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References from Vascular endothelial protective effects of longan (Dimocarpus longan Lour.) extract and underlying molecular mechanisms. Local targets link to admitted publications; unresolved targets remain external evidence.
Ultrahigh pressure-assisted enzymatic extraction maximizes the yield of longan pulp polysaccharides and their acetylcholinesterase inhibitory activity in vitro
10.1016/j.ijbiomac.2016.11.105 · 2017 · External reference
HPLC profile of Longan (cv. Shixia) pericarp-sourced phenolics and their antioxidant and cytotoxic effects
10.3390/molecules24030619 · 2019 · External reference
Longan pulp polysaccharides relieve intestinal injury in vivo and in vitro by promoting tight junction expression
10.1016/j.carbpol.2019.115475 · External reference
Structural elucidation, anti-inflammatory activity and intestinal barrier protection of longan pulp polysaccharide LPIIa
10.1016/j.carbpol.2020.116532 · External reference
Effects of polysaccharides of the Euphoria Longan (Lour.) steud on focal cerebral ischemia/reperfusion injury and its underlying mechanism
10.3109/02699052.2010.546824 · 2011 · External reference
Antioxidant activity, ascorbic acid and total phenol of exotic fruits occurring in Brazil
10.1080/09637480701780641 · 2009 · External reference
Historical perspective and future direction of blood vessel developments
10.1101/cshperspect.a025742 · 2018 · External reference
The impact of plant-derived polyphenols on combating efflux-mediated antibiotic resistance
10.3390/ijms26094030 · 2025 · External reference
A review of obesity, physical activity, and cardiovascular disease
10.1007/s13679-020-00403-z · 2020 · External reference
Longan extract suppresses food intake through regulation of POMC/AgRP neuronal activities and endoplasmic reticulum stress in hypothalamus of db/db mice
10.3389/fnut.2023.1143613 · 2023 · External reference
Endothelial dysfunction in normal and abnormal glucose metabolism
10.1159/000115120 · 2008 · External reference
Biological significance of urolithins, the gut microbial ellagic Acid-derived metabolites: the evidence so far
10.1155/2013/270418 · 2013 · External reference
Atherosclerosis: known and unknown
10.1111/pin.13202 · 2022 · External reference
Nitric oxide synthases: regulation and function
10.1093/eurheartj/ehr304 · 2012 · External reference
Recent advances in understanding dietary polyphenols protecting against hypertension
10.1016/j.tifs.2023.07.008 · 2023 · External reference
Comparison of the structure and immunomodulatory activity of polysaccharides from fresh and dried longan
10.1016/j.jff.2020.104323 · 2021 · External reference
A critical review on polyphenols and health benefits of black soybeans
10.3390/nu9050455 · 2017 · External reference
Modulation of nitric oxide synthases by oxidized LDLs: role in vascular inflammation and atherosclerosis development
10.3390/ijms20133294 · 2019 · External reference
Antioxidant and anti-aging activities of Longan crude and purified polysaccharide (LP-A) in nematode Caenorhabditis elegans
10.1016/j.ijbiomac.2024.131634 · 2024 · External reference
Adipose tissue dysfunction in obesity, diabetes, and vascular diseases
10.1093/eurheartj/ehn387 · 2008 · External reference
The immune system in atherosclerosis
10.1038/ni.2001 · 2011 · External reference
Free radicals and oxidative stress: mechanisms and therapeutic targets
10.3233/hab-240011 · 2024 · External reference
Longan seed polyphenols inhibit α-amylase activity and reduce postprandial glycemic response in mice
10.1039/d1fo02891j · 2021 · External reference
Mechanistic insights and emerging therapeutic strategies targeting endothelial dysfunction in cardiovascular diseases
10.1007/s12272-025-01542-4 · 2025 · External reference
Role of NADPH oxidases in blood-brain barrier disruption and ischemic stroke
10.3390/antiox11101966 · 2022 · External reference
Suppressive effect of a proanthocyanidin-rich extract from longan (Dimocarpus longan Lour.) flowers on nitric oxide production in LPS-stimulated macrophage cells
10.1021/jf0721186 · 2007 · External reference
Enhancement of phenolics content and biological activities of longan (Dimocarpus longan Lour.) treated with thermal and ageing process
10.1038/s41598-021-95605-3 · 2021 · External reference
A review on the chemical composition, biological activity, and potential health benefits applications of Longan (Dimocarpus longan Lour.)
