Research graph
References from Screening traditional Chinese medicine monomers for premature ovarian insufficiency: from network meta-analysis to the effects of a promising candidate on oxidative stress biomarkers. Local targets link to admitted publications; unresolved targets remain external evidence.
Unresolved reference
2007 · External reference
Safety aspects of the use of quercetin as a dietary supplement
10.1002/mnfr.201700447 · 2018 · External reference
Neuroprotection by anaesthetics in rodent models of traumatic brain injury: a systematic review and network meta-analysis
10.1016/j.bja.2018.07.024 · 2018 · External reference
An updated look into reactive oxygen species and cyclophosphamide-induced ovarian damage
10.1186/s13048-025-01849-2 · 2025 · External reference
Unresolved reference
2022 · External reference
Baicalin enhances proliferation and reduces inflammatory-oxidative stress effect in H2O2-induced granulosa cells apoptosis via USP48 protein regulation
10.1186/s12906-024-04346-z · 2024 · External reference
Intervention effect of resveratrol on mice with premature ovarian insufficiency
2025 · External reference
Quercetin and luteolin complexation with first-row transition metals in purely aqueous solutions: stoichiometry and binding site selectivity
10.1039/d5dt00478k · 2025 · External reference
Spie charts for quantifying treatment effectiveness and safety in multiple outcome network meta-analysis: a proof-of-concept study
10.1186/s12874-020-01128-2 · 2020 · External reference
Effect of puerarin-mediated autophagy on premature ovarian failure induced by cyclophosphamide in rats
2025 · External reference
Quercetin reduces systolic blood pressure and plasma oxidised low-density lipoprotein concentrations in overweight subjects with a high-cardiovascular disease risk phenotype: a double-blinded, placebo-controlled cross-over study
10.1017/s0007114509359127 · 2009 · External reference
Icariin inhibits cisplatin-induced ovarian toxicity via modulating NF-κB and PTEN/AKT/mTOR/AMPK axis
10.1007/s00210-024-03395-y · 2025 · External reference
The effect of quercetin on ovary functions in rats with cyclophosphamide induced ovary damage
10.31083/j.ceog5103067 · 2024 · External reference
Puerarin ameliorates premature ovarian failure by activation of mitochondrial biogenesis, dynamics, and mitophagy through up‐regulation of SIRT1
10.1002/adtp.202400310 · 2025 · External reference
Stachydrine protects against cyclophosphamide-induced premature ovarian insufficiency in wistar rats by inhibiting oxidative stress and apoptosis via the activation of the Nrf2/HO-1 signalling pathway
10.1111/1440-1681.70052 · 2025 · External reference
Systematic investigation of the potential multi-target pharmacological mechanisms of astragaloside IV in polycystic ovary syndrome via network pharmacology and in vivo/in vitro experiments
10.1007/s00210-025-04667-x · 2026 · External reference
Effect of quercetin on ovarian structure and function on rats with premature ovarian insufficiency by regulating the SDF-1/CXCR4 signaling axis
10.3969/j.issn.1002-7386.2024.21.007 · 2024 · External reference
Epidemiology, genetic etiology, and intervention of premature ovarian insufficiency
10.1210/endrev/bnaf011 · 2025 · External reference
Phytoestrogen genistein hinders ovarian oxidative damage and apoptotic cell death-induced by ionizing radiation: Co-operative role of ER-β, TGF-β, and FOXL-2
10.1038/s41598-020-70309-2 · 2020 · External reference
Redox properties of individual quercetin moieties
10.1016/j.freeradbiomed.2019.08.001 · 2019 · External reference
SYRCLE’s risk of bias tool for animal studies
10.1186/1471-2288-14-43 · 2014 · External reference
Efficacy of natural products on premature ovarian failure: a systematic review and meta-analysis of preclinical studies
