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References from Maternal diabetes-associated neural tube defects: evidence for β-hydroxybutyrate-related HDAC1/3-H3K27ac-MEST-LRP6 dysregulation. Local targets link to admitted publications; unresolved targets remain external evidence.
CBP/p300 inhibitor C646 prevents high glucose exposure induced neuroepithelial cell proliferation
10.1002/bdr2.1360 · 2018 · External reference
Identification of novel cell survival regulation in diabetic embryopathy via phospholipidomic profiling
10.1016/j.bbrc.2016.01.098 · 2016 · External reference
The effect of folic acid deficiency on Mest/Peg1 in neural tube defects
10.1080/00207454.2020.1750386 · 2021 · External reference
beta-hydroxybutyrate alleviates depressive behaviors in mice possibly by increasing the histone3-lysine9-beta-hydroxybutyrylation
10.1016/j.bbrc.2017.05.184 · 2017 · External reference
Threshold for neural tube defect risk by accumulated singleton loss-of-function variants
10.1038/s41422-018-0061-3 · 2018 · External reference
Neural tube defects: recent advances, unsolved questions, and controversies
10.1016/s1474-4422(13)70110-8 · 2013 · External reference
Diabetes mellitus and birth defects
10.1016/j.ajog.2008.06.028 · 2008 · External reference
Modulation of cellular biochemistry, epigenetics and metabolomics by ketone bodies. Implications of the ketogenic diet in the physiology of the organism and pathological states
10.3390/nu12030788 · 2020 · External reference
LncRNA GHET1 activated by H3K27 acetylation promotes cell tumorigenesis through regulating ATF1 in hepatocellular carcinoma
10.1016/j.biopha.2017.07.046 · 2017 · External reference
Histone marks in the 'Driver's seat': functional roles in steering the transcription cycle
10.1016/j.tibs.2017.10.004 · 2017 · External reference
High glucose-repressed CITED2 expression through miR-200b triggers the unfolded protein response and endoplasmic reticulum stress
10.2337/db15-0108 · 2016 · External reference
Metabolomics analysis of human vitreous in diabetic retinopathy and rhegmatogenous retinal detachment
10.1021/acs.jproteome.8b00169 · 2018 · External reference
An update to the list of mouse mutants with neural tube closure defects and advances toward a complete genetic perspective of neural tube closure
10.1002/bdra.20676 · 2010 · External reference
β-Hydroxybutyrate as an epigenetic modifier: Underlying mechanisms and implications
2023 · External reference
A potential mechanism of DL-beta-hydroxybutyrate-induced malformations in mouse embryos
10.1152/ajpendo.1987.253.1.e72 · 1987 · External reference
Mest/Peg1 inhibits Wnt signalling through regulation of LRP6 glycosylation
10.1042/bj20101512 · 2011 · External reference
beta-hydroxybutyrate ameliorates abeta-induced downregulation of trkA expression by inhibiting HDAC1/3 in SH-SY5Y cells
10.1177/1533317519883496 · 2020 · External reference
Non-multifactorial neural tube defects
10.1002/ajmg.c.30055 · 2005 · External reference
Effect of maternal diabetes on the embryo, fetus, and children: congenital anomalies, genetic and epigenetic changes and developmental outcomes
10.1002/bdrc.21090 · 2015 · External reference
p66SHC promotes apoptosis and antagonizes mitogenic signaling in T cells
10.1128/mcb.24.4.1747-1757.2004 · 2004 · External reference
Laboratory screening and diagnosis of open neural tube defects, 2019 revision: a technical standard of the American College of Medical Genetics and Genomics (ACMG)
10.1038/s41436-019-0681-0 · 2020 · External reference
JNK1/2 regulate Bid by direct phosphorylation at Thr59 in response to ALDH1L1
10.1038/cddis.2014.316 · 2014 · External reference
Neural tube defect genes and maternal diabetes during pregnancy
10.1002/bdra.20680 · 2010 · External reference
beta-Hydroxybutyrate activates the NF-kappaB signaling pathway to promote the expression of pro-inflammatory factors in calf hepatocytes
10.1159/000358664 · 2014 · External reference
Suppression of oxidative stress by beta-hydroxybutyrate, an endogenous histone deacetylase inhibitor
10.1126/science.1227166 · 2013 · External reference
Beta hydroxybutyrate induces lung cancer cell death, mitochondrial impairment and oxidative stress in a long term glucose-restricted condition
10.1007/s11033-024-09501-w · 2024 · External reference
Metabolic profiling of the diabetic heart: toward a richer picture
10.3389/fphys.2019.00639 · 2019 · External reference
Protein kinase C-alpha suppresses autophagy and induces neural tube defects via miR-129-2 in diabetic pregnancy
10.1038/ncomms15182 · 2017 · External reference
AS-IL6 promotes glioma cell invasion by inducing H3K27Ac enrichment at the IL6 promoter and activating IL6 transcription
10.1002/1873-3468.12485 · 2016 · External reference
Association between maternal diabetes and neurodevelopmental outcomes in children: a systematic review and meta-analysis of 202 observational studies comprising 56.1 million pregnancies
10.1016/s2213-8587(25)00036-1 · 2025 · External reference
High glucose-induced oxidative stress represses sirtuin deacetylase expression and increases histone acetylation leading to neural tube defects
10.1111/jnc.13587 · 2016 · External reference
Elevated H3K79 homocysteinylation causes abnormal gene expression during neural development and subsequent neural tube defects
10.1038/s41467-018-05451-7 · 2018 · External reference
Histone deacetylase inhibitor treated cell sheet from mouse tendon stem/progenitor cells promotes tendon repair
10.1016/j.biomaterials.2018.03.043 · 2018 · External reference
Intrarenal metabolomics reveals the association of local organic toxins with the progression of diabetic kidney disease
10.1016/j.jpba.2011.11.010 · 2012 · External reference
Chitosan oligosaccharides ameliorates maternal diabetes-induced embryonic neural tube defects via inhibitting excessive pyroptosis of neuroepithelial cells
10.1016/j.intimp.2025.114074 · 2025 · External reference