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References from Breathing and burning: metabolic control of alveolar macrophages by intracellular bacterial pathogens. Local targets link to admitted publications; unresolved targets remain external evidence.
The intracellular agent of q fever, coxiella burnetii, alters human alveolar macrophage metabolism and mitochondrial physiology
10.1128/mbio.01436-25 · 2025 · External reference
Breathe in, breathe out: Metabolic regulation of lung macrophages in host defense against bacterial infection
10.3389/fcimb.2022.934460 · 2022 · External reference
Ppargamma regulates the expression of cholesterol metabolism genes in alveolar macrophages
10.1016/j.bbrc.2010.02.056 · 2010 · External reference
Dot/icm type ivb secretion system requirements for coxiella burnetii growth in human macrophages
10.1128/mbio.00175-11 · 2011 · External reference
Determinants of resident tissue macrophage identity and function
10.1016/j.immuni.2020.05.014 · 2020 · External reference
Coxiella burnetii requires host eukaryotic initiation factor 2alpha activity for efficient intracellular replication
10.1128/iai.00096-20 · 2020 · External reference
Dynamics of human monocytes and airway macrophages during healthy aging and after transplant
10.1084/jem.20191236 · 2020 · External reference
Host evasion and exploitation schemes of mycobacterium tuberculosis
10.1016/j.cell.2014.11.024 · 2014 · External reference
Alveolar macrophages provide an early mycobacterium tuberculosis niche and initiate dissemination
10.4049/jimmunol.204.supp.231.32 · 2018 · External reference
Human airway macrophages are metabolically reprogrammed by ifn-gamma resulting in glycolysis-dependent functional plasticity
10.7554/elife.98449 · 2024 · External reference
Lipids derived from virulent francisella tularensis broadly inhibit pulmonary inflammation via toll-like receptor 2 and peroxisome proliferator-activated receptor alpha
10.1128/cvi.00319-13 · 2013 · External reference
Pathogenicity and virulence of francisella tularensis
10.1080/21505594.2023.2274638 · 2023 · External reference
Degradation of surfactant protein d by alveolar macrophages
10.1152/ajplung.1998.274.1.l97 · 1998 · External reference
Altered alveolar macrophage function in calorie-restricted rats
10.1165/ajrcmb.19.3.3114 · 1998 · External reference
Characterization of early stages of human alveolar infection by the q fever agent coxiella burnetii
10.1128/iai.00028-19 · 2019 · External reference
Legionella pneumophila modulates mitochondrial dynamics to trigger metabolic repurposing of infected macrophages
10.1016/j.chom.2017.07.020 · 2017 · External reference
A farnesylated coxiella burnetii effector forms a multimeric complex at the mitochondrial outer membrane during infection
10.1128/iai.01046-16 · 2017 · External reference
Proteomic identification of coxiella burnetii effector proteins targeted to the host cell mitochondria during infection
10.1074/mcp.ra120.002370 · 2021 · External reference
Bacterial colonization of host cells in the absence of cholesterol
10.1371/journal.ppat.1003107 · 2013 · External reference
Alveolar macrophages develop from fetal monocytes that differentiate into long-lived cells in the first week of life via gm-csf
10.1084/jem.20131199 · 2013 · External reference
Coxiella burnetii affects hif1alpha accumulation and hif1alpha target gene expression
10.3389/fcimb.2022.867689 · 2022 · External reference
Coxiella burnetii inhabits a cholesterol-rich vacuole and influences cellular cholesterol metabolism
10.1111/j.1462-5822.2005.00641.x · 2006 · External reference
Growth of mycobacterium tuberculosis in vivo segregates with host macrophage metabolism and ontogeny
10.1128/9781683670261.ch9 · 2018 · External reference
Alveolar macrophages: Plasticity in a tissue-specific context
10.1038/nri3600 · 2014 · External reference
The legionella pneumophila replication vacuole: Making a cosy niche inside host cells
10.1038/nrmicro1967 · 2009 · External reference
Lactate metabolism is exploited by francisella tularensis via its o-antigen capsule to limit macrophage-mediated activation and cell death
10.1128/mbio.00681-25 · 2025 · External reference
Temporal manipulation of mitochondrial function by virulent francisella tularensis to limit inflammation and control cell death
10.1128/iai.00044-18 · 2018 · External reference
Metabolic reprogramming in macrophages and dendritic cells in innate immunity
10.1038/cr.2015.68 · 2015 · External reference
Caseation of human tuberculosis granulomas correlates with elevated host lipid metabolism
10.1002/emmm.201000079 · 2010 · External reference
Macrophages inhibit coxiella burnetii by the acod1-itaconate pathway for containment of q fever
10.15252/emmm.202215931 · 2023 · External reference
Human ipsc-derived alveolar macrophages reveal macrophage subtype functions of itaconate in m. Tuberculosis defense
10.1172/jci.insight.198342 · 2026 · External reference
Alveolar macrophages from tuberculosis patients display an altered inflammatory gene expression profile
10.1016/j.tube.2017.08.012 · 2017 · External reference
Tissue-resident macrophage enhancer landscapes are shaped by the local microenvironment
10.1016/j.cell.2014.11.018 · 2014 · External reference
Transcriptome reveals the landscape of alveolar macrophages exposed to combined hypoxia with cigarette smoke extract
10.1186/s12931-025-03303-9 · 2025 · External reference
Coxiella co-opts the glutathione peroxidase 4 to protect the host cell from oxidative stress-induced cell death
10.1073/pnas.2308752120 · 2023 · External reference
Deletion of c-flip from cd11b(hi) macrophages prevents development of bleomycin-induced lung fibrosis
