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References from Preclinical effects of naringin on bone outcomes in animal models of osteoporosis: a systematic review and meta-analysis. Local targets link to admitted publications; unresolved targets remain external evidence.
Denosumab discontinuation and the rebound phenomenon: a narrative review
10.3390/jcm10010152 · 2021 · External reference
Naringin abrogates osteoclastogenesis and bone resorption via the inhibition of RANKL-induced NF-kappaB and ERK activation
10.1016/j.febslet.2011.07.046 · 2011 · External reference
Multiarm studies and how to handle them in a meta-analysis: a tutorial
10.1002/cesm.12033 · 2023 · External reference
Importance of systematic reviews and meta-analyses of animal studies: challenges for animal-to-human translation
10.30802/aalas-jaalas-19-000139 · 2020 · External reference
Analytical considerations and plans to standardize or harmonize assays for the reference bone turnover markers PINP and β-CTX in blood
10.1016/j.cca.2020.12.023 · 2021 · External reference
Guidelines for assessment of bone microstructure in rodents using micro-computed tomography
10.1002/jbmr.141 · 2010 · External reference
Current use of bone turnover markers in the management of osteoporosis
10.1016/j.clinbiochem.2022.09.002 · 2022 · External reference
Simultaneously quantitative analysis of naringin and its major human gut microbial metabolites naringenin and 3-(4′-hydroxyphenyl) propanoic acid via stable isotope deuterium-labeling coupled with RRLC-MS/MS method
10.3390/molecules24234287 · 2019 · External reference
Osteoporosis due to hormone imbalance: an overview of the effects of estrogen deficiency and glucocorticoid overuse on bone turnover
10.3390/ijms23031376 · 2022 · External reference
Naringin promotes osteoblast differentiation and ameliorates osteoporosis in ovariectomized mice
10.1038/s41598-025-97217-7 · 2025 · External reference
Use of bone turnover markers in postmenopausal osteoporosis
10.1016/s2213-8587(17)30184-5 · 2017 · External reference
Pharmacological management of osteoporosis in postmenopausal women: an endocrine society clinical practice guideline
10.1210/jc.2019-00221 · 2019 · External reference
The development of naringin for use against bone and cartilage disorders
10.3390/molecules28093716 · 2023 · External reference
Protective effects of naringin on glucocorticoid-induced osteoporosis through regulating the PI3K/Akt/mTOR signaling pathway
2021 · External reference
pH-responsive mesoporous silica nanoparticles loaded with naringin for targeted osteoclast inhibition and bone regeneration
10.2147/ijn.s456545 · 2024 · External reference
Double directional adjusting estrogenic effect of naringin from Rhizoma drynariae (Gusuibu)
10.1016/j.jep.2011.09.034 · 2011 · External reference
Facilitating healthcare decisions by assessing the certainty in the evidence from preclinical animal studies
10.1371/journal.pone.0187271 · 2018 · External reference
Effect of flavonoids from rhizoma drynariae on osteoporosis rats and osteocytes
10.1016/j.biopha.2022.113379 · 2022 · External reference
Pharmacokinetics of the citrus flavanone aglycones hesperetin and naringenin after single oral administration in human subjects
10.1038/sj.ejcn.1602543 · 2007 · External reference
Naringin inhibits iron deposition and cell apoptosis in bone tissue of osteoporotic rats
10.12307/2024.593 · 2025 · External reference
Effect of naringin on bone biomechanics and bone mineral density in rats with postmenopausal osteoporosis
2012 · External reference
Naringin promotes osteoblast differentiation and effectively reverses ovariectomy-associated osteoporosis
10.1007/s00776-013-0362-9 · 2013 · External reference
Naringin prevents ovariectomy-induced osteoporosis and promotes osteoclasts apoptosis through the mitochondria-mediated apoptosis pathway
10.1016/j.bbrc.2014.08.117 · 2014 · External reference
