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References from Beyond the brain circuit: a biopsychosocial integrative review of addiction neuroscience, epigenetic mechanisms, and multidisciplinary treatment. Local targets link to admitted publications; unresolved targets remain external evidence.
Neurobiology of addiction: A neurocircuitry analysis
10.1016/s2215-0366(16)00104-8 · 2016 · External reference
Neurobiology of addiction
10.1097/grf.0000000000000416 · 2019 · External reference
Adverse childhood experiences and their association with substance use disorders in adulthood: A general population study (Young-HUNT)
10.1016/j.abrep.2023.100488 · 2023 · External reference
Current and future prospects for epigenetic biomarkers of substance use disorders
10.3390/genes6040991 · 2015 · External reference
Investigation of the relationship between the starting age of substance, alcohol, cigarette use, attachment styles, and temperament features of substance users
10.5152/addicta.2021.21046 · 2022 · External reference
Opioidergic tuning of social attachment: reciprocal relationship between social deprivation and opioid abuse
10.3389/fnana.2024.1521016 · 2024 · External reference
The need for a new medical model: A challenge for biomedicine
10.1126/science.847460 · 1977 · External reference
The limbic system in co-occurring substance use and anxiety disorders: A narrative review using the RDoC framework
10.3390/brainsci14121285 · 2024 · External reference
Multiple dimensions approach in polysubstance use: An ESEM analysis based on the RDoC framework
10.1016/j.pscychresns.2025.111959 · 2025 · External reference
The neural basis of drug craving: An incentive-sensitization theory of addiction
10.1016/0165-0173(93)90013-p · 1993 · External reference
The integrative review: Updated methodology
10.1111/j.1365-2648.2005.03621.x · 2005 · External reference
Writing integrative literature reviews: Using the past and present to explore the future
10.1177/1534484316671606 · 2016 · External reference
Liking, wanting, and the incentive-sensitization theory of addiction
10.1037/amp0000059 · 2016 · External reference
Drug addiction: Updating actions to habits to compulsions ten years on
10.1146/annurev-psych-122414-033457 · 2016 · External reference
Neuroimaging impaired response inhibition and salience attribution in human drug addiction: A systematic review
10.1016/j.neuron.2018.03.048 · 2018 · External reference
Altered neural activities during response inhibition in adults with addiction: A voxel-wise meta-analysis
10.1017/s0033291721000362 · 2021 · External reference
Neuroimaging biomarkers in addiction
10.1038/s44220-024-00334-x · 2024 · External reference
Reward-related responses and tonic craving in cocaine addiction: An imaging study of the monetary incentive delay task
10.1093/ijnp/pyab016 · 2021 · External reference
Shared network-level functional alterations across substance use disorders: A multi-level kernel density meta-analysis of resting-state functional connectivity studies
10.1111/adb.13200 · 2022 · External reference
Brain reward system and its volumetric investigations in alcohol addiction
10.5152/addicta.2024.24076 · 2024 · External reference
DNA epigenetics in addiction susceptibility
10.3389/fgene.2022.806685 · 2022 · External reference
The genetics of alcohol dependence: Twin and SNP-based heritability, and genome-wide association study based on AUDIT scores
10.1002/ajmg.b.32379 · 2015 · External reference
Alcohol use disorder-associated DNA methylation in the nucleus accumbens and dorsolateral prefrontal cortex
10.1016/j.bpsgos.2024.100375 · 2024 · External reference
Genome-wide association meta-analyses identify novel genetic risk loci and polygenic phenotype associations for heroin, methamphetamine and alcohol dependences
10.1002/ctm2.659 · 2022 · External reference
Genetics of substance use disorders: A review
10.1017/s0033291721000969 · 2021 · External reference
Genetics of alcoholism
10.1007/s11920-019-1008-1 · 2019 · External reference
Solving the missing heritability problem
10.1371/journal.pgen.1008222 · 2019 · External reference
Considerations for the application of polygenic scores to clinical care of individuals with substance use disorders
10.1172/jci172882 · 2024 · External reference
A novel sibling-based design to quantify genetic and shared environmental effects: Application to drug abuse, alcohol use disorder and criminal behavior
10.1017/s003329171500224x · 2016 · External reference
The promise of genetics in alcohol use disorders and the problems of phenotype, polygenetic architecture, ancestry, and comorbidity
10.1176/appi.ajp.20250909 · 2025 · External reference
Candidate gene-environment interactions in substance abuse: A systematic review
10.1371/journal.pone.0287446 · 2023 · External reference
Gene–environment interaction between gaming addiction and perceived stress in late adolescents and young adults: A twin study
10.1556/2006.2024.00029 · 2024 · External reference
Addiction susceptibility: Genetic factors, personality traits, and epigenetic interactions with the gut microbiome
10.3390/genes16121447 · 2025 · External reference
DNA methylation and alcohol use disorders: Progress and challenges
10.1111/ajad.12465 · 2017 · External reference
Adverse childhood experiences and early initiation of substance use: A survival analysis
10.1177/00912174231195751 · 2024 · External reference
