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References from Recent advances in mass spectrometry methods for the investigation of oligomeric intermediates of amyloid protein aggregation. Local targets link to admitted publications; unresolved targets remain external evidence.
Time-resolved studies define the nature of toxic IAPP intermediates, providing insight for anti-amyloidosis therapeutics
10.7554/elife.12977 · 2016 · External reference
α-Synuclein aggregation landscape from phase separation to neurotoxic intermediates
10.1002/1873-3468.70393 · 2026 · External reference
Improved mass analysis of proteins and protein complexes present in common biological buffers and physiological concentrations of NaCl using solution additives delivered by theta emitters
10.1021/acs.analchem.5c03032 · 2025 · External reference
Differences in α-synuclein conformational states in physiologically relevant pH/Na+ concentrations and ammonium acetate solutions unveiled by native mass spectrometry
10.1039/d5an01336d · 2026 · External reference
Proteome-wide structural and interaction analysis using cross-linking mass spectrometry and its applications
10.1016/j.bpj.2026.03.062 · External reference
Cross-linking mass spectrometry: workflow enhancements for mapping large-scale interactomes
10.1016/j.bpj.2026.05.033 · External reference
A covalent protein painting assay differentiates Amyloid-β polymorphs in alzheimer disease
10.1021/acs.jproteome.5c00735 · 2026 · External reference
Molecular mechanisms of islet amyloid polypeptide aggregation: towards chemical strategies to prevent amyloid formation and to design non-aggregating peptide therapeutics
10.3390/ijms27062598 · 2026 · External reference
Traversing the drug discovery landscape using native mass spectrometry
10.1016/j.sbi.2025.102993 · 2025 · External reference
Recent advances in structural mass spectrometry methods in the context of biosimilarity assessment: from sequence heterogeneities to higher order structures
10.1016/j.jpba.2023.115696 · 2023 · External reference
Structures of oligomeric states of tau protein, Amyloid-β, α-Synuclein and prion protein implicated in alzheimer’s disease, parkinson’s disease and prionopathies
10.3390/ijms252313049 · 2024 · External reference
The aggregation of amyloid-β: from condensation, nucleation, and conformation to targeting therapy
10.1016/j.lfs.2026.124397 · 2026 · External reference
Mass spectrometry-based protein footprinting for protein structure characterization
10.1021/acs.accounts.4c00545 · 2025 · External reference
Top-down mass spectrometry-based structural and functional proteomics: a perspective
10.1002/jms.70044 · 2026 · External reference
Understanding the structural dynamics of human islet amyloid polypeptide: advancements in and applications of ion-mobility mass spectrometry
10.1016/j.bpc.2024.107285 · 2024 · External reference
Neuroinflammation and oxidative stress in parkinson’s disease, alzheimer’s disease, and COVID-19: microglia-neutrophil interaction
10.1021/acsomega.5c10397 · 2026 · External reference
Probing early α-Synuclein oligomers: insights into aggregation pathways of NACore and preNAC segments probed by trapped ion-mobility mass spectrometry and fluorescence spectroscopy
10.1002/pmic.70087 · 2026 · External reference
Developments in trapped ion mobility mass spectrometry to probe the early stages of peptide aggregation
10.1021/jasms.2c00253 · 2023 · External reference
IR action spectroscopy of Mass- and mobility-selected α-Synuclein segments: structure identification in early-stage oligomers via the amide A region
10.1021/acs.jpca.5c02819 · 2025 · External reference
Native ambient mass spectrometry of membrane proteins directly from bacterial colonies
10.1039/d4cc03881a · 2025 · External reference
Unresolved reference
2026 · External reference
Cyclic ion mobility-collision activation experiments elucidate protein behavior in the gas phase
10.1021/jasms.1c00018 · 2021 · External reference
3D proteomics: structural, functional, chemical and biomarker discovery proteomics with LiP-MS
10.1016/j.mcpro.2026.101552 · 2026 · External reference
Targeting TDP-43 in sporadic amyotrophic lateral sclerosis
10.1007/s00415-026-14023-5 · 2026 · External reference
Transient binding facilitates super-resolution imaging of functional amyloid fibrils on living bacteria
10.1002/pro.70398 · 2026 · External reference
Shared pathophysiology and therapeutic repurposing in Alzheimer’s disease and type 2 diabetes: a critical review of convergent mechanisms and clinical challenges
