References

Cytokine-induced alterations of gastrointestinal motility in gastrointestinal disorders

10.4291/wjgp.v2.i5.72 · 2011 · External reference

Mechanisms, evaluation, and management of chronic constipation

10.1053/j.gastro.2019.12.034 · 2020 · External reference

American gastroenterological association-american college of gastroenterology clinical practice guideline: pharmacological management of chronic idiopathic constipation

10.14309/ajg.0000000000002227 · 2023 · External reference

The neuroprotection of verbascoside in alzheimer's disease mediated through mitigation of neuroinflammation via blocking NF-κB-p65 signaling

10.3390/nu14071417 · 2022 · External reference

Loperamide-induced constipation activates inflammatory signaling pathways in the mid Colon of SD rats Via complement C3 and its receptors

10.2174/1566524021666210618124220 · 2022 · External reference

Lychee pulp-derived dietary fiber-bound phenolic complex upregulates the SCFAs-GPRs-ENS pathway and aquaporins in loperamide-induced constipated mice by reshaping gut microbiome

10.1021/acs.jafc.3c03734 · 2023 · External reference

Protocol to characterize longitudinal gut motility in mice using transit time, tissue harvest, and whole-mount immunostaining

10.1016/j.xpro.2025.103761 · 2025 · External reference

Muscularis macrophages controlled by NLRP3 maintain the homeostasis of excitatory neurons

10.7150/ijbs.91389 · 2024 · External reference

Acteoside alleviates dextran sulphate sodium-induced ulcerative colitis via regulation of the HO-1/HMGB1 signaling pathway

10.3892/mmr.2022.12877 · 2022 · External reference

Synergistic modulation of microglial polarization by acteoside and ferulic acid via dual targeting of Nrf2 and RORγt to alleviate depression-associated neuroinflammation

10.1002/advs.202503889 · 2025 · External reference

Decreased interstitial cell of cajal volume in patients with slow-transit constipation

10.1016/s0016-5085(00)70409-4 · 2000 · External reference

Mechanism and regulation of NLRP3 inflammasome activation

10.1016/j.tibs.2016.09.002 · 2016 · External reference

Loperamide increases mouse gut transit time in a dose-dependent manner with treatment duration-dependent effects on distinct gut microbial taxa

10.1017/gmb.2025.5 · 2025 · External reference

The intestinal neuro-immune axis: crosstalk between neurons, immune cells, and microbes

10.1038/s41385-020-00368-1 · 2021 · External reference

The NLRP3 inflammasome: an overview of mechanisms of activation and regulation

10.3390/ijms20133328 · 2019 · External reference

Cannabis sativa L. alleviates loperamide-induced constipation by modulating the composition of gut microbiota in mice

10.3389/fphar.2022.1033069 · 2022 · External reference

Regulation and therapeutic potential of NLRP3 inflammasome in intestinal diseases

10.1093/jleuko/qiaf014 · 2025 · External reference

Acteoside alleviates blood-brain barrier damage induced by ischemic stroke through inhibiting microglia HMGB1/TLR4/NLRP3 signaling

10.1016/j.bcp.2023.115968 · 2024 · External reference

Improvement of loperamide-induced slow transit constipation by Bifidobacterium bifidum G9-1 is mediated by the correction of butyrate production and neurotransmitter profile due to improvement in dysbiosis

10.1371/journal.pone.0248584 · 2021 · External reference

Acteoside as a multifunctional natural glycoside: therapeutic potential across various diseases

10.1007/s10787-025-01811-0 · 2025 · External reference

NLRP3 at the crossroads between immune/inflammatory responses and enteric neuroplastic remodelling in a mouse model of diet-induced obesity

10.1111/bph.15532 · 2021 · External reference

Dioscin ameliorates slow transit constipation in mice by up-regulation of the BMP2 secreted by muscularis macrophages

10.22038/ijbms.2022.64683.14236 · 2022 · External reference

The enteric nervous system

10.1152/physrev.00018.2022 · 2023 · External reference

Slow transit constipation: pathophysiological perspectives and management updates

10.1111/1751-2980.70030 · 2026 · External reference

Interleukin-1beta activates specific populations of enteric neurons and enteric glia in the Guinea pig ileum and Colon

10.1152/ajpgi.00073.2003 · 2003 · External reference

Idiopathic slow transit constipation: pathophysiology, diagnosis, and management

10.3390/medicina60010108 · 2024 · External reference

Enteric neuroimmune interactions coordinate intestinal responses in health and disease

10.1038/s41385-021-00443-1 · 2022 · External reference

Regulation of enteric nervous system via sacral nerve stimulation in opioid-induced constipated rats

10.3389/fnins.2023.1146883 · 2023 · External reference

Ameliorative effects of Atractylodes macrocephala insoluble dietary fiber on loperamide-induced functional constipation in rats

10.1016/j.foodres.2025.118256 · 2026 · External reference

Enteric nerves and interstitial cells of cajal are altered in patients with slow-transit constipation and megacolon

10.1053/gast.2002.36600 · 2002 · External reference

IL-1beta and IL-6 excite neurons and suppress nicotinic and noradrenergic neurotransmission in Guinea pig enteric nervous system

10.1172/jci5823 · 1999 · External reference

The pharmacokinetic property and pharmacological activity of acteoside: a review

10.1016/j.biopha.2022.113296 · 2022 · External reference

The NLRP3 inflammasome: activation and regulation

10.1016/j.tibs.2022.10.002 · 2023 · External reference

Batatasin III alleviates slow transit constipation by regulating gut microbiota and inhibiting the NLRP3-IL-1β pathway

10.1016/j.jnutbio.2025.110110 · 2026 · External reference

Overview of research on the application of medicine food homologous bioactive ingredients to functional constipation

10.26599/fmh.2025.9420057 · 2025 · External reference

NLRP3 inflammasome and inflammatory bowel disease

10.3389/fimmu.2019.00276 · 2019 · External reference

Verbascoside attenuates acute inflammatory injury caused by an intracerebral hemorrhage through the suppression of NLRP3

10.1007/s11064-020-03206-9 · 2021 · External reference