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References from H5N1 clade 2.3.2.1e lineage transition in Lao PDR during 2023–2024 associated with regional spread and human infection risk-associated receptor-binding features. Local targets link to admitted publications; unresolved targets remain external evidence.
Identification, characterization, and natural selection of mutations driving airborne transmission of a/H5N1 virus
10.1016/j.cell.2014.02.040 · 2014 · External reference
Avian influenza overview September–November 2025
10.2903/j.efsa.2025.9834 · 2025 · External reference
Genetic and pathogenic characteristics of clade 2.3.2.1c H5N1 highly pathogenic avian influenza viruses isolated from poultry outbreaks in Laos during 2015-2018
10.1111/tbed.13430 · 2020 · External reference
Technical Report: June 2024 Highly Pathogenic Avian Influenza A(H5N1) Viruses Centers for Disease Control and Prevention
2024 · External reference
Avian influenza and coronaviruses in live animal and wet markets in Laos: prevalence and public health considerations
10.3389/fcimb.2026.1786183 · 2026 · External reference
Epidemiology and risk modelling of influenza a virus within and between pig herds in northern Lao PDR
10.1155/tbed/2407533 · 2026 · External reference
Resurgence of zoonotic highly pathogenic avian influenza a(H5N1) virus in Cambodia
10.1056/nejmc2504302 · 2025 · External reference
Tiger deaths in Vietnam due to infection with H5N1 highly pathogenic avian influenza virus bearing mutations associated with mammalian host adaptation
10.1080/22221751.2025.2582252 · 2025 · External reference
Mammalian ANP32A and ANP32B proteins drive differential polymerase adaptations in avian influenza virus
10.1128/jvi.00213-23 · 2023 · External reference
Mammalian adaptation in the PB2 gene of avian H5N1 influenza virus
10.1128/jvi.01016-13 · 2013 · External reference
Disease Outbreak News; Avian Influenza A(H5N1) in Cambodia World Health Organization
2025 · External reference
Influenza and respiratory syncytial virus dynamics in Lao PDR during the COVID-19 pandemic: a hospital-based surveillance study
10.1136/bmjopen-2024-098006 · 2025 · External reference
Genetic variation and co-evolutionary relationship of RNA polymerase complex segments in influenza a viruses
10.1016/j.virol.2017.07.027 · 2017 · External reference
Molecular basis for high virulence of Hong Kong H5N1 influenza a viruses
10.1126/science.1062882 · 2001 · External reference
Phenotypic effects of substitutions within the receptor binding site of highly pathogenic avian influenza H5N1 virus observed during human infection
10.1128/jvi.00195-20 · 2020 · External reference
Haemagglutinin mutations responsible for the binding of H5N1 influenza a viruses to human-type receptors
10.1038/nature05264 · 2006 · External reference
A single mutation in bovine influenza H5N1 hemagglutinin switches specificity to human receptors
10.1126/science.adt0180 · 2024 · External reference
Assessing potential pathogenicity of novel highly pathogenic avian influenza (H5N6) viruses isolated from Mongolian wild duck feces using a mouse model
10.1080/22221751.2022.2069515 · 2022 · External reference
Next-generation sequencing: methodology and application
10.1038/jid.2013.248 · 2013 · External reference
MAFFT multiple sequence alignment software version 7: improvements in performance and usability
10.1093/molbev/mst010 · 2013 · External reference
MEGA12: molecular evolutionary genetic analysis version 12 for adaptive and green computing
10.1093/molbev/msae263 · 2024 · External reference
Bayesian phylogenetic and phylodynamic data integration using BEAST 1.10
10.1093/ve/vey016 · 2018 · External reference
Dating of the human-ape splitting by a molecular clock of mitochondrial DNA
10.1007/bf02101694 · 1985 · External reference
Relaxed phylogenetics and dating with confidence
10.1371/journal.pbio.0040088 · 2006 · External reference
Smooth Skyride through a rough skyline: Bayesian coalescent-based inference of population dynamics
10.1093/molbev/msn090 · 2008 · External reference
Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal omega
10.1038/msb.2011.75 · 2011 · External reference
Deciphering key features in protein structures with the new ENDscript server
10.1093/nar/gku316 · 2014 · External reference
qgis/QGIS: 3.44.0. 3.44.0
2025 · External reference
Unresolved reference
2025 · External reference