10.1016/j.foodchem.2025.145985 · 2025 · External reference
Oxidative stress-induced angiogenesis
10.1016/j.jocn.2019.02.019 · 2019 · External reference
Antioxidant and anti-inflammatory properties of Longan (Dimocarpus longan Lour.) pericarp
10.1155/2012/709483 · 2012 · External reference
Dynamic variation in biochemical properties and prebiotic activities of polysaccharides from longan pulp during fermentation process
10.1016/j.ijbiomac.2019.04.032 · External reference
Physicochemical and biological properties of longan pulp polysaccharides modified by Lactobacillus fermentum fermentation
10.1016/j.ijbiomac.2018.12.061 · External reference
Physicochemical properties and prebiotic activities of polysaccharides from longan pulp based on different extraction techniques
10.1016/j.carbpol.2018.11.012 · External reference
Chronic hyperglycemia and cardiovascular dysfunction: an in-depth exploration of metabolic and cellular pathways in type 2 diabetes mellitus
10.1186/s40842-025-00247-3 · 2025 · External reference
The renin-angiotensin system and its blockers
10.2298/sarh1412756i · 2014 · External reference
Endothelial dysfunction due to eNOS uncoupling: molecular mechanisms as potential therapeutic targets
10.1186/s11658-023-00423-2 · 2023 · External reference
Structural characteristics and antioxidant activities of oligosaccharides from longan fruit pericarp
10.1021/jf902534v · 2009 · External reference
Gallic acid inhibits histamine release and pro-inflammatory cytokine production in mast cells
10.1093/toxsci/kfj063 · 2006 · External reference
Bupleuri radix ameliorates vascular inflammation in human umbilical vein endothelial cells via modulation of tight junction protein expression and inhibition of nuclear Factor-κB activation
10.3831/kpi.2025.28.1.57 · 2025 · External reference
Longan (Dimocarpus longan Lour.) inhibits lipopolysaccharide-stimulated nitric oxide production in macrophages by suppressing NF-κB and AP-1 signaling pathways
10.1016/j.jep.2015.12.044 · 2016 · External reference
Glucose-rich polysaccharide from dried ‘Shixia' longan activates macrophages through Ca(2+) and CR3-mediated MAPKs and PI3K-AKT pathways
10.1016/j.ijbiomac.2020.11.040 · External reference
A novel polysaccharide isolated from fresh longan (Dimocarpus longan Lour.) activates macrophage via TLR2/4-Mediated PI3/AKT and MyD88/TRAF6 pathways
10.3389/fphar.2021.786127 · External reference
In vitro immunomodulatory activity of water-soluble glucans from fresh and dried Longan (Dimocarpus longan Lour.)
