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References from Adult-onset hippocampal α7 nicotinic acetylcholine receptor loss rapidly drives Alzheimer-like neuropathology in mice. Local targets link to admitted publications; unresolved targets remain external evidence.
Abnormal response to chronic social defeat stress and fear extinction in a mouse model of Lynx2-based cholinergic dysregulation
10.3389/fnins.2025.1466166 · 2025 · External reference
Relationships between regional neuronal loss and neurofibrillary changes in the hippocampal formation and duration and severity of Alzheimer disease
10.1097/00005072-199704000-00010 · 1997 · External reference
Dysregulation of C-X-C motif ligand 10 during aging and association with cognitive performance
10.1016/j.neurobiolaging.2017.11.009 · 2018 · External reference
BHLHB4 is a bHLH transcriptional regulator in pancreas and brain that marks the dimesencephalic boundary
10.1006/geno.2002.6708 · 2002 · External reference
Serotonergic system, cognition, and BPSD in Alzheimer’s disease
10.1016/j.neulet.2019.03.050 · 2019 · External reference
Role of cholinergic signaling in Alzheimer’s disease
10.3390/molecules27061816 · 2022 · External reference
Blood-brain barrier dysfunction and Alzheimer’s disease: associations, pathogenic mechanisms, and therapeutic potential
10.3389/fnagi.2023.1258640 · 2023 · External reference
Refining the interactions between microglia and astrocytes in Alzheimer’s disease pathology
10.1016/j.neuroscience.2025.03.033 · 2025 · External reference
The effect of α7 nicotinic receptor activation on glutamatergic transmission in the hippocampus
10.1016/j.bcp.2015.07.015 · 2015 · External reference
Nicotinic receptor function: new perspectives from knockout mice
10.1016/s0165-6147(00)01489-9 · 2000 · External reference
Apolipoprotein E, amyloid-beta, and neuroinflammation in Alzheimer’s disease
10.1007/s12264-013-1422-z · 2014 · External reference
Acetylcholinesterase: from 3D structure to function
10.1016/j.cbi.2010.01.042 · 2010 · External reference
Deletion of the alpha 7 nicotinic acetylcholine receptor gene improves cognitive deficits and synaptic pathology in a mouse model of Alzheimer’s disease
10.1523/jneurosci.6159-08.2009 · 2009 · External reference
Cotinine: a potential new therapeutic agent against Alzheimer’s disease
10.1111/j.1755-5949.2012.00317.x · 2012 · External reference
Cotinine reduces amyloid-β aggregation and improves memory in Alzheimer’s disease mice
10.3233/jad-2011-102136 · 2011 · External reference
Anti-inflammatory role of microglial alpha7 nAChRs and its role in neuroprotection
10.1016/j.bcp.2015.07.032 · 2015 · External reference
Glial fibrillary acidic protein: gfap-thirty-one years (1969–2000)
10.1023/a:1007677003387 · 2000 · External reference
Microglia and astrocytes in Alzheimer’s disease: implications for therapy
10.2174/1570159x15666170720095240 · 2018 · External reference
The α7 nAChR selective agonists as drug candidates for Alzheimer’s disease
10.1007/978-94-017-9245-5_21 · 2015 · External reference
An inside job: molecular determinants for postsynaptic localization of nicotinic acetylcholine receptors
10.3390/molecules26113065 · 2021 · External reference
The role of astrocytic α7 nicotinic acetylcholine receptors in Alzheimer disease
10.1038/s41582-023-00792-4 · 2023 · External reference
Reimagining cholinergic therapy for Alzheimer’s disease
10.1093/brain/awac096 · 2022 · External reference
Preservation of nucleus basalis neurons containing choline acetyltransferase and the vesicular acetylcholine transporter in the elderly with mild cognitive impairment and early Alzheimer’s disease
10.1002/(sici)1096-9861(19990906)411:4<693::aid-cne13>3.0.co;2-d · 1999 · External reference
Cotinine improves visual recognition memory and decreases cortical Tau phosphorylation in the Tg6799 mice