Naringin protects against bone loss in steroid-treated inflammatory bowel disease in a rat model
10.1016/j.abb.2018.05.011 · 2018 · External reference
Naringin inhibits the osteoblast-osteoclast pyroptosis cascade reaction mediated by accumulated bone marrow adipose tissue in the treatment of postmenopausal osteoporosis
10.1016/j.jot.2025.09.004 · 2025 · External reference
Global epidemiology and burden of osteoporosis among postmenopausal women: insights from the global burden of disease study 2021
10.1038/s41514-025-00269-2 · 2025 · External reference
Involvement of periostin-sclerostin-Wnt/β-catenin signaling pathway in the prevention of neurectomy-induced bone loss by naringin
10.1016/j.bbrc.2015.10.152 · 2015 · External reference
Stimulation of Wnt/β-catenin signaling pathway is involved in the effect of naringin on the prevention of disuse osteoporosis
10.3760/cma.j.issn.0253-2352.2016.08.006 · 2016 · External reference
Naringin ameliorates bone loss induced by sciatic neurectomy and increases semaphorin 3A expression in denervated bone
10.1038/srep24562 · 2016 · External reference
Multiplicity corrections in life sciences: challenges and consequences
10.1093/ije/dyaf098 · 2025 · External reference
Osteonecrosis of the jaw and concomitant atypical femoral fractures with bisphosphonates: a comprehensive literature review
10.7759/cureus.5113 · 2019 · External reference
A simple practice guide for dose conversion between animals and human
10.4103/0976-0105.177703 · 2016 · External reference
High-dose short-term administration of naringin did not alter talinolol pharmacokinetics in humans
10.1016/j.ejps.2014.12.001 · 2015 · External reference
Naringin improves bone properties in ovariectomized mice and exerts oestrogen-like activities in rat osteoblast-like (UMR-106) cells
10.1111/j.1476-5381.2010.00664.x · 2010 · External reference
Polyphenols and bone health: a comprehensive review of their role in osteoporosis prevention and treatment
10.3390/molecules30214154 · 2025 · External reference
Drug therapy for osteoporosis in older adults
10.1016/s0140-6736(21)02646-5 · 2022 · External reference
Interpretation of random effects meta-analyses
10.1136/bmj.d549 · 2011 · External reference
Naringin prevents bone loss in a rat model of type 1 diabetes mellitus
10.1016/j.abb.2017.12.001 · 2018 · External reference
Naringin prevents bone damage in the experimental metabolic syndrome induced by a fructose-rich diet
10.1139/apnm-2021-0473 · 2022 · External reference
The combined treatment of insulin and naringin improves bone properties in rats with type 1 diabetes mellitus
10.1139/apnm-2023-0267 · 2024 · External reference
Disuse osteoporosis: clinical and mechanistic insights
10.1007/s00223-021-00836-1 · 2022 · External reference
Cortical and trabecular bone microarchitecture as an independent predictor of incident fracture risk in older women and men in the bone microarchitecture international consortium (BoMIC): a prospective study
10.1016/s2213-8587(18)30308-5 · 2019 · External reference
Naringin inhibits vascular endothelial cell apoptosis via endoplasmic reticulum stress- and mitochondrial-mediated pathways and promotes intraosseous angiogenesis in ovariectomized rats
10.3892/ijmm.2017.3160 · 2017 · External reference
Naringin exerts anti-osteoporosis effect by promoting H-type angiogenesis through HIF-1α/VEGF signaling pathway
10.3969/j.issn.1006-7108.2022.12.008 · 2022 · External reference
The global burden of osteoporosis, low bone mass, and its related fracture in 204 countries and territories, 1990-2019
10.3389/fendo.2022.882241 · 2022 · External reference
Drynaria naringin alleviated mechanical stress deficiency-caused bone loss deterioration via Rspo1/Lgr4-mediated Wnt/β-catenin signalling pathway
10.1007/s11626-023-00815-w · 2023 · External reference
Naringin promotes fracture healing through stimulation of angiogenesis by regulating the VEGF/VEGFR-2 signaling pathway in osteoporotic rats
