Research graph
References from SIRT7 upregulation protects against TKI-induced cardiotoxicity by inhibiting MCU-mediated mitochondrial calcium overload. Local targets link to admitted publications; unresolved targets remain external evidence.
Calcium and cell death: the mitochondrial connection
10.1007/978-1-4020-6191-2_18 · 2007 · External reference
Calcium signaling and reactive oxygen species in mitochondria
10.1161/circresaha.118.310082 · 2018 · External reference
Calcium influx through the mitochondrial calcium uniporter holocomplex, MCU(cx)
10.1016/j.yjmcc.2020.10.015 · 2021 · External reference
SIRT3-dependent mitochondrial redox homeostasis mitigates CHK1 inhibition combined with gemcitabine treatment induced cardiotoxicity in hiPSC-CMs and mice
10.1007/s00204-023-03611-3 · 2023 · External reference
Pentraxin 3 regulates tyrosine kinase inhibitor-associated cardiomyocyte contraction and mitochondrial dysfunction via ERK/JNK signalling pathways
10.1016/j.biopha.2022.113962 · 2023 · External reference
Cardiotoxicity associated with tyrosine kinase inhibitor sunitinib
10.1016/s0140-6736(07)61865-0 · 2007 · External reference
Sirtuin-mediated modulation of cardiac fibrosis: emerging molecular insights and therapeutic perspectives
10.1016/j.phrs.2025.107970 · 2025 · External reference
Sir-viving cardiac stress: cardioprotection mediated by a longevity gene
10.1161/01.res.0000148666.20729.1c · 2004 · External reference
MICU1 controls both the threshold and cooperative activation of the mitochondrial Ca2+ uniporter
10.1016/j.cmet.2013.04.020 · 2013 · External reference
Targeting PDK4 to mitigate osimertinib-induced cardiotoxicity: insights into mitochondria-endoplasmic reticulum crosstalk and necroptosis
10.1016/j.freeradbiomed.2025.08.017 · 2025 · External reference
Roles of sirtuins in cardiovascular diseases: mechanisms and therapeutics
10.1161/circresaha.124.325440 · 2025 · External reference
Cardiotoxic effects of angiogenesis inhibitors
10.1042/cs20200305 · 2021 · External reference
Cardiotoxicity of kinase inhibitors: the prediction and translation of preclinical models to clinical outcomes
10.1038/nrd3252 · 2011 · External reference
Tyrosine kinase inhibitors induce cardiotoxicity by causing Ca(2+) overload through the inhibition of phosphoinositide 3-kinase activity
10.1016/j.bbrc.2025.152027 · 2025 · External reference
Kinase inhibitors and monoclonal antibodies in oncology: clinical implications
10.1038/nrclinonc.2015.213 · 2016 · External reference
Computational model of cardiomyocyte apoptosis identifies mechanisms of tyrosine kinase inhibitor-induced cardiotoxicity
10.1016/j.yjmcc.2021.02.014 · 2021 · External reference
Heart mitochondria: gates of life and death
10.1093/cvr/cvm005 · 2008 · External reference
Control of apoptosis by IP(3) and ryanodine receptor driven calcium signals
10.1054/ceca.2000.0169 · 2000 · External reference
Respiratory complex I-mediated NAD(+) regeneration regulates cancer cell proliferation through the transcriptional and translational control of p21(Cip1) expression by SIRT3 and SIRT7
10.1002/1878-0261.13808 · 2025 · External reference
Unresolved reference
1994 · External reference
High-affinity cooperative Ca(2+) binding by MICU1-MICU2 serves as an on-off switch for the uniporter
10.15252/embr.201643748 · 2017 · External reference
Sunitinib-induced cardiotoxicity is mediated by off-target inhibition of AMP-activated protein kinase
10.1111/j.1752-8062.2008.00090.x · 2009 · External reference
Regulation of cardiac calcium by mechanotransduction: role of mitochondria
10.1016/j.abb.2018.09.026 · 2018 · External reference
Calcium signaling and cardiac arrhythmias
10.1161/circresaha.117.310083 · 2017 · External reference
Off-target effects of cancer therapy on development of therapy-induced arrhythmia: a review
10.1159/000529260 · 2023 · External reference
Upregulation of phosphoinositide 3-kinase prevents sunitinib-induced cardiotoxicity in vitro and in vivo
10.1007/s00204-019-02448-z · 2019 · External reference
Acute osimertinib exposure induces electrocardiac changes by synchronously inhibiting the currents of cardiac ion channels
10.3389/fphar.2023.1177003 · 2023 · External reference
MCU overexpression rescues inotropy and reverses heart failure by reducing SR Ca(2+) leak
