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References from Increased detectability of Apolipoprotein E (ApoE) in cerebrospinal fluid samples of dogs with peracute and acute central nervous system lesions. Local targets link to admitted publications; unresolved targets remain external evidence.
Incidence of intervertebral disk degeneration-related diseases and associated mortality rates in dogs
10.2460/javma.240.11.1300 · 2012 · External reference
Canine neurological diseases in a referral hospital population between 1989 and 2000 in Switzerland
10.1111/j.1748-5827.2006.00106.x · 2006 · External reference
Inflammatory disease affecting the central nervous system in dogs: a retrospective study in England (2010-2019)
10.3389/fvets.2021.819945 · 2021 · External reference
A cohort study of epilepsy among 665,000 insured dogs: incidence, mortality and survival after diagnosis
10.1016/j.tvjl.2014.09.023 · 2014 · External reference
Biomarker definitions and their applications
10.1177/1535370217750088 · 2018 · External reference
Expression of human apolipoprotein E3 or E4 in the brains of Apoe-/- mice: isoform-specific effects on neurodegeneration
10.1523/jneurosci.19-12-04867.1999 · 1999 · External reference
Traumatic brain injury induces biphasic upregulation of ApoE and ApoJ protein in rats
10.1002/jnr.20607 · 2005 · External reference
ABCA1/ApoE/HDL signaling pathway facilitates myelination and oligodendrogenesis after stroke
10.3390/ijms21124369 · 2020 · External reference
Role of apolipoprotein E polymorphism as a prognostic marker in traumatic brain injury and neurodegenerative disease: a critical review
10.3171/2015.8.focus15329 · 2015 · External reference
Apolipoprotein E and the CNS response to injury
10.1097/00004647-199805000-00001 · 1998 · External reference
Apolipoprotein E: cholesterol transport protein with expanding role in cell biology
10.1126/science.3283935 · 1988 · External reference
Jr
10.1016/s0022-2275(20)34443-6 · 1984 · External reference
Astrocytes: regulation of brain homeostasis via apolipoprotein E
10.1016/j.biocel.2004.10.004 · 2005 · External reference
Apolipoprotein E and Alzheimer's Disease: Findings, Hypotheses, and Potential Mechanisms
10.1146/annurev-pathmechdis-030421-112756 · 2022 · External reference
Thematic review series: brain Lipids. Cholesterol metabolism in the central nervous system during early development and in the mature animal
10.1194/jlr.r400004-jlr200 · 2004 · External reference
Apolipoprotein E in animal models of CNS injury and in Alzheimer's disease
10.1016/0166-2236(94)90156-2 · 1994 · External reference
Genetic restoration of plasma apoe improves cognition and partially restores synaptic defects in ApoE-deficient mice
10.1523/jneurosci.1054-16.2016 · 2016 · External reference
Alterations in apolipoprotein E expression during aging and neurodegeneration
10.1016/s0301-0082(96)00038-x · 1996 · External reference
Apolipoprotein E deficiency exacerbates spinal cord injury in mice: inflammatory response and oxidative stress mediated by NF-kappaB signaling pathway
10.3389/fncel.2018.00142 · 2018 · External reference
Identification of the atherosclerosis phenotype in vivo by vascular duplex ultrasonography in ApoE-deficient dogs
10.1016/j.athplu.2021.12.001 · 2022 · External reference
Dogs lacking Apolipoprotein E show advanced atherosclerosis leading to apparent clinical complications
10.1007/s11427-021-2006-y · 2022 · External reference
Microglial activation by Alzheimer amyloid precursor protein and modulation by apolipoprotein E
10.1038/42257 · 1997 · External reference
Altered immune responses in apolipoprotein E-deficient mice
10.1016/s0022-2275(20)32409-3 · 2000 · External reference
Endogenous apolipoprotein E suppresses LPS-stimulated microglial nitric oxide production
10.1097/00001756-199803090-00010 · 1998 · External reference
Acute phase proteins in dogs and cats: current knowledge and future perspectives
10.1111/j.1939-165x.2005.tb00019.x · 2005 · External reference
Evaluation of intrathecal serum amyloid P (SAP) and C-reactive protein (CRP) synthesis in Alzheimer's disease with the use of index values
10.3233/jad-2010-100888 · 2010 · External reference
Hepatic but Not CNS-expressed human C-reactive protein inhibits experimental autoimmune encephalomyelitis in transgenic mice
10.1155/2015/640171 · 2015 · External reference
IL-1 beta and TNF-alpha suppress apolipoprotein (apo) E secretion and apo A-I expression in HepG2 cells
10.1006/cyto.1997.0291 · 1998 · External reference
Clinical and pathological analysis of epidural inflammation in intervertebral disk extrusion in dogs
10.1111/jvim.12095 · 2013 · External reference
The role of neuroinflammation in canine epilepsy
10.1016/j.tvjl.2023.106014 · 2023 · External reference
Measurement of apolipoprotein E (apoE) in cerebrospinal fluid
10.1023/a:1007516210548 · 2000 · External reference
International veterinary epilepsy task force consensus proposal: diagnostic approach to epilepsy in dogs
10.1186/s12917-015-0462-1 · 2015 · External reference
Classification of intervertebral disc disease
