Research graph
References from Alx1 is required for enamel knot formation during incisor morphogenesis. Local targets link to admitted publications; unresolved targets remain external evidence.
Concise review: cellular and molecular mechanisms regulation of tooth initiation
10.1002/stem.2917 · 2019 · External reference
Grainyhead-like transcription factors in craniofacial development
10.1177/0022034517719264 · 2017 · External reference
Msx1 controls inductive signaling in mammalian tooth morphogenesis
10.1242/dev.122.10.3035 · 1996 · External reference
Wnt/beta-catenin signaling plays an essential role in activation of odontogenic mesenchyme during early tooth development
10.1016/j.ydbio.2009.07.015 · 2009 · External reference
The primary enamel knot determines the position of the first buccal cusp in developing mice molars
10.1111/j.1432-0436.2006.00153.x · 2007 · External reference
Modification of gene activity in mouse embryos in utero by a tamoxifen-inducible form of Cre recombinase
10.1016/s0960-9822(07)00562-3 · 1998 · External reference
Analysis of epithelial-mesenchymal interactions in the initial morphogenesis of the mammalian tooth
10.1006/dbio.1998.8992 · 1998 · External reference
Comparative transcriptome profiles of human dental pulp stem cells from maxillary and mandibular teeth
10.1038/s41598-022-12867-1 · 2022 · External reference
Wnt/beta-catenin signaling in the dental mesenchyme regulates incisor development by regulating Bmp4
10.1016/j.ydbio.2010.09.009 · 2010 · External reference
The ALX1 transcription factor acts in the early cranial mesoderm to specify extraocular muscle formation
10.1242/dmm.052241 · 2026 · External reference
Alx1 deficient mice recapitulate craniofacial phenotype and reveal developmental basis of ALX1-related frontonasal dysplasia
10.3389/fcell.2022.777887 · 2022 · External reference
Continuous tooth generation in mouse is induced by activated epithelial Wnt/beta-catenin signaling
10.1073/pnas.0607289103 · 2006 · External reference
The life history of an embryonic signaling center: BMP-4 induces p21 and is associated with apoptosis in the mouse tooth enamel knot
10.1242/dev.125.2.161 · 1998 · External reference
Evidence for the role of the enamel knot as a control center in mammalian tooth cusp formation: non-dividing cells express growth stimulating Fgf-4 gene
10.1387/ijdb.7848830 · 1994 · External reference
Reiterative signaling and patterning during mammalian tooth morphogenesis
10.1016/s0925-4773(99)00322-6 · 2000 · External reference
Bmp4-Msx1 signaling and Osr2 control tooth organogenesis through antagonistic regulation of secreted Wnt antagonists
10.1016/j.ydbio.2016.10.001 · 2016 · External reference
Roles of Bmp4 during tooth morphogenesis and sequential tooth formation
10.1242/dev.081927 · 2013 · External reference
The canonical Wnt signaling activator, R-spondin2, regulates craniofacial patterning and morphogenesis within the branchial arch through ectodermal-mesenchymal interaction
10.1016/j.ydbio.2011.01.004 · 2011 · External reference
Signaling networks regulating tooth organogenesis and regeneration, and the specification of dental mesenchymal and epithelial cell lineages
10.1101/cshperspect.a008425 · 2012 · External reference
Transcription factors of the Alx family: evolutionarily conserved regulators of deuterostome skeletogenesis
10.3389/fgene.2020.569314 · 2020 · External reference
Lef1 expression is activated by BMP-4 and regulates inductive tissue interactions in tooth and hair development
10.1101/gad.10.11.1382 · 1996 · External reference
Activin and Bmp4 signaling converge on Wnt activation during odontogenesis
10.1177/0022034517713710 · 2017 · External reference
Molecular patterning of the mammalian dentition
10.1016/j.semcdb.2013.12.003 · 2014 · External reference
MSX1 drives tooth morphogenesis through controlling Wnt signaling activity
10.1177/00220345211070583 · 2022 · External reference
Wnt/beta-catenin signaling directs multiple stages of tooth morphogenesis
10.1016/j.ydbio.2007.10.016 · 2008 · External reference
The genetic control of early tooth development
10.1177/10454411970080010101 · 1997 · External reference
Wnt/beta-catenin signaling and Msx1 promote outgrowth of the maxillary prominences
10.3389/fphys.2012.00375 · 2012 · External reference
The initiation knot is a signaling center required for molar tooth development
10.1242/dev.194597 · 2021 · External reference
Msx1 and Pax3 cooperate to mediate FGF8 and WNT signals during Xenopus neural crest induction
10.1016/j.devcel.2004.12.017 · 2005 · External reference
The morphogenesis, pathogenesis, and molecular regulation of human tooth development-a histological review
10.3390/ijms26136209 · 2025 · External reference
Localization of Bmp-4, Shh and Wnt-5a transcripts during early mice tooth development by in situ hybridization
10.1590/s1806-83242007000200006 · 2007 · External reference
A Wnt-bmp feedback circuit controls intertissue signaling dynamics in tooth organogenesis
10.1126/scisignal.2002414 · 2012 · External reference
Pax9-deficient mice lack pharyngeal pouch derivatives and teeth and exhibit craniofacial and limb abnormalities
10.1101/gad.12.17.2735 · 1998 · External reference
ALX1-related frontonasal dysplasia results from defective neural crest cell development and migration
10.15252/emmm.202012013 · 2020 · External reference
Msx1 and Tbx2 antagonistically regulate Bmp4 expression during the bud-to-cap stage transition in tooth development
10.1242/dev.088393 · 2013 · External reference
Msx1 deficient mice exhibit cleft palate and abnormalities of craniofacial and tooth development
10.1038/ng0494-348 · 1994 · External reference
Sorting Sox: diverse roles for Sox transcription factors during neural crest and craniofacial development
10.3389/fphys.2020.606889 · 2020 · External reference
Lrp6-mediated canonical Wnt signaling is required for lip formation and fusion
10.1242/dev.037440 · 2009 · External reference
Epithelial-mesenchymal signalling regulating tooth morphogenesis
10.1242/jcs.00410 · 2003 · External reference
The enamel knot: a putative signaling center regulating tooth development
10.1101/sqb.1997.062.01.032 · 1997 · External reference
Enamel knots as signaling centers linking tooth morphogenesis and odontoblast differentiation
10.1177/08959374010150010401 · 2001 · External reference
The cutting-edge of mammalian development; how the embryo makes teeth
10.1038/nrg1380 · 2004 · External reference
Exome sequencing revealed a novel splice site variant in the ALX1 gene underlying frontonasal dysplasia
10.1111/cge.12822 · 2017 · External reference
Disruption of ALX1 causes extreme microphthalmia and severe facial clefting: expanding the spectrum of autosomal-recessive ALX-related frontonasal dysplasia
10.1016/j.ajhg.2010.04.002 · 2010 · External reference
The enamel knot as a signaling center in the developing mouse tooth
10.1016/0925-4773(95)00459-9 · 1996 · External reference
A developmental stage-specific network approach for studying dynamic co-regulation of transcription factors and microRNAs during craniofacial development
10.1242/dev.192948 · 2020 · External reference
Molecular and cellular mechanisms of tooth development, homeostasis and repair
10.1242/dev.184754 · 2020 · External reference
Making a tooth: growth factors, transcription factors, and stem cells
10.1038/sj.cr.7290299 · 2005 · External reference
