References

Revealing a hidden conducting state by manipulating the intracellular domains in KV10. 1 exposes the coupling between two gating mechanisms

10.7554/elife.91420.4 · 2024 · External reference

Translocation processes of Pt (II)-based drugs through human breast cancer cell membrane: in silico experiments

10.1021/acs.jcim.3c00943 · 2023 · External reference

Lipid rafts in signalling, diseases, and infections: what can be learned from fluorescence techniques?

10.3390/membranes15010006 · 2025 · External reference

Correction to: inhibition of the K+ conductance and cole-moore shift of the oncogenic Kv10. 1 channel by amiodarone

10.1007/s00424-018-2131-2 · 2018 · External reference

Molecular dynamics simulation of passive diffusion across a human breast cancer cell membrane model. Comparison between cisplatin and its Pt (IV) derivatives

10.1021/acs.jcim.5c02819 · 2026 · External reference

Astemizole inhibits cell proliferation in human prostate tumorigenic cells expressing ether í-go-go-1 potassium channels

10.14715/cmb/2017.63.12.4 · 2017 · External reference

Perturbing the dynamics and organization of cell membrane components: a new paradigm for cancer-targeted therapies

10.3390/ijms19123871 · 2018 · External reference

Cholesterol regulation of mechanosensitive ion channels

10.3389/fcell.2024.1352259 · 2024 · External reference

Oncogene amplification in growth factor signaling pathways renders cancers dependent on membrane lipid remodeling

10.1016/j.cmet.2019.06.014 · 2019 · External reference

Phosphatidylinositol 4, 5-bisphosphate interactions with the HERG K+ channel

10.1007/s00424-007-0292-5 · 2007 · External reference

HERG K+ channel activity is regulated by changes in phosphatidyl inositol 4, 5-bisphosphate

10.1161/hh2401.101375 · 2001 · External reference

Molecular analysis of PIP2 regulation of HERG and I Kr

10.1152/ajpheart.00120.2004 · 2004 · External reference

Phosphatidylserine is a global immunosuppressive signal in efferocytosis, infectious disease, and cancer

10.1038/cdd.2016.11 · 2016 · External reference

Polyunsaturated fatty acid modulation of voltage-gated ion channels

10.1007/s12013-008-9027-2 · 2008 · External reference

Biology of phosphatidylserine (PS): basic physiology and implications in immunology, infectious disease, and cancer

10.1186/s12964-020-00543-8 · 2020 · External reference

Flavonoid regulation of EAG1 channels

10.1085/jgp.201210900 · 2013 · External reference

Kv10. 1 potassium channel: from the brain to the tumors

10.1139/bcb-2017-0062 · 2017 · External reference

Protein-lipid interplay in fusion and fission of biological membranes

10.1146/annurev.biochem.72.121801.161504 · 2003 · External reference

Cholesterol modulates ion channels via down‐regulation of phosphatidylinositol 4, 5‐bisphosphate

10.1111/j.1471-4159.2009.06545.x · 2010 · External reference

Cholesterol and sphingolipid enriched lipid rafts as therapeutic targets in cancer

10.3390/ijms22020726 · 2021 · External reference

How lipids contribute to ion channel function, a fat perspective on direct and indirect interactions

10.1016/j.sbi.2018.03.015 · 2018 · External reference

PIP2 and PIP3: complex roles at the cell surface

10.1016/s0092-8674(00)80696-0 · 2000 · External reference

Clinical evaluation of QT/QTc prolongation and proarrhythmic potential for nonantiarrhythmic drugs: the international conference on harmonization of technical requirements for registration of pharmaceuticals for human use E14 guideline

10.1177/0091270006286436 · 2006 · External reference

Dual regulation of hEAG1 channels by phosphatidylinositol 4, 5-bisphosphate

10.1016/j.bbrc.2018.07.011 · 2018 · External reference

A comprehensive review of 20 years of progress in nonclinical QT evaluation and proarrhythmic assessment

10.1007/s10928-025-09979-2 · 2025 · External reference

Eag1 expression interferes with hypoxia homeostasis and induces angiogenesis in tumors

10.1074/jbc.m801830200 · 2008 · External reference

Targeting the hERG1/β1 integrin complex in lipid rafts potentiates statins anti-cancer activity in pancreatic cancer

10.1038/s41420-025-02321-2 · 2025 · External reference

Modeling of open, closed, and open-inactivated states of the hERG1 channel: structural mechanisms of the state-dependent drug binding

10.1021/ci300353u · 2012 · External reference

Membrane asymmetry and phospholipid translocases in eukaryotic cells

10.1007/978-981-13-0532-0_3 · 2018 · External reference

How cholesterol interacts with membrane proteins: an exploration of cholesterol-binding sites including CRAC, CARC, and tilted domains

