Contact and support
Need help, have a question, or want to contact the ResearchHub team?
© 2026 ResearchHub. Built for responsible scholarly connection.
Research graph
References from Artificial Intelligence in RNA Research: From Molecular Design to Translational Analytics and Quality Control. Local targets link to admitted publications; unresolved targets remain external evidence.
Geometric deep learning of RNA structure
10.1126/science.abe5650 · 2021 · External reference
A novel mechanism for the loss of mRNA activity in lipid nanoparticle delivery systems
10.1038/s41467-021-26926-0 · 2021 · External reference
Algorithm for optimized mRNA design improves stability and immunogenicity
10.1038/s41586-023-06127-z · 2023 · External reference
Accurate RNA 3D structure prediction using a language model-based deep learning approach
10.1038/s41592-024-02487-0 · 2024 · External reference
RiNALMo: General-purpose RNA language models can generalize well on structure prediction tasks
10.1038/s41467-025-60872-5 · 2025 · External reference
AI-powered design accelerates the development of mRNA therapeutics
10.1038/s41589-025-02074-0 · 2025 · External reference
mRNABERT: Advancing mRNA sequence design with a universal language model and comprehensive dataset
10.1038/s41467-025-65340-8 · 2025 · External reference
Predicting the translation efficiency of messenger RNA in mammalian cells
10.1038/s41587-025-02712-x · 2025 · External reference
Prediction of on-target and off-target activity of CRISPR–Cas13d guide RNAs using deep learning
10.1038/s41587-023-01830-8 · 2023 · External reference
RNAmigos2: Accelerated structure-based RNA virtual screening with deep graph learning
10.1038/s41467-025-57852-0 · 2025 · External reference
Accelerating ionizable lipid discovery for mRNA delivery using machine learning and combinatorial chemistry
10.1038/s41563-024-01867-3 · 2024 · External reference
Artificial intelligence-guided design of lipid nanoparticles for pulmonary gene therapy
10.1038/s41587-024-02490-y · 2024 · External reference
Lipid Nanoparticle Database towards structure-function modeling and data-driven design for nucleic acid delivery
10.1038/s41467-026-68818-1 · 2026 · External reference
10.1101/2024.12.19.629496
10.1101/2024.12.19.629496 · External reference
ViennaRNA Package 2.0
10.1186/1748-7188-6-26 · 2011 · External reference
10.1186/1471-2105-11-129
10.1186/1471-2105-11-129 · External reference
Mfold web server for nucleic acid folding and hybridization prediction
10.1093/nar/gkg595 · 2003 · External reference
RNA secondary structure prediction using an ensemble of two-dimensional deep neural networks and transfer learning
10.1038/s41467-019-13395-9 · 2019 · External reference
Unresolved reference
External reference
RNA secondary structure prediction using deep learning with thermodynamic integration
10.1038/s41467-021-21194-4 · 2021 · External reference
UFold: Fast and accurate RNA secondary structure prediction with deep learning
10.1093/nar/gkab1074 · 2022 · External reference
10.1371/journal.pcbi.1009291
10.1371/journal.pcbi.1009291 · External reference
Automated 3D structure composition for large RNAs
10.1093/nar/gks339 · 2012 · External reference
SimRNA: A coarse-grained method for RNA folding simulations and 3D structure prediction
10.1093/nar/gkv1479 · 2015 · External reference
FARFAR2: Improved De Novo Rosetta Prediction of Complex Global RNA Folds
10.1016/j.str.2020.05.011 · 2020 · External reference
RNA-Puzzles Round III: 3D RNA structure prediction of five riboswitches and one ribozyme
10.1261/rna.060368.116 · 2017 · External reference
RNA-Puzzles: A CASP-like evaluation of RNA three-dimensional structure prediction
10.1261/rna.031054.111 · 2012 · External reference
Computational modeling of RNA 3D structures, with the aid of experimental restraints
10.4161/rna.28826 · 2014 · External reference
Computational modeling of RNA 3D structure based on experimental data
10.1042/bsr20180430 · 2019 · External reference
Accurate structure prediction of biomolecular interactions with AlphaFold 3
10.1038/s41586-024-07487-w · 2024 · External reference
TrRosettaRNA: Automated prediction of RNA 3D structure with transformer network
10.1038/s41467-023-42528-4 · 2023 · External reference
NuFold: End-to-end approach for RNA tertiary structure prediction with flexible nucleobase center representation
10.1038/s41467-025-56261-7 · 2025 · External reference
Unresolved reference
External reference
Human 5′ UTR design and variant effect prediction from a massively parallel translation assay
10.1038/s41587-019-0164-5 · 2019 · External reference
Combinatorial optimization of mRNA structure, stability, and translation for RNA-based therapeutics
10.1038/s41467-022-28776-w · 2022 · External reference
Codon optimality is a major determinant of mRNA stability
10.1016/j.cell.2015.02.029 · 2015 · External reference
Codon identity regulates mRNA stability and translation efficiency during the maternal-to-zygotic transition
10.15252/embj.201694699 · 2016 · External reference
MRNA structure regulates protein expression through changes in functional half-life
10.1073/pnas.1908052116 · 2019 · External reference
