References

S-ketamine alleviates neuroinflammation and attenuates lipopolysaccharide-induced depression via targeting SIRT2

10.1002/advs.202416481 · ExternalCitation · doi-reference

The combination of Astragalus membranaceus and ligustrazine mitigates cerebral ischemia-reperfusion injury via regulating NR2B-ERK/CREB signaling

10.1002/brb3.2867 · ExternalCitation · doi-reference

S(+)-ketamine: current trends in emergency and intensive care medicine

10.1007/s00508-017-1299-3 · ExternalCitation · doi-reference

Ketamine exerts dual effects on the apoptosis of primary cultured hippocampal neurons from fetal rats in vitro

10.1007/s11011-023-01236-0 · ExternalCitation · doi-reference

Ketamine in the past, present, and future: mechanisms, metabolites, and toxicity

10.1007/s11916-021-00977-w · ExternalCitation · doi-reference

Esketamine prevents postoperative emotional and cognitive dysfunction by suppressing microglial M1 polarization and regulating the BDNF-TrkB pathway in ageing rats with preoperative sleep disturbance

10.1007/s12035-023-03860-4 · ExternalCitation · doi-reference

Phytochemicals with potential NMDAR-inhibitory activities: a review of neuroprotective mechanisms against excitotoxicity

10.1007/s44446-026-00101-2 · ExternalCitation · doi-reference

S-ketamine ameliorates post-stroke depression in mice via attenuation of neuroinflammation, synaptic restoration, and BDNF pathway activation

10.1016/j.bbrc.2025.151965 · ExternalCitation · doi-reference

Bifunctional modulation of NMDA and opioid receptors in ketamine reinforcement and misuse: implications for substance use disorder treatment

10.1016/j.biopsych.2025.11.021 · ExternalCitation · doi-reference

Comparative effects of dexmedetomidine, propofol, sevoflurane, and S-ketamine on regional cerebral glucose metabolism in humans: a positron emission tomography study

10.1016/j.bja.2018.04.008 · ExternalCitation · doi-reference

Stereoselective ketamine effect on cardiac output: a population pharmacokinetic/pharmacodynamic modelling study in healthy volunteers

10.1016/j.bja.2021.02.034 · ExternalCitation · doi-reference

Circulating oxylipin and bile acid profiles of dexmedetomidine, propofol, sevoflurane, and S-ketamine: a randomised controlled trial using tandem mass spectrometry

10.1016/j.bjao.2022.100114 · ExternalCitation · doi-reference

Esketamine alleviates postoperative cognitive decline via stimulator of interferon genes/TANK-binding kinase 1 signaling pathway in aged rats

10.1016/j.brainresbull.2022.07.004 · ExternalCitation · doi-reference

Esketamine improves cognitive function in sepsis-associated encephalopathy by inhibiting microglia-mediated neuroinflammation

10.1016/j.ejphar.2024.177014 · ExternalCitation · doi-reference

Effect of esketamine pretreatment on acute sepsis-associated encephalopathy

10.1016/j.expneurol.2023.114646 · ExternalCitation · doi-reference

Ketamine induced gut microbiota dysbiosis and barrier and hippocampal dysfunction in rats

10.1016/j.isci.2024.111089 · ExternalCitation · doi-reference

Efficacy and safety of adjunctive therapy using esketamine or racemic ketamine for adult treatment-resistant depression: a randomized, double-blind, non-inferiority study

10.1016/j.jad.2019.11.086 · ExternalCitation · doi-reference

Comparative effectiveness and safety of esketamine versus injectable racemic ketamine and oral antidepressants for major depressive disorder: a population-based target trial emulation

10.1016/j.jad.2026.121487 · ExternalCitation · doi-reference

Perioperative intravenous S-ketamine for acute postoperative pain in adults: a systematic review and meta-analysis

10.1016/j.jclinane.2020.110071 · ExternalCitation · doi-reference

The abuse liability of ketamine: a scoping review of preclinical and clinical studies

10.1016/j.jpsychires.2022.04.035 · ExternalCitation · doi-reference

Subanesthetic dose of S-ketamine improved cognitive dysfunction via the inhibition of hippocampal astrocytosis in a mouse model of post-stroke chronic stress

10.1016/j.jpsychires.2022.12.010 · ExternalCitation · doi-reference

CYP 450 enzymes influence (R,S)-ketamine brain delivery and its antidepressant activity

10.1016/j.neuropharm.2021.108936 · ExternalCitation · doi-reference

S-ketamine alleviates morphine-induced hyperalgesia via decreasing the gut enterobacteriaceae levels: comparison with R-ketamine

10.1016/j.neuroscience.2025.01.022 · ExternalCitation · doi-reference

Low-dose S-ketamine exerts antidepressant-like effects via enhanced hippocampal synaptic plasticity in postpartum depression rats

10.1016/j.ynstr.2021.100422 · ExternalCitation · doi-reference

Molecular mechanisms underlying the antidepressant actions of arketamine: beyond the NMDA receptor

