Research graph
References from Cirevetmab, a novel canine anti–TGFβ monoclonal antibody, exerts antifibrotic effects on renal cells in vitro. Local targets link to admitted publications; unresolved targets remain external evidence.
Pathophysiology of chronic kidney disease
10.12968/coan.2015.20.1.15 · 2015 · External reference
Chronic kidney disease in dogs and cats
10.1016/j.cvsm.2012.04.008 · 2012 · External reference
Chronic kidney disease in dogs in UK veterinary practices: prevalence, risk factors, and survival
10.1111/jvim.12090 · 2013 · External reference
Successful Management of Chronic Kidney Disease in Dogs
10.29005/ijcp.2021.13.2.54-57 · 2021 · External reference
Gaining insights into pet owner understanding/lived experience of canine chronic kidney disease using survey and social media data
10.3389/fvets.2025.1506272 · 2025 · External reference
Diverse Role of TGF-beta in Kidney Disease
10.3389/fcell.2020.00123 · 2020 · External reference
TGF-beta: the master regulator of fibrosis
10.1038/nrneph.2016.48 · 2016 · External reference
Development of Canine Chronic Kidney Disease Model: A Pilot Study
10.47278/journal.ijvs/2021.056 · 2021 · External reference
Kidney fibrosis: from mechanisms to therapeutic medicines
10.1038/s41392-023-01379-7 · 2023 · External reference
Anti-fibrotic treatments: A review of clinical evidence
10.1016/j.matbio.2018.02.017 · 2018 · External reference
Origin of myofibroblasts and cellular events triggering fibrosis
10.1038/ki.2014.287 · 2015 · External reference
Targeting renal fibrosis: Mechanisms and drug delivery systems
10.1016/j.addr.2017.12.019 · 2018 · External reference
Cellular and molecular mechanisms of kidney fibrosis
10.1016/j.mam.2018.06.002 · 2019 · External reference
Central role of dysregulation of TGF-beta/Smad in CKD progression and potential targets of its treatment
10.1016/j.biopha.2018.02.090 · 2018 · External reference
Transforming growth factor-beta1 differentially mediates fibronectin and inflammatory cytokine expression in kidney tubular cells
10.1152/ajprenal.00013.2006 · 2006 · External reference
Regulation of the Bioavailability of TGF-beta and TGF-beta-Related Proteins
10.1101/cshperspect.a021907 · 2016 · External reference
TGF-beta signal transduction: biology, function and therapy for diseases
10.1186/s43556-022-00109-9 · 2022 · External reference
Transforming growth factor-beta receptors: versatile mechanisms of ligand activation
10.1038/s41401-024-01235-6 · 2024 · External reference
TGF-beta signaling in health, disease, and therapeutics
10.1038/s41392-024-01764-w · 2024 · External reference
TGF-beta signaling in the kidney: profibrotic and protective effects
10.1152/ajprenal.00365.2015 · 2016 · External reference
Transforming Growth Factor-beta Receptors and Smads: Regulatory Complexity and Functional Versatility
10.1016/j.tcb.2017.04.005 · 2017 · External reference
Transforming growth factor-beta regulation of immune responses
10.1146/annurev.immunol.24.021605.090737 · 2006 · External reference
TGF-beta/Smad Signaling Pathway in Tubulointerstitial Fibrosis
10.3389/fphar.2022.860588 · 2022 · External reference
Role of transforming growth factor beta in human disease
10.1056/nejm200005043421807 · 2000 · External reference
TGF-β signaling
10.3390/biom10030487 · 2020 · External reference
The pivotal role of TGF-beta/Smad pathway in fibrosis pathogenesis and treatment
10.3389/fonc.2025.1649179 · 2025 · External reference
Receptor binding competition: A paradigm for regulating TGF-beta family action
10.1016/j.cytogfr.2020.09.003 · 2021 · External reference
Primary cell-based phenotypic assays to pharmacologically and genetically study fibrotic diseases in vitro
10.14440/jbm.2019.285 · 2019 · External reference
Mechanisms of Renal Fibrosis
10.1146/annurev-physiol-022516-034227 · 2018 · External reference
Transforming growth factor beta3 deficiency promotes defective lipid metabolism and fibrosis in murine kidney
10.1242/dmm.048249 · 2021 · External reference
TGF-beta3 and cancer: a review
10.1016/j.cytogfr.2009.07.002 · 2009 · External reference
Epithelial mesenchymal transition in the progression of renal disease in dogs
2014 · External reference
Pirfenidone inhibits TGF-beta1-induced fibrosis via downregulation of Smad and ERK pathway in MDCK cells
10.1007/s11259-024-10493-y · 2024 · External reference
Evaluation of renal biopsies in cats and dogs — histopathology in comparison with clinical data
10.1111/j.1748-5827.1994.tb03952.x · 2008 · External reference
