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References from K2P channels as emerging therapeutic targets for pain: insights from functional studies and transcriptomic analyses. Local targets link to admitted publications; unresolved targets remain external evidence.
Specialized cutaneous schwann cells initiate pain sensation
10.1126/science.aax6452 · 2019 · External reference
TREK2 expressed selectively in IB4-binding C-fiber nociceptors hyperpolarizes their membrane potentials and limits spontaneous pain
10.1523/jneurosci.4528-13.2014 · 2014 · External reference
Mass-spectrometric exploration of proteome structure and function
10.1038/nature19949 · 2016 · External reference
The K2P -channel TASK1 affects oligodendroglial differentiation but not myelin restoration
10.1002/glia.23577 · 2019 · External reference
Changes in expression of some two-pore domain potassium channel genes (KCNK) in selected brain regions of developing mice
10.1016/j.neuroscience.2007.12.011 · 2008 · External reference
TREK-1, a K+ channel involved in polymodal pain perception
10.1038/sj.emboj.7601116 · 2006 · External reference
The background K+ channel TRESK in sensory physiology and pain
10.3390/ijms21155206 · 2020 · External reference
Functional analysis of missense variants in the TRESK (KCNK18) K channel
10.1038/srep00237 · 2012 · External reference
TREK channel activation suppresses migraine pain phenotype
10.1016/j.isci.2021.102961 · 2021 · External reference
Regulation of two-pore-domain potassium TREK channels and their involvement in pain perception and migraine
10.1016/j.neulet.2022.136494 · 2022 · External reference
A high-throughput functional screen identifies small molecule regulators of Temperature- and mechano-sensitive K2P channels
10.1021/cb400289x · 2013 · External reference
TASK1 and TASK3 potassium channels: determinants of aldosterone secretion and adrenocortical zonation
10.1055/s-0029-1243601 · 2010 · External reference
Maternally inherited Birk Barel mental retardation dysmorphism syndrome caused by a mutation in the genomically imprinted potassium channel KCNK9
10.1016/j.ajhg.2008.07.010 · 2008 · External reference
Role of TASK2 potassium channels regarding volume regulation in primary cultures of mouse proximal tubules
10.1085/jgp.200308820 · 2003 · External reference
Cellular and molecular mechanisms of pain
10.1016/j.cell.2009.09.028 · 2009 · External reference
Mutations in KCNK4 that affect gating cause a recognizable neurodevelopmental syndrome
10.1016/j.ajhg.2018.09.001 · 2018 · External reference
TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents
10.1016/j.cell.2006.02.023 · 2006 · External reference
Pungent agents from Szechuan peppers excite sensory neurons by inhibiting two-pore potassium channels
10.1038/nn.2143 · 2008 · External reference
TACAN is an ion channel involved in sensing mechanical pain
10.1016/j.cell.2020.01.033 · 2020 · External reference
Ion channels in nociceptors: recent developments
10.1212/wnl.0000000000001382 · 2015 · External reference
A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man
10.1016/0304-3959(88)90209-6 · 1988 · External reference
The IASP classification of chronic pain for ICD-11: chronic cancer-related pain
10.1097/j.pain.0000000000001363 · 2019 · External reference
Motoneurons express heteromeric TWIK-related acid-sensitive K+ (TASK) channels containing TASK1 (KCNK3) and TASK3 (KCNK9) subunits
10.1523/jneurosci.1408-04.2004 · 2004 · External reference
Harmonized cross-species cell atlases of trigeminal and dorsal root ganglia
10.1126/sciadv.adj9173 · 2024 · External reference
Light-induced analgesia provides a drug-free optical method for pain relief via activation of TRAAK channels
10.1038/s41467-025-67819-w · 2026 · External reference
The role of two-pore-domain background K+ (K2p) channels in the thalamus
10.1007/s00424-014-1632-x · 2015 · External reference
TASK1 modulates inflammation and neurodegeneration in autoimmune inflammation of the central nervous system
10.1093/brain/awp163 · 2009 · External reference
Transcriptional expression of voltage-gated Na+ and voltage-independent K+ channels in the developing rat superficial dorsal horn