10.1038/s41380-021-01121-1 · ExternalCitation · doi-reference

Microglial ERK-NRBP1-CREB-BDNF signaling in sustained antidepressant actions of (R)-ketamine

10.1038/s41380-021-01377-7 · ExternalCitation · doi-reference

Pleiotropic modulation of the gut-brain-lung axis by ketamine and its enantiomers

10.1038/s41380-026-03590-8 · ExternalCitation · doi-reference

Balanced opioid-free anesthesia with lidocaine and esketamine versus balanced anesthesia with sufentanil for gynecological endoscopic surgery: a randomized controlled trial

10.1038/s41598-024-62824-3 · ExternalCitation · doi-reference

Astrocytic EAAT1 suppression by EV-ACLY underlies glutamate imbalance and cognitive impairment in POCD

10.1038/s42003-026-09888-1 · ExternalCitation · doi-reference

R-ketamine: a rapid-onset and sustained antidepressant without psychotomimetic side effects

10.1038/tp.2015.136 · ExternalCitation · doi-reference

Effect of esketamine on postoperative delirium and inflammatory response in patients undergoing off-pump coronary artery bypass grafting: a randomized controlled study

10.1053/j.jvca.2025.04.013 · ExternalCitation · doi-reference

Key considerations for the use of ketamine and esketamine for the treatment of depression: focusing on administration, safety, and tolerability

10.1080/14740338.2022.2069749 · ExternalCitation · doi-reference

Metabolism and metabolomics of ketamine: a toxicological approach

10.1080/20961790.2017.1285219 · ExternalCitation · doi-reference

Effect of S-Ketamine on postoperative delirium in elderly patients undergoing arthroplasty: a randomized controlled trial

10.1097/aln.0000000000005800 · ExternalCitation · doi-reference

Pharmacogenetic and drug interaction aspects on ketamine safety in its use as antidepressant - implications for precision dosing in a global perspective

10.1111/bcp.15467 · ExternalCitation · doi-reference

Neuroprotective effects of esketamine in central nervous system disorders: mechanisms and cellular targets

10.1111/bcpt.70221 · ExternalCitation · doi-reference

Ketamine use: a review

10.1111/j.1360-0443.2011.03576.x · ExternalCitation · doi-reference

Surgical stress and non-surgery related stress synergistically trigger meningeal CD8(+) T cells accumulation and subsequent brain dysfunction in mice

10.1111/jnc.70043 · ExternalCitation · doi-reference

Use of ketamine and esketamine in the pediatric population: current evidence and clinical applications

10.1176/appi.focus.20250040 · ExternalCitation · doi-reference

Evaluating the abuse liability of ketamine in the treatment of mood disorders: a systematic review

10.1177/02698811261453814 · ExternalCitation · doi-reference

Esketamine alleviates depressive-like behavior in mice via modulation of the microbiota-gut-brain axis and amino acid metabolism

10.1186/s12866-025-04181-3 · ExternalCitation · doi-reference

Determining the effective dose of esketamine for mitigating pain during propofol injection by Dixon's up-and-down method: a double-blind, prospective clinical study of drug dose response

10.1186/s12871-022-01914-z · ExternalCitation · doi-reference

General anesthesia with S-ketamine improves the early recovery and cognitive function in patients undergoing modified radical mastectomy: a prospective randomized controlled trial

10.1186/s12871-023-02161-6 · ExternalCitation · doi-reference

Esketamine and neurocognitive disorders in adult surgical patients: a meta-analysis

10.1186/s12871-024-02803-3 · ExternalCitation · doi-reference

Effect of esketamine on postoperative delirium in general anesthesia patients undergoing elective surgery: a meta-analysis of randomized controlled trials

10.1186/s12871-024-02833-x · ExternalCitation · doi-reference

Effect of perioperative esketamine administration on the incidence of postoperative delirium: a systematic review and meta-analysis

10.1186/s12871-026-03785-0 · ExternalCitation · doi-reference

Patient-reported side effects and satisfaction of pre-hospital analgesia with low-dose esketamine: a cross-sectional study

10.1186/s12873-023-00898-4 · ExternalCitation · doi-reference

The influence of low-dose s-ketamine on postoperative delirium and cognitive function in older adults undergoing thoracic surgery

10.1186/s13019-024-02811-x · ExternalCitation · doi-reference

Efficacy and safety of esketamine in preventing perioperative neurocognitive disorders: a meta-analysis of randomized controlled studies

10.1186/s13643-025-02807-1 · ExternalCitation · doi-reference

Effect of subclinical esketamine on NLRP3 and cognitive dysfunction in elderly ischemic stroke patients

10.1515/med-2025-1193 · ExternalCitation · doi-reference

Pharmacokinetics and safety of esketamine in Chinese patients undergoing painless gastroscopy in comparison with ketamine: a randomized, open-label clinical study