10.1016/j.carbpol.2021.118106 · External reference
Anti-inflammatory treatments for chronic diseases: a review
10.2174/18715281113129990053 · 2013 · External reference
Anti-inflammatory effect of longan seed extract in carrageenan stimulated sprague-dawley rats
2016 · External reference
Nitric oxide in the pathogenesis of vascular disease
10.1002/(sici)1096-9896(200002)190:3<244::aid-path575>3.0.co;2-8 · 2000 · External reference
In vitro hypoglycemic activity of the phenolic compounds in longan fruit (Dimocarpus longan var. Fen Ke) shell against α-Glucosidase and β-Galactosidase
10.1080/10942912.2015.1085398 · 2016 · External reference
G0S2 ameliorates oxidized low-density lipoprotein-induced vascular endothelial cell injury by regulating mitochondrial apoptosis
10.21037/atm-22-5618 · 2022 · External reference
Study on the mechanism of the leaves of Dimocarpus longan lour. in the management of type 2 diabetes based on metabolomics
10.2174/0113862073335304241023153906 · 2025 · External reference
Progress and challenges in translating the biology of atherosclerosis
10.1038/nature10146 · 2011 · External reference
Neuroprotective effects of longan (Dimocarpus longan Lour.) flower water extract on MPP+-induced neurotoxicity in rat brain
10.1021/jf302792t · 2012 · External reference
The adjuvant effects of high-molecule-weight polysaccharides purified from Antrodia cinnamomea on dendritic cell function and DNA vaccines
10.1371/journal.pone.0116191 · 2015 · External reference
Extraction, molecular weight distribution, and antioxidant activity of oligosaccharides from longan (Dimocarpus Longan Lour.) pulp
10.1007/s10068-016-0122-7 · 2016 · External reference
Phenolic profile and antioxidant activity of longan pulp of different cultivars from South China
10.1016/j.lwt.2022.113698 · 2022 · External reference
Polyphenol-rich longan (Dimocarpus longan Lour.)-flower-water-extract attenuates nonalcoholic fatty liver via decreasing lipid peroxidation and downregulating matrix metalloproteinases-2 and -9
10.1016/j.foodres.2011.11.007 · 2012 · External reference
Fermentation process optimization and chemical constituent analysis on longan (Dimocarpus longan Lour.) wine
10.1016/j.foodchem.2018.02.064 · 2018 · External reference
Inhibitory effect of paeonol on aortic endothelial inflammation in atherosclerotic rats by up-regulation of caveolin-1 expression and suppression of NF-κB pathway
10.19540/j.cnki.cjcmm.20200210.408 · 2020 · External reference
A comprehensive review on targeting diverse immune cells for anticancer therapy: beyond immune checkpoint inhibitors
10.1016/j.critrevonc.2025.104702 · 2025 · External reference
Buckwheat flavonoids modulate inflammation in RAW 264.7 macrophages at physiologically relevant concentrations via the LPS/COX-2 pathway
10.1021/acs.jafc.6c02109 · 2026 · External reference
Biotechnological production, characterization and in vitro antitumor activity of polysaccharides from a native strain of Lentinus crinitus
10.1016/j.ijbiomac.2020.08.191 · 2020 · External reference
Leaf ethanol extract of Dimocarpus longan lour. Ameliorates type 2 diabetes mellitus in rats by regulating metabolic pathways and Gut microbiota
10.1155/bri/3881971 · 2026 · External reference
Stimulus-specific responses in innate immunity: multilayered regulatory circuits
10.1016/j.immuni.2021.08.018 · 2021 · External reference
Methanol extract of Longanae Arillus augments pentobarbital-induced sleep behaviors through the modification of GABAergic systems
10.1016/j.jep.2009.01.012 · 2009 · External reference
Longan flower ethanol extract, Dimocarpus longan lour, mitigates oxidative damage and inflammatory responses while promoting sleep-related enzymes in cell models
10.3390/biomedicines13071588 · 2025 · External reference
Stress-responsive protein kinases in redox-regulated apoptosis signaling
10.1089/ars.2005.7.472 · 2005 · External reference
Structure and antitumor and immunomodulatory activities of a water-soluble polysaccharide from Dimocarpus longan pulp
10.3390/ijms15035140 · 2014 · External reference
More than just a monolayer: the multifaceted role of endothelial cells in the pathophysiology of atherosclerosis
10.1007/s11883-022-01023-9 · 2022 · External reference
