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References from Circadian rhythm in platelet: an emerging therapeutic target in human diseases. Local targets link to admitted publications; unresolved targets remain external evidence.
Multiple sclerosis: Melatonin, orexin, and ceramide interact with platelet activation coagulation factors and gut-microbiome-derived butyrate in the circadian dysregulation of mitochondria in glia and immune cells
10.3390/ijms20215500 · 2019 · External reference
Circadian time signatures of fitness and disease
10.1126/science.aah4965 · 2016 · External reference
Chronobiome medicine: circadian regulation of host-microbiota crosstalk in systemic physiology
10.3389/fendo.2025.1691172 · 2025 · External reference
Bidirectional interactions between circadian rhythms and the gut microbiome
10.1007/s00253-025-13570-7 · 2025 · External reference
Peripheral clocks and systemic zeitgeber interactions: from molecular mechanisms to circadian precision medicine
10.3389/fendo.2025.1606242 · 2025 · External reference
Tasimelteon (Hetlioz): a new melatonin receptor agonist for the treatment of non-24-hour sleep-wake disorder
10.1177/0897190014544792 · 2015 · External reference
Effect of aspirin intake at bedtime versus on awakening on circadian rhythm of platelet reactivity. A randomised cross-over trial
10.1160/th14-05-0453 · 2014 · External reference
Effects of aspirin for primary prevention in persons with diabetes mellitus
10.1016/j.jvs.2018.10.072 · 2018 · External reference
The circadian rhythm of selected parameters of the hemostasis system in healthy people
10.1016/j.thromres.2019.08.015 · 2019 · External reference
Mop3 is an essential component of the master circadian pacemaker in mammals
10.1016/s0092-8674(00)00205-1 · 2000 · External reference
Circadian rhythm of cardiovascular disease: the potential of chronotherapy with aspirin
10.3389/fcvm.2019.00084 · 2019 · External reference
Global, regional, and national burden of disorders affecting the nervous system, 1990-2021: a systematic analysis for the Global Burden of Disease Study 2021
10.1016/s1474-4422(24)00038-3 · 2024 · External reference
A circadian clock in the sinus node mediates day-night rhythms in Hcn4 and heart rate
10.1016/j.hrthm.2020.11.026 · 2021 · External reference
Tasimelteon: first global approval
10.1007/s40265-014-0200-1 · 2014 · External reference
SR9009 has REV-ERB-independent effects on cell proliferation and metabolism
10.1073/pnas.1904226116 · 2019 · External reference
The modulatory role of short-chain fatty acids on peripheral circadian gene expression: a systematic review
10.3389/fphys.2025.1595057 · 2025 · External reference
The definition and prevalence of obesity and metabolic syndrome
10.1007/978-3-319-48382-5_1 · 2017 · External reference
Author correction: Potential circadian effects on translational failure for neuroprotection
10.1038/s41586-020-2427-1 · 2020 · External reference
Metabolic syndrome: Updates on pathophysiology and management in 2021
10.3390/ijms23020786 · 2022 · External reference
Histone deacetylase inhibition by gut microbe-generated short-chain fatty acids entrains intestinal epithelial circadian rhythms
10.1053/j.gastro.2022.07.051 · 2022 · External reference
World Stroke Organization (WSO): Global stroke fact sheet 2022
10.1177/17474930211065917 · 2022 · External reference
Circadian variation of platelet function measured with the PFA-100
10.3109/09537100903226034 · 2009 · External reference
Tissue-specificity of antibodies raised against TrkB and p75(NTR) receptors; implications for platelets as models of neurodegenerative diseases
10.3389/fimmu.2021.606861 · 2021 · External reference
Microglia inflammatory responses are controlled by an intrinsic circadian clock
10.1016/j.bbi.2014.11.009 · 2015 · External reference
Platelets at the interface of thrombosis, inflammation, and cancer
10.1182/blood-2014-08-531582 · 2015 · External reference
Mediators of host-microbe circadian rhythms in immunity and metabolism
