Research graph
References from Developmental ecology of the infant oral ecosystem: a framework for early childhood caries. Local targets link to admitted publications; unresolved targets remain external evidence.
Global, regional, and national burden of caries in primary teeth from 1990 to 2021: results from the global burden of disease study 2021
10.1186/s12903-025-06691-y · 2025 · External reference
Oral diseases: a global public health challenge
10.1016/s0140-6736(19)31146-8 · 2019 · External reference
The WHO global strategy for oral health: an opportunity for bold action
10.1016/s0140-6736(21)01404-5 · 2021 · External reference
Oral health of Indigenous children and the influence of early childhood caries on childhood health and well-being
10.1016/j.pcl.2009.09.010 · 2009 · External reference
Associations between early childhood caries, malnutrition and anemia: a global perspective
10.1186/s40795-020-00340-z · 2020 · External reference
Role of Streptococcus mutans in human dental decay
10.1128/mr.50.4.353-380.1986 · 1986 · External reference
The oral microbiome in health and disease
10.1016/j.phrs.2012.11.006 · 2013 · External reference
Resilience of the oral Microbiota in health: mechanisms that prevent dysbiosis
10.1177/0022034517742139 · 2018 · External reference
Caries: review of human genetics research
10.1159/000358333 · 2014 · External reference
Genetic factors affecting dental caries risk
10.1111/adj.12262 · 2015 · External reference
Are dental diseases examples of ecological catastrophes?
10.1099/mic.0.26082-0 · 2003 · External reference
Solving the etiology of dental caries
10.1016/j.tim.2014.10.010 · 2015 · External reference
The oral microbiota: dynamic communities and host interactions
10.1038/s41579-018-0089-x · 2018 · External reference
Oral microbiome development during childhood: an ecological succession influenced by postnatal factors and associated with tooth decay
10.1038/s41396-018-0204-z · 2018 · External reference
Mode of birth delivery affects oral microbiota in infants
10.1177/0022034511418973 · 2011 · External reference
Early life factors and oral microbial signatures define the risk of caries in a Swedish cohort of preschool children
10.1038/s41598-024-59126-z · 2024 · External reference
The infant oral microbiome: developmental dynamics, modulating factors, and implications for oral and systemic health
10.3390/ijms26167983 · 2025 · External reference
The contribution of maternal factors to the oral microbiota of the child: influence from early life and clinical relevance
10.1016/j.jdsr.2023.06.002 · 2023 · External reference
Oral microbiome and pregnancy: a bidirectional relationship
10.1016/j.jri.2021.103293 · 2021 · External reference
Periodontitis during pregnancy: the effect on the gut microbiome and intestinal inflammation
10.1002/jper.70132 · 2026 · External reference
Maternal oral health influences infant salivary microbiome
10.1177/0022034520947665 · 2021 · External reference
Smoking, pregnancy and the subgingival microbiome
10.1038/srep30388 · 2016 · External reference
How maternal diet, probiotics, prebiotics, and postbiotics during pregnancy influence neurodevelopment in newborns
10.1016/j.gpeds.2025.100301 · 2025 · External reference
Stability of the vaginal, oral, and gut microbiota across pregnancy among African American women: the effect of socioeconomic status and antibiotic exposure
10.7717/peerj.8004 · 2019 · External reference
Inferring diet, disease and antibiotic resistance from ancient human oral microbiomes
10.1099/mgen.0.001251 · 2024 · External reference
Beyond breastfeeding: a one health decalogue for nurturing the infant microbiota
10.3389/fnut.2026.1784544 · 2026 · External reference
Transmission of maternal oral pathobionts to the infant gut predisposes offspring to exacerbated enteritis
10.1016/j.celrep.2025.115974 · 2025 · External reference
The intermucosal connection between the mouth and gut in commensal pathobiont-driven colitis
10.1016/j.cell.2020.05.048 · 2020 · External reference
Exploring the oral microbiota of children at various developmental stages of their dentition in the relation to their oral health