10.1186/s13048-024-01369-5 · 2024 · External reference
Effects of dodder flavonoids and quercetin on the ovarian function in rat model of premature ovarian failure induced by tripterygium glycosides
10.13699/j.cnki.1001-6821.2020.06.021 · 2020 · External reference
Puerarin modulates the gut-liver-ovarian axis to ameliorate reproductive aging in breeder hens
10.1186/s40168-026-02404-x · 2026 · External reference
The effect of quercetin on inflammatory factors and clinical symptoms in women with rheumatoid arthritis: a double-blind, randomized controlled trial
10.1080/07315724.2016.1140093 · 2017 · External reference
Revitalizing premature ovarian failure: quercetin counteracts imatinib-induced apoptosis via the PI3K/AKT signaling pathway based on network pharmacology
10.1007/s00210-024-03293-3 · 2025 · External reference
Effect of quercetin on ovarian function damage in rats with early-onset ovarian insufficiency by regulating the JAK2/STAT3 signaling pathway
10.19378/j.issn.1003-9783.2025.02.001 · 2025 · External reference
Optimising the therapeutic window: a systematic review and network meta-analysis of pregabalin dosing strategies for painful diabetic neuropathy
10.1111/dom.70748 · 2026 · External reference
Quercetin protects rat BMSCs from oxidative stress via ferroptosis
10.1530/jme-22-0086 · 2022 · External reference
Unresolved reference
2013 · External reference
Unresolved reference
2018 · External reference
Icariin exerts a protective effect against d-galactose induced premature ovarian failure via promoting DNA damage repair
10.1016/j.biopha.2019.109218 · 2019 · External reference
Icariin alleviates cisplatin-induced premature ovarian failure by inhibiting ferroptosis through activation of the Nrf2/ARE pathway
10.1038/s41598-024-67557-x · 2024 · External reference
Irisolidone ameliorates cyclophosphamide-induced POI via inhibiting inflammatory response
10.31083/fbl45744 · 2025 · External reference
Exploring the effect and mechanism of astragaloside IV on ovarian reserve function in premature ovarian failure rats based on oxidative stress
2025 · External reference
Optimal drug regimens for improving ALP biochemical levels in patients with primary biliary cholangitis refractory to UDCA: a systematic review and Bayesian network meta-analysis
10.1186/s13643-024-02460-0 · 2024 · External reference
Mechanisms of and potential medications for oxidative stress in ovarian granulosa cells: a review
10.3390/ijms24119205 · 2023 · External reference
Improving quercetin bioavailability: a systematic review and meta-analysis of human intervention studies
10.1016/j.foodchem.2025.143630 · 2025 · External reference
The potential value of traditional Chinese medicine monomers in cerebral ischemia-reperfusion injury: a network meta-analysis based on animal model
10.1186/s12906-025-04899-7 · 2025 · External reference
Study on the mechanism of quercetin regulating iron death through SLC7A11/GPX4/ACSL4 pathway to improve premature ovarian failure
10.13210/j.cnki.jhmu.20241016.002 · 2025 · External reference
Ameliorative effect of citrus lemon peel extract and resveratrol on premature ovarian failure rat model: role of iNOS/caspase-3 pathway
10.3390/molecules28010122 · 2022 · External reference
Synergistic effects of capsaicin and quercetin improved induced premature ovarian failure in rat
10.22074/cellj.2023.1989732.1234 · 2023 · External reference
Premature ovarians insufficiency
10.1136/bmj-2023-077469 · 2024 · External reference
CINeMA: an approach for assessing confidence in the results of a network meta-analysis
10.1371/journal.pmed.1003082 · 2020 · External reference
Quercetin exerts preventive, ameliorative and prophylactic effects on cadmium chloride-induced oxidative stress in the uterus and ovaries of female Wistar rats
10.1016/j.fct.2017.02.010 · 2017 · External reference
