Research graph
References from Squalene alleviates DSS-induced colitis by restoring Nrf2-dependent redox balance and gut microbiota homeostasis. Local targets link to admitted publications; unresolved targets remain external evidence.
Microbiota therapeutics for inflammatory bowel disease: the way forward
10.1016/s2468-1253(23)00441-7 · 2024 · External reference
Oxidative stress: an essential factor in the pathogenesis of gastrointestinal mucosal diseases
10.1152/physrev.00040.2012 · 2014 · External reference
Carthamin yellow alleviates dextran sodium sulfate-induced ulcerative colitis by repairing the intestinal barrier and activating the Nrf2/GPX4 axis
10.1016/j.intimp.2024.113020 · 2024 · External reference
Microbiotas from humans with inflammatory bowel disease alter the balance of gut Th17 and RORgammat(+) regulatory T cells and exacerbate colitis in mice
10.1016/j.immuni.2018.12.015 · 2019 · External reference
DADA2: high-resolution sample inference from Illumina amplicon data
10.1038/nmeth.3869 · 2016 · External reference
High-dose squalene ingestion increases type I procollagen and decreases ultraviolet-induced DNA damage in human skin in vivo but is associated with transient adverse effects
10.1111/j.1365-2230.2008.03133.x · 2009 · External reference
Hydroalcoholic extract from inflorescences of Achyrocline satureioides (Compositae) ameliorates dextran sulphate sodium-induced colitis in mice by attenuation in the production of inflammatory cytokines and oxidative mediators
10.1155/2016/3475356 · 2016 · External reference
AutoDock vina 1.2.0: new docking methods, expanded force field, and python bindings
10.1021/acs.jcim.1c00203 · 2021 · External reference
Effects of branched-chain amino acids on the inflammatory response induced by LPS in Caco-2 cells
10.3390/metabo14010076 · 2024 · External reference
Ulcerative colitis in adults: a review
10.1001/jama.2023.15389 · 2023 · External reference
Suppressor of cytokine signaling-1 ameliorates dextran sulfate sodium-induced colitis in mice
10.1093/intimm/dxn033 · 2008 · External reference
Protective effects of natural polysaccharides on intestinal barrier injury: a review
10.1021/acs.jafc.1c05966 · 2022 · External reference
The cellular thermal shift assay for evaluating drug target interactions in cells
10.1038/nprot.2014.138 · 2014 · External reference
Ulcerative colitis: signaling pathways, therapeutic targets and interventional strategies
10.1038/s41392-025-02345-1 · 2026 · External reference
Geniposidic acid attenuates DSS-induced colitis through inhibiting inflammation and regulating gut microbiota
10.1002/ptr.7819 · 2023 · External reference
alpha-Lipoic acid alleviates dextran sulfate sodium salt-induced ulcerative colitis via modulating the Keap1-Nrf2 signaling pathway and inhibiting ferroptosis
10.1002/jsfa.13053 · 2024 · External reference
Mucus layers in inflammatory bowel disease
10.1097/mib.0000000000000117 · 2014 · External reference
Highly accurate protein structure prediction with AlphaFold
10.1038/s41586-021-03819-2 · 2021 · External reference
Squalene mitigates muscle atrophy via the PI3K/Akt pathway in TNF-alpha-stimulated C2C12 myotubes and immobilization-induced C57BL/6J mice
10.1007/s10068-025-02058-9 · 2026 · External reference
Role of toll-like receptors in inflammatory bowel disease
10.1016/j.phrs.2017.11.017 · 2018 · External reference
Encapsulation of squalene in oil-in-water emulsions: utilization of heat-polymerized whey proteins as emulsifiers
10.1016/j.ijbiomac.2026.151090 · 2026 · External reference
Chitosan - Whey protein as efficient delivery system for squalene: characterization and functional food application
10.1016/j.ijbiomac.2019.05.153 · 2019 · External reference
The first international rome consensus conference on gut microbiota and faecal microbiota transplantation in inflammatory bowel disease
10.1136/gutjnl-2023-329948 · 2023 · External reference
Network pharmacology prediction and molecular docking-based strategy to explore the potential mechanism of squalene against inflammation
10.1007/s40203-024-00217-0 · 2024 · External reference
Emerging pharmacotherapy for inflammatory bowel diseases
10.1016/j.phrs.2022.106146 · 2022 · External reference
The effect of probiotics on the production of short-chain fatty acids by human intestinal microbiome
10.3390/nu12041107 · 2020 · External reference
Nanoemulsion-based oral delivery systems for lipophilic bioactive components: nutraceuticals and pharmaceuticals
10.4155/tde.13.46 · 2013 · External reference
Squalene: more than a step toward sterols
10.3390/antiox9080688 · 2020 · External reference
The NF-kappaB signaling system in the immunopathogenesis of inflammatory bowel disease