Human connection as a treatment for addiction
10.3389/fpsyg.2022.964671 · 2022 · External reference
Longitudinal DNA methylation dynamics as a practical indicator in clinical epigenetics
10.1186/s13148-021-01202-6 · 2021 · External reference
Epigenetic effects of addictive drugs in the nucleus accumbens
10.3389/fnmol.2022.828055 · 2022 · External reference
Histone modifications in cocaine, methamphetamine and opioids
10.1016/j.heliyon.2023.e16407 · 2023 · External reference
Epigenetic mechanisms involved in methamphetamine addiction
10.3389/fphar.2022.984997 · 2022 · External reference
Addictive drug abuse and depression—a focus on epigenetics
10.1038/s42003-026-09705-9 · 2026 · External reference
Shared genetics of ADHD, cannabis use disorder and cannabis use and prediction of cannabis use disorder in ADHD
10.1038/s44220-024-00277-3 · 2024 · External reference
The genetic landscape of substance use disorders
10.1038/s41380-024-02547-z · 2024 · External reference
Comorbidity between mood and substance-related disorders: A systematic review and meta-analysis
10.1177/00048674211054740 · 2022 · External reference
A study on the effects of addiction level, stress, and social support of drug relapse patients on changes in motivation of quitting substance misuse behaviors
10.1186/s40359-025-02917-4 · 2025 · External reference
A systematic review and meta-analysis of neuromodulation therapies for substance use disorders
10.1038/s41386-023-01776-0 · 2024 · External reference
Transcranial magnetic stimulation in alcohol use disorder treatment: A narrative review
10.5152/addicta.2024.24213 · 2024 · External reference
Transcranial magnetic stimulation: A review about its efficacy in the treatment of alcohol, tobacco and cocaine addiction
10.1016/j.addbeh.2020.106760 · 2021 · External reference
Transcranial direct current stimulation in substance use disorders: A systematic review of scientific literature
10.1097/yct.0000000000000401 · 2017 · External reference
Systematic review and meta-analysis: Combining transcranial magnetic stimulation or direct current stimulation with pharmacotherapy for treatment of substance use disorders
10.1111/ajad.13517 · 2024 · External reference
Deep brain stimulation for the treatment of drug addiction
10.3171/2018.5.focus18163 · 2018 · External reference
Deep brain stimulation for addictive disorders — Where are we now
10.1007/s13311-022-01229-4 · 2022 · External reference
Introduction: Testing and refining Marc Lewis's critique of the brain disease model of addiction
10.1007/s12152-017-9310-2 · 2017 · External reference
Received wisdom regarding the roles of craving and dopamine in addiction: A response to Lewis's critique of addiction: A disorder of choice
10.1177/1745691611400243 · 2011 · External reference
Brain disease or biopsychosocial model in addiction? Remembering the Vietnam veteran study
10.7334/psicothema2017.303 · 2018 · External reference
Recovery-supportive interventions for people with substance use disorders: a scoping review
10.3389/fpsyt.2024.1352818 · 2024 · External reference
Neurobiology, psychotherapeutic interventions, and emerging therapies in addiction: A systematic review
10.1080/10550887.2024.2440184 · 2026 · External reference
Buprenorphine versus methadone for the treatment of opioid dependence: A systematic review and meta-analysis of randomised and observational studies
10.1016/s2215-0366(23)00095-0 · 2023 · External reference
Comparative effectiveness associated with buprenorphine and naltrexone in opioid use disorder and cooccurring polysubstance use
10.1001/jamanetworkopen.2022.11363 · 2022 · External reference
Pharmacotherapy for alcohol use disorder: A systematic review and meta-analysis
10.1001/jama.2023.19761 · 2023 · External reference
Effectiveness of disulfiram as adjunct to addiction-focused treatment for persons with severe alcohol use disorder
10.1111/adb.70035 · 2025 · External reference
Emerging and established pharmacotherapies for smoking cessation: A review
10.1097/crd.0000000000001171 · 2026 · External reference
Integrative pharmacology in the treatment of substance use disorders
10.1080/15504263.2023.2293854 · 2024 · External reference
Project Harmony: A meta-analysis with individual patient data on behavioral and pharmacologic trials for comorbid posttraumatic stress and alcohol or other drug use disorders
10.1176/appi.ajp.22010071 · 2023 · External reference
Review of medication-assisted treatment for opioid use disorder
10.1515/jom-2021-0163 · 2022 · External reference
Meta-review on the efficacy of psychological therapies for the treatment of substance use disorders
10.1016/j.psychres.2023.115318 · 2023 · External reference
Effects of brief cognitive behavioral therapy on mental health in substance-related disorder: A randomized controlled trial
10.1186/s12888-023-05413-4 · 2023 · External reference
Developing a counselling and psychotherapy competency framework for addictions: A systematic review
10.1002/capr.70083 · 2026 · External reference
Prediction of addiction relapse based on perceived social support and childhood trauma
10.34172/ahj.2023.1434 · 2023 · External reference
A comparative interventional study on the effectiveness of acceptance and commitment therapy, emotion-focused therapy, and attachment-based therapy in improving emotion regulation among adolescents with digital game addiction
10.3389/fpsyg.2026.1780192 · 2026 · External reference