Estrogen modulating effects of resveratrol in female rats
10.5472/mmjoa.2902.06 · 2016 · External reference
Quercetin alleviates toxicity induced by high levels of copper in porcine follicular granulosa cells by scavenging reactive oxygen species and improving mitochondrial function
10.3390/ani13172745 · 2023 · External reference
Effects of quercetin on adiponectin-mediated insulin sensitivity in polycystic ovary syndrome: a randomized placebo-controlled double-blind clinical trial
10.1055/s-0042-118705 · 2017 · External reference
Multivariate and network meta-analysis of multiple outcomes and multiple treatments: rationale, concepts, and examples
10.1136/bmj.j3932 · 2017 · External reference
Quercetin ameliorates oxidative stress, inflammation and apoptosis in the heart of streptozotocin-nicotinamide-induced adult male diabetic rats
10.1016/j.biopha.2016.12.044 · 2017 · External reference
Resveratrol inhibits inflammatory signaling implicated in ionizing radiation-induced premature ovarian failure through antagonistic crosstalk between silencing information regulator 1 (SIRT1) and poly(ADP-ribose) polymerase 1 (PARP-1)
10.1016/j.bcp.2016.01.019 · 2016 · External reference
Decoding premature ovarian insufficiency: a full spectrum review from epidemiology to management with emphasis on cyclophosphamide-evoked ovarian injury
10.1016/j.fct.2025.115719 · 2025 · External reference
Dietary quercetin attenuates oxidant-induced endothelial dysfunction and atherosclerosis in apolipoprotein E knockout mice fed a high-fat diet: a critical role for heme oxygenase-1
10.1016/j.freeradbiomed.2013.08.185 · 2013 · External reference
Premature ovarian insufficiency: a review on the role of oxidative stress and the application of antioxidants
10.3389/fendo.2023.1172481 · 2023 · External reference
Reactive oxygen species in ovarian physiology
10.1007/bf03016135 · 2005 · External reference
ESHRE guideline: management of women with premature ovarian insufficiency
10.1093/humrep/dew027 · 2016 · External reference
Unresolved reference
2019 · External reference
Premature ovarian insufficiency
10.1038/s41572-024-00547-5 · 2024 · External reference
Oxidative stress in oocyte aging and female reproduction
10.1002/jcp.30468 · 2021 · External reference
Modulatory effect of quercetin on premature ovarian insufficiency induced by cyclophosphamide via the PARP1 and GSK3β
10.1038/s41598-025-21397-5 · 2025 · External reference
Astragaloside IV alleviates ovarian inflammation in a rat model of premature ovarian insufficiency induced by cyclophosphamide
2023 · External reference
Effects of icariin on cyclophosphamide induced premature ovarian failure in mice
10.19879/j.cnki.1005-5304.202205574 · 2023 · External reference
Icariin from Epimedium brevicornum Maxim promotes the biosynthesis of estrogen by aromatase (CYP19)
10.1016/j.jep.2012.11.031 · 2013 · External reference
Protective effect of astragaloside IV and human placental mesenchymal stem cell transplantation on ovarian function in rats with ovarian dysfunction
10.13863/j.issn1001-4454.2024.06.029 · 2024 · External reference
Icariin attenuates premature ovarian insufficiency via a phytoestrogenic mechanism mediated by the ERβ/SIRT3 pathway
10.1016/j.cellsig.2025.112334 · 2026 · External reference
Multi-target modulation of the homologous recombination pathway by resveratrol promotes DNA damage repair in POI: integrated network pharmacology, molecular dynamics simulation, and experimental validation
10.1097/js9.0000000000004655 · 2026 · External reference
Effect of puerarin on cisplatin induced premature ovarian failure in mouse
10.3969/j.issn.1005-8982.2021.15.012 · 2021 · External reference
Molecular mechanisms and therapeutic potential of quercetin in ovarian functions
10.1016/j.phymed.2025.156945 · 2025 · External reference