10.1126/scisignal.adh1641 · 2024 · External reference
Functional characterization of inflammatory bowel disease-associated gut dysbiosis in gnotobiotic mice
10.1016/j.jcmgh.2016.02.003 · 2016 · External reference
Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies
10.1016/s0140-6736(17)32448-0 · 2017 · External reference
The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress
10.1074/jbc.r900010200 · 2009 · External reference
Intestinal epithelial cells: regulators of barrier function and immune homeostasis
10.1038/nri3608 · 2014 · External reference
Ulcerative colitis: recent advances in the understanding of disease pathogenesis
10.12688/f1000research.20805.1 · 2020 · External reference
Squalene attenuates the oxidative stress and activates AKT/mTOR pathway against cisplatin-induced kidney damage in mice
10.3906/biy-1902-77 · 2019 · External reference
Dietary squalene supplementation improves DSS-induced acute colitis by downregulating p38 MAPK and NFkB signaling pathways
10.1002/mnfr.201400518 · 2015 · External reference
Microbial influences in inflammatory bowel diseases
10.1053/j.gastro.2007.11.059 · 2008 · External reference
Squalene: potential chemopreventive agent
10.1517/13543784.9.8.1841 · 2000 · External reference
Lactobacillus plantarum improves LPS-induced Caco2 cell line intestinal barrier damage via cyclic AMP-PKA signaling
10.1371/journal.pone.0267831 · 2022 · External reference
Unveiling colitis: a journey through the dextran sodium sulfate-induced model
10.1093/ibd/izad312 · 2024 · External reference
Regulatory role of short-chain fatty acids in inflammatory bowel disease
10.1186/s12964-022-00869-5 · 2022 · External reference
Biochanin a ameliorates DSS-induced ulcerative colitis by improving colonic barrier function and protects against the development of spontaneous colitis in the Muc2 deficient mice
10.1016/j.cbi.2024.111014 · 2024 · External reference
Moringin alleviates DSS-induced ulcerative colitis in mice by regulating Nrf2/NF-kappaB pathway and PI3K/AKT/mTOR pathway
10.1016/j.intimp.2024.112241 · 2024 · External reference
Free fatty acid receptor 4 deletion attenuates colitis by modulating treg cells via ZBED6-IL33 pathway
10.1016/j.ebiom.2022.104060 · 2022 · External reference
Ulcerative colitis in adults: a review
10.1001/jama.2023.15389 · ExternalCitation · doi-reference
alpha-Lipoic acid alleviates dextran sulfate sodium salt-induced ulcerative colitis via modulating the Keap1-Nrf2 signaling pathway and inhibiting ferroptosis
10.1002/jsfa.13053 · ExternalCitation · doi-reference
Dietary squalene supplementation improves DSS-induced acute colitis by downregulating p38 MAPK and NFkB signaling pathways
10.1002/mnfr.201400518 · ExternalCitation · doi-reference
Geniposidic acid attenuates DSS-induced colitis through inhibiting inflammation and regulating gut microbiota
10.1002/ptr.7819 · ExternalCitation · doi-reference
Squalene mitigates muscle atrophy via the PI3K/Akt pathway in TNF-alpha-stimulated C2C12 myotubes and immobilization-induced C57BL/6J mice
10.1007/s10068-025-02058-9 · ExternalCitation · doi-reference
Network pharmacology prediction and molecular docking-based strategy to explore the potential mechanism of squalene against inflammation
10.1007/s40203-024-00217-0 · ExternalCitation · doi-reference
Biochanin a ameliorates DSS-induced ulcerative colitis by improving colonic barrier function and protects against the development of spontaneous colitis in the Muc2 deficient mice
10.1016/j.cbi.2024.111014 · ExternalCitation · doi-reference
Free fatty acid receptor 4 deletion attenuates colitis by modulating treg cells via ZBED6-IL33 pathway
10.1016/j.ebiom.2022.104060 · ExternalCitation · doi-reference
Chitosan - Whey protein as efficient delivery system for squalene: characterization and functional food application
10.1016/j.ijbiomac.2019.05.153 · ExternalCitation · doi-reference
Encapsulation of squalene in oil-in-water emulsions: utilization of heat-polymerized whey proteins as emulsifiers
10.1016/j.ijbiomac.2026.151090 · ExternalCitation · doi-reference
Microbiotas from humans with inflammatory bowel disease alter the balance of gut Th17 and RORgammat(+) regulatory T cells and exacerbate colitis in mice
10.1016/j.immuni.2018.12.015 · ExternalCitation · doi-reference
Moringin alleviates DSS-induced ulcerative colitis in mice by regulating Nrf2/NF-kappaB pathway and PI3K/AKT/mTOR pathway
10.1016/j.intimp.2024.112241 · ExternalCitation · doi-reference
Carthamin yellow alleviates dextran sodium sulfate-induced ulcerative colitis by repairing the intestinal barrier and activating the Nrf2/GPX4 axis