10.3390/biology9120417 · 2020 · External reference
Disrupted rhythms, disrupted microbes: a systematic review of shift work and gut microbiota alterations
10.3390/nu17172894 · 2025 · External reference
The meter of metabolism
10.1016/j.cell.2008.08.022 · 2008 · External reference
Differential control of Bmal1 circadian transcription by REV-ERB and ROR nuclear receptors
10.1177/0748730405277232 · 2005 · External reference
Food-entrained rhythmic expression of PER2 and BMAL1 in murine megakaryocytes does not correlate with circadian rhythms in megakaryopoiesis
10.1111/j.1538-7836.2008.02978.x · 2008 · External reference
Generation of circadian rhythms in the suprachiasmatic nucleus
10.1038/s41583-018-0026-z · 2018 · External reference
N-methyl-D-aspartate receptor regulates the circadian clock in megakaryocytic cells and impacts cell proliferation through BMAL1
10.1080/09537104.2023.2206918 · 2023 · External reference
Aspirin administered at bedtime, but not on awakening, has an effect on ambulatory blood pressure in hypertensive patients
10.1016/j.jacc.2004.08.071 · 2005 · External reference
Chronotherapy in hypertensive patients: administration-time dependent effects of treatment on blood pressure regulation
10.1586/14779072.5.3.463 · 2007 · External reference
Novel melatonin-based therapies: potential advances in the treatment of major depression
10.1016/s0140-6736(11)60095-0 · 2011 · External reference
The aging clock: circadian rhythms and later life
10.1172/jci90328 · 2017 · External reference
Arterial thrombosis--insidious, unpredictable and deadly
10.1038/nm.2515 · 2011 · External reference
Convergence of melatonin and serotonin (5-HT) signaling at MT2/5-HT2C receptor heteromers
10.1074/jbc.m114.559542 · 2015 · External reference
Efficacy of the novel antidepressant agomelatine on the circadian rest-activity cycle and depressive and anxiety symptoms in patients with major depressive disorder: a randomized, double-blind comparison with sertraline
10.4088/jcp.09m05347blu · 2010 · External reference
Neurochemical properties of ramelteon (TAK-375), a selective MT1/MT2 receptor agonist
10.1016/j.neuropharm.2004.09.007 · 2005 · External reference
Modeling and validating chronic pharmacological manipulation of circadian rhythms
10.1038/psp.2013.34 · 2013 · External reference
Positional cloning of the mouse circadian clock gene
10.1016/s0092-8674(00)80245-7 · 1997 · External reference
Molecular components of the mammalian circadian clock
10.1093/hmg/ddl207 · 2006 · External reference
High-fat diet disrupts behavioral and molecular circadian rhythms in mice
10.1016/j.cmet.2007.09.006 · 2007 · External reference
REV-ERB and ROR nuclear receptors as drug targets
10.1038/nrd4100 · 2014 · External reference
Circulating platelets as mediators of immunity, inflammation, and thrombosis
10.1161/circresaha.117.310795 · 2018 · External reference
Effects of gut microbial metabolite trimethylamine N-oxide (TMAO) on platelets and endothelial cells
10.3233/ch-209206 · 2020 · External reference
Tasimelteon: a selective and unique receptor binding profile
10.1016/j.neuropharm.2014.12.004 · 2015 · External reference
Circadian rhythms in ischaemic heart disease: key aspects for preclinical and translational research: position paper of the ESC working group on cellular biology of the heart
10.1093/cvr/cvab293 · 2022 · External reference
Safety profile of tasimelteon, a melatonin MT1 and MT2 receptor agonist: pooled safety analyses from six clinical studies
10.1517/14740338.2015.1093112 · 2015 · External reference
Platelets in neurodegenerative conditions-friend or foe
10.3389/fimmu.2020.00747 · 2020 · External reference
Effects of diurnal variation of gut microbes and high-fat feeding on host circadian clock function and metabolism
10.1016/j.chom.2015.03.006 · 2015 · External reference
A review of preliminary observations on agomelatine in the treatment of anxiety disorders
10.1037/a0030263 · 2012 · External reference
Effects of serotonin on platelet activation in whole blood