10.1016/j.neuroscience.2012.11.053 · 2013 · External reference
LPS2336, a new TREK-1 channel activator identified by high throughput screening
10.3390/biom15050740 · 2025 · External reference
How ion channels sense mechanical force: insights from mechanosensitive K2P channels TRAAK, TREK1, and TREK2
10.1111/nyas.12874 · 2015 · External reference
The mechanosensitive ion channel TRAAK is localized to the mammalian node of Ranvier
10.7554/elife.50403 · 2019 · External reference
TREK1 channel activation as a new analgesic strategy devoid of opioid adverse effects
10.1111/bph.15243 · 2020 · External reference
TRESK background K + channel deletion selectively uncovers enhanced mechanical and cold sensitivity
10.1113/jp279203 · 2020 · External reference
The capsaicin receptor: a heat-activated ion channel in the pain pathway
10.1038/39807 · 1997 · External reference
Discrete change in volatile anesthetic sensitivity in mice with inactivated tandem pore potassium ion channel TRESK
10.1097/aln.0b013e3181f90ca5 · 2010 · External reference
Physiological genomics identifies genetic modifiers of long QT syndrome type 2 severity
10.1172/jci94996 · 2018 · External reference
Effects of GABAB receptor activation on excitability of IB4-positive maxillary trigeminal ganglion neurons: possible involvement of TREK2 activation
10.1177/17448069211042963 · 2021 · External reference
Silencing of the tandem pore domain halothane-inhibited K+ channel 2 (thik2) relies on combined intracellular retention and low intrinsic activity at the plasma membrane
10.1074/jbc.m113.503318 · 2013 · External reference
Mechanistic basis of the dynamic response of TWIK1 ionic selectivity to pH
10.1038/s41467-024-48067-w · 2024 · External reference
Altered and dynamic ion selectivity of K+ channels in cell development and excitability
10.1016/j.tips.2014.06.002 · 2014 · External reference
The two-pore domain potassium channel, TWIK1, has a role in the regulation of heart rate and atrial size
10.1016/j.yjmcc.2016.04.006 · 2016 · External reference
Functional identification of an outwardly rectifying pH- and anesthetic-sensitive leak K+ conductance in hippocampal astrocytes
10.1111/j.1460-9568.2010.07323.x · 2010 · External reference
TASK2: a K2P K+ channel with complex regulation and diverse physiological functions
10.3389/fphys.2013.00198 · 2013 · External reference
TASK3 gene knockdown dampens invasion and migration and promotes aqpoptosis in KATO III and MKN-45 human gastric adenocarcinoma cell lines
10.3390/ijms20236077 · 2019 · External reference
Discovery of a pharmacologically active antagonist of the two-pore-domain potassium channel K2P9.1 (TASK3)
10.1002/cmdc.201100351 · 2012 · External reference
Pancreatic β-cell-specific ablation of TASK1 channels augments glucose-stimulated calcium entry and insulin secretion, improving glucose tolerance
10.1210/en.2013-2051 · 2014 · External reference
Selective small molecule activators of TREK-2 channels stimulate dorsal root ganglion c-Fiber nociceptor two-pore-domain potassium channel currents and limit calcium influx
10.1021/acschemneuro.6b00301 · 2017 · External reference
TASK channel deletion in mice causes primary hyperaldosteronism
10.1073/pnas.0712000105 · 2008 · External reference
Development of covalent chemogenetic K2P channel activators
10.1016/j.chembiol.2024.06.006 · 2024 · External reference
Sodium permeable and “hypersensitive”TREK 1 channels cause ventricular tachycardia
10.15252/emmm.201606690 · 2017 · External reference
Molecular pharmacology of K2P potassium channels
10.33594/000000339 · 2021 · External reference
Spared nerve injury: an animal model of persistent peripheral neuropathic pain
10.1016/s0304-3959(00)00276-1 · 2000 · External reference
The TREK1 potassium channel is involved in both the analgesic and anti-proliferative effects of riluzole in bone cancer pain
10.1016/j.biopha.2024.116887 · 2024 · External reference
Oxaliplatin‐induced cold hypersensitivity is due to remodelling of ion channel expression in nociceptors
10.1002/emmm.201100134 · 2011 · External reference
Activation of TREK1 by morphine results in analgesia without adverse side effects