10.1186/1755-8794-4-22 · 2011 · External reference
Characterizing oral microbial communities across dentition states and colonization niches
10.1186/s40168-018-0443-2 · 2018 · External reference
Human milk oligosaccharides and gut microbes in host brain development and health
10.1093/oxfordhb/9780190931544.013.0018 · 2025 · External reference
Functional effects of human milk oligosaccharides (HMOs)
10.1080/19490976.2023.2186115 · 2023 · External reference
Role of human milk Microbiota in infant neurodevelopment: mechanisms and clinical implications
10.3390/children11121476 · 2024 · External reference
A one health decalogue for breastfeeding: microbiota-targeted strategies for infant gastrointestinal and neurodevelopmental health
10.3390/nu18071074 · 2026 · External reference
Human milk oligosaccharides: every baby needs a sugar mama
10.1093/glycob/cws074 · 2012 · External reference
Human milk oligosaccharides as prebiotics
10.1016/j.pedneo.2022.09.017 · 2023 · External reference
Human milk microbiome—a review of scientific reports
10.3390/nu16101420 · 2024 · External reference
Interactions of human milk oligosaccharides with the immune system
10.3389/fimmu.2024.1523829 · 2025 · External reference
tRNA-derived RNAs in human milk extracellular vesicles and associations with breastfeeding variables and maternal diet
10.1080/17501911.2024.2430943 · 2024 · External reference
Does breastfeeding increase the risk of early childhood caries (ECC)? A systematic review
10.1007/s40368-025-01051-4 · 2025 · External reference
Association of breastfeeding and early childhood caries: a systematic review and meta-analysis
10.3390/nu16091355 · 2024 · External reference
Breastfeeding and its association with early childhood caries – an umbrella review
10.17796/1053-4625-46.2.1 · 2022 · External reference
Impact of prolonged breastfeeding on dental caries: a population-based birth cohort study
10.1542/peds.2016-2943 · 2017 · External reference
Risk of early childhood dental caries associated with prolonged breastfeeding: a systematic review and meta-analysis
10.1111/ipd.13313 · 2025 · External reference
The oral–gut microbiome axis in health and disease
10.1038/s41579-024-01075-5 · 2024 · External reference
Oral microbiota assessment at different time points during the first year of life: delivery mode and breastfeeding shape the bacterial community
10.1186/s13006-026-00813-0 · 2026 · External reference
Early-life gut and oral microbiota development: a multi-niche study including mother-partner-infant triads
10.1186/s12866-025-04521-3 · 2025 · External reference
Shaping oral and intestinal microbiota and the immune system during the first 1,000 days of life
10.3389/fped.2025.1471743 · 2025 · External reference
Establishment of tongue microbiota by 18 months of age and determinants of its microbial profile
10.1128/mbio.01337-23 · 2023 · External reference
Transition of bacterial diversity and composition in tongue microbiota during the first two years of life
10.1128/msphere.00187-19 · 2019 · External reference
Oral health and caries prevention: how tongue hygiene helps maintain balance of microbiota and overall health in pediatric patients
10.3390/children11070816 · 2024 · External reference
The oral–gut microbiota axis across the lifespan: new insights on a forgotten interaction
10.3390/nu17152538 · 2025 · External reference
The oral microbiome: role of key organisms and complex networks in oral health and disease
10.1111/prd.12393 · 2021 · External reference
Ecological hypothesis of dentin and root caries
10.1159/000447309 · 2016 · External reference
Microbial indicators of dental health, dysbiosis, and early childhood caries
10.1177/00220345231160756 · 2023 · External reference
Initial acquisition of mutans streptococci by infants: evidence for a discrete window of infectivity
10.1177/00220345930720010501 · 1993 · External reference
Evaluating the ecological hypothesis: early life salivary microbiome assembly predicts dental caries in a longitudinal case-control study
10.1186/s40168-022-01442-5 · 2022 · External reference
Dental caries and their microbiomes in children: what do we do now?
