Research graph
References from Restructuring the gut microbiota in obesity: molecular mechanisms linking dysbiosis to systemic inflammation and therapeutic opportunities. Local targets link to admitted publications; unresolved targets remain external evidence.
Akkermansia muciniphila, a new generation of beneficial microbiota in modulating obesity: a systematic review
10.3390/microorganisms9051098 · 2021 · External reference
Association of firmicutes/bacteroidetes ratio with body mass index in Korean type 2 diabetes mellitus patients
10.3390/metabo14100518 · 2024 · External reference
Obesity: prevalence, causes, consequences, management, preventive strategies and future research directions
10.1016/j.metop.2025.100375 · 2025 · External reference
Microbial dysbiosis-induced obesity: role of gut microbiota in homoeostasis of energy metabolism
10.1017/s0007114520000380 · 2020 · External reference
Impact of diet-modulated butyrate production on intestinal barrier function and inflammation
10.3390/nu10101499 · 2018 · External reference
The gut microbiota as an environmental factor that regulates fat storage
10.1073/pnas.0407076101 · 2004 · External reference
Fatal aspiration pneumonia as a complication of fecal microbiota transplant
10.1093/cid/civ247 · 2015 · External reference
Obesity: global epidemiology and pathogenesis
10.1038/s41574-019-0176-8 · 2019 · External reference
Probiotics, prebiotics, synbiotics and other microbiome-based innovative therapeutics to mitigate obesity and enhance longevity via the gut-brain axis
10.20517/mrr.2024.05 · 2024 · External reference
Crosstalk between gut microbiota and dietary lipids aggravates WAT inflammation through TLR signaling
10.1016/j.cmet.2015.07.026 · 2015 · External reference
Metabolic endotoxemia initiates obesity and insulin resistance
10.2337/db06-1491 · 2007 · External reference
Akkermansia muciniphila: paradigm for next-generation beneficial microorganisms
10.1038/s41575-022-00631-9 · 2022 · External reference
Involvement of gut microbiota in the development of low-grade inflammation and type 2 diabetes associated with obesity
10.4161/gmic.19625 · 2012 · External reference
Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability
10.1136/gut.2008.165886 · 2009 · External reference
Probiotics supplementation improves intestinal permeability, obesity index and metabolic biomarkers in elderly Thai subjects: a randomized controlled trial
10.3390/foods11030268 · 2022 · External reference
Gut microbiota, low-grade inflammation, and metabolic syndrome
10.1177/0192623313508481 · 2014 · External reference
The critical role of gut microbiota in obesity
10.3389/fendo.2022.1025706 · 2022 · External reference
Discovery of farnesoid X receptor and its role in bile acid metabolism
10.1016/j.mce.2022.111618 · 2022 · External reference
Co-toxicity of endotoxin and indoxyl sulfate, gut-derived bacterial metabolites, to vascular endothelial cells in coronary arterial disease accompanied by gut dysbiosis
10.3390/nu14030424 · 2022 · External reference
The protective role of butyrate against obesity and obesity-related diseases
10.3390/molecules26030682 · 2021 · External reference
Changes in fatty liver index after consuming a Mediterranean diet: 6-year follow-up of the PREDIMED-Malaga trial
10.1016/j.medcle.2017.04.030 · 2017 · External reference
The gut microbiome and its role in obesity
10.1097/nt.0000000000000167 · 2016 · External reference
Donor metabolic characteristics drive effects of faecal microbiota transplantation on recipient insulin sensitivity, energy expenditure and intestinal transit time
10.1136/gutjnl-2019-318320 · 2020 · External reference
Higher fecal short-chain fatty acid levels are associated with gut microbiome dysbiosis, obesity, hypertension and cardiometabolic disease risk factors
10.3390/nu11010051 · 2018 · External reference
Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: a proof-of-concept exploratory study
10.1038/s41591-019-0495-2 · 2019 · External reference
Risk and safety of probiotics
10.1093/cid/civ085 · 2015 · External reference
