Research graph
References from A narrative review of emerging chemoprotective agents for chemotherapy-induced toxicity: nanoformulated natural products, dual COX-2/TNF-α inhibitors, and Nrf2 modulators. Local targets link to admitted publications; unresolved targets remain external evidence.
Chemoprevention of azoxymethane-initiated colon cancer in rat by using a novel polymeric nanocarrier-curcumin
10.1016/j.ejphar.2012.06.016 · 2012 · External reference
Akt is upstream and MAPKs are downstream of NF-κB in paclitaxel-induced survival signaling events, which are down-regulated by curcumin contributing to their synergism
10.1016/j.biocel.2010.09.011 · 2011 · External reference
Design, synthesis and biological evaluation of some pyrazole derivatives as anti-inflammatory-antimicrobial agents
10.1016/j.bmc.2004.01.037 · 2004 · External reference
Prognostic value of troponin I in cardiac risk stratification of cancer patients undergoing high-dose chemotherapy
10.1161/01.cir.0000130926.51766.cc · 2004 · External reference
New frontiers in the pathobiology and treatment of cancer regimen-related mucosal injury
10.3389/fphar.2017.00354 · 2017 · External reference
Unresolved reference
2006 · External reference
Natural products as a vital source for the discovery of cancer chemotherapeutic and chemopreventive agents
10.1159/000443404 · 2016 · External reference
10.1201/b11185
10.1201/b11185 · 2011 · External reference
Dietary curcumin: correlation between bioavailability and health potential
10.3390/nu11092147 · 2019 · External reference
Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis
10.1038/nature10189 · 2011 · External reference
Pancreatic cancer: recent advances in nanoformulation-based therapies
10.1615/critrevtherdrugcarriersyst.2018025459 · 2019 · External reference
Phase II trial of curcumin in patients with advanced pancreatic cancer
10.1158/1078-0432.ccr-08-0024 · 2008 · External reference
The National Cancer Institute Clinical Trials planning meeting for prevention and treatment of chemotherapy-induced peripheral neuropathy
10.1093/jnci/djz011 · 2019 · External reference
Sulforaphane protects against cisplatin-induced nephrotoxicity
10.1016/j.toxlet.2009.11.007 · 2010 · External reference
Cyclooxygenase-2 in cancer: a review
10.1002/jcp.27411 · 2019 · External reference
Oxidative stress in cancer: the Nrf2 paradox
10.1016/j.ccell.2020.06.001 · 2020 · External reference
CYP2C8*3 increases risk of neuropathy in breast cancer patients treated with paclitaxel
10.1093/annonc/mdt018 · 2013 · External reference
Unresolved reference
2015 · External reference
Kidney injury molecule-1: a tissue and urinary biomarker for nephrotoxicant-induced renal injury
10.1152/ajprenal.00285.2002 · 2004 · External reference
Selective estrogen receptor modulators and pharmacogenomic variation in ZNF423 regulation of BRCA1 expression: individualized breast cancer prevention
10.1158/2159-8290.cd-13-0038 · 2013 · External reference
Enhanced colon cancer chemoprevention of curcumin by nanoencapsulation with whey protein
10.1016/j.ejphar.2016.07.017 · 2016 · External reference
Review on nanoparticles and nanostructured materials: history, sources, toxicity and regulations
10.3762/bjnano.9.98 · 2018 · External reference
KEAP1-Nrf2 signaling: a target for cancer prevention by sulforaphane
10.1007/128_2012_339 · 2013 · External reference
Long-term effects, pathophysiological mechanisms, and risk factors of chemotherapy-induced peripheral neuropathies: a comprehensive literature review
10.3389/fphar.2017.00086 · 2017 · External reference
Amifostine: the first selective-target and broad-spectrum radioprotector
10.1634/theoncologist.12-6-738 · 2007 · External reference
Current diagnosis and management of immune related adverse events (irAEs) induced by immune checkpoint inhibitor therapy
10.3389/fphar.2017.00049 · 2017 · External reference
Dexrazoxane-associated risk for secondary malignancies in pediatric Hodgkin's disease: a claim without compelling evidence
10.1200/jco.2007.11.8778 · 2007 · External reference
Phase III randomized, placebo-controlled, double-blind study of intravenous calcium and magnesium to prevent oxaliplatin-induced sensory neurotoxicity (N08CB/Alliance)
10.1200/jco.2013.52.0536 · 2014 · External reference
Luteolin nanoparticle in chemoprevention: in vitro and in vivo anticancer activity
10.1158/1940-6207.capr-13-0230 · 2014 · External reference
Cancer chemoprevention: a strategic approach using phytochemicals
10.3389/fphar.2021.809308 · 2022 · External reference
Intranasal administration of resveratrol successfully prevents lung cancer in A/J mice
10.1038/s41598-018-32423-0 · 2018 · External reference
The essential medicinal chemistry of curcumin
10.1021/acs.jmedchem.6b00975 · 2017 · External reference
Natural products as sources of new drugs over the 30 years from 1981 to 2010
10.1021/np200906s · 2012 · External reference
Nrf2 and oxidative stress: a general overview of mechanisms and implications in human disease
10.3390/antiox11122345 · 2022 · External reference
Editorial: adverse effects of cancer chemotherapy: anything new to improve tolerance and reduce sequelae?