Effects of quercetin on ovarian function and regulation of the ovarian PI3K/Akt/FoxO3a signalling pathway and oxidative stress in a rat model of cyclophosphamide-induced premature ovarian failure
10.1111/bcpt.13696 · 2021 · External reference
Unresolved reference
2024 · External reference
Protective effect and mechanism of icarin regulating PI3K/Akt/mTOR pathway on ovarian structure and function in rats with early-onset ovarian insufficiency
2023 · External reference
Puerarin ameliorates premature ovarian failure by activation of mitochondrial biogenesis, dynamics, and mitophagy through up‐regulation of SIRT1
10.1002/adtp.202400310 · ExternalCitation · doi-reference
Oxidative stress in oocyte aging and female reproduction
10.1002/jcp.30468 · ExternalCitation · doi-reference
Safety aspects of the use of quercetin as a dietary supplement
10.1002/mnfr.201700447 · ExternalCitation · doi-reference
Reactive oxygen species in ovarian physiology
10.1007/bf03016135 · ExternalCitation · doi-reference
Revitalizing premature ovarian failure: quercetin counteracts imatinib-induced apoptosis via the PI3K/AKT signaling pathway based on network pharmacology
10.1007/s00210-024-03293-3 · ExternalCitation · doi-reference
Icariin inhibits cisplatin-induced ovarian toxicity via modulating NF-κB and PTEN/AKT/mTOR/AMPK axis
10.1007/s00210-024-03395-y · ExternalCitation · doi-reference
Systematic investigation of the potential multi-target pharmacological mechanisms of astragaloside IV in polycystic ovary syndrome via network pharmacology and in vivo/in vitro experiments
10.1007/s00210-025-04667-x · ExternalCitation · doi-reference
Resveratrol inhibits inflammatory signaling implicated in ionizing radiation-induced premature ovarian failure through antagonistic crosstalk between silencing information regulator 1 (SIRT1) and poly(ADP-ribose) polymerase 1 (PARP-1)
10.1016/j.bcp.2016.01.019 · ExternalCitation · doi-reference
Quercetin ameliorates oxidative stress, inflammation and apoptosis in the heart of streptozotocin-nicotinamide-induced adult male diabetic rats
10.1016/j.biopha.2016.12.044 · ExternalCitation · doi-reference
Icariin exerts a protective effect against d-galactose induced premature ovarian failure via promoting DNA damage repair
10.1016/j.biopha.2019.109218 · ExternalCitation · doi-reference
Neuroprotection by anaesthetics in rodent models of traumatic brain injury: a systematic review and network meta-analysis
10.1016/j.bja.2018.07.024 · ExternalCitation · doi-reference
Icariin attenuates premature ovarian insufficiency via a phytoestrogenic mechanism mediated by the ERβ/SIRT3 pathway
10.1016/j.cellsig.2025.112334 · ExternalCitation · doi-reference
Quercetin exerts preventive, ameliorative and prophylactic effects on cadmium chloride-induced oxidative stress in the uterus and ovaries of female Wistar rats
10.1016/j.fct.2017.02.010 · ExternalCitation · doi-reference
Decoding premature ovarian insufficiency: a full spectrum review from epidemiology to management with emphasis on cyclophosphamide-evoked ovarian injury
10.1016/j.fct.2025.115719 · ExternalCitation · doi-reference
Improving quercetin bioavailability: a systematic review and meta-analysis of human intervention studies
10.1016/j.foodchem.2025.143630 · ExternalCitation · doi-reference
Dietary quercetin attenuates oxidant-induced endothelial dysfunction and atherosclerosis in apolipoprotein E knockout mice fed a high-fat diet: a critical role for heme oxygenase-1
10.1016/j.freeradbiomed.2013.08.185 · ExternalCitation · doi-reference
Redox properties of individual quercetin moieties
10.1016/j.freeradbiomed.2019.08.001 · ExternalCitation · doi-reference
Icariin from Epimedium brevicornum Maxim promotes the biosynthesis of estrogen by aromatase (CYP19)
10.1016/j.jep.2012.11.031 · ExternalCitation · doi-reference