Lipopolysaccharides derived from gram-negative bacterial pool of human gut microbiota promote inflammation and obesity development
10.1080/08830185.2021.1996573 · 2022 · External reference
The multifaceted influence of beta‐hydroxybutyrate on autophagy, mitochondrial metabolism, and epigenetic regulation
10.1002/jcb.70050 · 2025 · External reference
Gut microbiome stability and resilience: elucidating the response to perturbations in order to modulate gut health
10.1136/gutjnl-2020-321747 · 2021 · External reference
Fecal Akkermansia muciniphila is associated with body composition and microbiota diversity in overweight and obese women with breast cancer participating in a presurgical weight loss trial
10.1016/j.jand.2018.08.164 · 2020 · External reference
Effect of faecal microbial transplant via colonoscopy in patients with severe obesity and insulin resistance: A randomized double-blind, placebo-controlled Phase 2 trial
10.1111/dom.14891 · 2023 · External reference
Expert consensus document: The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics
10.1038/nrgastro.2017.75 · 2017 · External reference
Donor composition and fiber promote strain engraftment in a randomized controlled trial of fecal microbiota transplant for ulcerative colitis
10.1016/j.medj.2025.100707 · 2025 · External reference
Intestinal permeability is associated with visceral adiposity in healthy women
10.1038/oby.2011.251 · 2011 · External reference
Faecalibacterium prausnitzii: A next‐generation probiotic in gut disease improvement
10.1155/2021/6666114 · 2021 · External reference
Macrophage phenotypic switch and obesity-associated metabolic risk: Mechanisms and targets
10.1155/omcl/6710641 · 2025 · External reference
Microbiota in health and diseases
10.1038/s41392-022-00974-4 · 2022 · External reference
Epigenetic factors in atherosclerosis: DNA methylation, folic acid metabolism, and intestinal microbiota
10.1016/j.cca.2020.11.013 · 2021 · External reference
Integrative metagenomic analysis reveals distinct gut microbial signatures related to obesity
10.1186/s12866-024-03278-5 · 2024 · External reference
Variability of strain engraftment and predictability of microbiome composition after fecal microbiota transplantation across different diseases
10.1038/s41591-022-01964-3 · 2022 · External reference
Therapeutic potential of prebiotics in modulating postprandial GLP-1, GLP-2, and glucose homeostasis in type 2 diabetes mellitus: Targeting gut dysbiosis and insulin resistance
10.1016/j.diabres.2026.113102 · 2026 · External reference
Probiotics, prebiotics, and postbiotics in health and disease
10.1002/mco2.420 · 2023 · External reference
Regulation of abdominal adiposity by probiotics (Lactobacillus gasseri SBT2055) in adults with obese tendencies in a randomized controlled trial
10.1038/ejcn.2010.19 · 2010 · External reference
Improvement of the inflammation-damaged intestinal barrier and modulation of the gut microbiota in ulcerative colitis after FMT in the SHIME® model
10.1186/s12906-025-04889-9 · 2025 · External reference
The association between the Firmicutes/Bacteroidetes ratio and body mass among European population with the highest proportion of adults with obesity: an observational follow-up study from Croatia
10.3390/biomedicines12102263 · 2024 · External reference
Obesity: a chronic low-grade inflammation and its markers
10.7759/cureus.22711 · 2022 · External reference
Crosstalk between FXR and TGR5 controls glucagon-like peptide 1 secretion to maintain glycemic homeostasis
10.5625/lar.2018.34.4.140 · 2018 · External reference
Improvement of insulin sensitivity after lean donor feces in metabolic syndrome is driven by baseline intestinal microbiota composition
10.1016/j.cmet.2017.09.008 · 2017 · External reference
Beyond weight loss: GLP-1 usage and appetite regulation in the context of eating disorders and psychosocial processes
10.3390/nu17233735 · 2025 · External reference
Prolonged transfer of feces from the lean mice modulates gut microbiota in obese mice
10.1186/s12986-016-0116-8 · 2016 · External reference