10.1016/j.bioorg.2026.110044 · 2026 · External reference
Amyloid beta oligomers as early triggers of neuronal cytoskeleton dysfunction in alzheimer’s disease
10.3390/pathophysiology33010014 · 2026 · External reference
Molecular structure of a prevalent amyloid-β fibril polymorph from Alzheimer’s disease brain tissue
10.1073/pnas.2023089118 · 2021 · External reference
Nanoscale interrogation of α-Synuclein oligomers: bridging biophysics, interface science, and neurobiology
10.1016/j.cis.2026.103965 · 2026 · External reference
Discovery and significance of protein-protein interactions in health and disease
10.1016/j.cell.2024.10.038 · 2024 · External reference
EGCG has dual and opposing effects on the N-terminal region of self-associating α-synuclein oligomers
10.1016/j.jmb.2022.167855 · 2022 · External reference
Elucidating the oligomerization and cellular interactions of a trimer derived from Aβ through fluorescence and mass spectrometric studies
10.1021/acschemneuro.2c00313 · 2022 · External reference
Cross-interactions of Aβ peptides implicated in alzheimer’s disease shape amyloid oligomer structures and aggregation
10.1021/acschemneuro.4c00492 · 2024 · External reference
Imaging of protein assemblies up to 231 kDa in tissues with Nano-DESI mass spectrometry
10.1021/acs.analchem.5c05767 · 2025 · External reference
Effects of hydration on transthyretin conformational dynamics and oligomerization
10.1021/acs.biochem.5c00589 · 2025 · External reference
State-of-the-Art and future directions in structural proteomics
10.1016/j.mcpro.2025.101065 · 2025 · External reference
Amyloid oligomers: expediting crystal growth and revisiting the corkscrew structures
10.1021/jacs.5c00656 · 2025 · External reference
Laser capture microdissection and native mass spectrometry for spatially-resolved analysis of intact protein assemblies in tissue
10.1039/d3sc04933g · 2024 · External reference
Exploration of resveratrol as a potent modulator of α-Synuclein fibril formation
10.1021/acschemneuro.3c00571 · 2024 · External reference
Toxic mechanisms of amyloid oligomers and therapeutic strategies
10.1002/pro.70519 · External reference
In vitro,, cellular and in vivo studies of amyloid oligomers structure and toxicity: challenges and advances
10.1002/pro.70525 · External reference
10.1101/2025.10.12.681486
10.1101/2025.10.12.681486 · 2025 · External reference
Aggregation of TDP-43307-319: a dual pathway to forming cylindrins and fibrils and a contribution to the etiology of amyotrophic lateral sclerosis
10.1021/acs.jpcb.5c02640 · 2025 · External reference
Mass spectrometry-based methods to characterize highly heterogeneous biopharmaceuticals, vaccines, and nonbiological complex drugs at the intact-mass level
10.1002/mas.21829 · 2024 · External reference
Regulatory sites of CaM-sensitive adenylyl cyclase AC8 revealed by cryo-EM and structural proteomics
10.1038/s44319-024-00076-y · 2024 · External reference
Probing differences among Aβ oligomers with two triangular trimers derived from Aβ
10.1073/pnas.2219216120 · 2023 · External reference
Mass-spectrometry-based GEE footprinting characterizes kinetic mechanisms and sites of conformational change in amyloid β 1-42 aggregation
10.1021/acschemneuro.5c00033 · 2025 · External reference
Dissecting hidden liraglutide oligomerization pathways via direct mass technology, electron-capture dissociation, and molecular dynamics
10.1021/acs.analchem.5c01851 · 2025 · External reference
Water plays key roles in stabilities of wild type and mutant transthyretin complexes
10.1021/jasms.4c00170 · 2024 · External reference
Hydration (H2O and D2O) dictates the stabilities and conformational entropy of transthyretin tetramers
10.1021/jacs.5c11055 · 2025 · External reference
Catalytic cross talk between key peptide fragments that couple alzheimer’s disease with amyotrophic lateral sclerosis
10.1021/jacs.0c12729 · 2021 · External reference
Membrane protein complexity revealed through native mass spectrometry
10.1146/annurev-biochem-081424-044501 · 2025 · External reference
Subsecond time-resolved mass spectrometry in dynamic structural biology
10.1021/acs.chemrev.1c00222 · 2022 · External reference
Amyloid-β oligomers, curvilinear and annular assemblies, imaged by cryo-ET, cryo-EM, and AFM
10.1126/sciadv.adx9030 · 2025 · External reference
Analysis of dimer and trimer complexes of the non-amyloidogenic rat islet amyloid polypeptide 21-37 by electrospray ionization-tandem mass spectrometry
10.1177/14690667241278462 · 2024 · External reference