Glycine at position 622 in PB1 contributes to the virulence of H5N1 avian influenza virus in mice
10.1128/jvi.02387-15 · 2016 · External reference
Synergistic effect of S224P and N383D substitutions in the PA of H5N1 avian influenza virus contributes to mammalian adaptation
10.1038/srep10510 · 2015 · External reference
Adamantane-resistant influenza a viruses in the world (1902-2013): frequency and distribution of M2 gene mutations
10.1371/journal.pone.0119115 · 2015 · External reference
The avian influenza virus NS1 ESEV PDZ binding motif associates with Dlg1 and scribble to disrupt cellular tight junctions
10.1128/jvi.05070-11 · 2011 · External reference
H5N1 avian influenza virus without 80-84 amino acid deletion at the NS1 protein hijacks the innate immune system of dendritic cells for an enhanced mammalian pathogenicity
10.1111/tbed.13904 · 2021 · External reference
Sequence requirements for cleavage activation of influenza virus hemagglutinin expressed in mammalian cells
10.1073/pnas.85.2.324 · 1988 · External reference
Analysis of a point mutation in H5N1 avian influenza virus hemagglutinin in relation to virus entry into live mammalian cells
10.1007/s00705-008-0255-y · 2008 · External reference
Human-like receptor specificity does not affect the neuraminidase-inhibitor susceptibility of H5N1 influenza viruses
10.1371/journal.ppat.1000043 · 2008 · External reference
Experimental adaptation of an influenza H5 HA confers respiratory droplet transmission to a reassortant H5 HA/H1N1 virus in ferrets
10.1038/nature10831 · 2012 · External reference
Detection of mammalian virulence determinants in highly pathogenic avian influenza H5N1 viruses: multivariate analysis of published data
10.1128/jvi.00608-09 · 2009 · External reference
Antigenic profile of avian H5N1 viruses in Asia from 2002 to 2007
10.1128/jvi.02256-07 · 2008 · External reference
Immunization by avian H5 influenza hemagglutinin mutants with altered receptor binding specificity
10.1126/science.1135165 · 2007 · External reference
Positive selection at the receptor-binding site of haemagglutinin H5 in viral sequences derived from human tissues
10.1099/vir.0.2008/002469-0 · 2008 · External reference
In vitro assessment of attachment pattern and replication efficiency of H5N1 influenza a viruses with altered receptor specificity
10.1128/jvi.02737-09 · 2010 · External reference
Changes in H5N1 influenza virus hemagglutinin receptor binding domain affect systemic spread
10.1073/pnas.0811052106 · 2009 · External reference
In vitro evolution of H5N1 avian influenza virus toward human-type receptor specificity
10.1016/j.virol.2011.10.006 · 2012 · External reference
Effect of receptor binding domain mutations on receptor binding and transmissibility of avian influenza H5N1 viruses
10.1016/j.virol.2011.02.015 · 2011 · External reference
Evolution of the receptor binding phenotype of influenza a (H5) viruses
10.1016/j.virol.2005.08.035 · 2006 · External reference
A mutation in H5 haemagglutinin that conferred human receptor recognition is not maintained stably during duck passage
10.1099/vir.0.018572-0 · 2010 · External reference
Genomic signature analysis of the recently emerged highly pathogenic a(H5N8) avian influenza virus: implying an evolutionary trend for bird-to-human transmission
10.1016/j.micinf.2017.08.006 · 2017 · External reference
Adaptation of H9N2 AIV in guinea pigs enables efficient transmission by direct contact and inefficient transmission by respiratory droplets
10.1038/srep15928 · 2015 · External reference
Structural and antigenic variation among diverse clade 2 H5N1 viruses
10.1371/journal.pone.0075209 · 2013 · External reference
The haemagglutinin gene of bovine-origin H5N1 influenza viruses currently retains receptor-binding and pH-fusion characteristics of avian host phenotype
10.1080/22221751.2025.2451052 · 2025 · External reference
Structure of a zoonotic H5N1 hemagglutinin reveals a receptor-binding site occupied by an auto-glycan
10.1016/j.str.2025.01.001 · 2025 · External reference
Characterization of the haemagglutinin properties of the H5N1 avian influenza virus that caused human infections in Cambodia
10.1080/22221751.2023.2244091 · 2023 · External reference
A rapid review of the avian influenza PB2 E627K mutation in human infection studies
10.14745/ccdr.v51i04a04 · 2025 · External reference
H5N1 2.3.4.4b: a review of mammalian adaptations and risk of pandemic emergence
10.1099/jgv.0.002109 · 2025 · External reference