Chlamydial LPS and high-sensitivity CRP levels in serum are associated with an elevated body mass index in patients with cardiovascular disease
10.1177/1753425908099172 · 2008 · External reference
The immune response to Prevotella bacteria in chronic inflammatory disease
10.1111/imm.12760 · 2017 · External reference
Bacterial endotoxin activity in human serum is associated with dyslipidemia, insulin resistance, obesity, and chronic inflammation
10.2337/dc10-2197 · 2011 · External reference
Mediterranean diet, gut microbiota, and type 2 diabetes: A systematic review and meta-analysis of intervention trials
10.1016/j.numecd.2025.104433 · 2025 · External reference
Effect of diet on the gut microbiota: Rethinking intervention duration
10.3390/nu11122862 · 2019 · External reference
Microbial ecology: human gut microbes associated with obesity
10.1038/4441022a · 2006 · External reference
Programmable probiotics as next-generation living therapeutics: bridging synthetic biology and precision medicine
10.1016/j.copbio.2025.103375 · 2025 · External reference
Durable coexistence of donor and recipient strains after fecal microbiota transplantation
10.1126/science.aad8852 · 2016 · External reference
The front line of enteric host defense against unwelcome intrusion of harmful microorganisms: mucins, antimicrobial peptides, and microbiota
10.1128/cmr.19.2.315-337.2006 · 2006 · External reference
Effect of dietary fiber on gut barrier function, gut microbiota, short‐chain fatty acids, inflammation, and clinical outcomes in critically ill patients: a systematic review and meta‐analysis
10.1002/jpen.2319 · 2022 · External reference
Formation of propionate and butyrate by the human colonic microbiota
10.1111/1462-2920.13589 · 2017 · External reference
Rational consideration of Akkermansia muciniphila targeting intestinal health: advantages and challenges
10.1038/s41522-022-00338-4 · 2022 · External reference
The Firmicutes/Bacteroidetes ratio: a relevant marker of gut dysbiosis in obese patients
10.3390/nu12051474 · 2020 · External reference
Faecalibacterium: a bacterial genus with promising human health applications
10.1093/femsre/fuad039 · 2023 · External reference
Western diets, gut dysbiosis, and metabolic diseases: Are they linked
10.1080/19490976.2016.1270811 · 2017 · External reference
Nucleotide-binding oligomerization domain-like receptors and inflammasomes in the pathogenesis of non-microbial inflammation and diseases
10.1159/000334247 · 2011 · External reference
Adipose tissue derived bacteria are associated with inflammation in obesity and type 2 diabetes
10.1136/gutjnl-2019-320118 · 2020 · External reference
Involvement of the antioxidant effect and anti-inflammatory response in butyrate-inhibited vascular smooth muscle cell proliferation
10.3390/ph7111008 · 2014 · External reference
Protective role of butyrate in obesity and diabetes: new insights
10.3389/fnut.2022.1067647 · 2022 · External reference
Strain-specificity and disease-specificity of probiotic efficacy: a systematic review and meta-analysis
10.3389/fmed.2018.00124 · 2018 · External reference
Gut microbiome-associated predictors as biomarkers of response to advanced therapies in inflammatory bowel disease: a systematic review
10.1080/19490976.2023.2287073 · 2023 · External reference
Regulation, risk and safety of Faecal Microbiota Transplant
10.1016/j.infpip.2020.100069 · 2020 · External reference
Assessing the safety of microbiome perturbations
10.1099/mgen.0.001405 · 2025 · External reference
A randomised controlled study shows supplementation of overweight and obese adults with lactobacilli and bifidobacteria reduces bodyweight and improves well-being
10.1038/s41598-020-60991-7 · 2020 · External reference
C-type lectin receptors in host defense against bacterial pathogens
10.3389/fcimb.2020.00309 · 2020 · External reference
The influence of Akkermansia muciniphila on intestinal barrier function
10.1186/s13099-024-00635-7 · 2024 · External reference
From one-size-fits-all to precision medicine: The promise of personalized probiotics