Molecular mechanisms and therapeutic potential of quercetin in ovarian functions
10.1016/j.phymed.2025.156945 · ExternalCitation · doi-reference
Quercetin reduces systolic blood pressure and plasma oxidised low-density lipoprotein concentrations in overweight subjects with a high-cardiovascular disease risk phenotype: a double-blinded, placebo-controlled cross-over study
10.1017/s0007114509359127 · ExternalCitation · doi-reference
Premature ovarian insufficiency
10.1038/s41572-024-00547-5 · ExternalCitation · doi-reference
Phytoestrogen genistein hinders ovarian oxidative damage and apoptotic cell death-induced by ionizing radiation: Co-operative role of ER-β, TGF-β, and FOXL-2
10.1038/s41598-020-70309-2 · ExternalCitation · doi-reference
Icariin alleviates cisplatin-induced premature ovarian failure by inhibiting ferroptosis through activation of the Nrf2/ARE pathway
10.1038/s41598-024-67557-x · ExternalCitation · doi-reference
Modulatory effect of quercetin on premature ovarian insufficiency induced by cyclophosphamide via the PARP1 and GSK3β
10.1038/s41598-025-21397-5 · ExternalCitation · doi-reference
Quercetin and luteolin complexation with first-row transition metals in purely aqueous solutions: stoichiometry and binding site selectivity
10.1039/d5dt00478k · ExternalCitation · doi-reference
Effects of quercetin on adiponectin-mediated insulin sensitivity in polycystic ovary syndrome: a randomized placebo-controlled double-blind clinical trial
10.1055/s-0042-118705 · ExternalCitation · doi-reference
The effect of quercetin on inflammatory factors and clinical symptoms in women with rheumatoid arthritis: a double-blind, randomized controlled trial
10.1080/07315724.2016.1140093 · ExternalCitation · doi-reference
ESHRE guideline: management of women with premature ovarian insufficiency
10.1093/humrep/dew027 · ExternalCitation · doi-reference
Multi-target modulation of the homologous recombination pathway by resveratrol promotes DNA damage repair in POI: integrated network pharmacology, molecular dynamics simulation, and experimental validation
10.1097/js9.0000000000004655 · ExternalCitation · doi-reference
Stachydrine protects against cyclophosphamide-induced premature ovarian insufficiency in wistar rats by inhibiting oxidative stress and apoptosis via the activation of the Nrf2/HO-1 signalling pathway
10.1111/1440-1681.70052 · ExternalCitation · doi-reference
Effects of quercetin on ovarian function and regulation of the ovarian PI3K/Akt/FoxO3a signalling pathway and oxidative stress in a rat model of cyclophosphamide-induced premature ovarian failure
10.1111/bcpt.13696 · ExternalCitation · doi-reference
Optimising the therapeutic window: a systematic review and network meta-analysis of pregabalin dosing strategies for painful diabetic neuropathy
10.1111/dom.70748 · ExternalCitation · doi-reference
Premature ovarians insufficiency
10.1136/bmj-2023-077469 · ExternalCitation · doi-reference
Multivariate and network meta-analysis of multiple outcomes and multiple treatments: rationale, concepts, and examples
10.1136/bmj.j3932 · ExternalCitation · doi-reference
SYRCLE’s risk of bias tool for animal studies
10.1186/1471-2288-14-43 · ExternalCitation · doi-reference
Spie charts for quantifying treatment effectiveness and safety in multiple outcome network meta-analysis: a proof-of-concept study
10.1186/s12874-020-01128-2 · ExternalCitation · doi-reference
Baicalin enhances proliferation and reduces inflammatory-oxidative stress effect in H2O2-induced granulosa cells apoptosis via USP48 protein regulation
10.1186/s12906-024-04346-z · ExternalCitation · doi-reference
The potential value of traditional Chinese medicine monomers in cerebral ischemia-reperfusion injury: a network meta-analysis based on animal model
10.1186/s12906-025-04899-7 · ExternalCitation · doi-reference