10.1038/ncomms3941 · 2013 · External reference
The TWIK2 potassium efflux channel in macrophages mediates NLRP3 inflammasome-induced inflammation
10.1016/j.immuni.2018.04.032 · 2018 · External reference
TRESK two pore domain K+ channels constitute a significant component of background potassium currents in murine dorsal root ganglion neurones
10.1113/jphysiol.2007.145649 · 2007 · External reference
Exome sequencing implicates impaired GABA signaling and neuronal ion transport in trigeminal Neuralgia
10.1016/j.isci.2020.101552 · 2020 · External reference
The two-pore potassium channel THIK1 regulates NLRP3 inflammasome activation
10.1002/glia.24174 · 2022 · External reference
TASK channel deletion reduces sensitivity to local anesthetic-induced seizures
10.1097/aln.0b013e3182343660 · 2011 · External reference
Nociceptors: the sensors of the pain pathway
10.1172/jci42843 · 2010 · External reference
TASK, a human background K+ channel to sense external pH variations near physiological pH
10.1093/emboj/16.17.5464 · 1997 · External reference
The neuroprotective agent riluzole activates the two P domain K(+) channels TREK1 and TRAAK
10.1016/s0026-895x(24)26499-3 · 2000 · External reference
Pancreatic two P domain K+ channels TALK‐1 and TALK‐2 are activated by nitric oxide and reactive oxygen species
10.1113/jphysiol.2004.071266 · 2005 · External reference
Ions in the fire: recent ion-channel research and approaches to pain therapy
10.1016/s0165-6147(99)01372-3 · 1999 · External reference
Two pore domain potassium channels in cerebral ischemia: a focus on K2P9.1 (TASK3, KCNK9)
10.1186/2040-7378-2-14 · 2010 · External reference
The CNS under pathophysiologic attack--examining the role of K2p channels
10.1007/s00424-014-1664-2 · 2015 · External reference
Evidence for cAMP-independent bTREK-1 inhibition by ACTH and NPS-ACTH in adrenocortical cells
10.1016/j.mce.2011.09.023 · 2012 · External reference
Molecular background of leak K+ currents: two-pore domain potassium channels
10.1152/physrev.00029.2009 · 2010 · External reference
Potassium channel clustering: mechanisms shaping axonal excitability
10.3389/fncel.2025.1627517 · 2025 · External reference
Pain and nociception: mechanisms of cancer-induced bone pain
10.1200/jco.2013.51.7219 · 2014 · External reference
The family of K2P channels: salient structural and functional properties
10.1113/jphysiol.2014.287268 · 2015 · External reference
Potent and selective inhibitors of the TASK-1 potassium channel through chemical optimization of a bis-amide scaffold
10.1016/j.bmcl.2014.06.032 · 2014 · External reference
Clinical and preclinical perspectives on chemotherapy-induced peripheral neuropathy (CIPN): a narrative review
10.1093/bja/aex229 · 2017 · External reference
RNA-Seq analysis of human trigeminal and dorsal root ganglia with a focus on chemoreceptors. McKemy DD
10.1371/journal.pone.0128951 · 2015 · External reference
Gain‐of‐function mutation in TASK4 channels and severe cardiac conduction disorder
10.15252/emmm.201303783 · 2014 · External reference
A systematic summary and comparison of animal models for chemotherapy induced (peripheral) neuropathy (CIPN)
10.1371/journal.pone.0221787 · 2019 · External reference
Spinal TASK1 and TASK3 modulate inflammatory and neuropathic pain
10.1016/j.ejphar.2019.172631 · 2019 · External reference
PKC- and PKA-dependent phosphorylation modulates TREK-1 function in naïve and neuropathic rats
10.1111/jnc.15204 · External reference
TREK1 potassium channels participate in acute and long-lasting nociceptive hypersensitivity induced by formalin in rats
10.1016/j.bbr.2021.113446 · External reference
Task2 potassium channels set central respiratory CO2 and O2 sensitivity
10.1073/pnas.0910059107 · 2010 · External reference
Two pore domain THIK2 potassium channels regulate acute and chronic pain signaling
10.1097/pr9.0000000000001481 · 2026 · External reference
Genomic and functional characteristics of novel human pancreatic 2P domain K+ channels
10.1006/bbrc.2001.4562 · 2001 · External reference
Genetic counselling in a national referral centre for pulmonary hypertension
10.1183/13993003.00717-2015 · 2016 · External reference