AlphaFold and structural mass spectrometry enable interrogations on the intrinsically disordered regions in cyanobacterial light-harvesting complex phycobilisome
10.1016/j.jmb.2022.167831 · 2022 · External reference
Native top-down mass spectrometry for higher-order structural characterization of proteins and complexes
10.1002/mas.21793 · 2023 · External reference
Computationally designed molecules modulate ALS-related amyloidogenic TDP-43307-319 aggregation
10.1021/acschemneuro.3c00582 · 2023 · External reference
Unbiased data-driven analysis of five amyloid-beta peptides for biomarker investigations in familial Alzheimer’s disease
10.1093/braincomms/fcag105 · 2026 · External reference
Brain-derived tau oligomer polymorphs: distinct aggregations, stability profiles, and biological activities
10.1038/s42003-025-07499-w · 2025 · External reference
Condensate state as determinant of amyloid pathology in neurodegeneration
10.3390/biom16040560 · 2026 · External reference
Differential role of C-terminal truncations on alpha-synuclein pathology and lewy body formation
10.1038/s41531-025-01084-y · 2025 · External reference
Modeling Parkinson’s pathology in human iPSC dopaminergic neurons uncovers key mechanisms of lewy body formation and heterogeneity
10.1126/sciadv.aed8851 · 2026 · External reference
Dimers of D76N-β2-microglobulin display potent antiamyloid aggregation activity
10.1016/j.jbc.2022.102659 · 2022 · External reference
The N terminus of α-synuclein dictates fibril formation
10.1073/pnas.2023487118 · 2021 · External reference
Defining essential charged residues in fibril formation of a lysosomal derived N-terminal α-synuclein truncation
10.1038/s41467-025-58899-9 · 2025 · External reference
The structure of human IAPP fibrils reflects membrane and pH conditions
10.1021/jacs.5c06971 · 2025 · External reference
Protein misfolding and amyloid nucleation through liquid-liquid phase separation
10.1039/d3cs01065a · 2024 · External reference
Recent advances in high-resolution traveling wave-based ion mobility separations coupled to mass spectrometry
10.1002/mas.21902 · 2025 · External reference
Cyclic peptide conformational landscapes through the lens of mass spectrometry and orthogonal spectroscopy
10.1002/jms.70058 · 2026 · External reference
Use of hydrogen deuterium exchange mass spectrometry in tandem with modern structural biology
10.1042/bcj20250131 · 2026 · External reference
Mass spectrometry detects folding intermediates populated during urea-induced protein denaturation
10.1039/d5sc05773f · 2025 · External reference
Integrating simple microfluidics design/fabrication with a novel ionization source for time-resolved chemical reaction studies by mass spectrometry
10.1021/acsomega.5c12681 · 2026 · External reference
The rise of trapped ion mobility spectrometry: principles, applications, and recent developments
10.1002/mas.70034 · 2026 · External reference
Cross-linking mass spectrometry for investigating protein conformations and protein-protein interactions─a method for all seasons
10.1021/acs.chemrev.1c00786 · 2022 · External reference
Spatially constrained disulfide bond shuffling delays insulin aggregation and enhances neurotoxicity
10.1038/s41467-025-62257-0 · 2025 · External reference
Combining electron microscopy (EM) and cross-linking mass spectrometry (XL-MS) for structural characterization of protein complexes
10.1007/978-1-0716-1936-0_17 · 2022 · External reference
Unfolding sequence-specific enigma in monomeric α-Synuclein: implications for parkinson’s disease
10.1021/acschemneuro.5c00423 · 2026 · External reference
Dissecting the structural heterogeneity of proteins by native mass spectrometry
10.1002/pro.4612 · 2023 · External reference
Fibrillation of human insulin B-chain by pulsed hydrogen-deuterium exchange mass spectrometry
10.1016/j.bpj.2022.10.042 · 2022 · External reference
A model study to assess fibrillation and product stability to support peptide drug design
10.1021/acs.molpharmaceut.3c00996 · 2024 · External reference
Analysis of baboon IAPP provides insight into amyloidogenicity and cytotoxicity of human IAPP
10.1016/j.bpj.2019.12.027 · 2020 · External reference
Advances in mass spectrometry to unravel the structure and function of protein condensates
10.1038/s41596-023-00900-0 · 2023 · External reference
A distinct tau oligomer strain defines the molecular and proteomic landscape of rapidly progressive Alzheimer’s disease
10.1007/s00401-026-02998-4 · 2026 · External reference
Interspecies variation affects islet amyloid polypeptide membrane binding