10.3389/fvets.2020.579025 · 2020 · External reference
Clinical findings and treatment of non-infectious meningoencephalomyelitis in dogs: a systematic review of 457 published cases from 1962 to 2008
10.1016/j.tvjl.2009.03.031 · 2010 · External reference
Canine degenerative myelopathy
10.1016/j.cvsm.2010.05.001 · 2010 · External reference
Diagnosis of inflammatory and infectious diseases of the central nervous system in dogs: a retrospective study
10.1111/j.1939-1676.1995.tb01089.x · 1995 · External reference
The role of APOE4 in disrupting the homeostatic functions of astrocytes and microglia in aging and alzheimer's disease
10.3389/fnagi.2019.00014 · 2019 · External reference
Histopathology and APOE genotype of the first Alzheimer disease patient, Auguste D
10.1007/s100480050033 · 1998 · External reference
Lipoproteins and their receptors in the central nervous system. Characterization of the lipoproteins in cerebrospinal fluid and identification of apolipoprotein B,E(LDL) receptors in the brain
10.1016/s0021-9258(18)47945-8 · 1987 · External reference
Cerebrospinal fluid apolipoprotein E concentration decreases after seizure
10.1016/j.seizure.2009.12.001 · 2010 · External reference
Age-dependent decline in the apolipoprotein E level in cerebrospinal fluid from control subjects and its increase in cerebrospinal fluid from patients with Alzheimer's disease
10.1159/000008157 · 2000 · External reference
Garcia-D'Angeli A, Brennan JP, Huo Q. Predicting detection limits of enzyme-linked immunosorbent assay (ELISA) and bioanalytical techniques in general
10.1039/c3an01835k · 2014 · External reference
The cell biology of APOE in the brain
10.1016/j.tcb.2023.09.004 · 2024 · External reference
A comparative pathological study on canine necrotizing meningoencephalitis and granulomatous meningoencephalomyelitis
10.1292/jvms.65.1233 · 2003 · External reference
Expression and secretion of apoE isoforms in astrocytes and microglia during inflammation
10.1002/glia.23974 · 2021 · External reference
Inflammatory markers associated with seizures
10.1684/epd.2016.0794 · 2016 · External reference
Lack of association between APOE gene polymorphisms and amyotrophic lateral sclerosis: a comprehensive meta-analysis
10.3109/21678421.2014.918149 · 2014 · External reference
Does apolipoprotein E genotype modify the clinical expression of ALS?
10.1111/j.1468-1331.2010.03225.x · 2011 · External reference
Apolipoprotein E is associated with age at onset of amyotrophic lateral sclerosis
10.1007/s10048-004-0193-0 · 2004 · External reference
Canine degenerative myelopathy: a model of human amyotrophic lateral sclerosis
10.1016/j.zool.2015.09.003 · 2016 · External reference
Central nervous system pathology in 25 dogs with chronic degenerative radiculomyelopathy
10.1136/vr.146.22.629 · 2000 · External reference
APOE: a potential marker of disease progression in ALS
10.1212/wnl.58.7.1112 · 2002 · External reference
Genetics, mechanisms, and therapeutics: where are we now?
10.3389/fnins.2019.01310 · 2019 · External reference
Concentrations of acute-phase proteins in dogs with steroid responsive meningitis-arteritis
10.1111/j.1939-1676.2008.0164.x · 2008 · External reference
Canine C-reactive protein measurements in cerebrospinal fluid by a time-resolved immunofluorimetric assay
10.1177/104063871102300109 · 2011 · External reference
Serum C-reactive protein is an early, simple and inexpensive prognostic marker for the progression of intramedullary lesion on magnetic resonance imaging from acute to subacute stage in patients with spinal cord injury
10.1038/s41393-021-00640-6 · 2021 · External reference
Blood-spinal cord barrier in spinal cord injury: a review
10.1089/neu.2020.7413 · 2021 · External reference
Acute phase proteins in cerebrospinal fluid from dogs with naturally-occurring spinal cord injury
10.1089/neu.2015.3895 · 2015 · External reference
Apolipoprotein E suppresses glial cell secretion of TNF alpha
10.1016/s0165-5728(97)00021-0 · 1997 · External reference
Apolipoprotein E-derived peptides reduce CNS inflammation: implications for therapy of neurological disease
10.1111/j.1600-0404.2006.00680.x · 2006 · External reference
Comparison of cerebellomedullary and lumbar cerebrospinal fluid analysis in dogs with neurological disease
10.1111/jvim.15700 · 2020 · External reference
Analysis of cerebrospinal fluid from the cerebellomedullary and lumbar cisterns of dogs with focal neurologic disease: 145 cases (1985-1987)
10.2460/javma.1990.196.11.1841 · 1990 · External reference
Generation of ApoE deficient dogs via combination of embryo injection of CRISPR/Cas9 with somatic cell nuclear transfer
10.1016/j.jgg.2017.11.003 · 2018 · External reference
Canine genetics comes of age
10.1016/s0168-9525(99)01958-7 · 2000 · External reference
Canine epilepsy as a translational model?
10.1111/epi.12138 · 2013 · External reference
Autologous olfactory mucosal cell transplants in clinical spinal cord injury: a randomized double-blinded trial in a canine translational model
10.1093/brain/aws268 · 2012 · External reference