10.1016/j.cbi.2016.10.020 · 2017 · External reference
Naringin and naringenin: their mechanisms of action and the potential anticancer activities
10.3390/biomedicines10071686 · 2022 · External reference
Effect of combined treatment of naringin and treadmill exercise on ovariectomized osteoporosis rats
10.3969/j.issn.1674-2591.2014.04.007 · 2014 · External reference
The effects of combined treatment with naringin and treadmill exercise on osteoporosis in ovariectomized rats
10.1038/srep13009 · 2015 · External reference
Stimulation of Wnt/β-catenin signaling to improve bone development by naringin via interacting with AMPK and akt
10.1159/000430319 · 2015 · External reference
Naringin promotes osteogenesis and ameliorates osteoporosis development by targeting JAK2/STAT3 signalling
10.1111/1440-1681.13591 · 2022 · External reference
Exploring the effects of naringin on oxidative stress-impaired osteogenic differentiation via the Wnt/β-catenin and PI3K/Akt pathways
10.1038/s41598-024-64952-2 · 2024 · External reference
Pharmacokinetic comparisons of naringenin and naringenin-nicotinamide cocrystal in rats by LC-MS/MS
10.1155/2020/8364218 · 2020 · External reference
Traditional Chinese medicine for osteoporosis management: from molecular mechanisms to drug discovery
10.1186/s13020-026-01353-9 · 2026 · External reference
Re-appraising the potential of naringin for natural, novel orthopedic biotherapies
10.1177/1759720x20966135 · 2020 · External reference
Pharmacokinetics and metabolism of naringin and active metabolite naringenin in rats, dogs, humans, and the differences between species
10.3389/fphar.2020.00447 · 2020 · External reference
Mechanism of naringin in ameliorating lipid-bone metabolism disorders in postmenopausal osteoporotic rats via activation of FXR/FGF19 pathway
10.19540/j.cnki.cjcmm.20250908.401 · 2025 · External reference
Effect of naringin treatment on postmenopausal osteoporosis in ovariectomized rats: a meta-analysis and systematic review
10.1155/2021/6016874 · 2021 · External reference
Multiarm studies and how to handle them in a meta-analysis: a tutorial
10.1002/cesm.12033 · ExternalCitation · doi-reference
Guidelines for assessment of bone microstructure in rodents using micro-computed tomography
10.1002/jbmr.141 · ExternalCitation · doi-reference
Disuse osteoporosis: clinical and mechanistic insights
10.1007/s00223-021-00836-1 · ExternalCitation · doi-reference
Naringin promotes osteoblast differentiation and effectively reverses ovariectomy-associated osteoporosis
10.1007/s00776-013-0362-9 · ExternalCitation · doi-reference
Drynaria naringin alleviated mechanical stress deficiency-caused bone loss deterioration via Rspo1/Lgr4-mediated Wnt/β-catenin signalling pathway
10.1007/s11626-023-00815-w · ExternalCitation · doi-reference
Naringin prevents bone loss in a rat model of type 1 diabetes mellitus
10.1016/j.abb.2017.12.001 · ExternalCitation · doi-reference
Naringin protects against bone loss in steroid-treated inflammatory bowel disease in a rat model
10.1016/j.abb.2018.05.011 · ExternalCitation · doi-reference
Naringin prevents ovariectomy-induced osteoporosis and promotes osteoclasts apoptosis through the mitochondria-mediated apoptosis pathway
10.1016/j.bbrc.2014.08.117 · ExternalCitation · doi-reference
Involvement of periostin-sclerostin-Wnt/β-catenin signaling pathway in the prevention of neurectomy-induced bone loss by naringin
10.1016/j.bbrc.2015.10.152 · ExternalCitation · doi-reference
Effect of flavonoids from rhizoma drynariae on osteoporosis rats and osteocytes
10.1016/j.biopha.2022.113379 · ExternalCitation · doi-reference
Naringin promotes fracture healing through stimulation of angiogenesis by regulating the VEGF/VEGFR-2 signaling pathway in osteoporotic rats
10.1016/j.cbi.2016.10.020 · ExternalCitation · doi-reference
Analytical considerations and plans to standardize or harmonize assays for the reference bone turnover markers PINP and β-CTX in blood
