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References from Cross-species gene expression analysis identifies a type I interferon-associated transcriptional signature in Tregs from atopic dermatitis. Local targets link to admitted publications; unresolved targets remain external evidence.
Skin barrier abnormalities and immune dysfunction in atopic dermatitis
10.3390/ijms21082867 · 2020 · External reference
Type 2 immunity in allergic diseases
10.1038/s41423-025-01261-2 · 2025 · External reference
Dupilumab in adults with moderate to severe atopic dermatitis: a 5-Year open-label extension study
10.1001/jamadermatol.2024.1536 · 2024 · External reference
Two phase 3 trials of dupilumab versus placebo in atopic dermatitis
10.1056/nejmoa1610020 · 2016 · External reference
Ocular side effects of dupilumab: a comprehensive overview of the literature
10.3390/jcm14072487 · 2025 · External reference
Real-world clinical, psychosocial and economic burden of atopic dermatitis: results from a multicountry study
10.1111/jdv.19500 · 2024 · External reference
Regulatory T cells and immune tolerance
10.1016/j.cell.2008.05.009 · 2008 · External reference
Regulatory T cells and their role in allergic disease
10.1111/all.16326 · 2025 · External reference
Increased frequency of skin-infiltrating FoxP3+ regulatory T cells as a diagnostic indicator of severe atopic dermatitis from cutaneous T cell lymphoma
10.1111/cei.12073 · 2013 · External reference
Foxp3+ regulatory T cells are expanded in severe atopic dermatitis patients
10.1111/all.12712 · 2015 · External reference
Deciphering dysfunctional regulatory T cells in atopic dermatitis
10.1111/all.16439 · 2025 · External reference
A mouse model of MC903-Induced atopic dermatitis
10.1002/cpz1.695 · 2023 · External reference
Exogenous drug-induced mouse models of atopic dermatitis
10.1016/j.cytogfr.2024.01.003 · 2024 · External reference
CD4+ T cells play an essential role in chronic MC903-induced skin inflammation
10.1016/j.bbrc.2022.04.106 · 2022 · External reference
Mouse models for atopic dermatitis
10.1002/cpz1.709 · 2023 · External reference
Foxp3 and Bcl6 deficiency synergistically induces spontaneous development of atopic dermatitis-like skin disease
10.1093/intimm/dxad018 · 2023 · External reference
Spontaneous antibody production caused by regulatory T cell deficiency occurs through a germinal center-independent pathway
10.1016/j.bbrc.2020.05.026 · 2020 · External reference
Bcl6 preserves the suppressive function of regulatory T cells during tumorigenesis
10.3389/fimmu.2020.00806 · 2020 · External reference
Dendritic cells support homeostatic expansion of Foxp3+ regulatory T cells in Foxp3.LuciDTR mice
10.4049/jimmunol.0902420 · 2010 · External reference
Flow cytometry analysis of the subpopulations of mouse keratinocytes and skin immune cells
10.1016/j.xpro.2021.101052 · 2022 · External reference
Spatial reconstruction of single-cell gene expression data
10.1038/nbt.3192 · 2015 · External reference
Comprehensive integration of single-cell data
10.1016/j.cell.2019.05.031 · 2019 · External reference
Fast, sensitive and accurate integration of single-cell data with harmony
10.1038/s41592-019-0619-0 · 2019 · External reference
GeneToList: a web application to assist with gene identifiers for the non-bioinformatics-savvy scientist
10.3390/biology11081113 · 2022 · External reference
SCENIC: single-cell regulatory network inference and clustering
10.1038/nmeth.4463 · 2017 · External reference
Revealing the critical regulators of cell identity in the mouse cell atlas
10.1016/j.celrep.2018.10.045 · 2018 · External reference
Dysregulation of humoral immunity in Foxp3 conditional-knockout mice
10.1016/j.bbrc.2019.04.090 · 2019 · External reference
The molecular signatures database hallmark gene set collection
10.1016/j.cels.2015.12.004 · 2015 · External reference
Bcl6 controls the Th2 inflammatory activity of regulatory T cells by repressing Gata3 function
10.4049/jimmunol.1201794 · 2012 · External reference
ChEA3: transcription factor enrichment analysis by orthogonal omics integration