Potassium leak channels and the KCNK family of two-p-domain subunits
10.1038/35058574 · 2001 · External reference
A KCNK16 mutation causing TALK-1 gain of function is associated with maturity-onset diabetes of the young
10.1172/jci.insight.138057 · 2021 · External reference
An overview of animal models of pain: disease models and outcome measures
10.1016/j.jpain.2013.06.008 · 2013 · External reference
Two-pore-domain K+ channels are a novel target for the anesthetic gases xenon, nitrous oxide, and cyclopropane
10.1124/mol.65.2.443 · 2004 · External reference
Expression pattern and functional characteristics of two novel splice variants of the two‐pore‐domain potassium channel TREK-2
10.1113/jphysiol.2001.013432 · 2002 · External reference
Decoding the mechanism of proanthocyanidins in central analgesia: redox regulation and KCNK3 blockade
10.1038/s12276-025-01412-5 · 2025 · External reference
Adrenal tissue-specific deletion of TASK channels causes aldosterone-driven angiotensin ii–independent hypertension
10.1161/hypertensionaha.118.11962 · 2019 · External reference
Over-expression of TRESK K+ channels reduces the excitability of trigeminal ganglion nociceptors
10.1371/journal.pone.0087029 · 2014 · External reference
TRESK K+Channel activity regulates trigeminal nociception and headache
10.1523/eneuro.0236-19.2019 · 2019 · External reference
Two-pore domain k channel, task-1, in pulmonary artery smooth muscle cells
10.1161/01.res.0000099883.68414.61 · 2003 · External reference
Enhanced expression of TREK1 is related with chronic constriction injury of neuropathic pain mouse model in dorsal root ganglion
10.4062/biomolther.2016.038 · 2016 · External reference
Mechanisms of cancer pain
10.3389/fpain.2022.1030899 · 2023 · External reference
Cutaneous inflammation regulates THIK1 expression in small C-like nociceptor dorsal root ganglion neurons
10.1016/j.mcn.2017.06.010 · 2017 · External reference
TASK1 channels in oligodendrocytes: a role in ischemia mediated disruption
10.1016/j.nbd.2013.03.016 · 2013 · External reference
Invalidation of TASK1 potassium channels disrupts adrenal gland zonation and mineralocorticoid homeostasis
10.1038/sj.emboj.7601934 · 2008 · External reference
Effect of 158 herbal remedies on human TRPV1 and the two-pore domain potassium channels KCNK2, 3 and 9
10.1016/j.jtcme.2020.04.005 · 2020 · External reference
Contribution of K2P potassium channels to cardiac physiology and pathophysiology
10.3390/ijms22126635 · 2021 · External reference
Distribution and expression of TREK1, a two-pore-domain potassium channel, in the adult rat CNS
10.1016/s0306-4522(01)00030-6 · 2001 · External reference
TREK1, a K+ channel involved in neuroprotection and general anesthesia
10.1038/sj.emboj.7600234 · 2004 · External reference
Deletion of the background potassium channel TREK1 results in a depression-resistant phenotype
10.1038/nn1749 · 2006 · External reference
Sodium butyrate restored TRESK current controlling neuronal hyperexcitability in a mouse model of oxaliplatin-induced peripheral neuropathic pain
10.1016/j.neurot.2024.e00481 · 2025 · External reference
An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat
10.1016/0304-3959(92)90041-9 · 1992 · External reference
A quantitative description of membrane current and its application to conduction and excitation in nerve
10.1113/jphysiol.1952.sp004764 · 1952 · External reference
Comparative neurotoxicity of oxaliplatin, cisplatin, and ormaplatin in a wistar rat model
10.1006/toxs.1998.2558 · 1998 · External reference
The neuronal background K2P channels: focus on TREK1
10.1038/nrn2117 · 2007 · External reference
Development of non-opioid analgesics targeting two-pore domain potassium channels
10.2174/1570159x19666210407152528 · 2022 · External reference
Endosomal trafficking of two-pore K+ efflux channel TWIK2 to plasmalemma mediates NLRP3 inflammasome activation and inflammatory injury
10.7554/elife.83842 · 2023 · External reference
X-ray irradiation reduces ATP-dependent activation of NLRP3 inflammasome by inhibiting TWIK2 activity in macrophages
10.1016/j.imlet.2024.106967 · 2025 · External reference
