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References from Garlic-derived allyl sulfides attenuate house dust mite-induced allergic airway inflammation associated with reduced PI3K/NF-κB signaling. Local targets link to admitted publications; unresolved targets remain external evidence.
The house dust mite allergen Der p 1, unlike Der p 3, stimulates the expression of interleukin-8 in human airway epithelial cells via a proteinase-activated receptor-2-independent mechanism
10.1074/jbc.m507140200 · 2006 · External reference
Allergic endotypes and phenotypes of asthma
10.1016/j.jaip.2019.11.008 · 2020 · External reference
Immunomodulation and anti-inflammatory effects of garlic compounds
10.1155/2015/401630 · 2015 · External reference
House dust mite allergens induce proinflammatory cytokines from respiratory epithelial cells: the cysteine protease allergen, Der p 1, activates protease-activated receptor (PAR)-2 and inactivates PAR-1
10.4049/jimmunol.169.8.4572 · 2002 · External reference
The NF-kappa B and I kappa B proteins: new discoveries and insights
10.1146/annurev.immunol.14.1.649 · 1996 · External reference
Th2 cytokines and asthma: an introduction
10.1186/rr39 · 2001 · External reference
IFN-gamma enhances secretion of IgG2a from IgG2a-committed LPS-stimulated murine B cells: implications for the role of IFN-gamma in class switching
10.1016/0008-8749(91)90257-c · 1991 · External reference
Macrophages orchestrate airway inflammation, remodeling, and resolution in asthma
10.3390/ijms241310451 · 2023 · External reference
Dendritic cell-CD4(+) T cell interaction: the differential role of IL-4/IL-13 in serum IgE levels in house dust mite allergic patients
10.3892/etm.2020.9527 · 2021 · External reference
The antioxidant mechanisms underlying the aged garlic extract- and S-allylcysteine-induced protection
10.1155/2012/907162 · 2012 · External reference
The role of M1/M2 macrophage polarization in Rheumatoid arthritis synovitis
10.3389/fimmu.2022.867260 · 2022 · External reference
PI3K activity in dendritic cells exerts paradoxical effects during autoimmune inflammation
10.1016/j.molimm.2019.03.015 · 2019 · External reference
Emerging roles of T helper subsets in the pathogenesis of asthma
10.3109/08820131003615498 · 2010 · External reference
Kaempferol suppresses eosionphil infiltration and airway inflammation in airway epithelial cells and in mice with allergic asthma
10.3945/jn.111.150748 · 2012 · External reference
IL-4 and IL-13 signaling in allergic airway disease
10.1016/j.cyto.2015.05.014 · 2015 · External reference
The basic immunology of asthma
10.1016/j.cell.2021.02.016 · 2021 · External reference
Alveolar macrophages stimulate enhanced cytokine production by pulmonary CD4+ T-lymphocytes in an exacerbation of murine chronic asthma
10.2353/ajpath.2010.100019 · 2010 · External reference
Comparing the Protection Imparted by Different Fraction Extracts of Garlic (Allium sativum L.) against Der p-Induced Allergic Airway Inflammation in Mice
10.3390/ijms20194879 · 2019 · External reference
S-allyl cysteine as potent anti-gout drug: insight into the xanthine oxidase inhibition and anti-inflammatory activity
10.1016/j.biochi.2018.07.015 · 2018 · External reference
Paraprobiotic Levilactobacillus brevis KU15151 exhibits antioxidative and anti-inflammatory activities in LPS-induced A549 cells
10.1016/j.micpath.2024.107143 · 2025 · External reference
Immune responses of macrophages and dendritic cells regulated by mTOR signalling
10.1042/bst20130032 · 2013 · External reference
S-allyl cysteine protects against lipopolysaccharide-induced acute kidney injury in the C57BL/6 mouse strain: involvement of oxidative stress and inflammation
10.1016/j.intimp.2019.01.026 · 2019 · External reference
Der p 2.1 Peptide Abrogates House Dust Mites-Induced Asthma Features in Mice and Humanized Mice by Inhibiting DC-Mediated T Cell Polarization
10.3389/fimmu.2020.565431 · 2020 · External reference
Inhibition of phosphoinositide 3-kinase delta attenuates allergic airway inflammation and hyperresponsiveness in murine asthma model
10.1096/fj.05-5045com · 2006 · External reference
Recruited alveolar macrophages, in response to airway epithelial-derived monocyte chemoattractant protein 1/CCl2, regulate airway inflammation and remodeling in allergic asthma