10.1007/s12602-025-10815-9 · 2025 · External reference
Gut microbiome-Mediterranean diet interactions in improving host health
10.12688/f1000research.18992.1 · 2019 · External reference
Short-chain fatty acid metabolites propionate and butyrate are unique epigenetic regulatory elements linking diet, metabolism and gene expression
10.1038/s42255-024-01191-9 · 2025 · External reference
Oral and gut microbial carbohydrate-active enzymes landscape in health and disease
10.3389/fmicb.2021.653448 · 2021 · External reference
The role of lipopolysaccharide-induced cell signalling in chronic inflammation
10.1177/24705470221076390 · 2022 · External reference
Leaky gut and autoimmunity: an intricate balance in individuals health and the diseased state
10.3390/ijms21249770 · 2020 · External reference
Intestine farnesoid X receptor agonist and the gut microbiota activate G‐protein bile acid receptor‐1 signaling to improve metabolism
10.1002/hep.29857 · 2018 · External reference
A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice
10.1038/nm.4236 · 2017 · External reference
A human gut microbial gene catalogue established by metagenomic sequencing
10.1038/nature08821 · 2010 · External reference
Effects of fecal microbiota transplantation in metabolic syndrome: A meta-analysis of randomized controlled trials
10.1371/journal.pone.0288718 · 2023 · External reference
The effects of synbiotic supplementation on body mass index, metabolic and inflammatory biomarkers, and appetite in patients with metabolic syndrome: A triple-blind randomized controlled trial
10.1080/19390211.2018.1455788 · 2019 · External reference
Inflammasome, inflammation, and tissue homeostasis
10.1016/j.molmed.2018.01.004 · 2018 · External reference
Dietary fibers as beneficial microbiota modulators: A proposed classification by prebiotic categories
10.1016/j.nut.2021.111217 · 2021 · External reference
Engineering bacteria for diagnostic and therapeutic applications
10.1038/nrmicro.2017.172 · 2018 · External reference
Bifidobacteria and butyrate-producing colon bacteria: importance and strategies for their stimulation in the human gut
10.3389/fmicb.2016.00979 · 2016 · External reference
Environment dominates over host genetics in shaping human gut microbiota
10.1038/nature25973 · 2018 · External reference
Inulin-type fructans modulate intestinal Bifidobacterium species populations and decrease fecal short-chain fatty acids in obese women
10.1016/j.clnu.2014.06.001 · 2015 · External reference
Inflammatory mechanisms linking obesity and metabolic disease
10.1172/jci92035 · 2017 · External reference
Gut microbiota as a trigger for metabolic inflammation in obesity and type 2 diabetes
10.3389/fimmu.2020.571731 · 2020 · External reference
The promise of the gut microbiome as part of individualized treatment strategies
10.1038/s41575-021-00499-1 · 2022 · External reference
TLR4 links innate immunity and fatty acid–induced insulin resistance
10.1172/jci28898 · 2006 · External reference
Microbiota and short chain fatty acid relationships underlie clinical heterogeneity and identify key microbial targets in irritable bowel syndrome (IBS)
10.1038/s41598-025-19363-2 · 2025 · External reference
Implication of obesity and gut microbiome dysbiosis in the etiology of colorectal cancer
10.3390/cancers15061913 · 2023 · External reference
Microbiota metabolite short chain fatty acids, GPCR, and inflammatory bowel diseases
10.1007/s00535-016-1242-9 · 2017 · External reference
Advances in research on the role of gut microbiota in the pathogenesis and precision management of gallstone disease
10.3389/fmed.2025.1535355 · 2025 · External reference
Microbial predictors, data integration, machine learning, and clinical trial
10.1007/978-981-95-2104-3_9 · 2025 · External reference
Introduction to the human gut microbiota
10.1042/bcj20160510 · 2017 · External reference
Adipocytokines: mediators linking adipose tissue, inflammation and immunity
10.1038/nri1937 · 2006 · External reference
The intestinal microbiota fuelling metabolic inflammation