Endothelial cell dysfunction: onset, progression, and consequences
10.31083/j.fbl2906223 · 2024 · External reference
Dietary patterns and endothelium dysfunction: a literature review
10.1016/j.numecd.2025.104484 · 2026 · External reference
Two novel ACE inhibitory peptides isolated from longan seeds: purification, inhibitory kinetics and mechanisms
10.1039/d0ra00093k · 2020 · External reference
Nitric oxide and peroxynitrite in health and disease
10.1152/physrev.00029.2006 · 2007 · External reference
Plant polyphenols as dietary antioxidants in human health and disease
10.4161/oxim.2.5.9498 · 2009 · External reference
The memory-enhancing effects of Euphoria longan fruit extract in mice
10.1016/j.jep.2010.01.001 · 2010 · External reference
Plant-based nutrition: an essential component of cardiovascular disease prevention and management
10.1007/s11886-017-0909-z · 2017 · External reference
Exhaustive plant profile of “Dimocarpus longan Lour” with significant phytomedicinal properties: a literature based-review
10.3390/pr9101803 · 2021 · External reference
The superoxide radical switch in the biology of nitric oxide and peroxynitrite
10.1152/physrev.00005.2022 · 2022 · External reference
Classification of insomnia using the traditional Chinese medicine system: a systematic review
10.1155/2012/735078 · 2012 · External reference
Enhanced antioxidant and antityrosinase activities of longan fruit pericarp by ultra-high-pressure-assisted extraction
10.1016/j.jpba.2009.02.033 · 2010 · External reference
Epigallocatechin gallate induces expression of heme oxygenase-1 in endothelial cells via p38 MAPK and Nrf-2 that suppresses proinflammatory actions of TNF-α
10.1016/j.jnutbio.2011.06.007 · 2012 · External reference
Identification and quantification of polyphenolic compounds in Longan (Euphoria longana Lam.) fruit
10.1021/jf0403484 · 2005 · External reference
Nitric oxide represses inhibitory kappaB kinase through S-nitrosylation
10.1073/pnas.0400588101 · 2004 · External reference
Structural characterization of an active polysaccharide of longan and evaluation of immunological activity
10.1016/j.carbpol.2019.03.007 · 2019 · External reference
Oxidative stress, AGE, and atherosclerosis
10.1038/sj.ki.5002382 · 2007 · External reference
Pharmacokinetics of gallic acid and its relative bioavailability from tea in healthy humans
10.1093/jn/131.4.1207 · 2001 · External reference
Lipoproteins and lipids in cardiovascular disease: from mechanistic insights to therapeutic targeting
10.1016/j.addr.2020.07.019 · 2020 · External reference
Tissue factor in cardiovascular diseases: molecular mechanisms and clinical implications
10.1161/circulationaha.105.567297 · 2006 · External reference
Dysregulated cellular metabolism in atherosclerosis: mediators and therapeutic opportunities
10.1038/s42255-024-01015-w · 2024 · External reference
Polyphenol profile, antioxidant activity, and hypolipidemic effect of longan byproducts
10.3390/molecules28052083 · 2023 · External reference
Polyphenols and alkaloids in byproducts of longan fruits (Dimocarpus Longan Lour.) and their bioactivities
10.3390/molecules24061186 · 2019 · External reference
MAP kinase signaling at the crossroads of inflammasome activation
10.1111/imr.13436 · 2025 · External reference
Comparative inhibitory potential of selected dietary bioactive polyphenols, phytosterols on CYP3A4 and CYP2D6 with fluorometric high-throughput screening
10.1007/s13197-014-1472-x · 2015 · External reference
Phenolic content, antioxidant capacity, and α-amylase and α-glucosidase inhibitory activities of Dimocarpus longan Lour
10.1007/s10068-019-00708-3 · 2020 · External reference
Antioxidant, bacteriostatic and preservative effects of extractable condensed tannins isolated from longan pericarps and seeds
10.3390/plants12030512 · 2023 · External reference
Comparative study on the mechanism of macrophage activation induced by polysaccharides from fresh and dried longan
10.3390/nu16111654 · 2024 · External reference
Longan polysaccharides promote Th1 and Treg cell differentiation via dendritic cells
10.1016/j.ijbiomac.2025.146462 · 2025 · External reference
Unraveling corilagin's absorption and metabolism: a multimodal approach
10.1039/d5fo05706j · 2026 · External reference