10.1016/j.cca.2020.12.023 · ExternalCitation · doi-reference
Current use of bone turnover markers in the management of osteoporosis
10.1016/j.clinbiochem.2022.09.002 · ExternalCitation · doi-reference
High-dose short-term administration of naringin did not alter talinolol pharmacokinetics in humans
10.1016/j.ejps.2014.12.001 · ExternalCitation · doi-reference
Naringin abrogates osteoclastogenesis and bone resorption via the inhibition of RANKL-induced NF-kappaB and ERK activation
10.1016/j.febslet.2011.07.046 · ExternalCitation · doi-reference
Double directional adjusting estrogenic effect of naringin from Rhizoma drynariae (Gusuibu)
10.1016/j.jep.2011.09.034 · ExternalCitation · doi-reference
Naringin inhibits the osteoblast-osteoclast pyroptosis cascade reaction mediated by accumulated bone marrow adipose tissue in the treatment of postmenopausal osteoporosis
10.1016/j.jot.2025.09.004 · ExternalCitation · doi-reference
Drug therapy for osteoporosis in older adults
10.1016/s0140-6736(21)02646-5 · ExternalCitation · doi-reference
Use of bone turnover markers in postmenopausal osteoporosis
10.1016/s2213-8587(17)30184-5 · ExternalCitation · doi-reference
Cortical and trabecular bone microarchitecture as an independent predictor of incident fracture risk in older women and men in the bone microarchitecture international consortium (BoMIC): a prospective study
10.1016/s2213-8587(18)30308-5 · ExternalCitation · doi-reference
Global epidemiology and burden of osteoporosis among postmenopausal women: insights from the global burden of disease study 2021
10.1038/s41514-025-00269-2 · ExternalCitation · doi-reference
Exploring the effects of naringin on oxidative stress-impaired osteogenic differentiation via the Wnt/β-catenin and PI3K/Akt pathways
10.1038/s41598-024-64952-2 · ExternalCitation · doi-reference
Naringin promotes osteoblast differentiation and ameliorates osteoporosis in ovariectomized mice
10.1038/s41598-025-97217-7 · ExternalCitation · doi-reference
Pharmacokinetics of the citrus flavanone aglycones hesperetin and naringenin after single oral administration in human subjects
10.1038/sj.ejcn.1602543 · ExternalCitation · doi-reference
The effects of combined treatment with naringin and treadmill exercise on osteoporosis in ovariectomized rats
10.1038/srep13009 · ExternalCitation · doi-reference
Naringin ameliorates bone loss induced by sciatic neurectomy and increases semaphorin 3A expression in denervated bone
10.1038/srep24562 · ExternalCitation · doi-reference
Multiplicity corrections in life sciences: challenges and consequences
10.1093/ije/dyaf098 · ExternalCitation · doi-reference
Naringin promotes osteogenesis and ameliorates osteoporosis development by targeting JAK2/STAT3 signalling
10.1111/1440-1681.13591 · ExternalCitation · doi-reference
Naringin improves bone properties in ovariectomized mice and exerts oestrogen-like activities in rat osteoblast-like (UMR-106) cells
10.1111/j.1476-5381.2010.00664.x · ExternalCitation · doi-reference
Interpretation of random effects meta-analyses
10.1136/bmj.d549 · ExternalCitation · doi-reference
Naringin prevents bone damage in the experimental metabolic syndrome induced by a fructose-rich diet
10.1139/apnm-2021-0473 · ExternalCitation · doi-reference
The combined treatment of insulin and naringin improves bone properties in rats with type 1 diabetes mellitus
10.1139/apnm-2023-0267 · ExternalCitation · doi-reference
Pharmacokinetic comparisons of naringenin and naringenin-nicotinamide cocrystal in rats by LC-MS/MS
10.1155/2020/8364218 · ExternalCitation · doi-reference
Effect of naringin treatment on postmenopausal osteoporosis in ovariectomized rats: a meta-analysis and systematic review
10.1155/2021/6016874 · ExternalCitation · doi-reference
Stimulation of Wnt/β-catenin signaling to improve bone development by naringin via interacting with AMPK and akt