10.1097/00001721-199711000-00006 · 1997 · External reference
Rhythmicity of the intestinal microbiota is regulated by gender and the host circadian clock
10.1073/pnas.1501305112 · 2015 · External reference
Research progress on the correlation between biological rhythms and the blood-brain barrier after ischemic stroke
10.3389/fneur.2025.1627172 · 2025 · External reference
Tasimelteon for non-24-hour sleep-wake disorder in totally blind people (SET and RESET): two multicentre, randomised, double-masked, placebo-controlled phase 3 trials
10.1016/s0140-6736(15)60031-9 · 2015 · External reference
Role of circadian clock in the chronoefficacy and chronotoxicity of clopidogrel
10.1111/bph.16188 · 2023 · External reference
From the editors: New insights into lipid disorders in children and adolescents as well as cardiovascular benefits of pharmacotherapy for weight loss
10.1016/j.jacl.2024.01.008 · 2024 · External reference
Circadian rhythms and metabolic syndrome: from experimental genetics to human disease
10.1161/circresaha.109.208355 · 2010 · External reference
Agomelatine in the treatment of mild-to-moderate depression in patients with cardiovascular disease: results of the national multicenter observational study PULSE
10.2147/ndt.s129793 · 2017 · External reference
Entrainment of disrupted circadian behavior through inhibition of casein kinase 1 (CK1) enzymes
10.1073/pnas.1005101107 · 2010 · External reference
Circadian variation of blood-pressure
10.1016/s0140-6736(78)92998-7 · 1978 · External reference
New hypnotics ramelteon for the treatment of insomniacs with circadian rhythm disturbance
2012 · External reference
Pharmacology of ramelteon, a selective MT1/MT2 receptor agonist: a novel therapeutic drug for sleep disorders
10.1111/j.1755-5949.2008.00066.x · 2009 · External reference
The impact of the circadian timing system on cardiovascular and metabolic function
10.1016/b978-0-444-59427-3.00019-8 · 2012 · External reference
Proteostasis failure exacerbates neuronal circuit dysfunction and sleep impairments in Alzheimer's disease
10.1186/s13024-023-00617-4 · 2023 · External reference
Circadian variation in the frequency of onset of acute myocardial infarction
10.1056/nejm198511213132103 · 1985 · External reference
Circadian variation and triggers of onset of acute cardiovascular disease
10.1159/000177040 · 1989 · External reference
Mechanisms linking circadian clocks, sleep, and neurodegeneration
10.1126/science.aah4968 · 2016 · External reference
Acetylsalicylic acid dosed at bedtime vs. dosed in the morning for circadian rhythm of blood pressure- a systematic review and meta-analysis
10.3389/fcvm.2024.1346265 · 2024 · External reference
Circadian rhythm dysfunction in neurodegenerative diseases: A bidirectional perspective and therapeutic potential
10.2147/nss.s561326 · 2025 · External reference
Tasimelteon for treating non-24-h sleep-wake rhythm disorder
10.1080/14656566.2019.1603293 · 2019 · External reference
Worldwide trends in metabolic syndrome from 2000 to 2023: a systematic review and modelling analysis
10.1038/s41467-025-67268-5 · 2025 · External reference
The functional and clinical significance of the 24-hour rhythm of circulating glucocorticoids
10.1210/er.2015-1080 · 2017 · External reference
The physiological period length of the human circadian clock in vivo is directly proportional to period in human fibroblasts
10.1371/journal.pone.0013376 · 2010 · External reference
Circadian physiology of metabolism
10.1126/science.aah4967 · 2016 · External reference
Coordinated transcription of key pathways in the mouse by the circadian clock
10.1016/s0092-8674(02)00722-5 · 2002 · External reference
Pharmacotherapy of insomnia with ramelteon: safety, efficacy and clinical applications
10.4137/jcnsd.s1611 · 2011 · External reference
Molecular architecture of the mammalian circadian clock
10.1016/j.tcb.2013.07.002 · 2014 · External reference
Circadian regulation of glucose, lipid, and energy metabolism in humans
10.1016/j.metabol.2017.11.017 · 2018 · External reference