10.1016/j.pnpbp.2017.05.010 · 2017 · External reference
Decreased protein levels of nicotinic receptor subunits in the hippocampus and temporal cortex of patients with Alzheimer’s disease
10.1046/j.1471-4159.2000.0740237.x · 2000 · External reference
Neuromodulatory action of picomolar extracellular Aβ42 oligomers on presynaptic and postsynaptic mechanisms underlying synaptic function and memory
10.1523/jneurosci.0163-19.2019 · 2019 · External reference
The cholinergic system in the pathophysiology and treatment of Alzheimer’s disease
10.1093/brain/awy132 · 2018 · External reference
Tau phosphorylation: the therapeutic challenge for neurodegenerative disease
10.1016/j.molmed.2009.01.003 · 2009 · External reference
Regional distribution of nicotinic receptor subunit mRNAs in human brain: comparison between Alzheimer and normal brain
10.1016/s0169-328x(99)00030-3 · 1999 · External reference
Loss of alpha7 nicotinic receptors enhances beta-amyloid oligomer accumulation, exacerbating early-stage cognitive decline and septohippocampal pathology in a mouse model of Alzheimer’s disease
10.1523/jneurosci.5038-09.2010 · 2010 · External reference
Molecular mechanisms of GFAP and PTPRC in Alzheimer’s disease: an analysis of neuroinflammatory response and progression
10.2174/0115672050333760241010061547 · 2024 · External reference
Microglia-specific localisation of a novel calcium binding protein
10.1016/s0169-328x(98)00040-0 · 1998 · External reference
Rodent A beta modulates the solubility and distribution of amyloid deposits in transgenic mice
10.1074/jbc.m611050200 · 2007 · External reference
Activation of microglia and astrocytes: a roadway to neuroinflammation and Alzheimer’s disease
10.1007/s10787-019-00580-x · 2019 · External reference
Network compensation of cyclic GMP-dependent protein kinase II knockout in the hippocampus by Ca2+-permeable AMPA receptors
10.1073/pnas.1417498112 · 2015 · External reference
Agitation and irritability in Alzheimer’s disease: evidenced-based treatments and the black-box warning
10.1007/s11920-015-0640-7 · 2016 · External reference
Neuron loss from the hippocampus of Alzheimer’s disease exceeds extracellular neurofibrillary tangle formation
10.1007/s00401-001-0477-5 · 2002 · External reference
Hippocampal tau pathology is related to neuroanatomical connections: an ageing population-based study
10.1093/brain/awp059 · 2009 · External reference
A cog in cognition: how the alpha 7 nicotinic acetylcholine receptor is geared towards improving cognitive deficits
10.1016/j.pharmthera.2009.03.009 · 2009 · External reference
α7 nicotinic acetylcholine receptors in the hippocampal circuit: taming complexity
10.1016/j.tins.2021.11.006 · 2022 · External reference
Differentially expressed genes in Alzheimer’s disease highlighting the roles of microglia genes including OLR1 and astrocyte gene CDK2AP1
10.1016/j.bbih.2021.100227 · 2021 · External reference
Focal-type, but not diffuse-type, amyloid beta plaques are correlated with Alzheimer’s neuropathology, cognitive dysfunction, and neuroinflammation in the Human Hippocampus
10.1007/s12264-022-00927-5 · 2022 · External reference
Functional compensation of mouse duplicates by their paralogs expressed in the same tissues
10.1093/gbe/evac126 · 2022 · External reference
Toxic tau: structural origins of tau aggregation in Alzheimer’s disease
10.4103/1673-5374.274329 · 2020 · External reference
The relationship between anxiety and Alzheimer’s disease
10.3233/adr-210294 · 2021 · External reference
Cholinergic signaling in the hippocampus regulates social stress resilience and anxiety- and depression-like behavior
10.1073/pnas.1219731110 · 2013 · External reference
Ante-mortem plasma phosphorylated tau (181) predicts Alzheimer’s disease neuropathology and regional tau at autopsy