10.1093/nar/gkz446 · 2019 · External reference
Regulatory T cell lineage specification by the forkhead transcription factor Foxp3
10.1016/j.immuni.2005.01.016 · 2005 · External reference
Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse
10.1038/83784 · 2001 · External reference
Temporal and context-dependent requirements for the transcription factor Foxp3 expression in regulatory T cells
10.1038/s41590-025-02295-4 · 2025 · External reference
Inducible protein degradation reveals inflammation-dependent function of the treg cell lineage–defining transcription factor Foxp3
10.1126/sciimmunol.adr7057 · 2025 · External reference
Bcl6 sets a threshold for antiviral signaling by restraining IRF7 transcriptional program
10.1038/srep18778 · 2016 · External reference
BCL6 represses antiviral resistance in follicular T helper cells
10.1189/jlb.4a1216-513rr · 2017 · External reference
Identification of novel gene signatures in atopic dermatitis complicated by eczema herpeticum
10.1016/j.jaci.2013.12.690 · 2014 · External reference
Plasmacytoid dendritic cells: a new cutaneous dendritic cell subset with distinct role in inflammatory skin diseases
10.1046/j.1523-1747.2002.19515.x · 2002 · External reference
Type I IFN derived from Ly6Chi monocytes suppresses type 2 inflammation in a murine model of atopic dermatitis
10.1016/j.jid.2023.08.022 · 2024 · External reference
Transcriptional regulation of antiviral interferon-stimulated genes
10.1016/j.tim.2017.01.001 · 2017 · External reference
IRF7: role and regulation in immunity and autoimmunity
10.3389/fimmu.2023.1236923 · 2023 · External reference
Loss of regulatory capacity in treg cells following rhinovirus infection
10.1016/j.jaci.2021.05.045 · 2021 · External reference
Interferon-stimulated viperin impairs treg function in autoimmune thrombocytopenia
10.1186/s12964-025-02511-6 · 2025 · External reference
IFNα/βR signaling promotes regulatory T cell development and function under stress conditions
10.4049/jimmunol.1500036 · 2015 · External reference
Dupilumab in adults with moderate to severe atopic dermatitis: a 5-Year open-label extension study
10.1001/jamadermatol.2024.1536 · ExternalCitation · doi-reference
A mouse model of MC903-Induced atopic dermatitis
10.1002/cpz1.695 · ExternalCitation · doi-reference
Mouse models for atopic dermatitis
10.1002/cpz1.709 · ExternalCitation · doi-reference
Dysregulation of humoral immunity in Foxp3 conditional-knockout mice
10.1016/j.bbrc.2019.04.090 · ExternalCitation · doi-reference
Spontaneous antibody production caused by regulatory T cell deficiency occurs through a germinal center-independent pathway
10.1016/j.bbrc.2020.05.026 · ExternalCitation · doi-reference
CD4+ T cells play an essential role in chronic MC903-induced skin inflammation
10.1016/j.bbrc.2022.04.106 · ExternalCitation · doi-reference
Regulatory T cells and immune tolerance
10.1016/j.cell.2008.05.009 · ExternalCitation · doi-reference
Comprehensive integration of single-cell data
10.1016/j.cell.2019.05.031 · ExternalCitation · doi-reference
Revealing the critical regulators of cell identity in the mouse cell atlas
10.1016/j.celrep.2018.10.045 · ExternalCitation · doi-reference
The molecular signatures database hallmark gene set collection
10.1016/j.cels.2015.12.004 · ExternalCitation · doi-reference
Exogenous drug-induced mouse models of atopic dermatitis
10.1016/j.cytogfr.2024.01.003 · ExternalCitation · doi-reference
Regulatory T cell lineage specification by the forkhead transcription factor Foxp3
10.1016/j.immuni.2005.01.016 · ExternalCitation · doi-reference
Identification of novel gene signatures in atopic dermatitis complicated by eczema herpeticum
10.1016/j.jaci.2013.12.690 · ExternalCitation · doi-reference
Loss of regulatory capacity in treg cells following rhinovirus infection
10.1016/j.jaci.2021.05.045 · ExternalCitation · doi-reference
Type I IFN derived from Ly6Chi monocytes suppresses type 2 inflammation in a murine model of atopic dermatitis
10.1016/j.jid.2023.08.022 · ExternalCitation · doi-reference
