Research graph
References from A model to simulate cardio-respiratory responses to fentanyl analgesia after traumatic injury. Local targets link to admitted publications; unresolved targets remain external evidence.
Tolerance to opioid‐induced respiratory depression in chronic high‐dose opioid users: a model‐based comparison with opioid‐naive individuals
10.1002/cpt.2027 · 2021 · External reference
Differences in magnitude and duration of opioid-induced respiratory depression and analgesia with fentanyl and sufentanil
10.1213/00000539-199001000-00003 · 1990 · External reference
Whole body physiology model to simulate respiratory depression of fentanyl and associated naloxone reversal
10.1038/s43856-024-00536-5 · 2024 · External reference
The influence of cardiac output on propofol and fentanyl pharmacokinetics and pharmacodynamics in patients undergoing abdominal aortic surgery
10.1007/s10928-020-09712-1 · 2020 · External reference
Influence of cardiac output on the pharmacokinetics of sufentanil in anesthetized pigs
10.1097/aln.0000000000002160 · 2018 · External reference
Acute overventilation does not cause lung damage in moderately hemorrhaged swine
10.1152/japplphysiol.01048.2020 · 2021 · External reference
Testing of novel spectral device sensor in swine model of airway obstruction
10.14814/phy2.14246 · 2019 · External reference
Ghost in the Machine: leveraging artificial intelligence in the trauma bay
10.1136/tsaco-2026-002259 · 2026 · External reference
Ethical and IACUC considerations regarding analgesia and pain management in laboratory rodents
10.30802/aalas-cm-18-000149 · 2019 · External reference
Pharmacokinetic and pharmacodynamic modeling in BioGears
2016 · External reference
Unresolved reference
2024 · External reference
Seven mathematical models of hemorrhagic shock
10.1155/2021/6640638 · 2021 · External reference
Volume kinetics of Ringer's solution in hypovolemic volunteers
10.1097/00000542-199901000-00013 · 1999 · External reference
Death on the battlefield, (2001–2011): implications for the future of combat casualty care
10.1097/ta.0b013e3182755dcc · 2012 · External reference
Fentanyl pharmacokinetics in hemorrhagic shock: a porcine model
10.1097/00000542-199907000-00024 · 1999 · External reference
Pharmacokinetics and pharmacodynamics of intranasal versus intravenous fentanyl in patients with pain after oral surgery
10.1345/aph.1l168 · 2008 · External reference
Intravenous sub-anesthetic ketamine for perioperative analgesia
10.4103/0970-9185.182085 · 2016 · External reference
Euler’s method
10.1007/978-0-85729-148-6_2 · 2010 · External reference
Fentanyl clearance and volume of distribution are increased in patients with major burns
10.1177/0091270007299756 · 2007 · External reference
Assessment and training of Ukrainian trauma and combat casualty care via international symposia
10.1097/ta.0000000000004722 · 2025 · External reference
Patterns of palliation: a review of casualties that received pain management before reaching role 2 in Afghanistan
10.1093/milmed/usac211 · 2023 · External reference
AI algorithm for personalized resource allocation and treatment of hemorrhage casualties
10.3389/fphys.2024.1327948 · 2024 · External reference
A model to simulate human cardio-respiratory responses to airway obstruction
10.3389/fphys.2025.1699315 · 2025 · External reference
Development and validation of a mathematical model to simulate human cardiovascular and respiratory responses to battlefield trauma
10.1002/cnm.3662 · 2023 · External reference
A model to simulate human cardio-respiratory responses to different fluid resuscitation treatments after hemorrhagic injury
10.3389/fphys.2025.1613874 · 2025 · External reference
A model to simulate human cardio-respiratory responses to ketamine analgesia
10.3389/fphys.2025.1654768 · 2025 · External reference
The effects of low-dose ketamine on acute pain in an emergency setting: a systematic review and meta-analysis
10.1371/journal.pone.0165461 · 2016 · External reference
Human and animal models for studying hemorrhagic shock
10.1186/s13049-025-01434-y · 2025 · External reference
Opioid-induced respiratory depression: a mathematical model for fentanyl
10.1109/tbme.2004.827344 · 2004 · External reference
Development of a translational model to assess the impact of opioid overdose and naloxone dosing on respiratory depression and cardiac arrest
10.1002/cpt.2696 · 2022 · External reference
Validation of a computer model of haemorrhage and transcapillary refill
10.1016/1350-4533(95)95712-j · 1995 · External reference
Pulmonary administration of aerosolised fentanyl: pharmacokinetic analysis of systemic delivery
10.1046/j.1365-2125.1998.00035.x · 1998 · External reference
The effect of low‐dose ketamine on fentanyl‐induced respiratory depression
10.1046/j.1365-2044.1998.00519.x · 1998 · External reference
The concentration-effect relationship of the respiratory depressant effects of alfentanil and fentanyl
10.1097/00000539-200110000-00028 · 2001 · External reference
Animal models of pain: progress and challenges
10.1038/nrn2606 · 2009 · External reference
Modeling buprenorphine reduction of fentanyl-induced respiratory depression
10.1172/jci.insight.156973 · 2022 · External reference
The CYP 3A4 inhibitor itraconazole has no effect on the pharmacokinetics of iv fentanyl
10.1093/bja/81.4.598 · 1998 · External reference
Clinical implications of opioid-induced ventilatory impairment
10.1177/0310057x211070292 · 2022 · External reference
Validation of new method for predicting human skin temperatures during cold exposure: The Cold Weather Ensemble Decision Aid (CoWEDA)
10.1016/j.imu.2020.100301 · 2020 · External reference
Prehospital lessons from the war in Ukraine: damage control resuscitation and surgery experiences from point of injury to role 2
10.1093/milmed/usad253 · 2024 · External reference
Multicenter, prospective study of prehospital administration of analgesia in the US combat theater of Afghanistan
10.1080/10903127.2017.1335814 · 2017 · External reference
A 3-D whole-body human thermoregulatory model to simulate extreme cold stress
10.1038/s41598-026-57039-7 · 2026 · External reference
A reinforcement learning algorithm to optimize resource utilization in combat casualty care
10.1038/s41598-025-28021-6 · 2025 · External reference
Crystalloid infusion rate during fluid resuscitation from acute haemorrhage
10.1093/bja/aem165 · 2007 · External reference
Unresolved reference
External reference
Establishing a link between heart rate and pain in healthy subjects: a gender effect
10.1016/j.jpain.2005.01.351 · 2005 · External reference
10.1186/1471-2253-5-2 · 2005 · Admitted local publication
Fentanyl-induced ventilatory depression: population pharmacokinetic–pharmacodynamic framework for evaluation of opioid-induced ventilatory depression
10.1097/aln.0000000000005710 · 2025 · External reference
2B-Alert App 2.0: personalized caffeine recommendations for optimal alertness
10.1093/sleep/zsad080 · 2023 · External reference
Comparing the effects of low-dose ketamine, fentanyl, and morphine on hemorrhagic tolerance and analgesia in humans
10.1080/10903127.2023.2172493 · 2023 · External reference
Fentanyl impairs but ketamine preserves the microcirculatory response to hemorrhage
10.1097/ta.0000000000002604 · 2020 · External reference
Mechanism‐based PK/PD modeling of the respiratory depressant effect of buprenorphine and fentanyl in healthy volunteers
10.1038/sj.clpt.6100025 · 2007 · External reference
Propaq M operator's guide
2016 · External reference