10.1165/rcmb.2017-0154oc · 2018 · External reference
Human alveolar macrophage metabolism is compromised during mycobacterium tuberculosis infection
10.3389/fimmu.2022.1044592 · 2022 · External reference
Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production
10.1073/pnas.1218599110 · 2013 · External reference
Itaconate is an anti-inflammatory metabolite that activates nrf2 via alkylation of keap1
10.1038/nature25986 · 2018 · External reference
Role of cholesterol in mycobacterium tuberculosis infection
2009 · External reference
Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span
10.1084/jem.20162152 · 2017 · External reference
The contribution of nutrient metal acquisition and metabolism to acinetobacter baumannii survival within the host
10.3389/fcimb.2013.00095 · 2013 · External reference
Single cell rna sequencing identifies unique inflammatory airspace macrophage subsets
10.1172/jci.insight.126556 · 2019 · External reference
Elevated cholesterol in the coxiella burnetii intracellular niche is bacteriolytic
10.1128/mbio.02313-16 · 2017 · External reference
Patrolling alveolar macrophages conceal bacteria from the immune system to maintain homeostasis
10.1016/j.cell.2020.08.020 · 2020 · External reference
Macrophage metabolic reprogramming during chronic lung disease
10.1038/s41385-020-00356-5 · 2021 · External reference
Mycobacterial persistence requires the utilization of host cholesterol
10.1073/pnas.0711159105 · 2008 · External reference
Human alveolar macrophages do not rely on glucose metabolism upon activation by lipopolysaccharide
10.1016/j.bbadis.2022.166488 · 2022 · External reference
Paradoxical pro-inflammatory responses by human macrophages to an amoebae host-adapted legionella effector
10.1016/j.chom.2020.03.003 · 2020 · External reference
Turning yersinia pathogenesis outside in: Subversion of macrophage function by intracellular yersiniae
10.1016/j.clim.2004.07.013 · 2005 · External reference
Legionella and coxiella effectors: Strength in diversity and activity
10.1038/nrmicro.2017.67 · 2017 · External reference
Glutamate utilization couples oxidative stress defense and the tricarboxylic acid cycle in francisella phagosomal escape
10.1371/journal.ppat.1003893 · 2014 · External reference
Mycobacterium tuberculosis (mtb)-stimulated production of nitric oxide by human alveolar macrophages and relationship of nitric oxide production to growth inhibition of mtb
10.1016/s0962-8479(97)90005-8 · 1997 · External reference
Itaconate indirectly influences expansion of effector t cells following vaccination with francisella tularensis live vaccine strain
10.1016/j.cellimm.2022.104485 · 2022 · External reference
Identification of early interactions between francisella and the host
10.1128/iai.01654-13 · 2014 · External reference
Alveolar macrophages generate a noncanonical nrf2-driven transcriptional response to mycobacterium tuberculosis in vivo
10.1126/sciimmunol.aaw6693 · 2019 · External reference
Alveolar macrophages are essential for protection from respiratory failure and associated morbidity following influenza virus infection
10.1371/journal.ppat.1004053 · 2014 · External reference
Tularemia: History, epidemiology, pathogen physiology, and clinical manifestations
10.1196/annals.1409.009 · 2007 · External reference
The lung environment controls alveolar macrophage metabolism and responsiveness in type 2 inflammation
10.1038/s41590-019-0352-y · 2019 · External reference
The role of monocyte-derived macrophages in the lung: It's all about context
10.1016/j.biocel.2023.106421 · 2023 · External reference
Succinate is an inflammatory signal that induces il-1beta through hif-1alpha
10.1038/nature11986 · 2013 · External reference
Lounging in a lysosome: The intracellular lifestyle of coxiella burnetii
10.1111/j.1462-5822.2007.00901.x · 2007 · External reference
Coxiella burnetii inhibits apoptosis in human thp-1 cells and monkey primary alveolar macrophages
10.1002/9783527629176.ch16 · 2007 · External reference
Metabolism of tissue macrophages in homeostasis and pathology
10.1038/s41423-021-00791-9 · 2022 · External reference
Oxidative phosphorylation selectively orchestrates tissue macrophage homeostasis
10.1016/j.immuni.2023.01.011 · 2023 · External reference
Sessile alveolar macrophages communicate with alveolar epithelium to modulate immunity
10.1038/nature12902 · 2014 · External reference
Coxiella burnetii subverts p62/sequestosome 1 and activates nrf2 signaling in human macrophages
10.1128/iai.00608-17 · 2018 · External reference
Coxiella burnetii type iv secretion-dependent recruitment of macrophage autophagosomes
10.1128/iai.01236-13 · 2014 · External reference
Differences in glycolytic metabolism between tissue-resident alveolar macrophages and recruited lung macrophages
10.3389/fimmu.2025.1535796 · 2025 · External reference
Tissue-resident alveolar macrophages do not rely on glycolysis for lps-induced inflammation
10.1165/rcmb.2019-0244oc · 2020 · External reference
Hif-1alpha induces glycolytic reprograming in tissue-resident alveolar macrophages to promote cell survival during acute lung injury
10.1201/b14532-31 · 2022 · External reference
Metabolic reprogramming of host cells by virulent francisella tularensis for optimal replication and modulation of inflammation
10.4049/jimmunol.1502456 · 2016 · External reference
Interaction between host cell mitochondria and coxiella burnetii
10.1016/bs.ircmb.2023.01.005 · 2023 · External reference
The cytokine tgf-beta promotes the development and homeostasis of alveolar macrophages
10.1016/j.immuni.2017.10.007 · 2017 · External reference