Transcriptional regulation of antiviral interferon-stimulated genes
10.1016/j.tim.2017.01.001 · ExternalCitation · doi-reference
Flow cytometry analysis of the subpopulations of mouse keratinocytes and skin immune cells
10.1016/j.xpro.2021.101052 · ExternalCitation · doi-reference
Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse
10.1038/83784 · ExternalCitation · doi-reference
Spatial reconstruction of single-cell gene expression data
10.1038/nbt.3192 · ExternalCitation · doi-reference
SCENIC: single-cell regulatory network inference and clustering
10.1038/nmeth.4463 · ExternalCitation · doi-reference
Type 2 immunity in allergic diseases
10.1038/s41423-025-01261-2 · ExternalCitation · doi-reference
Temporal and context-dependent requirements for the transcription factor Foxp3 expression in regulatory T cells
10.1038/s41590-025-02295-4 · ExternalCitation · doi-reference
Fast, sensitive and accurate integration of single-cell data with harmony
10.1038/s41592-019-0619-0 · ExternalCitation · doi-reference
Bcl6 sets a threshold for antiviral signaling by restraining IRF7 transcriptional program
10.1038/srep18778 · ExternalCitation · doi-reference
Plasmacytoid dendritic cells: a new cutaneous dendritic cell subset with distinct role in inflammatory skin diseases
10.1046/j.1523-1747.2002.19515.x · ExternalCitation · doi-reference
Two phase 3 trials of dupilumab versus placebo in atopic dermatitis
10.1056/nejmoa1610020 · ExternalCitation · doi-reference
Foxp3 and Bcl6 deficiency synergistically induces spontaneous development of atopic dermatitis-like skin disease
10.1093/intimm/dxad018 · ExternalCitation · doi-reference
ChEA3: transcription factor enrichment analysis by orthogonal omics integration
10.1093/nar/gkz446 · ExternalCitation · doi-reference
Foxp3+ regulatory T cells are expanded in severe atopic dermatitis patients
10.1111/all.12712 · ExternalCitation · doi-reference
Regulatory T cells and their role in allergic disease
10.1111/all.16326 · ExternalCitation · doi-reference
Deciphering dysfunctional regulatory T cells in atopic dermatitis
10.1111/all.16439 · ExternalCitation · doi-reference
Increased frequency of skin-infiltrating FoxP3+ regulatory T cells as a diagnostic indicator of severe atopic dermatitis from cutaneous T cell lymphoma
10.1111/cei.12073 · ExternalCitation · doi-reference
Real-world clinical, psychosocial and economic burden of atopic dermatitis: results from a multicountry study
10.1111/jdv.19500 · ExternalCitation · doi-reference
Inducible protein degradation reveals inflammation-dependent function of the treg cell lineage–defining transcription factor Foxp3
10.1126/sciimmunol.adr7057 · ExternalCitation · doi-reference
Interferon-stimulated viperin impairs treg function in autoimmune thrombocytopenia
10.1186/s12964-025-02511-6 · ExternalCitation · doi-reference
BCL6 represses antiviral resistance in follicular T helper cells
10.1189/jlb.4a1216-513rr · ExternalCitation · doi-reference
Bcl6 preserves the suppressive function of regulatory T cells during tumorigenesis
10.3389/fimmu.2020.00806 · ExternalCitation · doi-reference
IRF7: role and regulation in immunity and autoimmunity
10.3389/fimmu.2023.1236923 · ExternalCitation · doi-reference
GeneToList: a web application to assist with gene identifiers for the non-bioinformatics-savvy scientist
10.3390/biology11081113 · ExternalCitation · doi-reference
Skin barrier abnormalities and immune dysfunction in atopic dermatitis
10.3390/ijms21082867 · ExternalCitation · doi-reference
Ocular side effects of dupilumab: a comprehensive overview of the literature
10.3390/jcm14072487 · ExternalCitation · doi-reference
Dendritic cells support homeostatic expansion of Foxp3+ regulatory T cells in Foxp3.LuciDTR mice
10.4049/jimmunol.0902420 · ExternalCitation · doi-reference
Bcl6 controls the Th2 inflammatory activity of regulatory T cells by repressing Gata3 function
10.4049/jimmunol.1201794 · ExternalCitation · doi-reference
IFNα/βR signaling promotes regulatory T cell development and function under stress conditions
10.4049/jimmunol.1500036 · ExternalCitation · doi-reference
