Research graph
References from Artificial intelligence–driven risk prediction of polypharmacy in older adults: current advances, clinical applications, and future perspectives. Local targets link to admitted publications; unresolved targets remain external evidence.
Polypharmacy in older adults: a narrative review of definitions, epidemiology and consequences
10.1007/s41999-021-00479-3 · 2021 · External reference
Polypharmacy prevalence among older adults based on the survey of health, ageing and retirement in Europe: an update
10.3390/jcm14041330 · 2025 · External reference
Polypharmacy appropriateness in Italian Long-term care facilities: the nationwide prescription day point survey
10.1007/s40520-025-03183-5 · 2025 · External reference
Persistent polypharmacy and fall injury risk: the health, aging and body composition study
10.1186/s12877-021-02695-9 · 2021 · External reference
Frailty, polypharmacy, and health outcomes in older adults: the frailty and dependence in Albacete study
10.1016/j.jamda.2017.07.008 · 2018 · External reference
Polypharmacy, hospitalization, and mortality risk: a nationwide cohort study
10.1038/s41598-020-75888-8 · 2020 · External reference
Polypharmacy is a risk factor for hospital admission due to a fall: evidence from the English longitudinal study of ageing
10.1186/s12889-020-09920-x · 2020 · External reference
Multi-trajectories of polypharmacy composition and clinical outcomes by frailty status: a longitudinal cohort study
10.1093/ageing/afaf336 · 2025 · External reference
Polypharmacy, chronic kidney disease, and mortality among older adults: a prospective study of National Health and nutrition examination survey, 1999-2018
10.3389/fpubh.2023.1116583 · 2023 · External reference
Polypharmacy among people living with type 2 diabetes mellitus in rural communes in Vietnam
10.1371/journal.pone.0249849 · 2021 · External reference
What is polypharmacy in patients with chronic kidney disease? A systematic review
10.1016/j.clinthera.2023.08.007 · 2023 · External reference
Polypharmacy in the geriatric oncology population
10.1007/s11912-017-0632-3 · 2017 · External reference
Emerging approaches to polypharmacy among older adults
10.1038/s43587-021-00045-3 · 2021 · External reference
Reducing potentially inappropriate prescriptions for older patients using computerized decision support tools: systematic review
10.2196/15385 · 2019 · External reference
Artificial intelligence in the Management of Polypharmacy among older adults: a scoping review
10.7759/cureus.90867 · 2025 · External reference
Optimizing elderly care: a data-driven AI model for predicting polypharmacy risk in the elderly using SHARE data
10.1016/j.neuroscience.2025.05.004 · 2025 · External reference
Exploring polypharmacy with artificial intelligence: data analysis protocol
10.1186/s12911-021-01583-x · 2021 · External reference
A polypharmacy risk prediction model for elderly patients based on sociodemographic and clinical factors
10.5414/cp203238 · 2018 · External reference
Predicting polypharmacy in half a million adults in the Iranian population: comparison of machine learning algorithms
10.1186/s12911-023-02177-5 · 2023 · External reference
PolyLLM: polypharmacy side effect prediction via LLM-based SMILES encodings
10.3389/fphar.2025.1617142 · 2025 · External reference
Clinically relevant drug-drug interactions and the risk for drug adverse effects among home-dwelling older persons with and without type 2 diabetes
10.1111/jcpt.12854 · 2019 · External reference
Medication regimen complexity and polypharmacy as factors associated with all-cause mortality in older people: a population-based cohort study
10.1177/1060028015621071 · 2016 · External reference
An update on the clinical consequences of polypharmacy in older adults: a narrative review
10.1080/14740338.2018.1546841 · 2018 · External reference
Patient-experienced burden of treatment in patients with multimorbidity - A systematic review of qualitative data
10.1371/journal.pone.0179916 · 2017 · External reference
Polypharmacy management in the older adults: a scoping review of available interventions
10.3389/fphar.2021.734045 · 2021 · External reference
Interventions to improve the appropriate use of polypharmacy for older people
10.1002/14651858.cd008165.pub5 · 2023 · External reference
Polypharmacy and trajectories of health-related quality of life in older adults: an Australian cohort study
10.1007/s11136-022-03136-9 · 2022 · External reference
Polypharmacy and potentially inappropriate medications in older adults who use long-term care services: a cross-sectional study
10.1186/s12877-024-05296-4 · 2024 · External reference
Association of medication use with falls and mortality among long-term care residents: a longitudinal cohort study
10.1186/s12877-023-04096-6 · 2023 · External reference
Polypharmacy difference between older people with and without diabetes: evidence from the English longitudinal study of ageing