10.3389/fphys.2013.00031 · 2013 · External reference

Molecular determinants of dofetilide block of HERG K+ channels

10.1161/01.res.82.3.386 · 1998 · External reference

The GLOBOCAN 2022 cancer estimates: data sources, methods, and a snapshot of the cancer burden worldwide

10.1002/ijc.35278 · 2025 · External reference

Effect of the membrane environment on pharmacologic inhibition of hERG K+ channel activity

10.1016/j.jacep.2024.11.016 · 2025 · External reference

PKC regulation of ion channels: the involvement of PIP2

10.1016/j.jbc.2022.102035 · 2022 · External reference

Activation of hEAG1 potassium channels by arachidonic acid

10.1007/s00424-006-0173-3 · 2007 · External reference

Inhibition of hEAG1 and hERG1 potassium channels by clofilium and its tertiary analogue LY97241

10.1038/sj.bjp.0705025 · 2003 · External reference

Molecular determinants for high-affinity block of human EAG potassium channels by antiarrhythmic agents

10.1124/mol.65.5.1120 · 2004 · External reference

Development of a high-throughput electrophysiological assay for the human ether-à-go-go related potassium channel hERG

10.1016/j.vascn.2012.10.002 · 2013 · External reference

Different relevance of inactivation and F468 residue in the mechanisms of hEag1 channel blockage by astemizole, imipramine and dofetilide

10.1016/j.febslet.2006.08.030 · 2006 · External reference

New diarylamine KV10. 1 inhibitors and their anticancer potential

10.3390/pharmaceutics14091963 · 2022 · External reference

ω-3 and ω-6 polyunsaturated fatty acids block HERG channels

10.1152/ajpcell.00036.2005 · 2005 · External reference

Involvement of Caveolin-1 in probucol-reduced hERG membrane expression

10.1016/j.bpj.2010.12.764 · 2011 · External reference

The structural mechanism of KCNH-channel regulation by the eag domain

10.1038/nature12487 · 2013 · External reference

Human EAG channels are directly modulated by PIP2 as revealed by electrophysiological and optical interference investigations

10.1038/srep23417 · 2016 · External reference

Eag1 K+ channel: endogenous regulation and functions in nervous system

10.1155/2017/7371010 · 2017 · External reference

Beyond fluidity: the role of lipid unsaturation in membrane function

10.1101/cshperspect.a041409 · 2023 · External reference

PIP2: a critical regulator of vascular ion channels hiding in plain sight

10.1073/pnas.2006737117 · 2020 · External reference

Overexpression of Eag1 potassium channels in clinical tumours

10.1186/1476-4598-5-41 · 2006 · External reference

The complex and intriguing lives of PIP2 with ion channels and transporters

10.1126/stke.2001.111.re19 · 2001 · External reference

Regulating membrane curvature

2004 · External reference

Complex roles of PIP2 in the regulation of ion channels and transporters

10.1152/ajprenal.00400.2007 · 2007 · External reference

PIP2 regulation of TRPV4 channels: binding sites and dynamic coupling

10.1016/j.bpj.2025.08.006 · 2025 · External reference

Lipid organization of the plasma membrane

10.1021/ja507832e · 2014 · External reference

KV10. 1 K+-channel plasma membrane discrete domain partitioning and its functional correlation in neurons

10.1016/j.bbamem.2013.11.007 · 2014 · External reference

Development of safe drugs: the hERG challenge

10.1002/med.21445 · 2018 · External reference

The role of cholesterol in cancer

10.1158/0008-5472.can-15-2613 · 2016 · External reference

The interaction between CD 300a and phosphatidylserine inhibits tumor cell killing by NK cells

10.1002/eji.201343433 · 2013 · External reference

Phosphatidylserine exposure during apoptosis reflects bidirectional trafficking between plasma membrane and cytoplasm

10.1038/cdd.2012.93 · 2013 · External reference

Inositol and PIP2/PIP3 ratio: at the crossroad of the biodynamic interface between cells and their microenvironment

10.3390/biom15030451 · 2025 · External reference

Cholesterol and ion channels

10.1007/978-90-481-8622-8_19 · 2010 · External reference

Cholesterol binding to ion channels

10.3389/fphys.2014.00065 · 2014 · External reference

Mechanisms underlying the dual effect of polyunsaturated fatty acid analogs on Kv7. 1

10.1016/j.celrep.2018.08.031 · 2018 · External reference

Understanding the global cancer statistics 2022: growing cancer burden

10.1007/s11427-024-2657-y · 2024 · External reference

Lipid rafts–protein association and the regulation of protein activity

10.1016/j.abb.2004.03.020 · 2004 · External reference

The Kv10. 1 channel: a promising target in cancer

10.3390/ijms23158458 · 2022 · External reference

Structure and roles of phospholipase C (PLC), phosphatidylinositol 4, 5-bisphosphate (PIP2), and Inositol 1, 4, 5-trisphosphate (IP3) in metabolism and disease: a systematic review