10.1161/circresaha.120.318562 · 2021 · External reference
Plasma levels of sirtuin 7 are decreased in patients with essential hypertension
10.1016/j.clinbiochem.2024.110766 · 2024 · External reference
Suppression of phosphoinositide 3-kinase signaling and alteration of multiple ion currents in drug-induced long QT syndrome
10.1126/scitranslmed.3003623 · 2012 · External reference
The Flt3-inhibitor quizartinib augments apoptosis and promotes maladaptive remodeling after myocardial infarction in mice
10.1007/s10495-023-01911-8 · 2024 · External reference
Effects of acute and chronic sunitinib treatment on cardiac function and calcium/calmodulin-dependent protein kinase II
10.1111/bph.13213 · 2015 · External reference
Molecular identity of the mitochondrial permeability transition pore and its role in ischemia-reperfusion injury
10.1016/j.yjmcc.2014.08.015 · 2015 · External reference
The physiological role of mitochondrial calcium revealed by mice lacking the mitochondrial calcium uniporter
10.1038/ncb2868 · 2013 · External reference
FLT3 activation improves post-myocardial infarction remodeling involving a cytoprotective effect on cardiomyocytes
10.1016/j.jacc.2013.08.1647 · 2014 · External reference
The versatility of mitochondrial calcium signals: from stimulation of cell metabolism to induction of cell death
10.1016/j.bbabio.2008.05.449 · 2008 · External reference
A SIRT7-dependent acetylation switch of GABPβ1 controls mitochondrial function
10.1016/j.cmet.2014.08.001 · 2014 · External reference
Mitochondrial calcium overload is a key determinant in heart failure
10.1073/pnas.1513047112 · 2015 · External reference
Targeting sirtuins for cancer therapy: epigenetics modifications and beyond
10.7150/thno.100667 · 2024 · External reference
Mechanistic systems modeling to improve understanding and prediction of cardiotoxicity caused by targeted cancer therapeutics
10.3389/fphys.2017.00651 · 2017 · External reference
Adverse effects of tyrosine kinase inhibitors in cancer therapy: pathophysiology, mechanisms and clinical management
10.1038/s41392-023-01469-6 · 2023 · External reference
Ponatinib-induced cardiotoxicity: delineating the signalling mechanisms and potential rescue strategies
10.1093/cvr/cvz006 · 2019 · External reference
Cardiac metabolic deregulation induced by the tyrosine kinase receptor inhibitor sunitinib is rescued by endothelin receptor antagonism
10.7150/thno.19551 · 2017 · External reference
Sunitinib-induced cardiac hypertrophy and the endothelin axis
10.7150/thno.49837 · 2021 · External reference
Increased afterload augments sunitinib-induced cardiotoxicity in an engineered cardiac microtissue model
10.1016/j.jacbts.2017.12.007 · 2018 · External reference
Dual functions of a small regulatory subunit in the mitochondrial calcium uniporter complex
10.7554/elife.15545 · 2016 · External reference
Sirt7 increases stress resistance of cardiomyocytes and prevents apoptosis and inflammatory cardiomyopathy in mice
10.1161/circresaha.107.164558 · 2008 · External reference
Practical recommendations for therapeutic drug monitoring of kinase inhibitors in oncology
10.1002/cpt.787 · 2017 · External reference
Three tyrosine kinase inhibitors cause cardiotoxicity by inducing endoplasmic reticulum stress and inflammation in cardiomyocytes
10.1186/s12916-023-02838-2 · 2023 · External reference
Mitochondrial calcium and the regulation of metabolism in the heart
10.1016/j.yjmcc.2014.10.019 · 2015 · External reference
Protective effects of sirtuins in cardiovascular diseases: from bench to bedside
10.1093/eurheartj/ehv290 · 2015 · External reference
Phosphoproteomics reveals a novel mechanism underlying the proarrhythmic effects of nilotinib, vandetanib, and mobocertinib
10.1016/j.tox.2024.153830 · 2024 · External reference
Analysis of the structure and function of EMRE in a yeast expression system
10.1016/j.bbabio.2016.03.019 · 2016 · External reference
Sirt3 promotes sensitivity to sunitinib-induced cardiotoxicity via inhibition of GTSP1/JNK/autophagy pathway in vivo and in vitro
10.1007/s00204-019-02573-9 · 2019 · External reference
Effects of resveratrol on H(2)O(2)-induced apoptosis and expression of SIRTs in H9c2 cells
10.1002/jcb.22169 · 2009 · External reference