10.1080/20002297.2023.2198433 · 2023 · External reference
Infant gut microbiome reprogramming following introduction of solid foods (weaning)
10.1080/19490976.2025.2571428 · 2025 · External reference
The development of human gut microbiota fermentation capacity during the first year of life
10.1111/1751-7915.14165 · 2022 · External reference
Development of the breastfed infant oral microbiome over the first two years of life in the BLOSOM cohort
10.3389/fcimb.2025.1534750 · 2025 · External reference
The predominant oral microbiota is acquired early in an organized pattern
10.1038/s41598-019-46923-0 · 2019 · External reference
From birth to weaning: a window of opportunity for microbiota
10.3390/nu16020272 · 2024 · External reference
Microbial ecology of dental plaque and its significance in health and disease
10.1177/08959374940080022001 · 1994 · External reference
Dental plaque as a biofilm and a microbial community – implications for health and disease
10.1186/1472-6831-6-s1-s14 · 2006 · External reference
Dental caries
10.1038/nrdp.2017.30 · 2017 · External reference
Acid profile in carious dentin
10.1177/00220345910700030501 · 1991 · External reference
Effects of collagenase on root demineralization
10.1177/00220345970760011001 · 1997 · External reference
Sugars and dental caries: evidence for setting a recommended threshold for intake
10.3945/an.115.009365 · 2016 · External reference
The consumption of processed sugar- and starch-containing foods, and dental caries: a systematic review
10.1111/eos.12743 · 2020 · External reference
Overview: the food matrix and its role in the diet
10.1080/10408398.2025.2453074 · 2025 · External reference
Nutritional factors associated with dental caries across the lifespan: a review
10.3390/app132413254 · 2023 · External reference
Changes in hydrogen-ion concentration on tooth surfaces and in carious lesions
10.14219/jada.archive.1940.0178 · 1940 · External reference
Salivary flow patterns and the health of hard and soft oral tissues
10.14219/jada.archive.2008.0351 · 2008 · External reference
A review of saliva: normal composition, flow, and function
10.1067/mpr.2001.113778 · 2001 · External reference
Diet, nutrition and the prevention of dental diseases
10.1079/phn2003589 · 2004 · External reference
A new understanding of the relationship between sugars, dental caries and fluoride use: implications for limits on sugars consumption
10.1017/s136898001400113x · 2014 · External reference
The role of bacteria in the caries process
10.1177/0022034510379602 · 2011 · External reference
Impact of dairy products and plant-based alternatives on dental health: food matrix effects
10.3390/nu15061469 · 2023 · External reference
The food matrix: implications in processing, nutrition and health
10.1080/10408398.2018.1502743 · 2019 · External reference
Sugars and dental caries
10.1093/ajcn/78.4.881s · 2003 · External reference
Remineralization of enamel subsurface lesions by casein phosphopeptide-stabilized calcium phosphate solutions
10.1177/00220345970760091101 · 1997 · External reference
Oral ecological environment modifications by hard-cheese: from pH to microbiome: a prospective cohort study based on 16S rRNA metabarcoding approach
10.1186/s12967-022-03506-4 · 2022 · External reference
Diet type and the oral microbiome
10.3389/fnut.2025.1691952 · 2026 · External reference
Oral microbiome: a review of its impact on oral and systemic health
10.3390/microorganisms12091797 · 2024 · External reference
The evolving microbiome of dental caries
10.3390/microorganisms12010121 · 2024 · External reference
Competition and coexistence between Streptococcus mutans and Streptococcus sanguinis in the dental biofilm
10.1128/jb.187.21.7193-7203.2005 · 2005 · External reference
Oral biofilms: pathogens, matrix, and polymicrobial interactions in microenvironments
10.1016/j.tim.2017.09.008 · 2018 · External reference
The biofilm matrix
10.1038/nrmicro2415 · 2010 · External reference
Targeting microbial biofilms: current and prospective therapeutic strategies
10.1038/nrmicro.2017.99 · 2017 · External reference
Symbiotic relationship between Streptococcus mutans and Candida albicans synergizes virulence of plaque biofilms in vivo
10.1128/iai.00087-14 · 2014 · External reference
Sugars – the arch criminal?
10.1159/000077767 · 2004 · External reference
Questioning the fetal microbiome illustrates pitfalls of low-biomass microbial studies
10.1038/s41586-022-05546-8 · 2023 · External reference
Is there a placental microbiota? A critical review and re-analysis of published placental microbiota datasets
10.1186/s12866-023-02764-6 · 2023 · External reference
The dogma of the sterile uterus revisited: does microbial seeding occur during fetal life in humans and animals?
