Research graph
References from Extracellular vesicle-integrated brain organoid-on-a-chip systems for neuroimmune communication and precision therapy in viral encephalitis. Local targets link to admitted publications; unresolved targets remain external evidence.
Neuropathogenesis-on-chips for neurodegenerative diseases
10.1038/s41467-024-46554-8 · 2024 · External reference
Tubular human brain organoids to model microglia-mediated neuroinflammation
10.1039/d1lc00030f · 2021 · External reference
Strategic design of extracellular vesicle drug delivery systems
10.1016/j.addr.2018.06.017 · 2018 · External reference
Stem cell-derived organoids for cancer therapy: precision medicine and drug selection
10.3390/ijms27072954 · 2026 · External reference
Application of a blood–brain barrier Organ-on-a-Chip model for assessment of countermeasure efficiency against eastern equine encephalitis virus
10.3390/v18050548 · 2026 · External reference
Herpes simplex Virus-1 encephalitis in adults: pathophysiology, diagnosis, and management
10.1007/s13311-016-0433-7 · 2016 · External reference
Acute neurologic emerging flaviviruses
10.1177/20499361221102664 · 2022 · External reference
Diagnosis and treatment of viral encephalitis
10.1136/pmj.78.924.575 · 2002 · External reference
The role of microglia in viral encephalitis: a review
10.1186/s12974-019-1443-2 · 2019 · External reference
In situ detection of neuroinflammation using multicellular 3D Neurovascular‐Unit‐on‐a‐Chip
10.1002/adfm.202304382 · 2023 · External reference
Extracellular vesicles as nanotheranostic platforms for targeted neurological disorder interventions
10.1186/s40580-024-00426-5 · 2024 · External reference
Everything you always wanted to know about rabies virus (but were afraid to ask)
10.1146/annurev-virology-100114-055157 · 2015 · External reference
Histological evidence for the enteric nervous system and the choroid plexus as alternative routes of neuroinvasion by SARS-CoV2
10.3389/fnana.2020.596439 · 2020 · External reference
Organ-on-a-chip meets artificial intelligence in drug evaluation
10.7150/thno.87266 · 2023 · External reference
Circulating ACE2-expressing extracellular vesicles block broad strains of SARS-CoV-2
10.1038/s41467-021-27893-2 · 2022 · External reference
Navigating the brain: the role of exosomal shuttles in precision therapeutics
10.3389/fneur.2023.1324216 · 2024 · External reference
The spread and evolution of rabies virus: conquering new frontiers
10.1038/nrmicro.2018.11 · 2018 · External reference
Viral CNS infections: role of glial pattern recognition receptors in neuroinflammation
10.3389/fmicb.2012.00201 · 2012 · External reference
Enrichment of extracellular vesicles from tissues of the central nervous system by PROSPR
10.1186/s13024-016-0108-1 · 2016 · External reference
Rethinking organoid technology through bioengineering
10.1038/s41563-020-00804-4 · 2020 · External reference
Global landscape of encephalitis: key priorities to reduce future disease burden
10.1093/cid/ciad417 · 2023 · External reference
Elucidating design principles for engineering cell‐derived vesicles to inhibit SARS‐CoV‐2 infection
10.1002/smll.202200125 · 2022 · External reference
Naturally enveloped AAV vectors for shielding neutralizing antibodies and robust gene delivery in vivo
10.1016/j.biomaterials.2014.05.032 · 2014 · External reference
Extracellular vesicles as a means of viral immune evasion, CNS invasion, and glia-induced neurodegeneration
10.3389/fncel.2021.695899 · 2021 · External reference
Research progress, challenges, and breakthroughs of organoids as disease models
10.3389/fcell.2021.740574 · 2021 · External reference
Imaging-based spectrometer-less optofluidic biosensors based on dielectric metasurfaces for detecting extracellular vesicles
10.1038/s41467-021-23257-y · 2021 · External reference
Engineered small extracellular vesicles displaying ACE2 variants on the surface protect against SARS‐CoV‐2 infection
10.1002/jev2.12179 · 2022 · External reference
The longitudinal health economic impact of viral encephalitis in the United States
10.1099/jmm.0.001153 · 2020 · External reference
Extracellular vesicles as tools and targets in therapy for diseases
10.1038/s41392-024-01735-1 · 2024 · External reference
Brain organoids as models of extracellular vesicle-mediated human neural communication
10.4103/nrr.nrr-d-25-01806 · 2026 · External reference
CaBLAM: a high-contrast bioluminescent Ca2+ indicator derived from an engineered Oplophorus gracilirostris luciferase
10.1038/s41592-025-02972-0 · 2025 · External reference
Intranasal delivery of engineered extracellular vesicles promotes neurofunctional recovery in traumatic brain injury
10.1186/s12951-025-03181-9 · External reference
Mesenchymal stem cell-derived extracellular vesicles: current advances in preparation and therapeutic applications for neurological disorders
10.3389/fcell.2025.1626996 · External reference
Machine learning to analyse omic-data for COVID-19 diagnosis and prognosis
10.1186/s12859-022-05127-6 · 2023 · External reference
Engineering extracellular vesicles secreted by human brain organoids with different regional identity
10.1021/acsami.4c22692 · 2025 · External reference
A role for extracellular vesicles in SARS-CoV-2 therapeutics and prevention
10.1007/s11481-020-09981-0 · 2021 · External reference
Deposition chamber technology as building blocks for a standardized brain-on-chip framework
10.1038/s41378-022-00406-x · 2022 · External reference
Herpes simplex encephalitis treated with acyclovir: diagnosis and long term outcome
10.1136/jnnp.63.3.321 · 1997 · External reference
SARS-CoV-2: is there neuroinvasion?
