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References from Integrative genome-scale metabolic model of GABAergic neurons reveals metabolic signatures across the mild cognitive impairment – Alzheimer disease continuum. Local targets link to admitted publications; unresolved targets remain external evidence.
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Transcriptome-informed metabolic modeling reveals astrocyte-specific vulnerabilities in mild cognitive impairment and Alzheimer’s disease progression
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Characterization of GABAergic marker expression in the chronic unpredictable stress model of depression
10.1177/2470547017720459 · 2017 · External reference
Neuronal medium that supports basic synaptic functions and activity of human neurons in vitro
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Context-specific metabolic networks are consistent with experiments
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GABAergic dysfunction in excitatory and inhibitory (E/I) imbalance drives the pathogenesis of Alzheimer’s disease
10.1002/alz.12088 · 2020 · External reference
Microarray analyses of laser-captured hippocampus reveal distinct gray and white matter signatures associated with incipient Alzheimer’s disease
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Constraint-based models predict metabolic and associated cellular functions
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Risk factors for the progression of mild cognitive impairment to dementia
10.1016/j.cger.2013.07.009 · 2013 · External reference
Risk factors for the progression of mild cognitive impairment in different types of neurodegenerative disorders
10.1155/2018/6929732 · 2018 · External reference
Unresolved reference
External reference
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10.1007/978-1-4614-7320-6_100691-1 · 2020 · External reference
Increased hippocampal activation in mild cognitive impairment compared to normal aging and AD
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Mild cognitive impairment and dementia
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Decreased GABA levels of the anterior and posterior cingulate cortex are associated with executive dysfunction in mild cognitive impairment
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GABAergic neurons maturation is regulated by a delicate network
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10.1038/s41596-018-0098-2 · 2011 · External reference
Creation and analysis of biochemical constraint-based models using the COBRA toolbox
2019 · External reference
GABAergic neuron-specific whole-brain transduction by AAV-PHP.B incorporated with a new GAD65 promoter
10.1186/s13041-021-00746-1 · 2021 · External reference
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10.1016/j.jalz.2018.02.018 · 2018 · External reference
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Review of current human genome-scale metabolic models for brain cancer and neurodegenerative diseases
10.3390/cells11162486 · 2022 · External reference
Transcriptomics technologies
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Proteomic and metabolic profiling reveals APOE4 -dependent shifts in whole brain, neuronal, and astrocytic mitochondrial function and glycolysis
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A seven-year longitudinal study of the Alzheimer’s disease blood metabolome
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Genome-scale metabolic modelling predicts biomarkers and therapeutic targets for neuropsychiatric disorders
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Mild cognitive impairment: pathology and mechanisms
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Energy metabolism and brain aging: strategies to delay neuronal degeneration
10.1007/s10571-025-01555-z · 2025 · External reference
The role of GABA neurotransmitter in the human central nervous system, physiology, and pathophysiology
10.24875/rmn.20000050 · 2021 · External reference
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What is flux balance analysis?
10.1038/nbt.1614 · 2010 · External reference
Unresolved reference
2016 · External reference
IL-1β expression is increased and regulates GABA transmission following chronic ethanol in mouse central amygdala
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Neuropsychiatric symptoms in MCI subtypes: the importance of executive dysfunction
10.1002/gps.2535 · 2011 · External reference
Unresolved reference
2012 · External reference
Regulation of glutamate, GABA and dopamine transporter uptake, surface mobility and expression
10.3389/fncel.2021.670346 · 2021 · External reference
Functional metabolic mapping reveals highly active branched-chain amino acid metabolism in human astrocytes, which is impaired in iPSC-Derived astrocytes in Alzheimer’s disease
10.3389/fnagi.2021.736580 · 2021 · External reference
Astrocytic control of biosynthesis and turnover of the neurotransmitters glutamate and GABA
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Plasma microRNA biomarkers for detection of mild cognitive impairment
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Brain metabolism in health and neurodegeneration: the iInterplay among neurons and astrocytes
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Free-choice high-fat diet consumption reduces lateral hypothalamic GABAergic activity, without disturbing neural response to sucrose drinking in mice
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Unresolved reference
2005 · External reference
New insight into GABAergic neurons in the hypothalamic feeding regulation
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