10.1021/jasms.3c00005 · 2023 · External reference
A targetable N-Terminal motif orchestrates α-Synuclein oligomer-to-fibril conversion
10.1021/jacs.4c02262 · 2024 · External reference
The expanding amyloid family: structure, stability, function, and pathogenesis
10.1016/j.cell.2021.08.013 · 2021 · External reference
High-resolution structural information of membrane-bound α-synuclein provides insight into the MoA of the anti-parkinson drug UCB0599
10.1073/pnas.2201910120 · 2023 · External reference
Alpha-synuclein interacts with regulators of ATP homeostasis in mitochondria
10.1038/s41467-025-62895-4 · 2025 · External reference
Structure-function relationship of alpha-synuclein fibrillar polymorphs derived from distinct synucleinopathies
10.1038/s44320-026-00199-5 · 2026 · External reference
Amyloid-β, tau protein, α-Synuclein, TDP-43, and FUS in mixed pathology: and intrinsic disorder to rule them all
10.3390/ijms27083669 · 2026 · External reference
Factors responsible for alpha-Synuclein aggregation
10.1016/bs.pmbts.2024.11.004 · 2025 · External reference
Quantitative structural proteomics in living cells by covalent protein painting
10.1016/bs.mie.2022.08.046 · 2023 · External reference
Mechanism of inhibition of acid-mediated transthyretin aggregation by designed peptides
10.1016/j.jbc.2025.110594 · 2025 · External reference
Submicrometer emitter ESI tips for native mass spectrometry of membrane proteins in ionic and nonionic detergents
10.1007/s13361-017-1793-x · 2018 · External reference
Aβ43 levels determine the onset of pathological amyloid deposition
10.1016/j.jbc.2023.104868 · 2023 · External reference
Emerging biophysical origins and pathogenic implications of amyloid oligomers
10.1038/s41467-025-58335-y · 2025 · External reference
What’s the defect? Using mass defects to study oligomerization of membrane proteins and peptides in nanodiscs with native mass spectrometry
10.1016/j.ymeth.2023.07.004 · 2023 · External reference
Direct observation of “elongated” conformational states in α-Synuclein upon liquid-liquid phase separation
10.1002/anie.202205726 · 2022 · External reference
The roles of intrinsically disordered proteins in neurodegeneration
10.1016/j.bbagen.2025.130772 · 2025 · External reference
Protein analysis by desorption electrospray ionization mass spectrometry
10.1002/mas.21900 · 2025 · External reference
Collision-induced unfolding, tandem MS, Bottom-up proteomics, and interactomics for identification of protein complexes in native surface mass spectrometry
10.1021/jasms.3c00261 · 2024 · External reference
Analysis of amyloid beta oligomers by cyclic ion mobility-mass spectrometry
10.1007/s00216-026-06349-w · 2026 · External reference
Using mass spectrometry-based methods to understand amyloid formation and inhibition of alpha-synuclein and amyloid beta
10.1002/mas.21814 · 2024 · External reference
C-Terminal radical oxidation inhibits α-Synuclein aggregation and cytotoxicity via an oxidative oligomer-disrupting pathway
10.1021/jacs.5c06792 · External reference
Oligomerization propensity governs self-assembly morphology: insights from steady-state oligomer analysis
10.1021/acs.analchem.5c02258 · External reference
Recommendations and considerations for hydroxyl radical protein footprinting-mass spectrometry
10.1038/s41592-026-03083-0 · 2026 · External reference
Kinetics of amyloid oligomer formation
10.1146/annurev-biophys-080124-122953 · 2025 · External reference
Surface-sampling mass spectrometry to study proteins and protein complexes
10.1042/ebc20220191 · 2023 · External reference
Tuning the rate of aggregation of hIAPP into amyloid using small-molecule modulators of assembly
10.1038/s41467-022-28660-7 · 2022 · External reference
Insights into the consequences of co-polymerisation in the early stages of IAPP and Aβ peptide assembly from mass spectrometry
10.1039/c5an00865d · 2015 · External reference
Artificial intelligence-based HDX (AI-HDX) prediction reveals fundamental characteristics to protein dynamics: mechanisms on SARS-CoV-2 immune escape
10.1016/j.isci.2023.106282 · 2023 · External reference
“Prion-like” seeding and propagation of oligomeric protein assemblies in neurodegenerative disorders
10.3389/fnins.2024.1436262 · 2024 · External reference
Biofluid biomarkers in Alzheimer’s disease and other neurodegenerative dementias
10.1038/s41586-025-10018-w · 2026 · External reference
Heterogeneous dynamics of the fuzzy coat of full-length phospho-mimetic tau fibrils
10.1021/jacs.5c18540 · 2026 · External reference