10.1016/j.diabres.2021.108842 · 2021 · External reference
Association between polypharmacy and health-related quality of life among US adults with cardiometabolic risk factors
10.1007/s11136-019-02377-5 · 2020 · External reference
Systematic review and Meta-analysis on the associations of polypharmacy and potentially inappropriate medication with adverse outcomes in older Cancer patients
10.1093/gerona/glaa128 · 2021 · External reference
Number of medications and polypharmacy are associated with frailty in older adults: results from the midlife in the United States study
10.3389/fpubh.2023.1148671 · 2023 · External reference
What is polypharmacy? A systematic review of definitions
10.1186/s12877-017-0621-2 · 2017 · External reference
Polypharmacy definitions for multimorbid older adults need stronger foundations to guide research, clinical practice and public health
10.3390/pharmacy7030126 · 2019 · External reference
Disentangling concepts of inappropriate polypharmacy in old age: a scoping review
10.1186/s12889-023-15013-2 · 2023 · External reference
Prevalence of potentially harmful multidrug interactions on medication lists of elderly ambulatory patients
10.1186/s12877-021-02594-z · 2021 · External reference
Classifying polypharmacy according to pharmacotherapeutic and clinical risks in older adults: a latent class analysis in Quebec, Canada
10.1007/s40266-023-01028-2 · 2023 · External reference
Longitudinal trajectories of polypharmacy in older people, and their association with the risk of mortality: a joint latent class model analysis of real-world data from the UK and the Netherlands
10.1093/ageing/afaf233 · 2025 · External reference
Machine learning-based asthma attack prediction models from routinely collected electronic health records: systematic scoping review
10.2196/46717 · 2023 · External reference
Challenges and strategies for wide-scale artificial intelligence (AI) deployment in healthcare practices: a perspective for healthcare organizations
10.1016/j.artmed.2024.102861 · 2024 · External reference
Opportunities and challenges in developing deep learning models using electronic health records data: a systematic review
10.1093/jamia/ocy068 · 2018 · External reference
Modeling polypharmacy side effects with graph convolutional networks
10.1093/bioinformatics/bty294 · 2018 · External reference
Adverse drug reactions and events in an ageing PopulaTion risk prediction (ADAPTiP) tool: the development and validation of a model for predicting adverse drug reactions and events in older patients
10.1007/s41999-024-01152-1 · 2025 · External reference
A NASSS framework-guided systematic review and exploratory modelling of digital health interventions for polypharmacy management in older adults
10.1186/s12877-025-06602-4 · 2025 · External reference
Decision-support systems for managing polypharmacy in the elderly: a scoping review
10.1016/j.jbi.2022.104074 · 2022 · External reference
Polypharmacy management interventions in older adults: an umbrella review of meta-analyses of randomized controlled trials
10.1016/j.puhe.2025.106077 · 2026 · External reference
Machine learning to predict adverse drug events based on electronic health records: a systematic review and meta-analysis
10.1177/03000605241302304 · 2024 · External reference
Artificial intelligence-supported web application design and development for reducing polypharmacy side effects and supporting rational drug use in geriatric patients
10.3389/fmed.2023.1029198 · 2023 · External reference
Predicting adverse drug events in older inpatients: a machine learning study
10.1007/s11096-022-01468-7 · 2022 · External reference
Prediction models using artificial intelligence and longitudinal data from electronic health records: a systematic methodological review
10.1093/jamia/ocad168 · 2023 · External reference
Phar-LSTM: a pharmacological representation-based LSTM network for drug-drug interaction extraction
10.7717/peerj.16606 · 2023 · External reference
Transformers and large language models in healthcare: a review
10.1016/j.artmed.2024.102900 · 2024 · External reference
Large language models in medicine: the potentials and pitfalls: a narrative review
10.7326/m23-2772 · 2024 · External reference
Extracting medication changes in clinical narratives using pre-trained language models
10.1016/j.jbi.2023.104302 · 2023 · External reference
Adverse drug event detection using natural language processing: a scoping review of supervised learning methods
10.1371/journal.pone.0279842 · 2023 · External reference
Risk prediction in IgA nephropathy: from conventional models to machine learning, deep learning, and precision nephrology
10.1080/0886022x.2026.2613606 · 2026 · External reference
Explainable prediction self-assessment model for potentially inappropriate prescribing risk in older adults
10.1016/j.ijmedinf.2025.106137 · 2026 · External reference
Understanding the relationship between comorbidities, medication nonadherence, activities of daily living, and heart condition status among older adults in the United States: a regression analysis and machine learning approach