10.1186/s12987-021-00267-y · 2021 · External reference
Clinical and experimental studies in Japanese encephalitis: lessons learnt
10.1055/s-0040-1712808 · 2020 · External reference
West nile virus neuroinvasive disease: neurological manifestations and prospective longitudinal outcomes
10.1186/1471-2334-14-248 · 2014 · External reference
Exploring the role of brain-derived extracellular vesicles in viral infections: from pathological insights to biomarker potential
10.3389/fcimb.2024.1423394 · 2024 · External reference
MiR-219a-5p enriched extracellular vesicles induce OPC differentiation and EAE improvement more efficiently than liposomes and polymeric nanoparticles
10.3390/pharmaceutics12020186 · 2020 · External reference
Organotypic culture of human brain explants as a preclinical model for AI-driven antiviral studies
10.1038/s44321-024-00039-9 · 2024 · External reference
Orchestration of antiviral responses within the infected central nervous system
10.1038/s41423-024-01181-7 · 2024 · External reference
A microengineered brain-chip to model neuroinflammation in humans
10.1016/j.isci.2022.104813 · 2022 · External reference
West nile virus: review of the literature
10.1001/jama.2013.8042 · 2013 · External reference
Immunomodulatory strategies in Herpes simplex virus encephalitis
10.1128/cmr.00105-19 · 2020 · External reference
Extracellular vesicles: masters of intercellular communication and potential clinical interventions
10.1172/jci87316 · 2016 · External reference
Youth and environmental enrichment generate serum exosomes containing miR‐219 that promote CNS myelination
10.1002/glia.22606 · 2013 · External reference
Technical challenges of working with extracellular vesicles
10.1039/c7nr08360b · 2017 · External reference
Viral-induced neuroinflammation: different mechanisms converging to similar exacerbated glial responses
10.3389/fnins.2023.1108212 · 2023 · External reference
Engineered extracellular vesicles for delivery of siRNA promoting targeted repair of traumatic spinal cord injury
10.1016/j.bioactmat.2022.11.011 · 2022 · External reference
Progress and potential in organoid research
10.1038/s41576-018-0051-9 · 2018 · External reference
Modelling viral encephalitis caused by herpes simplex virus 1 infection in cerebral organoids
10.1038/s41564-023-01405-y · 2023 · External reference
Encephalitic arboviruses: emergence, clinical presentation, and neuropathogenesis
10.1007/s13311-016-0443-5 · 2016 · External reference
Exosomes as nanocarriers for brain-targeted delivery of therapeutic nucleic acids: advances and challenges
10.1186/s12951-025-03528-2 · 2025 · External reference
New technologies for analysis of extracellular vesicles
10.1021/acs.chemrev.7b00534 · 2018 · External reference
New windows into the brain: central nervous system-derived extracellular vesicles in blood
10.1016/j.pneurobio.2019.01.005 · 2019 · External reference
Bottom-up assembly of biomedical relevant fully synthetic extracellular vesicles
10.1126/sciadv.abg6666 · 2021 · External reference
Neurotropic viruses, astrocytes, and COVID-19
10.3389/fncel.2021.662578 · 2021 · External reference
The choroid plexus and its role in the pathogenesis of neurological infections
10.1186/s12987-022-00372-6 · 2022 · External reference
Nanotechnology-inspired extracellular vesicles theranostics for diagnosis and therapy of central nervous system diseases
10.1021/acsami.2c07981 · 2022 · External reference
Microfluidic Brain‐on‐a‐Chip: from key technology to system integration and application
10.1002/smll.202304427 · 2023 · External reference
Harnessing the power of artificial intelligence for human living organoid research
10.1016/j.bioactmat.2024.08.027 · External reference
Human organoids-on-chips for biomedical research and applications
10.7150/thno.90492 · External reference
Brain‐derived extracellular vesicles: potential diagnostic biomarkers for central nervous system diseases
10.1111/pcn.13610 · 2023 · External reference
Neuroinvasion, neurotropic, and neuroinflammatory events of SARS-CoV-2: understanding the neurological manifestations in COVID-19 patients
10.1007/s10072-020-04575-3 · 2020 · External reference
Dysregulation of brain and choroid plexus cell types in severe COVID-19
10.1038/s41586-021-03710-0 · 2021 · External reference
Role of extracellular vesicles derived from HIV-Infected T cells and microglial cells in neuroinflammation and neuropathogenesis using a blood–brain barrier and cerebral organoid co-culture model
10.1007/s13365-025-01297-0 · 2026 · External reference
Cellular nanosponges inhibit SARS-CoV-2 infectivity
10.1021/acs.nanolett.0c02278 · 2020 · External reference
Interfacing brain organoids with precision medicine and machine learning
10.1016/j.xcrp.2022.100974 · 2022 · External reference
Extracellular vesicle-liposome-darunavir formulation for the treatment of HIV neuropathogenesis
10.1021/acsanm.4c04637 · 2025 · External reference