10.36401/iddb-24-7 · 2025 · External reference

Liensinine, a novel and food-derived compound, exerts potent antihepatoma efficacy via inhibiting the Kv10. 1 channel

10.1021/acs.jafc.3c06142 · External reference

Corydaline binds to a druggable pocket of hEAG1 channel and inhibits hepatic carcinoma cell viability

10.1016/j.ejphar.2023.176240 · External reference

Leaflet-specific effects of charged lipids on a voltage-gated potassium channel

10.1016/j.jlr.2025.100934 · 2025 · External reference

Structural modeling of the hERG potassium channel and associated drug interactions

10.3389/fphar.2022.966463 · 2022 · External reference

Review of PIP2 in cellular signaling, functions and diseases

10.3390/ijms21218342 · 2020 · External reference

Analysis of the expression of Kv10. 1 potassium channel in patients with brain metastases and glioblastoma multiforme: impact on survival

10.1186/s12885-015-1848-y · 2015 · External reference

Lipid rafts as signaling hubs in cancer cell survival/death and invasion: implications in tumor progression and therapy: thematic review series: biology of lipid rafts

10.1194/jlr.tr119000439 · 2020 · External reference

Procyanidin B1, a novel and specific inhibitor of Kv10. 1 channel, suppresses the evolution of hepatoma

10.1016/j.bcp.2020.114089 · 2020 · External reference

Imaging lipid domains in cell membranes: the advent of super-resolution fluorescence microscopy

10.3389/fpls.2013.00503 · 2013 · External reference

The lipid raft hypothesis revisited–new insights on raft composition and function from super‐resolution fluorescence microscopy

10.1002/bies.201200044 · 2012 · External reference

Changes in lipids composition and metabolism in colorectal cancer: a review

10.1186/s12944-019-0977-8 · 2019 · External reference

The dynamic interplay of PIP2 and ATP in the regulation of the KATP channel

10.1113/jp283345 · 2022 · External reference

Lipid modulation of ion channels through specific binding sites

10.1016/j.bbamem.2013.10.023 · 2014 · External reference

Towards understanding the molecular basis of ion channel modulation by lipids: mechanistic models and current paradigms

10.1016/j.bbamem.2017.04.003 · 2017 · External reference

Regulation of the ATP-sensitive K channel Kir6. 2 by ATP and PIP2

10.1016/j.yjmcc.2004.11.018 · 2005 · External reference

Membrane-active host defense peptides–challenges and perspectives for the development of novel anticancer drugs

10.1016/j.chemphyslip.2011.09.004 · 2011 · External reference

Phosphatidylinositol-4, 5-bisphosphate (PIP2) stabilizes the open pore conformation of the Kv11. 1 (hERG) channel

10.1016/j.bpj.2010.06.013 · 2010 · External reference

Dual regulation of voltage-sensitive ion channels by PIP2

10.3389/fphar.2012.00170 · 2012 · External reference

Regulation of ion channels by membrane lipids

10.1002/cphy.c110001 · 2012 · External reference

Regulation of phospholipid distribution in the lipid bilayer by flippases and scramblases

10.1038/s41580-023-00604-z · 2023 · External reference

Enhancing hERG risk assessment with interpretable classificatory and regression models

10.1021/acs.chemrestox.3c00400 · 2024 · External reference

Kv11. 1 (hERG1) channels and cardiac arrhythmia

10.1007/978-3-031-33588-4_11 · 2023 · External reference

Membrane potential modulates ERK activity and cell proliferation

10.7554/elife.101613 · 2025 · External reference

Cholesterol, lipid rafts, and disease

10.1172/jci16390 · 2002 · External reference

Blockade of HERG channels expressed in Xenopus oocytes by the histamine receptor antagonists terfenadine and astemizole

10.1016/0014-5793(96)00355-9 · 1996 · External reference

Lipid composition of the cancer cell membrane

10.1007/s10863-020-09846-4 · 2020 · External reference

Phosphoinositides, key molecules for regulation of actin cytoskeletal organization and membrane traffic from the plasma membrane

10.1016/s1388-1981(01)00165-2 · 2001 · External reference

Striking a balance: PIP2 and PIP3 signaling in neuronal health and disease

10.37349/ent.2021.00008 · 2021 · External reference

Phosphatidylinositol 4, 5-bisphosphate (PIP2) and Ca2+ are both required to open the Cl− channel TMEM16A

10.1074/jbc.ra118.007128 · 2019 · External reference

Inhibition of the current of heterologously expressed HERG potassium channels by imipramine and amitriptyline