10.1159/000430319 · ExternalCitation · doi-reference
Re-appraising the potential of naringin for natural, novel orthopedic biotherapies
10.1177/1759720x20966135 · ExternalCitation · doi-reference
Traditional Chinese medicine for osteoporosis management: from molecular mechanisms to drug discovery
10.1186/s13020-026-01353-9 · ExternalCitation · doi-reference
Pharmacological management of osteoporosis in postmenopausal women: an endocrine society clinical practice guideline
10.1210/jc.2019-00221 · ExternalCitation · doi-reference
Naringin inhibits iron deposition and cell apoptosis in bone tissue of osteoporotic rats
10.12307/2024.593 · ExternalCitation · doi-reference
Facilitating healthcare decisions by assessing the certainty in the evidence from preclinical animal studies
10.1371/journal.pone.0187271 · ExternalCitation · doi-reference
Mechanism of naringin in ameliorating lipid-bone metabolism disorders in postmenopausal osteoporotic rats via activation of FXR/FGF19 pathway
10.19540/j.cnki.cjcmm.20250908.401 · ExternalCitation · doi-reference
pH-responsive mesoporous silica nanoparticles loaded with naringin for targeted osteoclast inhibition and bone regeneration
10.2147/ijn.s456545 · ExternalCitation · doi-reference
Importance of systematic reviews and meta-analyses of animal studies: challenges for animal-to-human translation
10.30802/aalas-jaalas-19-000139 · ExternalCitation · doi-reference
The global burden of osteoporosis, low bone mass, and its related fracture in 204 countries and territories, 1990-2019
10.3389/fendo.2022.882241 · ExternalCitation · doi-reference
Pharmacokinetics and metabolism of naringin and active metabolite naringenin in rats, dogs, humans, and the differences between species
10.3389/fphar.2020.00447 · ExternalCitation · doi-reference
Naringin and naringenin: their mechanisms of action and the potential anticancer activities
10.3390/biomedicines10071686 · ExternalCitation · doi-reference
Osteoporosis due to hormone imbalance: an overview of the effects of estrogen deficiency and glucocorticoid overuse on bone turnover
10.3390/ijms23031376 · ExternalCitation · doi-reference
Denosumab discontinuation and the rebound phenomenon: a narrative review
10.3390/jcm10010152 · ExternalCitation · doi-reference
Simultaneously quantitative analysis of naringin and its major human gut microbial metabolites naringenin and 3-(4′-hydroxyphenyl) propanoic acid via stable isotope deuterium-labeling coupled with RRLC-MS/MS method
10.3390/molecules24234287 · ExternalCitation · doi-reference
The development of naringin for use against bone and cartilage disorders
10.3390/molecules28093716 · ExternalCitation · doi-reference
Polyphenols and bone health: a comprehensive review of their role in osteoporosis prevention and treatment
10.3390/molecules30214154 · ExternalCitation · doi-reference
Stimulation of Wnt/β-catenin signaling pathway is involved in the effect of naringin on the prevention of disuse osteoporosis
10.3760/cma.j.issn.0253-2352.2016.08.006 · ExternalCitation · doi-reference
Naringin inhibits vascular endothelial cell apoptosis via endoplasmic reticulum stress- and mitochondrial-mediated pathways and promotes intraosseous angiogenesis in ovariectomized rats
10.3892/ijmm.2017.3160 · ExternalCitation · doi-reference
Naringin exerts anti-osteoporosis effect by promoting H-type angiogenesis through HIF-1α/VEGF signaling pathway
10.3969/j.issn.1006-7108.2022.12.008 · ExternalCitation · doi-reference
Effect of combined treatment of naringin and treadmill exercise on ovariectomized osteoporosis rats
10.3969/j.issn.1674-2591.2014.04.007 · ExternalCitation · doi-reference
A simple practice guide for dose conversion between animals and human
10.4103/0976-0105.177703 · ExternalCitation · doi-reference
Osteonecrosis of the jaw and concomitant atypical femoral fractures with bisphosphonates: a comprehensive literature review
10.7759/cureus.5113 · ExternalCitation · doi-reference