10.1097/jcn.0000000000001150 · 2024 · External reference
Unlocking the potential of advanced large language models in medication review and reconciliation: a proof-of-concept investigation
10.1016/j.rcsop.2024.100492 · 2024 · External reference
High-performance medicine: the convergence of human and artificial intelligence
10.1038/s41591-018-0300-7 · 2019 · External reference
The unseen hand: AI-based prescribing decision support tools and the evaluation of drug safety and effectiveness
10.1007/s40264-023-01376-3 · 2024 · External reference
The use of artificial intelligence to optimize medication alerts generated by clinical decision support systems: a scoping review
10.1093/jamia/ocae076 · 2024 · External reference
Performance of predictive AI-based clinical decision support systems across clinical domains: a systematic review and meta-analysis
10.1371/journal.pdig.0001310 · 2026 · External reference
Potentiality of algorithms and artificial intelligence adoption to improve medication management in primary care: a systematic review
10.1136/bmjopen-2022-065301 · 2023 · External reference
Artificial intelligence in the field of pharmacy practice: a literature review
10.1016/j.rcsop.2023.100346 · 2023 · External reference
STOPP/START criteria for potentially inappropriate prescribing in older people: version 3
10.1007/s41999-023-00777-y · 2023 · External reference
A systematic review shows no performance benefit of machine learning over logistic regression for clinical prediction models
10.1016/j.jclinepi.2019.02.004 · 2019 · External reference
Using tree-based machine learning for health studies: literature review and case series
10.3390/ijerph192316080 · 2022 · External reference
Scoping review of studies evaluating frailty and its association with medication harm
10.1007/s40266-022-00940-3 · 2022 · External reference
AI-based decision support to optimize complex care for preventing medication-related falls
10.1038/s41591-023-02780-z · 2024 · External reference
The applications of artificial intelligence for assessing fall risk: systematic review
10.2196/54934 · 2024 · External reference
Deep learning for healthcare: review, opportunities and challenges
10.1093/bib/bbx044 · 2018 · External reference
Prediction of new-onset atrial fibrillation in sepsis patients by machine learning: a systematic review
10.1177/20552076251384237 · 2025 · External reference
A survey of models composed of graph neural networks and large language models for molecular science
10.1093/bioinformatics/btag387 · 2026 · External reference
Graph neural networks in modern AI-aided drug discovery
10.1021/acs.chemrev.5c00461 · 2025 · External reference
Development of artificial intelligence powered apps and tools for clinical pharmacy services: a systematic review
10.1016/j.ijmedinf.2022.104983 · 2023 · External reference
Management of polypharmacy through deprescribing in older patients: a review of the role of AI tools
10.1080/17512433.2025.2519648 · 2025 · External reference
Applications of artificial intelligence in current pharmacy practice: a scoping review
10.1016/j.sapharm.2024.12.007 · 2025 · External reference
To warrant clinical adoption AI models require a multi-faceted implementation evaluation
10.1038/s41746-024-01064-1 · 2024 · External reference
Predictors of health care practitioners' intention to use AI-enabled clinical decision support systems: meta-analysis based on the unified theory of acceptance and use of technology
10.2196/57224 · 2024 · External reference
Systematic review to understand users perspectives on AI-enabled decision aids to inform shared decision making
10.1038/s41746-024-01326-y · 2024 · External reference
Evidence supporting the best clinical management of patients with multimorbidity and polypharmacy: a systematic guideline review and expert consensus
10.1111/joim.12842 · 2019 · External reference
American Geriatrics Society 2023 updated AGS beers criteria(R) for potentially inappropriate medication use in older adults
10.1111/jgs.18372 · 2023 · External reference
Interventions to reduce medication errors in adult medical and surgical settings: a systematic review
10.1177/2042098620968309 · 2020 · External reference
Identifying recruitment strategies to improve the reach of evidence-based health promotion, disease prevention, and disease self-management interventions: a scoping review
10.3389/fpubh.2025.1515042 · 2025 · External reference
Changes in polypharmacy and potentially inappropriate medications in homebound older adults in Japan, 2015-2019: a nationwide study
10.1007/s11606-023-08364-4 · 2023 · External reference
Differential privacy in health research: a scoping review
10.1093/jamia/ocab135 · 2021 · External reference
Post-discharge medicines management: the experiences, perceptions and roles of older people and their family carers
10.1111/hex.13145 · 2020 · External reference