Circadian rhythms and cardiovascular health
10.1016/j.smrv.2011.04.003 · 2012 · External reference
The orphan nuclear receptor REV-ERBalpha controls circadian transcription within the positive limb of the mammalian circadian oscillator
10.1016/s0092-8674(02)00825-5 · 2002 · External reference
Coordination of circadian timing in mammals
10.1038/nature00965 · 2002 · External reference
Circadian phase-shifting effects of repeated ramelteon administration in healthy adults
10.5664/jcsm.27282 · 2008 · External reference
Circadian rhythm as a therapeutic target
10.1038/s41573-020-00109-w · 2021 · External reference
Platelets bridging the gap between gut dysbiosis and neuroinflammation in stress-linked disorders: A narrative review
10.1016/j.jneuroim.2023.578155 · 2023 · External reference
Endothelial dysfunction and hemostatic system activation in relation to shift workers, social jetlag, and chronotype in female nurses
10.3390/ijms26020482 · 2025 · External reference
Direct and indirect suppression of interleukin-6 gene expression in murine macrophages by nuclear orphan receptor REV-ERBalpha
10.1155/2014/685854 · 2014 · External reference
The human endogenous circadian system causes greatest platelet activation during the biological morning independent of behaviors
10.1371/journal.pone.0024549 · 2011 · External reference
Circadian disruption, clock genes, and metabolic health
10.1172/jci170998 · 2024 · External reference
Circadian nuclear receptor Rev-erbalpha is expressed by platelets and potentiates platelet activation and thrombus formation
10.1093/eurheartj/ehac544.3035 · 2022 · External reference
An effect of valdoxan on the hemostasis in patients with acute coronary syndrome in the combination with anxiety and depressive disorders
10.17116/jnevro20151152130-36 · 2015 · External reference
Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists
10.1038/nature11030 · 2012 · External reference
Deficiency in core circadian protein Bmal1 is associated with a prothrombotic and vascular phenotype
10.1002/jcp.22314 · 2011 · External reference
Inhibition of casein kinase I epsilon/delta produces phase shifts in the circadian rhythms of Cynomolgus monkeys
10.1007/s00213-009-1503-x · 2009 · External reference
Pharmacological activation of REV-ERBs is lethal in cancer and oncogene-induced senescence
10.1038/nature25170 · 2018 · External reference
Blood-brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders
10.1038/nrneurol.2017.188 · 2018 · External reference
Transcriptional architecture of the mammalian circadian clock
10.1038/nrg.2016.150 · 2017 · External reference
RORgamma directly regulates the circadian expression of clock genes and downstream targets in vivo
10.1093/nar/gks630 · 2012 · External reference
Transkingdom control of microbiota diurnal oscillations promotes metabolic homeostasis
10.1016/j.cell.2014.09.048 · 2014 · External reference
Role of the circadian system in cardiovascular disease
10.1172/jci80590 · 2018 · External reference
Concurrent morning increase in platelet aggregability and the risk of myocardial infarction and sudden cardiac death
10.1056/nejm198706113162405 · 1987 · External reference
Chrono-pharmacology-based antiplatelet therapy for acute myocardial infarction
10.1093/eurheartj/ehac120 · 2022 · External reference
An overview of the circadian clock in the frame of chronotherapy: From bench to bedside
10.3390/pharmaceutics14071424 · 2022 · External reference
Relationship between overnight neuroendocrine activity and morning haemostasis in working men
10.1042/cs20030355 · 2004 · External reference
Selective inhibition of casein kinase 1 epsilon minimally alters circadian clock period
10.1124/jpet.109.151415 · 2009 · External reference
Chronic low-dose REV-ERBs agonist SR9009 mitigates constant light-induced weight gain and insulin resistance via adipogenesis modulation
10.1016/j.bj.2025.100830 · 2025 · External reference
The clock gene Per2 is required for normal platelet formation and function
10.1016/j.thromres.2010.11.025 · 2011 · External reference
