Research graph
References from Physical exercise and circulating α-Klotho in humans: a systematic review and meta-analysis with emphasis on older adults. Local targets link to admitted publications; unresolved targets remain external evidence.
Unresolved reference
2022 · External reference
Hallmarks of aging: an expanding universe
10.1016/j.cell.2022.11.001 · 2023 · External reference
Mutation of the mouse Klotho gene leads to a syndrome resembling ageing
10.1038/36285 · 1997 · External reference
Klotho proteins in health and disease
10.1038/s41581-018-0078-3 · 2019 · External reference
Suppression of aging in mice by the hormone Klotho
10.1126/science.1112766 · 2005 · External reference
The prognostic value of serum α-klotho in age-related diseases among the US population: a prospective population-based cohort study
10.1016/j.pmedr.2024.102730 · 2024 · External reference
Serum Klotho levels and mortality patterns in frail individuals: unraveling the U-shaped association
10.1007/s40520-024-02755-1 · 2024 · External reference
Klotho: a potential therapeutic target in aging and neurodegeneration beyond chronic kidney disease
10.1093/ckj/sfad276 · 2023 · External reference
α-Klotho expression in human tissues
10.1210/jc.2015-1800 · 2015 · External reference
Pathobiology of the Klotho antiaging protein and therapeutic considerations
10.3389/fragi.2022.931331 · 2022 · External reference
Klotho in aging and diseases: molecular features, expressions, and functional implications
10.1007/s11010-025-05445-2 · 2026 · External reference
Klotho antiaging protein: molecular mechanisms and therapeutic potential in diseases
10.1186/s43556-025-00253-y · 2025 · External reference
Low serum Klotho associated with all-cause mortality among a nationally representative sample of American adults
10.1093/gerona/glab308 · 2022 · External reference
FGF23 and Klotho at the intersection of kidney and cardiovascular disease
10.1038/s41569-023-00903-0 · 2024 · External reference
Relationship between klotho and physical function in healthy aging
10.1038/s41598-023-48685-2 · 2023 · External reference
Relationship of α-Klotho with frailty Index and sarcopenia: a bidirectional Mendelian randomization study
10.1089/rej.2024.0089 · 2025 · External reference
High serum Klotho levels are inversely associated with the risk of low muscle mass in middle-aged adults
10.3389/fnut.2024.1390517 · 2024 · External reference
Relationship of Klotho with cognition and dementia: a systematic review and meta-analysis
10.1016/j.arr.2024.102649 · 2025 · External reference
Serum soluble alpha-Klotho and cognitive functioning in older adults aged 60 to 79 years: nHANES 2011–2014
10.1186/s12877-024-04846-0 · 2024 · External reference
Beneficial effects of physical exercise on the osteo-renal Klotho-FGF-23 axis in chronic kidney disease: a systematic review with meta-analysis
10.7150/ijms.90195 · 2024 · External reference
Correlation between soluble Klotho and chronic kidney disease–mineral and bone disorder: a meta-analysis
10.1038/s41598-024-54936-3 · 2024 · External reference
A systematic review and meta-analysis demonstrating Klotho as an emerging exerkine
10.1038/s41598-022-22123-1 · 2022 · External reference
The effects of aerobic and anaerobic exercises on circulating soluble-Klotho and IGF-I in young and elderly adults and in CAD patients
10.1177/1849454417733388 · 2017 · External reference
Klotho: an emerging factor with ergogenic potential
10.3389/fresc.2021.807123 · 2022 · External reference
Acute effects of a single bout of high-intensity strength and endurance exercise on cognitive biomarkers in young adults and elderly men: a within-subjects crossover study
10.1186/s12967-025-06705-z · 2025 · External reference
Aerobic exercise training increases plasma Klotho levels and reduces arterial stiffness in postmenopausal women
10.1152/ajpheart.00429.2013 · 2014 · External reference
Dynamic, not isometric, resistance training blunts osteo-renal disease and improves the sclerostin/FGF23/Klotho axis in maintenance hemodialysis patients: a randomized clinical trial
10.1152/japplphysiol.00768.2020 · 2021 · External reference
Blood flow restriction training blunts chronic kidney disease progression: a best-evidence resistance-training approach
10.3389/fphys.2020.01083 · 2020 · External reference
Exercise training increases the S-Klotho plasma levels in sedentary middle-aged adults: a randomised controlled trial. The FIT-AGEING study
10.1007/s13105-019-00690-6 · 2019 · External reference
Exercise attenuates bed rest-induced increases in insulin resistance while α-Klotho increases in 55- to 65-year-old women and men
10.1038/s41598-025-12770-5 · 2025 · External reference
Benefits of high-intensity exercise training to patients with chronic obstructive pulmonary disease: a controlled study
10.1159/000464139 · 2017 · External reference
The effects of home-based progressive resistance training in chronic kidney disease patients
10.1016/j.exger.2022.112030 · 2023 · External reference
Strength but not power training increases soluble alpha Klotho levels in pre-frail older adults
10.1016/j.exger.2025.113002 · 2025 · External reference
Resistance training modulates reticulum endoplasmic stress, independent of oxidative and inflammatory responses, in elderly people
10.3390/antiox11112242 · 2022 · External reference
Anti-inflammatory role of the klotho protein and relevance to aging
10.3390/cells13171413 · 2024 · External reference
Impact of APOE, Klotho, and sex on cognitive decline with aging
10.1073/pnas.2416042122 · 2025 · External reference
Klotho protein concentrations as a function of sex, APOE, family history of Alzheimer’s disease or biomarker status in an at-risk cohort
10.1002/alz.055750 · 2021 · External reference
Effect of sixteen weeks combined training on FGF-23, Klotho, and Fetuin-A levels in patients on maintenance hemodialysis
2020 · External reference
Exercise-induced changes in plasma S-Klotho levels are associated with the obtained enhancements of heart rate variability in sedentary middle-aged adults: the FIT-AGEING study
10.1007/s13105-023-01005-8 · 2024 · External reference
Longevity protein klotho is induced by a single bout of exercise
10.1136/bjsports-2016-096139 · 2017 · External reference
Exercise-linked irisin prevents mortality and enhances cognition in a mouse model of cerebral ischemia by regulating klotho expression
10.14336/ad.2020.1029 · 2021 · External reference
Physical exercise improves memory in sedentary middle-aged adults: are these exercise-induced benefits associated with S-Klotho and 1,25-dihydroxyvitamin D? The FIT-AGEING RCT
10.1111/sms.14519 · 2024 · External reference
Unresolved reference
2023 · External reference