Respiratory complex I-mediated NAD(+) regeneration regulates cancer cell proliferation through the transcriptional and translational control of p21(Cip1) expression by SIRT3 and SIRT7
10.1002/1878-0261.13808 · ExternalCitation · doi-reference
Practical recommendations for therapeutic drug monitoring of kinase inhibitors in oncology
10.1002/cpt.787 · ExternalCitation · doi-reference
Effects of resveratrol on H(2)O(2)-induced apoptosis and expression of SIRTs in H9c2 cells
10.1002/jcb.22169 · ExternalCitation · doi-reference
Calcium and cell death: the mitochondrial connection
10.1007/978-1-4020-6191-2_18 · ExternalCitation · doi-reference
Upregulation of phosphoinositide 3-kinase prevents sunitinib-induced cardiotoxicity in vitro and in vivo
10.1007/s00204-019-02448-z · ExternalCitation · doi-reference
Sirt3 promotes sensitivity to sunitinib-induced cardiotoxicity via inhibition of GTSP1/JNK/autophagy pathway in vivo and in vitro
10.1007/s00204-019-02573-9 · ExternalCitation · doi-reference
SIRT3-dependent mitochondrial redox homeostasis mitigates CHK1 inhibition combined with gemcitabine treatment induced cardiotoxicity in hiPSC-CMs and mice
10.1007/s00204-023-03611-3 · ExternalCitation · doi-reference
The Flt3-inhibitor quizartinib augments apoptosis and promotes maladaptive remodeling after myocardial infarction in mice
10.1007/s10495-023-01911-8 · ExternalCitation · doi-reference
Regulation of cardiac calcium by mechanotransduction: role of mitochondria
10.1016/j.abb.2018.09.026 · ExternalCitation · doi-reference
The versatility of mitochondrial calcium signals: from stimulation of cell metabolism to induction of cell death
10.1016/j.bbabio.2008.05.449 · ExternalCitation · doi-reference
Analysis of the structure and function of EMRE in a yeast expression system
10.1016/j.bbabio.2016.03.019 · ExternalCitation · doi-reference
Tyrosine kinase inhibitors induce cardiotoxicity by causing Ca(2+) overload through the inhibition of phosphoinositide 3-kinase activity
10.1016/j.bbrc.2025.152027 · ExternalCitation · doi-reference
Pentraxin 3 regulates tyrosine kinase inhibitor-associated cardiomyocyte contraction and mitochondrial dysfunction via ERK/JNK signalling pathways
10.1016/j.biopha.2022.113962 · ExternalCitation · doi-reference
Plasma levels of sirtuin 7 are decreased in patients with essential hypertension
10.1016/j.clinbiochem.2024.110766 · ExternalCitation · doi-reference
MICU1 controls both the threshold and cooperative activation of the mitochondrial Ca2+ uniporter
10.1016/j.cmet.2013.04.020 · ExternalCitation · doi-reference
A SIRT7-dependent acetylation switch of GABPβ1 controls mitochondrial function
10.1016/j.cmet.2014.08.001 · ExternalCitation · doi-reference
Targeting PDK4 to mitigate osimertinib-induced cardiotoxicity: insights into mitochondria-endoplasmic reticulum crosstalk and necroptosis
10.1016/j.freeradbiomed.2025.08.017 · ExternalCitation · doi-reference
Increased afterload augments sunitinib-induced cardiotoxicity in an engineered cardiac microtissue model
10.1016/j.jacbts.2017.12.007 · ExternalCitation · doi-reference
FLT3 activation improves post-myocardial infarction remodeling involving a cytoprotective effect on cardiomyocytes
10.1016/j.jacc.2013.08.1647 · ExternalCitation · doi-reference
Sirtuin-mediated modulation of cardiac fibrosis: emerging molecular insights and therapeutic perspectives
10.1016/j.phrs.2025.107970 · ExternalCitation · doi-reference
Phosphoproteomics reveals a novel mechanism underlying the proarrhythmic effects of nilotinib, vandetanib, and mobocertinib
10.1016/j.tox.2024.153830 · ExternalCitation · doi-reference
Molecular identity of the mitochondrial permeability transition pore and its role in ischemia-reperfusion injury
10.1016/j.yjmcc.2014.08.015 · ExternalCitation · doi-reference
Mitochondrial calcium and the regulation of metabolism in the heart
10.1016/j.yjmcc.2014.10.019 · ExternalCitation · doi-reference
Calcium influx through the mitochondrial calcium uniporter holocomplex, MCU(cx)
10.1016/j.yjmcc.2020.10.015 · ExternalCitation · doi-reference
Computational model of cardiomyocyte apoptosis identifies mechanisms of tyrosine kinase inhibitor-induced cardiotoxicity
10.1016/j.yjmcc.2021.02.014 · ExternalCitation · doi-reference
Cardiotoxicity associated with tyrosine kinase inhibitor sunitinib
