by targeting ferroptosis via Nrf-2/GPx4-SLC7A11
10.1002/tox.70035 · 2026 · External reference
Effect of a soy isoflavone supplement on lung function and clinical outcomes in patients with poorly controlled asthma: a randomized clinical trial
10.1001/jama.2015.5024 · 2015 · External reference
Cordyceps militaris polysaccharide alleviates ovalbμMin-induced allergic asthma through the Nrf2/HO-1 and NF-κB signaling pathways and regulates the gut microbiota
10.1016/j.ijbiomac.2023.124333 · 2023 · External reference
Type 2 innate lymphoid cells disrupt bronchial epithelial barrier integrity by targeting tight junctions through IL-13 in asthmatic patients
10.1016/j.jaci.2017.02.038 · 2018 · External reference
Quercetin inhibits ferroptosis through the SIRT1/Nrf2/HO-1 signaling pathway and alleviates asthma disease
10.21037/tp-24-193 · 2024 · External reference
Saponin-enriched extract of Asparagus cochinchinensis alleviates airway inflammation and remodeling in ovalbμMin-induced asthma model
10.3892/ijmm.2017.3147 · 2017 · External reference
Tight junction, mucin, and inflammasome-related molecules are differentially expressed in eosinophilic, mixed, and neutrophilic experimental asthma in mice
10.1111/all.13619 · 2019 · External reference
Airway remodeling in asthma: mechanisms, diagnosis, treatment, and future directions
10.1016/j.arbres.2024.09.007 · 2025 · External reference
T cells and eosinophils cooperate in the induction of bronchial epithelial cell apoptosis in asthma
10.1067/mai.2002.121460 · 2002 · External reference
Potentially overlooked risk for neuropsychiatric symptoms in children: Montelukast treatment
10.1111/jpc.70092 · 2025 · External reference
Der p 1 facilitates transepithelial allergen delivery by disruption of tight junctions
10.1172/jci5844 · 1999 · External reference
Tectorigenin inhibits inflammation and pulmonary fibrosis in allergic asthma model of ovalbμMin-sensitized Guinea pigs
10.1111/jphp.13271 · 2020 · External reference
Protective effects of total flavonoids from Qu Zhi Qiao (fruit of citrus paradisi cv. Changshanhuyou) on OVA-induced allergic airway inflammation and remodeling through MAPKs and Smad2/3 signaling pathway
10.1016/j.biopha.2021.111421 · 2021 · External reference
Luteolin inhibits autophagy in allergic asthma by activating PI3K/Akt/mTOR signaling and inhibiting Beclin-1-PI3KC3 complex
10.1016/j.intimp.2021.107460 · 2021 · External reference
Sophoraflavanone G from Sophora flavescens ameliorates allergic airway inflammation by suppressing Th2 response and oxidative stress in a murine asthma model
10.3390/ijms23116104 · 2022 · External reference
Mechanistic study of salidroside on ovalbμMin-induced asthmatic model mice based on untargeted metabolomics analysis
10.1039/d2fo02225g · 2023 · External reference
Trend analysis of the burden of major allergic diseases among children and adolescents in China from 1990 to 2021
10.11783/j.issn.1002-3674.2025.05.016 · 2025 · External reference
Icariin inhibits NF-κB signaling in asthmatic lung EpitheliμM by promoting Nrf2 signaling
10.1002/ptr.70124 · 2026 · External reference
Leonurus sibiricus root extracts decrease airway remodeling markers expression in fibroblasts
10.1111/cei.13481 · 2020 · External reference
Induction of epithelial-mesenchymal transition in alveolar epithelial cells by transforming growth factor-beta1: potential role in idiopathic pulmonary fibrosis
10.1016/s0002-9440(10)62351-6 · 2005 · External reference
Flavonoid quercetin enhances nuclear factor erythroid 2-related factor 2 (Nrf2) pathway activation and reduces inflammatory cytokines in asthmatic airway epithelial cells
10.1159/000548106 · 2025 · External reference
T(H)17 cells and corticosteroid insensitivity in severe asthma
10.1016/j.jaci.2021.12.769 · 2022 · External reference
Platycoside E alleviates allergic airway inflammation in obesity-related asthma mouse model
10.1016/j.molimm.2023.08.008 · 2023 · External reference
Multiple components rapidly screened from perilla leaves attenuate asthma airway inflammation by synergistic targeting on syk
10.2147/jir.s281393 · 2020 · External reference
Involucrasin B suppresses airway inflammation in obese asthma by inhibiting the TLR4-NF-κB-NLRP3 pathway
10.1016/j.phymed.2024.155850 · 2024 · External reference
Formononetin attenuates airway inflammation and oxidative stress in murine allergic asthma
10.3389/fphar.2020.533841 · 2020 · External reference
Apigenin ameliorates non-eosinophilic inflammation, dysregulated immune homeostasis and mitochondria-mediated airway epithelial cell apoptosis in chronic obese asthma via the ROS-ASK1-MAPK pathway
10.1016/j.phymed.2023.154646 · 2023 · External reference
The epidemiology of asthma in mainland China: a systematic review and meta-analysis
10.1186/s12889-024-20330-1 · 2024 · External reference
Undaria pinnatifida extract attenuates combined allergic rhinitis and asthma syndrome by the modulation of epithelial cell dysfunction and oxidative stress
10.3724/abbs.2024190 · 2024 · External reference
Wogonoside ameliorates airway inflammation and mucus hypersecretion via NF-κB/STAT6 signaling in OvalbμMin-Induced murine acute asthma
10.1021/acs.jafc.3c04082 · 2024 · External reference
The protective effects of arctiin in asthma by attenuating airway inflammation and inhibiting p38/NF-κB signaling
10.18632/aging.205584 · 2024 · External reference
Tolerance and effect of an add-on treatment with a cough medicine containing ivy leaves dry extract on lung function in children with bronchial asthma
10.1016/j.phymed.2014.05.006 · 2014 · External reference
Baicalin regulates the development of pediatric asthma via upregulating microRNA-103 and mediating the TLR4/NF-κB pathway
10.1080/10799893.2021.1900865 · 2022 · External reference
Ephedrae herba polysaccharides inhibit the inflammation of ovalbμMin induced asthma by regulating Th1/Th2 and Th17/Treg cell immune imbalance
10.1016/j.molimm.2022.09.009 · 2022 · External reference
Artesunate inhibits airway remodeling in asthma via the MAPK signaling pathway
10.3389/fphar.2023.1145188 · 2023 · External reference
Stigmasterol alleviates allergic airway inflammation and airway hyperresponsiveness in asthma mice through inhibiting substance-P receptor
10.1080/13880209.2023.2173252 · 2023 · External reference
PlμMbagin alleviates obesity-related asthma: targeting inflammation, oxidative stress, and the AMPK pathway
10.1002/iid3.1025 · 2023 · External reference
Breviscapine attenuates lipopolysaccharide-induced airway dysfunction in normal HμMan bronchial epithelial cells by suppressing the TLR4/MyD88 signaling pathway
10.1111/cbdd.70096 · 2025 · External reference
Cordyceps polysaccharide ameliorates airway inflammation in an ovalbμMin-induced mouse model of asthma via TGF-β1/Smad signaling pathway
10.1016/j.resp.2020.103412 · 2020 · External reference
The role and mechanisms of traditional Chinese medicine for airway inflammation and remodeling in asthma: overview and progress
10.3389/fphar.2022.917256 · 2022 · External reference
Cycloastragenol alleviates airway inflammation in asthmatic mice by inhibiting autophagy
10.3892/mmr.2021.12445 · 2021 · External reference