10.1038/s41577-019-0198-4 · 2020 · External reference
A prebiotic-enhanced lipid-based nutrient supplement (LNSp) increases Bifidobacterium relative abundance and enhances short-chain fatty acid production in simulated colonic microbiota from undernourished infants
10.1093/femsec/fiaa105 · 2020 · External reference
Loss-of-function mutation in Toll-like receptor 4 prevents diet-induced obesity and insulin resistance
10.2337/db06-1595 · 2007 · External reference
An obesity-associated gut microbiome with increased capacity for energy harvest
10.1038/nature05414 · 2006 · External reference
Science of fecal microbiota transplant: From history to cutting-edge clinical practice
10.4253/wjge.v18.i1.113133 · 2026 · External reference
The role of methyl donors of the methionine cycle in gastrointestinal infection and inflammation
2021 · External reference
Duodenal infusion of donor feces for recurrent Clostridium difficile
10.1056/nejmoa1205037 · 2013 · External reference
Transfer of intestinal microbiota from lean donors increases insulin sensitivity in individuals with metabolic syndrome
10.1053/j.gastro.2012.06.031 · 2012 · External reference
Faecalibacterium prausnitzii supplementation prevents intestinal barrier injury and gut microflora dysbiosis induced by sleep deprivation
10.3390/nu16081100 · 2024 · External reference
Biochemotaxis‐oriented engineering bacteria expressing GLP‐1 enhance diabetes therapy by regulating the balance of immune
10.1002/adhm.202303958 · 2024 · External reference
Biochemotaxis-oriented engineering bacteria expressing GLP-1 enhance diabetes therapy by regulating the balance of immune
10.1002/adhm.202303958 · 2024 · External reference
Microbial short chain fatty acids: Effective histone deacetylase inhibitors in immune regulation
10.3892/ijmm.2025.5687 · 2025 · External reference
Role of NLRP3 inflammasome activation in obesity-mediated metabolic disorders
10.3390/ijerph18020511 · 2021 · External reference
Prebiotic inulin‐type fructans and galacto‐oligosaccharides: definition, specificity, function, and application in gastrointestinal disorders
10.1111/jgh.13700 · 2017 · External reference
Diversification of host bile acids by members of the gut microbiota
10.1080/19490976.2019.1674124 · 2020 · External reference
Gut dysbiosis: ecological causes and causative effects on human disease
10.1073/pnas.2316579120 · 2023 · External reference
Research progress on fecal microbiota transplantation in tumor prevention and treatment
10.1515/biol-2022-0954 · 2025 · External reference
Fecal microbiota transplantation for the improvement of metabolism in obesity: The FMT-TRIM double-blind placebo-controlled pilot trial
10.1371/journal.pmed.1003051 · 2020 · External reference
The role of short-chain fatty acid in metabolic syndrome and its complications: focusing on immunity and inflammation
10.3389/fimmu.2025.1519925 · 2025 · External reference
Chronic adipose tissue inflammation linking obesity to insulin resistance and type 2 diabetes
10.3389/fphys.2019.01607 · 2019 · External reference
Fecal microbiota transplantation in obesity metabolism: A meta analysis and systematic review
10.1016/j.diabres.2023.110803 · 2023 · External reference
The effect of Bifidobacterium animalis subsp. lactis MN-Gup on glucose metabolism, gut microbiota, and their metabolites in type 2 diabetic mice
10.3390/nu16111691 · 2024 · External reference
Akkermansia muciniphila supplementation in patients with overweight/obese type 2 diabetes: Efficacy depends on its baseline levels in the gut
10.1016/j.cmet.2024.12.010 · 2025 · External reference
The interplay between gastrointestinal dysfunction and gut microbiota dynamics in sepsis
10.3389/fcimb.2026.1761536 · 2026 · External reference
Faecalibacterium prausnitzii produces butyrate to maintain Th17/Treg balance and to ameliorate colorectal colitis by inhibiting histone deacetylase 1
10.1093/ibd/izy182 · 2018 · External reference
Bile Acid Injection Regulated Blood Glucose in T2DM Rats Via the TGR5/GLP-1 Rather than FXR/FGF15 Pathway
2024 · External reference