TWIK-related spinal cord K+ channel expression is increased in the spinal dorsal horn after spinal nerve ligation
10.3349/ymj.2015.56.5.1307 · 2015 · External reference
Altered functional properties of a missense variant in the TRESK K+ channel (KCNK18) associated with migraine and intellectual disability
10.1007/s00424-020-02382-5 · 2020 · External reference
Two-pore potassium channel TREK1 (K2P2.1) regulates NLRP3 inflammasome activity in macrophages
10.1152/ajplung.00313.2023 · 2024 · External reference
Synapse development is regulated by microglial THIK-1 K + channels
10.1073/pnas.2106294118 · 2021 · External reference
Neuroinflammation and central sensitization in chronic and widespread pain
10.1097/aln.0000000000002130 · 2018 · External reference
Molecular mechanisms of nociception
10.1038/35093019 · 2001 · External reference
Cross-species transcriptomic atlas of dorsal root ganglia reveals species-specific programs for sensory function
10.1038/s41467-023-36014-0 · 2023 · External reference
The pharmacology of two-pore domain potassium channels
10.1007/164_2021_462 · 2021 · External reference
TREK1 and TRAAK are Principal K+ channels at the nodes of Ranvier for rapid action potential conduction on mammalian myelinated afferent nerves
10.1016/j.neuron.2019.08.042 · 2019 · External reference
Axonal membrane stretch suppresses neuronal excitability by activating mechanosensitive K2P channels at the node of Ranvier
10.1186/s13041-023-01000-6 · 2023 · External reference
Expression of thermosensitive two‐pore domain K+ channels in human keratinocytes cell line HaCaT cells
10.1111/j.1600-0625.2007.00626.x · 2007 · External reference
THIK1 (K2P13.1) is a small-conductance background K+ channel in rat trigeminal ganglion neurons
10.1007/s00424-013-1358-1 · 2014 · External reference
A new family of outwardly rectifying potassium channel proteins with two pore domains in tandem
10.1038/376690a0 · 1995 · External reference
Structure of the human TWIK2 potassium channel and its inhibition by pimozide
10.1073/pnas.2425709122 · 2025 · External reference
Alkaline-sensitive two-pore domain potassium channels form functional heteromers in pancreatic β-cells
10.1016/j.jbc.2022.102447 · 2022 · External reference
Physiology and pharmacology of two-pore domain potassium channels
10.2174/1381612054546824 · 2005 · External reference
Role of K2P channels in stimulus-secretion coupling
10.1007/s00424-014-1663-3 · 2015 · External reference
TASK-3, a new member of the tandem pore K+ channel family
10.1074/jbc.275.13.9340 · 2000 · External reference
Microglia-specific K2P channel THIK1: structure, fFunction, and therapeutic potential
10.1111/apha.70224 · 2026 · External reference
Local anesthetic inhibition of baseline potassium channels with two pore domains in tandem
10.1097/00000542-199904000-00024 · 1999 · External reference
Amide local anesthetics potently inhibit the human tandem pore domain background K+ channel TASK2 (KCNK5)
10.1124/jpet.103.049809 · 2003 · External reference
Colitis decreases mechanosensitive K2P channel expression and function in mouse colon sensory neurons
10.1152/ajpgi.00417.2010 · 2011 · External reference
Differences in the expression of transient receptor potential channel V1, transient receptor potential channel A1 and mechanosensitive two pore-domain K+ channels between the lumbar splanchnic and pelvic nerve innervations of mouse urinary bladder and colon
10.1016/j.neuroscience.2011.04.049 · 2011 · External reference
A dominant-negative mutation in the TRESK potassium channel is linked to familial migraine with aura
10.1038/nm.2216 · 2010 · External reference
Deletion of TRAAK potassium channel affects brain metabolism and protects against ischemia. Mongin AA
10.1371/journal.pone.0053266 · 2012 · External reference
A photoswitchable inhibitor of TREK channels controls pain in wild-type intact freely moving animals
10.1038/s41467-023-36806-4 · 2023 · External reference
K+-dependent cerebellar granule neuron apoptosis
10.1074/jbc.m302631200 · 2003 · External reference
Cross-talk between the mechano‐gated K2P channel TREK1 and the actin cytoskeleton
10.1038/sj.embor.7400449 · 2005 · External reference
