Research graph
References from The success-failure inversion in modern medicine. Local targets link to admitted publications; unresolved targets remain external evidence.
Decline in cardiovascular mortality: possible causes and implications
10.1161/circresaha.116.309115 · 2017 · External reference
Explaining the decrease in US deaths from coronary disease
10.1056/nejmsa053935 · 2007 · External reference
Heart disease mortality in the United States
10.1161/jaha.124.038644 · 2025 · External reference
Decline in deaths from heart disease and stroke–United States, 1900-1999
1999 · External reference
Acute lymphoblastic leukemia in children
10.1056/nejmra1400972 · 2015 · External reference
Global efforts toward the cure of childhood acute lymphoblastic leukaemia
10.1016/s2352-4642(18)30066-x · 2018 · External reference
Comparison of overall and comorbidity-free life expectancy between insured adults with and without HIV infection, 2000-2016
10.1001/jamanetworkopen.2020.7954 · 2020 · External reference
Survival of HIV-positive patients starting antiretroviral therapy between 1996 and 2013: a collaborative analysis of cohort studies
10.1016/s2352-3018(17)30066-8 · 2017 · External reference
The internal secretion of the pancreas
2007 · External reference
The changing tides of the type 2 diabetes epidemic–smooth sailing or troubled waters ahead? Kelly West Award Lecture 2016
10.2337/dci16-0055 · 2017 · External reference
Cancer statistics, 2024
10.3322/caac.21820 · 2024 · External reference
Where is the disease?
10.13140/rg.2.2.29549.76004 · 2026 · External reference
From lifespan to healthspan
10.1001/jama.2018.12621 · 2018 · External reference
Life expectancy and mortality rates in the United States, 1959–2017
10.1001/jama.2019.16932 · 2019 · External reference
Global burden of dementia death from 1990 to 2019, with projections to 2050: an analysis of 2019 global burden of disease study
10.14283/jpad.2024.21 · 2024 · External reference
Estimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050: An analysis for the Global Burden of Disease Study 2019
10.1002/alz.051496 · 2022 · External reference
Alzheimer disease in the United States (2010-2050) estimated using the 2010 census
10.1212/wnl.0b013e31828726f5 · 2013 · External reference
Revisiting FDA approval of aducanumab
10.1056/nejmp2110468 · 2021 · External reference
The amyloid hypothesis in Alzheimer disease: new insights from new therapeutics
10.1038/s41573-022-00391-w · 2022 · External reference
Aducanumab for Alzheimer's disease?
10.1136/bmj.n1682 · 2021 · External reference
Schizophrenia: from neurochemistry to circuits, symptoms and treatments
10.1038/s41582-023-00904-0 · 2024 · External reference
No support for historical candidate gene or candidate gene-by-interaction hypotheses for major depression across multiple large samples
10.1176/appi.ajp.2018.18070881 · 2019 · External reference
The serotonin theory of depression: a systematic umbrella review of the evidence
10.1038/s41380-022-01661-0 · 2023 · External reference
Origins and evolution of antibiotic resistance
10.1128/mmbr.00016-10 · 2010 · External reference
The epidemiologic transition: a theory of the epidemiology of population change
10.1111/j.1468-0009.2005.00398.x · 2005 · External reference
Regulation of the immune system by biodiversity from the natural environment: an ecosystem service essential to health
10.1073/pnas.1313731110 · 2013 · External reference
Hay fever, hygiene, and household size
10.1136/bmj.299.6710.1259 · 1989 · External reference
10.7551/mitpress/8328.001.0001
10.7551/mitpress/8328.001.0001 · 2010 · External reference
The dappled nature of causes of psychiatric illness: replacing the organic-functional/hardware-software dichotomy with empirically based pluralism
10.1038/mp.2011.182 · 2012 · External reference
10.1093/acprof:oso/9780199299317.001.0001
10.1093/acprof:oso/9780199299317.001.0001 · 2007 · External reference
The epistemic policies of anti-ageing medicines in the European Union
10.1007/s10728-024-00497-9 · 2024 · External reference
10.1017/cbo9780511802683
10.1017/cbo9780511802683 · 2003 · External reference
A network theory of mental disorders
10.1002/wps.20375 · 2017 · External reference
Brain disorders? Not really: why network structures block reductionism in psychopathology research
10.1017/s0140525x18002091 · 2019 · External reference
The need for a new medical model: a challenge for biomedicine
10.1126/science.847460 · 1977 · External reference
Causes
10.1093/oxfordjournals.aje.a112335 · 1976 · External reference
Causation and causal inference in epidemiology
10.2105/ajph.2004.059204 · 2005 · External reference
Causes and conditions
1965 · External reference
From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus
10.2337/db09-9028 · 2009 · External reference
Geroscience: linking aging to chronic disease
10.1016/j.cell.2014.10.039 · 2014 · External reference
Hallmarks of aging: an expanding universe
10.1016/j.cell.2022.11.001 · 2023 · External reference
World-Wide FINGERS network: a global approach to risk reduction and prevention of dementia
10.1002/alz.12123 · 2020 · External reference
A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial
10.1016/s0140-6736(15)60461-5 · 2015 · External reference
From dementia prevention research to global FINGER-based multi-domain interventions and implementation strategies