Evaluation of longan (Dimocarpus longan) peel powder as fruit by-product additive in Nile tilapia (Oreochromis niloticus) feed: effects on growth, immunity, and immune-antioxidant gene expressions
10.1016/j.heliyon.2024.e41609 · 2025 · External reference
Screening of potential tropical fruits in protecting endothelial dysfunction in vitro
10.29219/fnr.v65.7807 · 2021 · External reference
Pro- and anti-inflammatory prostaglandins and cytokines in humans: a mini review
10.3390/ijms24119647 · 2023 · External reference
The biphasic dose effect of lychee (Litchi chinensis Sonn.) pulp phenolic extract on alcoholic liver disease in mice
10.1039/c6fo01166g · 2017 · External reference
Protein kinase C: a potential therapeutic target for endothelial dysfunction in diabetes
10.1016/j.jdiacomp.2023.108565 · 2023 · External reference
Advances on bioactive polysaccharides from medicinal plants
10.1080/10408398.2015.1069255 · 2016 · External reference
The role of cellular senescence in cardiovascular disease
10.1038/s41420-025-02720-5 · 2025 · External reference
Antiobesity and hypolipidemic effects of polyphenol-rich longan (Dimocarpus longans Lour.) flower water extract in hypercaloric-dietary rats
10.1021/jf903355q · 2010 · External reference
Extraction and pharmacological properties of bioactive compounds from longan (Dimocarpus longan Lour.) fruit - a review
10.1016/j.foodres.2010.10.019 · 2011 · External reference
Physicochemical characteristics and immunomodulatory activities of three polysaccharide-protein complexes of longan pulp
10.3390/molecules16076148 · External reference
Immunomodulatory activity of polysaccharide-protein complex of longan (Dimocarpus longan Lour.) pulp
10.3390/molecules161210324 · External reference
Characterization of polysaccharide from longan pulp as the macrophage stimulator
10.1039/c5ra16044h · 2015 · External reference
Extraction, purification, structural features and biological activities of longan fruit pulp (Longyan) polysaccharides: a review
10.3389/fnut.2022.914679 · 2022 · External reference
Potential of longan (Dimocarpus longan Lour.) in functional food: a review of molecular mechanism-directing health benefit properties
10.1016/j.foodchem.2023.137812 · 2024 · External reference
Phytochemical constituents and biological activities of longan (Dimocarpus longan Lour.) fruit: a review
10.1016/j.fshw.2020.03.001 · 2020 · External reference
Longan aril polysaccharides ameliorate cognitive impairment in AD mice via restoration of the immune phagocytosis of microglia
10.1016/j.jep.2025.119464 · 2025 · External reference
Protective effects of polyphenolic extracts from longan seeds promote healing of deep second-degree burn in mice
10.1039/c8fo02330a · 2019 · External reference
Longan Arillus: a comprehensive review of botany, traditional uses, phytochemistry, pharmacologic activities, pharmacokinetics, quality control, toxicity, and clinical applications
10.1016/j.jep.2025.120131 · 2025 · External reference
Development and validation of an UPLC-PDA method for the determination of corilagin in rat plasma and its application to pharmacokinetic study
10.1016/j.jchromb.2016.07.039 · 2016 · External reference
Examining gut microbiota and metabolites to clarify mechanisms of Dimocarpus longan lour leaf components against type 2 diabetes
10.4239/wjd.v16.i7.104512 · 2025 · External reference
Evaluation of radicals scavenging, immunity-modulatory and antitumor activities of longan polysaccharides with ultrasonic extraction on in S180 tumor mice models
10.1016/j.ijbiomac.2010.05.022 · 2010 · External reference
Oxidative stress and inflammatory response in cerebral infarction due to hyperlipidemia and lipid-lowering, anti-inflammatory, and antioxidant therapy
10.1016/j.jns.2025.123620 · 2025 · External reference
Structural identification of (1→6)-α-d-glucan, a key responsible for the health benefits of longan, and evaluation of anticancer activity
10.1021/bm400349y · 2013 · External reference
Research progress on macrophages in cardiovascular diseases
10.1186/s13019-025-03541-4 · 2025 · External reference
Nutritional and therapeutic potential of longan fruit By-products for liver diseases: pathway to functional foods
10.1007/s13668-025-00617-4 · 2025 · External reference