10.1165/rcmb.2014-0255oc · 2015 · External reference
N-acetylcysteine decreases airway inflammation and responsiveness in asthma by modulating claudin 18 expression
10.3904/kjim.2019.105 · 2020 · External reference
PI3K/AKT/mTOR and TLR4/MyD88/NF-κB signaling inhibitors attenuate pathological mechanisms of allergic asthma
10.1007/s10753-021-01466-3 · 2021 · External reference
Antiviral activity of diallyl trisulfide against H9N2 avian influenza virus infection in vitro and in vivo
10.1186/s12985-021-01641-w · 2021 · External reference
The role of the transcription factor NF-kB in the pathogenesis of inflammation and carcinogenesis. Modulation capabilities
10.3897/pharmacia.72.e146759 · 2025 · External reference
The NF-kappaB pathway
10.1242/jcs.02579 · 2005 · External reference
Methyl P-Coumarate ameliorates the inflammatory response in activated-airway epithelial cells and mice with allergic asthma
10.3390/ijms232314909 · 2022 · External reference
NF-kappa B activation in airways modulates allergic inflammation but not hyperresponsiveness
10.4049/jimmunol.173.11.7003 · 2004 · External reference
S-Allyl-L-Cysteine — a garlic bioactive: physicochemical nature, mechanism, pharmacokinetics, and health promoting activities
10.1016/j.jff.2023.105657 · 2023 · External reference
Calpain-activated mTORC2/Akt pathway mediates airway smooth muscle remodelling in asthma
10.1111/cea.12805 · 2017 · External reference
PGC-1α regulates airway epithelial barrier dysfunction induced by house dust mite
10.1186/s12931-021-01663-6 · 2021 · External reference
T helper cell type 1-associated and cytotoxic T lymphocyte-mediated tumor immunity is impaired in interleukin 4-deficient mice
10.1084/jem.189.5.803 · 1999 · External reference
Qualitative and quantitative analysis of nonneoplastic lesions in toxicology studies
10.1080/01926230252824761 · 2002 · External reference
Diallyl-disulfide, an organosulfur compound of garlic, attenuates airway inflammation via activation of the Nrf-2/HO-1 pathway and NF-kappaB suppression
10.1016/j.fct.2013.09.012 · 2013 · External reference
S-Allyl cysteine reduces eosinophilic airway inflammation and mucus overproduction on ovalbumin-induced allergic asthma model
10.1016/j.intimp.2019.01.001 · 2019 · External reference
Differential regulation of IgG1 and IgE synthesis by interleukin 4
10.1084/jem.167.1.183 · 1988 · External reference
Biological functions of diallyl disulfide, a garlic-derived natural organic sulfur compound
10.1155/2021/5103626 · 2021 · External reference
The mechanisms and therapeutic implications of PI3K signaling in airway inflammation and remodeling in asthma
10.2147/btt.s497622 · 2025 · External reference
The effect of allergen-induced airway inflammation on airway remodeling in a murine model of allergic asthma
10.1007/pl00000243 · 2001 · External reference
PPAR-alpha and -gamma but not -delta agonists inhibit airway inflammation in a murine model of asthma: in vitro evidence for an NF-kappaB-independent effect
10.1038/sj.bjp.0705232 · 2003 · External reference
Evaluation of airway inflammation by quantitative Th1/Th2 cytokine mRNA measurement in sputum of asthma patients
10.1136/thx.2005.052399 · 2006 · External reference
Der p 1 facilitates transepithelial allergen delivery by disruption of tight junctions
10.1172/jci5844 · 1999 · External reference
Molecular mechanisms that influence the macrophage m1-m2 polarization balance
10.3389/fimmu.2014.00614 · 2014 · External reference
Targeting PI3K/AKT signaling for treatment of idiopathic pulmonary fibrosis
10.1016/j.apsb.2021.07.023 · 2022 · External reference
Pathogenesis of allergic diseases and implications for therapeutic interventions
10.1038/s41392-023-01344-4 · 2023 · External reference
Baiheqingjin formula reduces inflammation in mice with asthma by inhibiting the PI3K/AKT/NF-κb signaling pathway
10.1016/j.jep.2023.117565 · 2024 · External reference
Activation of the mTOR signaling pathway is required for asthma onset
10.1038/s41598-017-04826-y · 2017 · External reference
Disequilibrium of M1 and M2 macrophages correlates with the development of experimental inflammatory bowel diseases
10.3109/08820139.2014.909456 · 2014 · External reference