10.1016/j.cccb.2025.100385 · 2025 · External reference
Nutrition and physical activity in the prevention and treatment of sarcopenia: systematic review
10.1007/s00198-017-3980-9 · 2017 · External reference
Resistance training for older adults: position statement from the National Strength and Conditioning Association
10.1519/jsc.0000000000003230 · 2019 · External reference
Progressive resistance strength training for improving physical function in older adults
10.1002/14651858.cd002759.pub2 · 2009 · External reference
Global distribution of research efforts, disease burden, and impact of US public funding withdrawal
10.1038/s41591-025-03923-0 · 2025 · External reference
Rescuing US biomedical research from its systemic flaws
10.1073/pnas.1404402111 · 2014 · External reference
Addressing systemic problems in the biomedical research enterprise
10.1073/pnas.1500969112 · 2015 · External reference
The persistence of very low correlations between NIH research funding and disease burdens
10.1016/j.puhip.2024.100580 · 2025 · External reference
NIH disease funding levels and burden of disease
10.1371/journal.pone.0016837 · 2011 · External reference
Falsification and the methodology of scientific research programmes
10.1017/cbo9781139171434.009 · 1970 · External reference
Toward the future of psychiatric diagnosis: the seven pillars of RDoC
10.1186/1741-7015-11-126 · 2013 · External reference
Distal symmetric polyneuropathy: a review
10.1001/jama.2015.13611 · 2015 · External reference
The epidemiology and risk factors of chronic polyneuropathy
10.1007/s10654-015-0094-6 · 2016 · External reference
Emerging biomarkers, tools, and treatments for diabetic polyneuropathy
10.1210/er.2018-00107 · 2019 · External reference
Sauver JL, Dyck PJ, Klein CJ. Impairments and comorbidities of polyneuropathy revealed by population-based analyses
10.1212/wnl.0000000000001492 · 2015 · External reference
Causes of neuropathy in patients referred as “idiopathic neuropathy”
10.1002/mus.24969 · 2016 · External reference
Incidence of polyneuropathy in Utrecht, the Netherlands
10.1212/wnl.0000000000001160 · 2015 · External reference
Mitochondrial dynamics and peripheral neuropathy
10.1177/1073858407307354 · 2008 · External reference
Mechanisms of axon degeneration: from development to disease
10.1016/j.pneurobio.2007.07.007 · 2007 · External reference
Axo-glial interdependence in peripheral nerve development
10.1242/dev.151704 · 2019 · External reference
Diminished schwann cell repair responses underlie age-associated impaired axonal regeneration
10.1016/j.neuron.2014.06.016 · 2014 · External reference
Vascular factors and metabolic interactions in the pathogenesis of diabetic neuropathy
10.1007/s001250100001 · 2001 · External reference
Role of advanced glycation end products in diabetic neuropathy
10.2174/138161208784139774 · 2008 · External reference
Metabolic syndrome components are associated with symptomatic polyneuropathy independent of glycemic status
10.2337/dc16-0081 · 2016 · External reference
Metabolic syndrome is related to polyneuropathy and impaired peripheral nerve function: a prospective population-based cohort study
10.1136/jnnp-2016-314171 · 2016 · External reference
The neuroinflammatory role of schwann cells in disease
10.1016/j.nbd.2013.03.005 · 2013 · External reference
Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis
10.1016/s1474-4422(14)70251-0 · 2015 · External reference
Oral and topical treatment of painful diabetic polyneuropathy: practice guideline update summary: report of the AAN guideline subcommittee
10.1212/wnl.0000000000013038 · 2022 · External reference
The effect of exercise on neuropathic symptoms, nerve function, and cutaneous innervation in people with diabetic peripheral neuropathy
10.1016/j.jdiacomp.2012.05.007 · 2012 · External reference
Lifestyle intervention for pre-diabetic neuropathy
10.2337/dc06-0224 · 2006 · External reference
Exercise intervention studies in patients with peripheral neuropathy: a systematic review
10.1007/s40279-014-0207-5 · 2014 · External reference
Current concepts in the management of diabetic polyneuropathy
10.1111/jdi.13401 · 2021 · External reference
Sarcopenia: revised European consensus on definition and diagnosis
10.1093/ageing/afy169 · 2019 · External reference
Sarcopenia: aging-related loss of muscle mass and function
10.1152/physrev.00061.2017 · 2019 · External reference
Myostatin antibody (LY2495655) in older weak fallers: a proof-of-concept, randomised, phase 2 trial
10.1016/s2213-8587(15)00298-3 · 2015 · External reference
Treatment of sarcopenia with bimagrumab: results from a phase II, randomized, controlled, proof-of-concept study
10.1111/jgs.14927 · 2017 · External reference
A deep-learning framework reveals whole-body perturbations at cell level
10.1038/s41586-026-10535-2 · 2026 · External reference
Bevacizumab injection in patients with neovascular age-related macular degeneration increases angiogenic biomarkers
10.1016/j.oret.2017.04.004 · 2018 · External reference
Ranibizumab and bevacizumab for neovascular age-related macular degeneration
10.1056/nejmoa1102673 · 2011 · External reference
Ranibizumab for neovascular age-related macular degeneration
10.1056/nejmoa054481 · 2006 · External reference
The divide-and-conquer approach to delaying age-related functional decline: where are we now?