10.3389/fphar.2018.00245 · 2018 · External reference
Nanoparticles increase the efficacy of cancer chemopreventive agents in cells exposed to cigarette smoke condensate
10.1093/carcin/bgv008 · 2015 · External reference
Unraveling the anticancer effect of curcumin and resveratrol
10.3390/nu8110628 · 2016 · External reference
Effects of curcuminoids plus piperine on glycemic, hepatic and inflammatory biomarkers in patients with Type 2 diabetes mellitus: a randomized double-blind placebo-controlled trial
10.1055/s-0044-101752 · 2018 · External reference
Hyaluronic acid decorated naringenin nanoparticles: appraisal of chemopreventive and curative potential for lung cancer
10.3390/pharmaceutics10010033 · 2018 · External reference
Nicotine-induced survival signaling in lung cancer cells is dependent on their p53 status while its down-regulation by curcumin is independent
10.1186/1476-4598-9-220 · 2010 · External reference
Delayed chemotherapy-induced nausea and vomiting: pathogenesis, incidence, and current management
10.3389/fphar.2017.00019 · 2017 · External reference
Risk-benefit of dexrazoxane for preventing anthracycline-related cardiotoxicity: re-evaluating the European labeling
10.2217/fon-2018-0210 · 2018 · External reference
Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism
10.1073/pnas.1014275108 · 2011 · External reference
Nitric-oxide-donating NSAIDs as agents for cancer prevention
10.1016/j.molmed.2004.05.004 · 2004 · External reference
The effect of metformin on chemotherapy-induced toxicities in non-diabetic breast cancer patients: a randomised controlled study
10.1007/s40264-023-01305-4 · 2023 · External reference
A nexus consisting of beta-catenin and STAT3 attenuates BRAF inhibitor efficacy and mediates acquired resistance to vemurafenib
10.1016/j.ebiom.2016.04.037 · 2016 · External reference
p38 and JNK MAPK pathways control the balance of apoptosis and autophagy in response to chemotherapeutic agents
10.1016/j.canlet.2013.11.019 · 2014 · External reference
Nanotechnology-based drug delivery systems for curcumin and its derivatives in the treatment of cardiovascular diseases
10.1016/j.jff.2024.106476 · 2024 · External reference
Limb hypothermia for preventing paclitaxel-induced peripheral neuropathy in breast cancer patients: a pilot study
10.3389/fonc.2016.00274 · 2017 · External reference
Molecular basis of the KEAP1-Nrf2 system
10.1016/j.freeradbiomed.2015.06.006 · 2015 · External reference
Dual COX-2/TNF-α inhibitors as promising anti-inflammatory and cancer chemopreventive agents: a review
10.5812/ijpr-151312 · 2024 · External reference
Sulforaphane and prostate cancer interception
10.1016/j.drudis.2014.07.007 · 2018 · External reference
Cardiovascular risk of nonsteroidal anti-inflammatory drugs: an under-recognized public health issue
10.7759/cureus.1144 · 2017 · External reference
Resveratrol as a chemopreventive agent in lung cancer therapy
10.37275/bsm.v6i9.557 · 2022 · External reference
NO-donating aspirin inhibits the activation of NF-κB in human cancer cell lines and Min mice
10.1093/carcin/bgm275 · 2008 · External reference
The impact of cold therapy on the incidence and severity of paclitaxel induced peripheral neuropathy: a pilot study
10.5430/jst.v6n2p43 · 2016 · External reference
Inflammation and tumor progression: signaling pathways and targeted intervention
10.1038/s41392-021-00658-5 · 2021 · External reference
Reactive oxygen species scavengers ameliorate mechanical allodynia in a rat model of cancer-induced bone pain
10.1016/j.redox.2017.10.011 · 2017 · External reference