10.1530/rep-23-0078 · 2024 · External reference
Ecology of the oral microbiome: beyond bacteria
10.1016/j.tim.2016.12.012 · 2017 · External reference
Acquiring and maintaining a normal oral microbiome: current perspective
10.3389/fcimb.2014.00085 · 2014 · External reference
Oral microbiome: possible harbinger for children’s health
10.1038/s41368-020-0082-x · 2020 · External reference
Probiotics for oral health: a critical evaluation of bacterial strains
10.3389/fmicb.2024.1430810 · 2024 · External reference
Influence of the probiotic Streptococcus salivarius strain M18 on indices of dental health in children: a randomized double-blind, placebo-controlled trial
10.1099/jmm.0.056663-0 · 2013 · External reference
Regular consumption of Lactobacillus reuteri-containing lozenges reduces pregnancy gingivitis: an RCT
10.1111/jcpe.12606 · 2016 · External reference
The caries microbiome: implications for reversing dysbiosis
10.1177/0022034517736496 · 2018 · External reference
Systematic review of evidence pertaining to factors that modify risk of early childhood caries
10.1177/2380084418824262 · 2019 · External reference
Selection of beneficial bacterial strains with potential as oral probiotic candidates
10.1007/s12602-021-09896-z · 2022 · External reference
Health-associated niche inhabitants as oral probiotics: the case of Streptococcus dentisani
10.3389/fmicb.2017.00379 · 2017 · External reference
Probiotic Weissella cibaria displays antibacterial and anti-biofilm effect against cavity-causing Streptococcus mutans
10.1016/j.micpath.2023.106151 · 2023 · External reference
Maternal influences on oral microbiome development and implications for early childhood health: a systematic review
10.1128/iai.00585-25 · 2026 · External reference
The human oral microbiome
10.1128/jb.00542-10 · 2010 · External reference
What is dental caries – and why we need fluoride
10.1159/000552843 · 2026 · External reference
Remarkable decline and sustained low levels of caries in the nordic populations—explanations and implications for public oral health
10.1111/eos.70114 · 2026 · External reference
Mechanisms of action of fluoride for caries control
10.1159/000325151 · 2011 · External reference
Growth inhibition of Streptococcus mutans with low Xylitol concentrations
10.1007/s00284-007-9076-6 · 2008 · External reference
The effect of arginine on oral biofilm communities
10.1111/omi.12044 · 2014 · External reference
Probiotics for caries prevention and control
10.1177/0022034512449465 · 2012 · External reference
The international scientific association of probiotics and prebiotics (ISAPP) consensus statement on the definition and scope of postbiotics
10.1038/s41575-021-00440-6 · 2021 · External reference
A spontaneous lactate dehydrogenase deficient mutant of Streptococcus rattus for use as a probiotic in the prevention of dental caries
10.1111/j.1365-2672.2009.04333.x · 2009 · External reference
Prediction of early childhood caries via spatial-temporal variations of oral microbiota
10.1016/j.chom.2015.08.005 · 2015 · External reference
The one health concept: 10 years old and a long road ahead
10.3389/fvets.2018.00014 · 2018 · External reference
The microbiome in early life: implications for health outcomes
10.1038/nm.4142 · 2016 · External reference
Prenatal maternal factors, intergenerational transmission of disease, and child oral health outcomes
10.1016/j.cden.2017.02.001 · 2017 · External reference
Developmental enamel defects in the primary dentition: aetiology and clinical management
10.1111/adj.12039 · 2013 · External reference
Association between developmental defects of enamel and early childhood caries in children under 6 years old: a systematic review and meta-analysis
10.1016/j.heliyon.2022.e10479 · 2022 · External reference
Relationship between preterm, low birth weight, and development defects of enamel in the primary dentition: a meta-analysis
10.3389/fped.2022.975340 · 2022 · External reference
The impact of prenatal vitamin D on enamel defects and tooth erosion: a systematic review
10.3390/nu15183863 · 2023 · External reference
Are molar-incisor hypomineralization and hypomineralized second primary molars predictive of dental caries? A systematic review
10.1055/s-0042-1749360 · 2023 · External reference
Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns
10.1073/pnas.1002601107 · 2010 · External reference
Oral microbiome transmission and infant feeding habits
10.1128/mbio.00325-22 · 2022 · External reference
Breastfeeding in the 21st century: epidemiology, mechanisms, and lifelong effect
10.1016/s0140-6736(15)01024-7 · 2016 · External reference
Composition and variation of the human milk microbiota are influenced by maternal and early-life factors
10.1016/j.chom.2019.01.011 · 2019 · External reference
The western diet–microbiome-host interaction and its role in metabolic disease
10.3390/nu10030365 · 2018 · External reference
Influences on children’s oral health: a conceptual model
10.1542/peds.2006-3084 · 2007 · External reference
Acquisition and establishment of the oral microbiota
10.1111/prd.12366 · 2021 · External reference
Immunological effects of human milk oligosaccharides
10.3389/fped.2018.00190 · 2018 · External reference
Streptococcal bacteriocins and the case for Streptococcus salivarius as model oral probiotics
10.2217/fmb.09.61 · 2009 · External reference
Drugs for the quorum sensing inhibition of oral biofilm: new frontiers and insights in the treatment of periodontitis
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Synthetic biology and engineered live biotherapeutics: toward increasing system complexity
10.1016/j.cels.2018.06.008 · 2018 · External reference
How probiotics, prebiotics, synbiotics, and postbiotics prevent dental caries: an oral microbiota perspective
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One health: a new definition for a sustainable and healthy future
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