10.1093/brain/awac175 · 2022 · External reference
Nicotinic receptor agonists and antagonists increase sAPPalpha secretion and decrease Abeta levels in vitro
10.1016/j.neuint.2008.12.001 · 2009 · External reference
Mutations in the C-terminal domain of ColQ in endplate acetylcholinesterase deficiency compromise ColQ-MuSK interaction
10.1002/humu.22325 · 2013 · External reference
Activation of α7 nicotinic receptor affects APP processing by regulating secretase activity in SH-EP1-α7 nAChR-hAPP695 cells
10.1016/j.brainres.2010.07.110 · 2010 · External reference
Nicotinic receptor abnormalities of Alzheimer’s disease: therapeutic implications
10.1016/s0006-3223(00)01125-2 · 2001 · External reference
Recent advances in the search for effective anti-Alzheimer’s drugs
10.3390/ijms26010157 · 2024 · External reference
Novel approaches to study the involvement of α7-nAChR in human diseases
10.2174/138945012800398838 · 2012 · External reference
Cotinine halts the advance of Alzheimer’s disease-like pathology and associated depressive-like behavior in Tg6799 mice
10.3389/fnagi.2014.00162 · 2014 · External reference
CD44 splice variants as potential players in Alzheimer’s disease pathology
10.3233/jad-161245 · 2017 · External reference
AAV.PHP.eB-based strategies for precise modulation of α7 nicotinic acetylcholine receptor in neurons and astrocytes in the adult mouse brain
10.1038/s41598-026-46279-2 · 2026 · External reference
The keystone of Alzheimer pathogenesis might be sought in Aβ physiology
10.1016/j.neuroscience.2015.08.039 · 2015 · External reference
Amyloid toxicity in Alzheimer’s disease
10.1515/revneuro-2017-0063 · 2018 · External reference
Neuronal and glial α7 nicotinic acetylcholine receptors: role in Alzheimer’s disease pathophysiology
10.3390/life15071032 · 2025 · External reference
Biomarkers of agitation and aggression in Alzheimer’s disease: a systematic review
10.1016/j.jalz.2018.04.013 · 2018 · External reference
Cotinine ameliorates memory and learning impairment in senescent mice
10.1016/j.brainresbull.2020.08.010 · 2020 · External reference
Mild cognitive impairment and the cholinergic hypothesis: a very different take on recent data
10.1002/ana.10308 · 2002 · External reference
The cholinergic system in aging and neuronal degeneration
10.1016/j.bbr.2010.11.058 · 2011 · External reference
Levels of total tau and tau protein phosphorylated at threonine 181 in patients with incipient and manifest Alzheimer’s disease
10.1016/s0304-3940(02)01481-7 · 2003 · External reference
Role of the extracellular matrix in Alzheimer’s Disease
10.3389/fnagi.2021.707466 · 2021 · External reference
Neuroinflammation in Alzheimer’s Disease: current progress in molecular signaling and therapeutics
10.1007/s10753-022-01721-1 · 2023 · External reference
Recent development of radioligands for imaging α7 nicotinic acetylcholine receptors in the brain
10.2174/156802610793176828 · 2010 · External reference
Genetic deletion of α7 nicotinic acetylcholine receptors induces an age-dependent Alzheimer’s disease-like pathology
10.1016/j.pneurobio.2021.102154 · 2021 · External reference
Acute tau knockdown in the hippocampus of adult mice causes learning and memory deficits
10.1111/acel.12775 · 2018 · External reference
Involvement of baroreflex deficiency in the age-related loss of estrogen efficacy against cerebral ischemia
10.3389/fnagi.2023.1167170 · 2023 · External reference
Loss of MeCP2 in cholinergic neurons causes part of RTT-like phenotypes via α7 receptor in hippocampus
10.1038/cr.2016.48 · 2016 · External reference
Tau pathology epigenetically remodels the neuron-glial cross-talk in Alzheimer’s disease
10.1126/sciadv.abq7105 · 2023 · External reference
CDK3 induces neuronal death and brain atrophy in Alzheimer’s disease
10.1038/s43587-025-01026-6 · 2026 · External reference