Anesthetic activation of central respiratory chemoreceptor neurons involves inhibition of a THIK1-like background K+ current
10.1523/jneurosci.1956-10.2010 · 2010 · External reference
TASK1 regulates apoptosis and proliferation in a subset of non-small cell lung cancers
10.1371/journal.pone.0157453 · 2016 · External reference
TRESK and TREK-2 two-pore-domain potassium channel subunits form functional heterodimers in primary somatosensory neurons
10.1074/jbc.ra120.014125 · 2020 · External reference
Negative influence by the force: mechanically induced hyperpolarization via K2P background potassium channels
10.3390/ijms22169062 · 2021 · External reference
Pharmacology of neuronal background potassium channels
10.1016/s0028-3908(02)00339-8 · 2003 · External reference
Molecular and functional properties of two-pore-domain potassium channels
10.1152/ajprenal.2000.279.5.f793 · 2000 · External reference
TWIK1, a ubiquitous human weakly inward rectifying K+ channel with a novel structure
10.1002/j.1460-2075.1996.tb00437.x · External reference
Assignment of the human weak inward rectifier K+Channel TWIK1 gene to chromosome 1q42–q43
10.1006/geno.1996.0259 · External reference
Cloning and expression of human TRAAK, a polyunsaturated fatty acids-activated and mechano‐sensitive K+ channel
10.1016/s0014-5793(00)01388-0 · 2000 · External reference
Role of leak potassium channels in pain signaling
10.1016/j.brainresbull.2015.08.007 · 2015 · External reference
TRESK alleviates trigeminal neuralgia induced by infraorbital nerve chronic constriction injury in rats
10.1177/1744806919882511 · 2019 · External reference
Selective activation of TWIK-related acid-sensitive K+ 3 subunit–containing channels is analgesic in rodent models
10.1126/scitranslmed.aaw8434 · 2019 · External reference
The TASK of breathing: anesthetic relevance of background two-pore domain potassium channels as therapeutic targets for respiratory control
10.1213/ane.0000000000007365 · 2025 · External reference
The in vivo contributions of TASK1-containing channels to the actions of inhalation anesthetics, the α2 adrenergic sedative dexmedetomidine, and cannabinoid agonists
10.1124/jpet.105.098525 · 2006 · External reference
Potent activation of the human tandem pore domain K channel TRESK with clinical concentrations of volatile anesthetics
10.1213/01.ane.0000136849.07384.44 · 2004 · External reference
Contribution of TRESK two-pore domain potassium channel to bone cancer-induced spontaneous pain and evoked cutaneous pain in rats
10.1177/17448069211023230 · 2021 · External reference
S100A9 plays a role in neuropathic pain by regulating GPR153/Kcnk16 function in DRG neurons
10.1016/j.cellsig.2025.112101 · 2025 · External reference
TRESK background potassium channel regulates MrgprA3+ pruriceptor excitability, acute and chronic itch
10.1097/j.pain.0000000000003540 · 2025 · External reference
Disruption of K2P6.1 produces vascular dysfunction and hypertension in mice
10.1161/hypertensionaha.111.175349 · 2011 · External reference
GI‐530159, a novel, selective, mechanosensitive two‐pore‐domain potassium (K2P) channel opener, reduces rat dorsal root ganglion neuron excitability
10.1111/bph.14098 · 2018 · External reference
Contribution of neuronal and glial two-pore-domain potassium channels in health and neurological disorders
10.1155/2021/8643129 · 2021 · External reference
TASK-3-expressing sensory neurons mediate acute and chronic itch via enhancing dorsal horn gastrin-releasing peptide neurons activity
10.1097/j.pain.000000000000393 · 2026 · External reference
An ankyrin G–binding motif mediates TRAAK periodic localization at axon initial segments of hippocampal pyramidal neurons
10.1073/pnas.2310120121 · 2024 · External reference
TWIK1 two-pore domain potassium channels change ion selectivity and conduct inward leak sodium currents in hypokalemia
10.1126/scisignal.2001726 · 2011 · External reference
A novel channelopathy in pulmonary arterial hypertension
10.1056/nejmoa1211097 · 2013 · External reference
TREK-1 channel expression in smooth muscle as a target for regulating murine intestinal contractility: therapeutic implications for motility disorders