10.1038/sj.bjp.0702800 · 1999 · External reference

The antipsychotic drug chlorpromazine inhibits HERG potassium channels

10.1038/sj.bjp.0705283 · 2003 · External reference

Functional role of glycosphingolipids and gangliosides in control of cell adhesion, motility, and growth, through glycosynaptic microdomains

10.1016/j.bbagen.2007.10.008 · 2008 · External reference

A new mechanism of voltage-dependent gating exposed by KV10. 1 channels interrupted between voltage sensor and pore

10.1085/jgp.201611742 · 2017 · External reference

3D pharmacophore-based discovery of novel KV10. 1 inhibitors with antiproliferative activity

10.3390/cancers13061244 · 2021 · External reference

Overcoming challenges of HERG potassium channel liability through rational design: Eag1 inhibitors for cancer treatment

10.1002/med.21808 · 2022 · External reference

Interaction of drugs with lipid raft membrane domains as a possible target

10.33393/dti.2020.2185 · 2020 · External reference

Binding of cholesterol to the N-terminal domain of the NPC1L1 transporter: analysis of the epimerization-related binding selectivity and loop mutations

10.1021/acs.jcim.3c01319 · 2023 · External reference

Membrane lipids: where they are and how they behave

10.1038/nrm2330 · 2008 · External reference

Interaction with the hERG channel and cytotoxicity of amiodarone and amiodarone analogues

10.1038/bjp.2008.287 · 2008 · External reference

Potential mechanisms for the enhancement of HERG K+ channel function by phospholipid metabolites

10.1038/sj.bjp.0705646 · 2004 · External reference

Tetrandrine, a novel inhibitor of ether‐à‐go‐go‐1 (Eag1), targeted to cervical cancer development

10.1002/jcp.27470 · 2019 · External reference

Identification of undecylenic acid as EAG channel inhibitor using surface plasmon resonance-based screen of KCNH channels

10.1186/s40360-019-0324-8 · 2019 · External reference

Chlorpromazine binding to the PAS domains uncovers the effect of ligand modulation on EAG channel activity

10.1074/jbc.ra119.012377 · 2020 · External reference

Molecular mechanism of EAG1 channel inhibition by imipramine binding to the PAS domain

10.1016/j.jbc.2023.105391 · 2023 · External reference

Silencing the activity and proliferative properties of the human EagI potassium channel by RNA interference

10.1074/jbc.m600883200 · 2006 · External reference

Structure of the voltage-gated K+ channel Eag1 reveals an alternative voltage sensing mechanism

10.1126/science.aaf8070 · 2016 · External reference

Regulation of Eag1 gating by its intracellular domains

10.7554/elife.49188 · 2019 · External reference

Unresolved reference

2024 · External reference

Ginsenoside Rg3, a gating modifier of EAG family K+ channels

10.1124/mol.116.104091 · 2016 · External reference

Drug repurposing for cancer therapy

10.1038/s41392-024-01808-1 · 2024 · External reference

Phosphatidylinositol‐4, 5‐bisphosphate (PIP2) regulation of strong inward rectifier Kir2. 1 channels: multilevel positive cooperativity

10.1113/jphysiol.2007.147868 · 2008 · External reference

Dual control of cardiac Na+–Ca2+ exchange by PIP2: electrophysiological analysis of direct and indirect mechanisms

10.1113/jphysiol.2007.132712 · 2007 · External reference

Membrane phosphatidylserine regulates surface charge and protein localization

10.1126/science.1152066 · 2008 · External reference

Determining the target of membrane sterols on voltage-gated potassium channels

10.1016/j.bbalip.2018.12.006 · 2019 · External reference

Direct and indirect cholesterol effects on membrane proteins with special focus on potassium channels

10.1016/j.bbalip.2020.158706 · 2020 · External reference

Cell membrane modulation as adjuvant in cancer therapy

10.1016/j.ctrv.2016.10.008 · 2017 · External reference

The role of PIP2 in the voltage-dependent activation of Kv7. 1

10.1016/j.bpj.2011.11.1816 · 2012 · External reference

Accumulation of raft lipids in T‐cell plasma membrane domains engaged in TCR signalling

10.1038/emboj.2009.6 · 2009 · External reference

Effect of cholesterol on cellular uptake of cancer drugs pirarubicin and ellipticine

10.1021/acs.jpcb.5b12337 · 2016 · External reference

The lipid rafts in cancer stem cell: a target to eradicate cancer

10.1186/s13287-022-03111-8 · 2022 · External reference

Voltage-gated potassium channels and genetic epilepsy

10.3389/fneur.2024.1466075 · 2024 · External reference

Lipid-dependent gating of a voltage-gated potassium channel

10.1038/ncomms1254 · 2011 · External reference

Membrane potential modulates plasma membrane phospholipid dynamics and K-Ras signaling

10.1126/science.aaa5619 · 2015 · External reference