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References from Locomotor and endocrine alterations link to metabolic dysfunction induced by pathopharmacological interaction between neurodevelopmental disorders and antipsychotics: evidence from clinical and animal study. Local targets link to admitted publications; unresolved targets remain external evidence.
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Autism and its correlation with increased cardiovascular mortality and diseases
10.1016/j.cjca.2025.05.014 · 2025 · External reference
Health-related quality of life and metabolic risk in patients with psychosis
10.1016/j.schres.2013.11.029 · 2014 · External reference
Risperidone for non-psychotic disorders in paediatric patients: which child is to benefit
10.1111/dmcn.12527 · 2014 · External reference
AHRQ comparative effectiveness reviews
2017 · External reference
Real-world data on the adverse metabolic effects of second-generation antipsychotics and their potential determinants in adult patients: A systematic review of population-based studies
10.1007/s12325-021-01689-8 · 2021 · External reference
Safety of 80 antidepressants, antipsychotics, anti-attention-deficit/hyperactivity medications and mood stabilizers in children and adolescents with psychiatric disorders: a large scale systematic meta-review of 78 adverse effects
10.1002/wps.20765 · 2020 · External reference
Editorial: metabolic disturbances in mental illness: neuropathogenetic mechanisms and therapeutic implications
10.3389/fnins.2020.00021 · 2020 · External reference
Metabolic syndrome in drug naive schizophrenic patients
10.1016/j.dsx.2017.11.006 · 2018 · External reference
Metabolic syndrome in drug-naive and drug-free patients with schizophrenia and in their siblings
10.1016/j.schres.2015.05.004 · 2015 · External reference
Aspects of metabolic changes in first-episode drug-naive schizophrenic patients
10.1017/neu.2013.1 · 2013 · External reference
The common pathophysiology underlying the metabolic syndrome, schizophrenia and depression. A review
10.5507/bp.2014.060 · 2015 · External reference
Aripiprazole-induced adverse metabolic alterations in polyI:C neurodevelopmental model of schizophrenia in rats
10.1016/j.neuropharm.2017.06.003 · 2017 · External reference
Modeling of antipsychotic-induced metabolic alterations in mice: An experimental approach precluding psychosis as a predisposing factor
10.1016/j.taap.2019.114643 · 2019 · External reference
Pathophysiology of the metabolic syndrome
10.1016/j.clindermatol.2017.09.004 · 2018 · External reference
Food groups and risk of overweight, obesity, and weight gain: A systematic review and dose-response meta-analysis of prospective studies
10.1093/advances/nmy092 · 2019 · External reference
Child eating behaviors and caregiver feeding practices in children with autism spectrum disorders
10.1111/phn.12146 · 2015 · External reference
Anthropometric profile, overweight/obesity prevalence, and socioeconomic impact in moroccan children aged 6–12 years old with autism spectrum disorder
10.3390/ijerph21060672 · 2024 · External reference
Feeding behavior and dietary intake of male children and adolescents with autism spectrum disorder: A case-control study
10.1016/j.ijdevneu.2016.07.003 · 2016 · External reference
Weight gain in antipsychotic-naive patients: a review and meta-analysis
10.1017/s0033291709990407 · 2010 · External reference
Exploring patterns of disturbed eating in psychosis: A scoping review
10.3390/nu12123883 · 2020 · External reference
Multiscale network dynamics between heart rate and locomotor activity are altered in schizophrenia
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Metabolic functions of prolactin: Physiological and pathological aspects
10.1111/jne.12888 · 2020 · External reference
The role of leptin/adiponectin ratio in metabolic syndrome and diabetes
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The EDCMET project: metabolic effects of endocrine disruptors
10.3390/ijms21083021 · 2020 · External reference
Plasma prolactin levels are associated with the severity of illness in drug-naive first-episode psychosis female patients
10.1007/s00737-018-0899-x · 2019 · External reference
Adiponectin regulation and function
10.1002/cphy.c170046 · 2018 · External reference
Insulin resistance and adiponectin levels in drug-free patients with schizophrenia: A preliminary report
10.1177/070674370605100608 · 2006 · External reference
Leptin function and regulation
10.1002/cphy.c160041 · 2017 · External reference
Role of leptin in mood disorder and neurodegenerative disease
10.3389/fnins.2019.00378 · 2019 · External reference
Maternal prenatal infection, early susceptibility to illness and adult psychotic experiences: a birth cohort study
10.1016/j.schres.2014.04.013 · 2014 · External reference
Associations between maternal infection during pregnancy, childhood infections, and the risk of subsequent psychotic disorder--A swedish cohort study of nearly 2 million individuals
10.1093/schbul/sbv112 · 2016 · External reference
Maternal immune activation: Implications for neuropsychiatric disorders