10.2147/dddt.s224553 · ExternalCitation · doi-reference

Effect of subanesthetic dose of esketamine on perioperative neurocognitive disorders in elderly undergoing gastrointestinal surgery: a randomized controlled trial

10.2147/dddt.s401161 · ExternalCitation · doi-reference

Effect of S-Ketamine on postoperative nausea and vomiting in patients undergoing video-assisted thoracic surgery: a randomized controlled trial

10.2147/dddt.s449705 · ExternalCitation · doi-reference

Esketamine at a clinical dose attenuates cerebral ischemia/reperfusion injury by inhibiting AKT signaling pathway to facilitate microglia M2 polarization and autophagy

10.2147/dddt.s504179 · ExternalCitation · doi-reference

Progress in the application of esketamine during the perioperative period

10.2147/dddt.s579462 · ExternalCitation · doi-reference

N-Methyl-D-Aspartate (NMDA) receptor antagonists and their pharmacological implication: a medicinal chemistry-oriented perspective outline

10.2174/0109298673288031240405061759 · ExternalCitation · doi-reference

Effects of esketamine on postoperative pain and inflammatory factors in children undergoing tonsillectomy and adenoidectomy

10.23736/s0375-9393.24.18277-6 · ExternalCitation · doi-reference

Modulation of peripheral CD4(+)CD25(+)Foxp3(+) regulatory T cells ameliorates surgical stress-induced atherosclerotic plaque progression in ApoE-Deficient mice

10.3389/fcvm.2021.682458 · ExternalCitation · doi-reference

Cefazolin improves anesthesia and surgery-induced cognitive impairments by modulating blood-brain barrier function, gut bacteria and short chain fatty acids

10.3389/fnagi.2021.748637 · ExternalCitation · doi-reference

Evaluating the effects of S-ketamine on postoperative delirium in elderly patients following total hip or knee arthroplasty under intraspinal anesthesia: a single-center randomized, double-blind, placebo-controlled, pragmatic study protocol

10.3389/fnagi.2023.1298661 · ExternalCitation · doi-reference

Esketamine ameliorates postoperative cognitive dysfunction aggravated by preoperative acute sleep deprivation in aged mice via the TLR4/NF-kappaB pathway

10.3389/fnagi.2026.1798915 · ExternalCitation · doi-reference

Intravenous lidocaine and ketamine infusions for headache disorders: a retrospective cohort study

10.3389/fneur.2022.842082 · ExternalCitation · doi-reference

S-ketamine plus dexmedetomidine vs. S-ketamine plus propofol for sedation-analgesia during positioning for spinal anesthesia in older adults undergoing lower extremity fracture surgery

10.3389/fneur.2026.1706118 · ExternalCitation · doi-reference

A single low dose of dexmedetomidine efficiently attenuates esketamine-induced overactive behaviors and neuronal hyperactivities in mice

10.3389/fnhum.2021.735569 · ExternalCitation · doi-reference

Recent advances in the study of anesthesia-and analgesia-related mechanisms of S-ketamine

10.3389/fphar.2023.1228895 · ExternalCitation · doi-reference

Comparing the adverse effects of ketamine and esketamine between genders using FAERS data

10.3389/fphar.2024.1329436 · ExternalCitation · doi-reference

Neurotoxicity mechanisms and clinical implications of six common recreational drugs

10.3389/fphar.2025.1526270 · ExternalCitation · doi-reference

S-ketamine facilitates motor function recovery after brachial plexus root avulsion and reimplantation in mice

10.3389/fphar.2025.1630158 · ExternalCitation · doi-reference

Ketamine, esketamine, and arketamine: their mechanisms of action and applications in the treatment of depression and alleviation of depressive symptoms

10.3390/biomedicines12102283 · ExternalCitation · doi-reference

Modulation of metabotropic glutamate receptors as a strategy to improve the efficacy and safety of ketamine as an antidepressant

10.3390/cells14241967 · ExternalCitation · doi-reference

Biochemical changes in cardiopulmonary bypass in cardiac surgery: new insights

10.3390/jpm13101506 · ExternalCitation · doi-reference

Gut microbiome-derived short-chain fatty acids in glomerular protection and modulation of chronic kidney disease progression

10.3390/nu17172904 · ExternalCitation · doi-reference

General anesthesia in psychiatric patients undergoing orthopedic surgery: a mechanistic narrative review-when the brain is unstable, keep it awake

10.3390/reports8040263 · ExternalCitation · doi-reference

Electroacupuncture relieves postoperative cognitive dysfunction in elderly rats via regulating amp-activated protein kinase autophagy signaling

10.4103/cjp.cjp_108_21 · ExternalCitation · doi-reference

Effects of esketamine on postoperative cognitive function in elderly patients undergoing pulmonary lobectomy: a randomised, single-blind controlled clinical trial

10.62641/aep.v53i6.2044 · ExternalCitation · doi-reference