Efficacy of natural products on premature ovarian failure: a systematic review and meta-analysis of preclinical studies
10.1186/s13048-024-01369-5 · ExternalCitation · doi-reference
An updated look into reactive oxygen species and cyclophosphamide-induced ovarian damage
10.1186/s13048-025-01849-2 · ExternalCitation · doi-reference
Optimal drug regimens for improving ALP biochemical levels in patients with primary biliary cholangitis refractory to UDCA: a systematic review and Bayesian network meta-analysis
10.1186/s13643-024-02460-0 · ExternalCitation · doi-reference
Puerarin modulates the gut-liver-ovarian axis to ameliorate reproductive aging in breeder hens
10.1186/s40168-026-02404-x · ExternalCitation · doi-reference
Epidemiology, genetic etiology, and intervention of premature ovarian insufficiency
10.1210/endrev/bnaf011 · ExternalCitation · doi-reference
Study on the mechanism of quercetin regulating iron death through SLC7A11/GPX4/ACSL4 pathway to improve premature ovarian failure
10.13210/j.cnki.jhmu.20241016.002 · ExternalCitation · doi-reference
Effects of dodder flavonoids and quercetin on the ovarian function in rat model of premature ovarian failure induced by tripterygium glycosides
10.13699/j.cnki.1001-6821.2020.06.021 · ExternalCitation · doi-reference
CINeMA: an approach for assessing confidence in the results of a network meta-analysis
10.1371/journal.pmed.1003082 · ExternalCitation · doi-reference
Protective effect of astragaloside IV and human placental mesenchymal stem cell transplantation on ovarian function in rats with ovarian dysfunction
10.13863/j.issn1001-4454.2024.06.029 · ExternalCitation · doi-reference
Quercetin protects rat BMSCs from oxidative stress via ferroptosis
10.1530/jme-22-0086 · ExternalCitation · doi-reference
Effect of quercetin on ovarian function damage in rats with early-onset ovarian insufficiency by regulating the JAK2/STAT3 signaling pathway
10.19378/j.issn.1003-9783.2025.02.001 · ExternalCitation · doi-reference
Effects of icariin on cyclophosphamide induced premature ovarian failure in mice
10.19879/j.cnki.1005-5304.202205574 · ExternalCitation · doi-reference
Synergistic effects of capsaicin and quercetin improved induced premature ovarian failure in rat
10.22074/cellj.2023.1989732.1234 · ExternalCitation · doi-reference
Irisolidone ameliorates cyclophosphamide-induced POI via inhibiting inflammatory response
10.31083/fbl45744 · ExternalCitation · doi-reference
The effect of quercetin on ovary functions in rats with cyclophosphamide induced ovary damage
10.31083/j.ceog5103067 · ExternalCitation · doi-reference
Premature ovarian insufficiency: a review on the role of oxidative stress and the application of antioxidants
10.3389/fendo.2023.1172481 · ExternalCitation · doi-reference
Quercetin alleviates toxicity induced by high levels of copper in porcine follicular granulosa cells by scavenging reactive oxygen species and improving mitochondrial function
10.3390/ani13172745 · ExternalCitation · doi-reference
Mechanisms of and potential medications for oxidative stress in ovarian granulosa cells: a review
10.3390/ijms24119205 · ExternalCitation · doi-reference
Ameliorative effect of citrus lemon peel extract and resveratrol on premature ovarian failure rat model: role of iNOS/caspase-3 pathway
10.3390/molecules28010122 · ExternalCitation · doi-reference
Effect of quercetin on ovarian structure and function on rats with premature ovarian insufficiency by regulating the SDF-1/CXCR4 signaling axis
10.3969/j.issn.1002-7386.2024.21.007 · ExternalCitation · doi-reference
Effect of puerarin on cisplatin induced premature ovarian failure in mouse
10.3969/j.issn.1005-8982.2021.15.012 · ExternalCitation · doi-reference
Estrogen modulating effects of resveratrol in female rats
10.5472/mmjoa.2902.06 · ExternalCitation · doi-reference