10.1126/science.aag3194 · 2016 · External reference
Toll-like receptors in antiviral innate immunity
10.1016/j.jmb.2013.11.024 · 2014 · External reference
Maternal Immune Activation by Poly I:C as a preclinical Model for Neurodevelopmental Disorders: A focus on Autism and Schizophrenia
10.1016/j.neubiorev.2020.04.012 · 2020 · External reference
Virus-induced maternal immune activation as an environmental factor in the etiology of autism and schizophrenia
10.3389/fnins.2022.834058 · 2022 · External reference
P2X7 receptors drive poly(I:C) induced autism-like behavior in mice
10.1523/jneurosci.1895-18.2019 · 2019 · External reference
Sex differences in the effect of maternal immune activation on cognitive and psychosis-like behaviour in Long Evans rats
10.1111/ejn.14671 · 2020 · External reference
Time-dependent changes and potential mechanisms of glucose-lipid metabolic disorders associated with chronic clozapine or olanzapine treatment in rats
10.1038/s41598-017-02884-w · 2017 · External reference
The long-lasting effects of early antipsychotic exposure during juvenile period on adult behaviours - A study in a poly I:C rat model
10.1016/j.pbb.2022.173453 · 2022 · External reference
Prenatal poly I:C challenge affects behaviors and neurotransmission via elevated neuroinflammation responses in female juvenile rats
10.1093/ijnp/pyab087 · 2022 · External reference
Prenatal Poly I:C exposure affects tryptophan-kynurenine metabolism associated with intestinal microbiome in female juvenile rats
10.3389/fimmu.2025.1669845 · 2025 · External reference
Antipsychotic drugs for women: a narrative review and clinical guidelines
2023 · External reference
Pharmacokinetics and tissue distribution of olanzapine in rats
10.1002/1099-081x(199911)20:8<369::aid-bdd200>3.0.co;2-6 · 1999 · External reference
Mechanism-based pharmacokinetic-pharmacodynamic modeling of the dopamine D2 receptor occupancy of olanzapine in rats
10.1007/s11095-011-0477-7 · 2011 · External reference
Comparative effects of 18 antipsychotics on metabolic function in patients with schizophrenia, predictors of metabolic dysregulation, and association with psychopathology: a systematic review and network meta-analysis
10.1016/s2215-0366(19)30416-x · 2020 · External reference
Dose translation from animal to human studies revisited
10.1096/fj.07-9574lsf · 2008 · External reference
Antipsychotic dosing in preclinical models is often unrepresentative of the clinical condition: a suggested solution based on in vivo occupancy
10.1124/jpet.102.046987 · 2003 · External reference
Sterol and lipid analyses identifies hypolipidemia and apolipoprotein disorders in autism associated with adaptive functioning deficits
10.1038/s41398-021-01580-8 · 2021 · External reference
The assessment of serum lipid profiles of children with attention deficit hyperactivity disorder
10.1016/j.psychres.2018.04.006 · 2018 · External reference
Olanzapine induces weight gain in offspring of prenatally exposed poly I:C rats by reducing brown fat thermogenic activity
10.3389/fphar.2022.1001919 · 2022 · External reference
Sex differences in the association between prenatal exposure to maternal obesity and hippocampal volume in children
10.1002/brb3.1522 · 2020 · External reference
Sex-specific differences in lipid and glucose metabolism
10.3389/fendo.2014.00241 · 2014 · External reference
Glucose metabolism, hippocampal subfields and cognition in first-episode and never-treated schizophrenia
10.1016/j.ijchp.2023.100402 · 2023 · External reference
The metabolic programming of pubertal onset
10.1111/cen.15138 · 2025 · External reference
Considering sex as a biological variable in preclinical research
10.1096/fj.201600781r · 2017 · External reference
Sex differences in schizophrenia
10.3109/09540261.2010.515205 · 2010 · External reference
A comprehensive approach to modeling maternal immune activation in rodents
10.3389/fnins.2022.1071976 · 2022 · External reference
Sex and gender bias in the experimental neurosciences: the case of the maternal immune activation model
10.1038/s41398-019-0423-8 · 2019 · External reference
Maternal immune activation causes social behavior deficits and hypomyelination in male rat offspring with an autism-like microbiota profile
10.3390/brainsci11081085 · 2021 · External reference
Metabolic and cardiovascular adverse effects associated with antipsychotic drugs
10.1038/nrendo.2011.156 · 2011 · External reference
Sex differences between female and male individuals in antipsychotic efficacy and adverse effects in the treatment of schizophrenia
10.1007/s40263-024-01089-w · 2024 · External reference
Epigenetic histone methylation of PPARgamma and CPT1A signaling contributes to betahistine preventing olanzapine-induced dyslipidemia
10.3390/ijms24119143 · 2023 · External reference
Olanzapine modulate lipid metabolism and adipose tissue accumulation via hepatic muscarinic M3 receptor-mediated alk-related signaling
10.3390/biomedicines12071403 · 2024 · External reference
Timing of maternal immune activation and sex influence schizophrenia-relevant cognitive constructs and neuregulin and GABAergic pathways
10.1016/j.bbi.2021.11.006 · 2022 · External reference