10.3389/fphys.2018.00157 · 2018 · External reference
Microglial ramification, surveillance, and interleukin-1β release are regulated by the two-pore domain K+ channel THIK1
10.1016/j.neuron.2017.12.002 · 2018 · External reference
Role of dorsal root ganglion K2P 1.1 in peripheral nerve injury-induced neuropathic pain
10.1177/1744806917701135 · 2017 · External reference
DNMT3a-triggered downregulation of K2p 1.1 gene in primary sensory neurons contributes to paclitaxel-induced neuropathic pain
10.1002/ijc.32155 · 2019 · External reference
Leak K+ channel mRNAs in dorsal root ganglia: relation to inflammation and spontaneous pain behaviour
10.1016/j.mcn.2012.01.002 · 2012 · External reference
Two-pore domain potassium channels: potential therapeutic targets for the treatment of pain
10.1007/s00424-014-1655-3 · 2015 · External reference
Symposium review: gating of two pore domain potassium channels: gating of K2P channels
10.1113/jphysiol.2010.192344 · 2010 · External reference
Two-pore domain potassium channels as drug targets: anesthesia and beyond
10.1146/annurev-pharmtox-030920-111536 · 2021 · External reference
Spadin, a sortilin-derived peptide targeting rodent TREK1 channels: a new concept in the antidepressant drug design
10.1371/journal.pbio.1000355 · 2010 · External reference
Distribution analysis of human two pore domain potassium channels in tissues of the central nervous system and periphery
10.1016/s0169-328x(00)00263-1 · 2001 · External reference
Glial-derived neurotrophic factor regulates the expression of TREK2 in rat primary sensory neurons leading to attenuation of axotomy-induced neuropathic pain
10.1016/j.expneurol.2022.114190 · 2022 · External reference
A disulphide-linked heterodimer of TWIK1 and TREK1 mediates passive conductance in astrocytes
10.1038/ncomms4227 · 2014 · External reference
Theories of pain: from specificity to gate control
10.1152/jn.00457.2012 · 2013 · External reference
Animal models of pain: progress and challenges
10.1038/nrn2606 · 2009 · External reference
Ion channel profile of TRPM8 cold receptors reveals a role of TASK-3 potassium channels in thermosensation
10.1016/j.celrep.2014.08.003 · 2014 · External reference
Structural insights into the mechanisms and pharmacology of K2P potassium channels
10.1016/j.jmb.2021.166995 · 2021 · External reference
An homozygous mutation in KCNK3 is associated with an aggressive form of hereditary pulmonary arterial hypertension
10.1111/cge.12869 · 2017 · External reference
Inhibition of human two-pore domain K+ channel TREK1 by local anesthetic lidocaine: negative cooperativity and half-of-sites saturation kinetics
10.1124/mol.109.056838 · 2009 · External reference
Single-nucleus transcriptomic analysis of human dorsal root ganglion neurons
10.7554/elife.71752 · 2021 · External reference
The IASP classification of chronic pain for ICD-11: chronic primary pain
10.1097/j.pain.0000000000001390 · 2019 · External reference
Expression and insights on function of potassium channel TWIK1 in mouse kidney
10.1007/s00424-005-1480-9 · 2005 · External reference
Modulation of the two-pore domain acid-sensitive K+ channel TASK2 (KCNK5) by changes in cell volume
10.1074/jbc.m107192200 · 2001 · External reference
Gating, regulation, and structure in K2P K+ channels: in varietate concordia?
10.1124/mol.116.103895 · 2016 · External reference
The mechano-activated K+ channels TRAAK and TREK1 control both warm and cold perception
10.1038/emboj.2009.57 · 2009 · External reference
Sensory Schwann cells set perceptual thresholds for touch and selectively regulate mechanical nociception
10.1038/s41467-024-44845-8 · 2024 · External reference
Impact of TASK1 in human pulmonary artery smooth muscle cells
10.1161/01.res.0000219677.12988.e9 · 2006 · External reference
Central modulation of pain
10.1172/jci43766 · 2010 · External reference
TWIK2 channel deficiency leads to pulmonary hypertension through a rho-kinase–mediated process
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Effects of analgesics and antidepressants on TREK-2 and TRESK currents
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