10.1016/j.intimp.2024.113020 · ExternalCitation · doi-reference
Functional characterization of inflammatory bowel disease-associated gut dysbiosis in gnotobiotic mice
10.1016/j.jcmgh.2016.02.003 · ExternalCitation · doi-reference
Role of toll-like receptors in inflammatory bowel disease
10.1016/j.phrs.2017.11.017 · ExternalCitation · doi-reference
Emerging pharmacotherapy for inflammatory bowel diseases
10.1016/j.phrs.2022.106146 · ExternalCitation · doi-reference
Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies
10.1016/s0140-6736(17)32448-0 · ExternalCitation · doi-reference
Microbiota therapeutics for inflammatory bowel disease: the way forward
10.1016/s2468-1253(23)00441-7 · ExternalCitation · doi-reference
Protective effects of natural polysaccharides on intestinal barrier injury: a review
10.1021/acs.jafc.1c05966 · ExternalCitation · doi-reference
AutoDock vina 1.2.0: new docking methods, expanded force field, and python bindings
10.1021/acs.jcim.1c00203 · ExternalCitation · doi-reference
DADA2: high-resolution sample inference from Illumina amplicon data
10.1038/nmeth.3869 · ExternalCitation · doi-reference
The cellular thermal shift assay for evaluating drug target interactions in cells
10.1038/nprot.2014.138 · ExternalCitation · doi-reference
Intestinal epithelial cells: regulators of barrier function and immune homeostasis
10.1038/nri3608 · ExternalCitation · doi-reference
Ulcerative colitis: signaling pathways, therapeutic targets and interventional strategies
10.1038/s41392-025-02345-1 · ExternalCitation · doi-reference
Highly accurate protein structure prediction with AlphaFold
10.1038/s41586-021-03819-2 · ExternalCitation · doi-reference
Microbial influences in inflammatory bowel diseases
10.1053/j.gastro.2007.11.059 · ExternalCitation · doi-reference
The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress
10.1074/jbc.r900010200 · ExternalCitation · doi-reference
Unveiling colitis: a journey through the dextran sodium sulfate-induced model
10.1093/ibd/izad312 · ExternalCitation · doi-reference
Suppressor of cytokine signaling-1 ameliorates dextran sulfate sodium-induced colitis in mice
10.1093/intimm/dxn033 · ExternalCitation · doi-reference
Mucus layers in inflammatory bowel disease
10.1097/mib.0000000000000117 · ExternalCitation · doi-reference
High-dose squalene ingestion increases type I procollagen and decreases ultraviolet-induced DNA damage in human skin in vivo but is associated with transient adverse effects
10.1111/j.1365-2230.2008.03133.x · ExternalCitation · doi-reference
The NF-kappaB signaling system in the immunopathogenesis of inflammatory bowel disease
10.1126/scisignal.adh1641 · ExternalCitation · doi-reference
The first international rome consensus conference on gut microbiota and faecal microbiota transplantation in inflammatory bowel disease
10.1136/gutjnl-2023-329948 · ExternalCitation · doi-reference
Oxidative stress: an essential factor in the pathogenesis of gastrointestinal mucosal diseases
10.1152/physrev.00040.2012 · ExternalCitation · doi-reference
Hydroalcoholic extract from inflorescences of Achyrocline satureioides (Compositae) ameliorates dextran sulphate sodium-induced colitis in mice by attenuation in the production of inflammatory cytokines and oxidative mediators
10.1155/2016/3475356 · ExternalCitation · doi-reference
Regulatory role of short-chain fatty acids in inflammatory bowel disease
10.1186/s12964-022-00869-5 · ExternalCitation · doi-reference
Ulcerative colitis: recent advances in the understanding of disease pathogenesis
10.12688/f1000research.20805.1 · ExternalCitation · doi-reference
Lactobacillus plantarum improves LPS-induced Caco2 cell line intestinal barrier damage via cyclic AMP-PKA signaling
10.1371/journal.pone.0267831 · ExternalCitation · doi-reference
Squalene: potential chemopreventive agent
10.1517/13543784.9.8.1841 · ExternalCitation · doi-reference
Squalene: more than a step toward sterols
10.3390/antiox9080688 · ExternalCitation · doi-reference
Effects of branched-chain amino acids on the inflammatory response induced by LPS in Caco-2 cells
10.3390/metabo14010076 · ExternalCitation · doi-reference
The effect of probiotics on the production of short-chain fatty acids by human intestinal microbiome
10.3390/nu12041107 · ExternalCitation · doi-reference
Squalene attenuates the oxidative stress and activates AKT/mTOR pathway against cisplatin-induced kidney damage in mice
10.3906/biy-1902-77 · ExternalCitation · doi-reference
Nanoemulsion-based oral delivery systems for lipophilic bioactive components: nutraceuticals and pharmaceuticals
10.4155/tde.13.46 · ExternalCitation · doi-reference