Identification and treatment of individuals with childhood-onset and early-onset schizophrenia
10.1016/j.euroneuro.2024.02.005 · 2024 · External reference
Intrinsic and antipsychotic drug-induced metabolic dysfunction in schizophrenia
10.3389/fnins.2017.00432 · 2017 · External reference
Amisulpride, aripiprazole, and olanzapine in patients with schizophrenia-spectrum disorders (BeSt InTro): a pragmatic, rater-blind, semi-randomised trial
10.1016/s2215-0366(20)30341-2 · 2020 · External reference
The sex-dependent impact of chronic clozapine and haloperidol treatment on characteristics of the metabolic syndrome in a rat model
10.1055/s-0032-1321907 · 2013 · External reference
Priming of metabolic dysfunctions by prenatal immune activation in mice: relevance to schizophrenia
10.1093/schbul/sbr178 · 2013 · External reference
Atypical antipsychotics and metabolic syndrome: from molecular mechanisms to clinical differences
10.3390/ph14030238 · 2021 · External reference
Visceral obesity in normal-weight patients suffering from chronic schizophrenia
10.1186/1471-244x-14-35 · 2014 · External reference
Adiposity in schizophrenia: A systematic review and meta-analysis
10.1111/acps.13365 · 2021 · External reference
Improved social interaction, recognition and working memory with cannabidiol treatment in a prenatal infection (poly I:C) rat model
10.1038/npp.2017.40 · 2017 · External reference
Physical activity and maternal obesity: cardiovascular adaptations, exercise recommendations, and pregnancy outcomes
10.1111/nure.12064 · 2013 · External reference
Resistance exercise, disability, and pain catastrophizing in obese adults with back pain
10.1249/mss.0000000000000294 · 2014 · External reference
Physical activity and training against obesity
10.1556/oh.2010.28802 · 2010 · External reference
Effects of walkability on physical activity and obesity: a prospective observational study protocol
10.1136/bmjopen-2019-034882 · 2020 · External reference
Olanzapine, but not aripiprazole, weight-independently elevates serum triglycerides and activates lipogenic gene expression in female rats
10.1017/s1461145711001271 · 2012 · External reference
Altered circadian rhythms in a mouse model of neurodevelopmental disorders based on prenatal maternal immune activation
10.1016/j.bbi.2020.12.030 · 2021 · External reference
The dynamical association between physical activity and affect in the daily life of individuals with ADHD
10.1016/j.euroneuro.2022.01.110 · 2022 · External reference
Risperidone-induced weight gain and reduced locomotor activity in juvenile female rats: The role of histaminergic and NPY pathways
10.1016/j.phrs.2015.03.004 · 2015 · External reference
Olanzapine reduced brown adipose tissue thermogenesis and locomotor activity in female rats
10.1016/j.pnpbp.2014.02.003 · 2014 · External reference
Towards an immuno-precipitated neurodevelopmental animal model of schizophrenia
10.1016/j.neubiorev.2004.10.012 · 2005 · External reference
Early-onset bipolar disorder: characteristics and outcomes in the clinic
10.1089/cap.2017.0058 · 2017 · External reference
Antipsychotic-induced hyperprolactinemia
10.1592/phco.29.1.64 · 2009 · External reference
Focus on prolactin as a metabolic hormone
10.1016/j.tem.2006.02.005 · 2006 · External reference
Changes in insulin resistance following bariatric surgery and the adipoinsular axis: role of the adipocytokines, leptin, adiponectin and resistin
10.1381/0960892053923789 · 2005 · External reference
The cellular and molecular bases of leptin and ghrelin resistance in obesity
10.1038/nrendo.2016.222 · 2017 · External reference
Effects of the second-generation antipsychotic drugs aripiprazole and olanzapine on human adipocyte differentiation
10.1016/j.mce.2022.111828 · 2023 · External reference
Hyperleptinemia contributes to antipsychotic drug-associated obesity and metabolic disorders
10.1126/scitranslmed.ade8460 · 2023 · External reference
Leptin action via neurotensin neurons controls orexin, the mesolimbic dopamine system and energy balance
10.1016/j.cmet.2011.06.016 · 2011 · External reference
Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis
10.1016/j.neuron.2004.06.004 · 2004 · External reference
Bidirectional prospective associations of metabolic syndrome components with depression, anxiety, and antidepressant use
10.1002/da.22512 · 2016 · External reference
Dopamine neurons modulate neural encoding and expression of depression-related behaviour
10.1038/nature11740 · 2013 · External reference
Striatal dopamine synthesis capacity and its association with negative symptoms upon resolution of positive symptoms in first-episode schizophrenia and delusional disorder
10.1007/s00213-022-06088-7 · 2022 · External reference
Mood disorders: A potential link between ghrelin and leptin on human body
10.5493/wjem.v5.i2.103 · 2015 · External reference
Modulation of the mesolimbic dopamine system by leptin
10.1016/j.brainres.2010.04.028 · 2010 · External reference
Adiponectin modulates ventral tegmental area dopamine neuron activity and anxiety-related behavior through AdipoR1
10.1038/s41380-018-0102-9 · 2019 · External reference