10.1016/s0140-6736(07)61865-0 · ExternalCitation · doi-reference
The physiological role of mitochondrial calcium revealed by mice lacking the mitochondrial calcium uniporter
10.1038/ncb2868 · ExternalCitation · doi-reference
Kinase inhibitors and monoclonal antibodies in oncology: clinical implications
10.1038/nrclinonc.2015.213 · ExternalCitation · doi-reference
Cardiotoxicity of kinase inhibitors: the prediction and translation of preclinical models to clinical outcomes
10.1038/nrd3252 · ExternalCitation · doi-reference
Adverse effects of tyrosine kinase inhibitors in cancer therapy: pathophysiology, mechanisms and clinical management
10.1038/s41392-023-01469-6 · ExternalCitation · doi-reference
Cardiotoxic effects of angiogenesis inhibitors
10.1042/cs20200305 · ExternalCitation · doi-reference
Control of apoptosis by IP(3) and ryanodine receptor driven calcium signals
10.1054/ceca.2000.0169 · ExternalCitation · doi-reference
Mitochondrial calcium overload is a key determinant in heart failure
10.1073/pnas.1513047112 · ExternalCitation · doi-reference
Heart mitochondria: gates of life and death
10.1093/cvr/cvm005 · ExternalCitation · doi-reference
Ponatinib-induced cardiotoxicity: delineating the signalling mechanisms and potential rescue strategies
10.1093/cvr/cvz006 · ExternalCitation · doi-reference
Protective effects of sirtuins in cardiovascular diseases: from bench to bedside
10.1093/eurheartj/ehv290 · ExternalCitation · doi-reference
Effects of acute and chronic sunitinib treatment on cardiac function and calcium/calmodulin-dependent protein kinase II
10.1111/bph.13213 · ExternalCitation · doi-reference
Sunitinib-induced cardiotoxicity is mediated by off-target inhibition of AMP-activated protein kinase
10.1111/j.1752-8062.2008.00090.x · ExternalCitation · doi-reference
Suppression of phosphoinositide 3-kinase signaling and alteration of multiple ion currents in drug-induced long QT syndrome
10.1126/scitranslmed.3003623 · ExternalCitation · doi-reference
Off-target effects of cancer therapy on development of therapy-induced arrhythmia: a review
10.1159/000529260 · ExternalCitation · doi-reference
Sir-viving cardiac stress: cardioprotection mediated by a longevity gene
10.1161/01.res.0000148666.20729.1c · ExternalCitation · doi-reference
Sirt7 increases stress resistance of cardiomyocytes and prevents apoptosis and inflammatory cardiomyopathy in mice
10.1161/circresaha.107.164558 · ExternalCitation · doi-reference
Calcium signaling and cardiac arrhythmias
10.1161/circresaha.117.310083 · ExternalCitation · doi-reference
Calcium signaling and reactive oxygen species in mitochondria
10.1161/circresaha.118.310082 · ExternalCitation · doi-reference
MCU overexpression rescues inotropy and reverses heart failure by reducing SR Ca(2+) leak
10.1161/circresaha.120.318562 · ExternalCitation · doi-reference
Roles of sirtuins in cardiovascular diseases: mechanisms and therapeutics
10.1161/circresaha.124.325440 · ExternalCitation · doi-reference
Three tyrosine kinase inhibitors cause cardiotoxicity by inducing endoplasmic reticulum stress and inflammation in cardiomyocytes
10.1186/s12916-023-02838-2 · ExternalCitation · doi-reference
High-affinity cooperative Ca(2+) binding by MICU1-MICU2 serves as an on-off switch for the uniporter
10.15252/embr.201643748 · ExternalCitation · doi-reference
Acute osimertinib exposure induces electrocardiac changes by synchronously inhibiting the currents of cardiac ion channels
10.3389/fphar.2023.1177003 · ExternalCitation · doi-reference
Mechanistic systems modeling to improve understanding and prediction of cardiotoxicity caused by targeted cancer therapeutics
10.3389/fphys.2017.00651 · ExternalCitation · doi-reference
Targeting sirtuins for cancer therapy: epigenetics modifications and beyond
10.7150/thno.100667 · ExternalCitation · doi-reference
Cardiac metabolic deregulation induced by the tyrosine kinase receptor inhibitor sunitinib is rescued by endothelin receptor antagonism
10.7150/thno.19551 · ExternalCitation · doi-reference
Sunitinib-induced cardiac hypertrophy and the endothelin axis
10.7150/thno.49837 · ExternalCitation · doi-reference
Dual functions of a small regulatory subunit in the mitochondrial calcium uniporter complex
10.7554/elife.15545 · ExternalCitation · doi-reference