10.1089/rej.2023.0057 · 2023 · External reference
SENS vs. the hallmarks of aging: competing visions, shared challenges
10.1007/s10522-025-10248-5 · 2025 · External reference
Aging and immortality: quasi-programmed senescence and its pharmacologic inhibition
10.4161/cc.5.18.3288 · 2006 · External reference
The hoverfly and the wasp: a critique of the hallmarks of aging as a paradigm
10.1016/j.arr.2021.101407 · 2021 · External reference
A complex systems approach to aging biology
10.1038/s43587-022-00252-6 · 2022 · External reference
Evolution of ageing
10.1038/270301a0 · 1977 · External reference
Inflammaging: a new immune-metabolic viewpoint for age-related diseases
10.1038/s41574-018-0059-4 · 2018 · External reference
Distinguishing between driver and passenger mechanisms of aging
10.1038/s41588-023-01627-0 · 2024 · External reference
Targeting the “hallmarks of aging” to slow aging and treat age-related disease: fact or fiction?
10.1038/s41380-022-01680-x · 2023 · External reference
The Hallmarks of aging: paradigms and scientific progress
10.1016/j.arr.2026.103181 · 2026 · External reference
Targeting multiple hallmarks of mammalian aging with combinations of interventions
10.18632/aging.206078 · 2024 · External reference
Challenges in developing Geroscience trials
10.1038/s41467-023-39786-7 · 2023 · External reference
Can geroscience be translated into healthcare?
10.1007/s00391-024-02326-z · 2024 · External reference
10.1007/s11357-018-0042-y · 2018 · Admitted local publication
10.1093/9780197830062.001.0001
10.1093/9780197830062.001.0001 · 2026 · External reference
Is ageing undesirable? An ethical analysis
10.1136/jme-2022-108823 · 2023 · External reference
The ethics case for longevity science
10.1016/j.arr.2026.103054 · 2026 · External reference
10.7551/mitpress/14110.001.0001
10.7551/mitpress/14110.001.0001 · 2022 · External reference
Clashing perspectives? Two approaches to the desirability of biological aging
2026 · External reference
Untangling the concepts of disability, frailty, and comorbidity: implications for improved targeting and care
10.1093/gerona/59.3.m255 · 2004 · External reference
Designing health care for the most common chronic condition–multimorbidity
10.1001/jama.2012.5265 · 2012 · External reference
Prescribing for frail older people
10.18773/austprescr.2017.055 · 2017 · External reference
What is polypharmacy? A systematic review of definitions
10.1186/s12877-017-0621-2 · 2017 · External reference
Efficacy of second generation antidepressants in late-life depression: a meta-analysis of the evidence
10.1097/01.jgp.0000308883.64832.ed · 2008 · External reference
Dementia prevention, intervention, and care: 2024 report of the Lancet standing commission
10.1016/s0140-6736(24)01296-0 · 2024 · External reference
Measuring polarization changes in the human outer retina with polarization-sensitive optical coherence tomography
10.1002/jbio.201700134 · 2018 · External reference
Long-term effects of vitamins C and E, β-carotene, and zinc on age-related macular degeneration: AREDS report no 35
10.1016/j.ophtha.2013.01.021 · 2013 · External reference
A double-masked, randomized, sham-controlled, single-center study with photobiomodulation for the treatment of dry age-related macular degeneration
10.1097/iae.0000000000002632 · 2020 · External reference
Mediterranean diet and incidence of advanced age-related macular degeneration: the EYE-RISK Consortium
10.1016/j.ophtha.2018.08.006 · 2019 · External reference
Retinal imaging with polarization-sensitive optical coherence tomography and adaptive optics
10.1364/oe.17.021634 · 2009 · External reference
Volumetric retinal imaging with ultrahigh-resolution spectral-domain optical coherence tomography and adaptive optics using two broadband light sources
10.1364/oe.17.004095 · 2009 · External reference
Two concepts for ultra-high-resolution polarization-sensitive optical coherence tomography with a single camera
10.1364/josaa.458631 · 2022 · External reference
Non-invasive retinal blood vessel wall measurements with polarization-sensitive optical coherence tomography for diabetes assessment: a quantitative study
10.3390/biom13081230 · 2023 · External reference
Hypertension-associated changes in retinal blood vessel walls measured in vivo with polarization-sensitive optical coherence tomography
10.1016/j.optlaseng.2023.107838 · 2023 · External reference