Suppression of RNA recognition by Toll-like receptors: The impact of nucleoside modification and the evolutionary origin of RNA
10.1016/j.immuni.2005.06.008 · 2005 · External reference
N1-methylpseudouridine-incorporated mRNA outperforms pseudouridine-incorporated mRNA by providing enhanced protein expression and reduced immunogenicity in mammalian cell lines and mice
10.1016/j.jconrel.2015.08.051 · 2015 · External reference
N1-methyl-pseudouridine in mRNA enhances translation through eIF2α-dependent and independent mechanisms by increasing ribosome density
10.1093/nar/gkx135 · 2017 · External reference
Impact of mRNA chemistry and manufacturing process on innate immune activation
10.1126/sciadv.aaz6893 · 2020 · External reference
A 5′ UTR Language Model for Decoding Untranslated Regions of mRNA and Function Predictions
10.1038/s42256-024-00823-9 · 2023 · External reference
Unresolved reference
External reference
Unresolved reference
External reference
10.1101/2022.08.06.503062
10.1101/2022.08.06.503062 · External reference
An interpretable RNA foundation model for exploring functional RNA motifs in plants
10.1038/s42256-024-00946-z · 2024 · External reference
10.1101/2024.03.31.587283
10.1101/2024.03.31.587283 · External reference
MRNA vaccines—A new era in vaccinology
10.1038/nrd.2017.243 · 2018 · External reference
An Insight on RNA Based Therapeutics and Vaccines: Challenges and Opportunities
10.2174/1568026621666211118095451 · 2021 · External reference
Challenges in developing personalized neoantigen cancer vaccines
10.1038/s41577-023-00937-y · 2023 · External reference
Identification of neoantigens for individualized therapeutic cancer vaccines
10.1038/s41573-021-00387-y · 2022 · External reference
Cancer mRNA vaccines: Clinical advances and future opportunities
10.1038/s41571-024-00902-1 · 2024 · External reference
MRNA-based cancer therapeutics
10.1038/s41568-023-00586-2 · 2023 · External reference
Design of a genome-wide siRNA library using an artificial neural network
10.1038/nbt1118 · 2005 · External reference
Machine learning for siRNA efficiency prediction: A systematic review
2024 · External reference
AttSiOff: A self-attention-based approach on siRNA design with inhibition and off-target effect prediction
10.1007/s44258-024-00019-1 · 2024 · External reference
Reduction of Off-Target Effects of Gapmer Antisense Oligonucleotides by Oligonucleotide Extension
10.1007/s40291-021-00573-z · 2022 · External reference
Deep learning facilitates efficient optimization of antisense oligonucleotide drugs
10.1016/j.omtn.2024.102208 · 2024 · External reference
Small molecule approaches to targeting RNA
10.1038/s41570-023-00569-9 · 2024 · External reference
Targeting RNA structures with small molecules
10.1038/s41573-022-00521-4 · 2022 · External reference
Validation of Automated Docking Programs for Docking and Database Screening against RNA Drug Targets
10.1021/jm030650o · 2004 · External reference
Validation of an empirical RNA-ligand scoring function for fast flexible docking using RiboDock®
10.1023/b:jcam.0000035199.48747.1e · 2004 · External reference
10.1371/journal.pcbi.1003571
10.1371/journal.pcbi.1003571 · External reference
LigandRNA: Computational predictor of RNA-ligand interactions
10.1261/rna.039834.113 · 2013 · External reference
Discovery of Key Physicochemical, Structural, and Spatial Properties of RNA-Targeted Bioactive Ligands
10.1002/anie.201707641 · 2017 · External reference
Drugging the RNA World
10.1101/cshperspect.a034769 · 2018 · External reference
SMN2 splice modulators enhance U1–pre-mRNA association and rescue SMA mice
10.1038/nchembio.1837 · 2015 · External reference
Discovery of Risdiplam, a Selective Survival of Motor Neuron-2 (SMN2) Gene Splicing Modifier for the Treatment of Spinal Muscular Atrophy (SMA)
10.1021/acs.jmedchem.8b00741 · 2018 · External reference
Structural basis of a small molecule targeting RNA for a specific splicing correction
10.1038/s41589-019-0384-5 · 2019 · External reference
Binding to SMN2 pre-mRNA-protein complex elicits specificity for small molecule splicing modifiers
10.1038/s41467-017-01559-4 · 2017 · External reference
10.3390/vaccines9040359
10.3390/vaccines9040359 · External reference
Intracellular RNA delivery by lipid nanoparticles: Diffusion, degradation, and release
10.1016/j.biosystems.2019.104032 · 2019 · External reference
Lipid-Based Nanoparticles for Drug/Gene Delivery: An Overview of the Production Techniques and Difficulties Encountered in Their Industrial Development
10.1021/acsmaterialsau.3c00032 · 2023 · External reference
Exploring the landscape of Lipid Nanoparticles (LNPs): A comprehensive review of LNPs types and biological sources of lipids
2024 · External reference
Lipid nanoparticles for mRNA delivery
10.1038/s41578-021-00358-0 · 2021 · External reference
Lipid Nanoparticles from Liposomes to MRNA Vaccine Delivery, a Landscape of Research Diversity and Advancement
10.1021/acsnano.1c04996 · 2021 · External reference
mRNA-lipid nanoparticle COVID-19 vaccines: Structure and stability
10.1016/j.ijpharm.2021.120586 · 2021 · External reference
10.3390/ph15070897
10.3390/ph15070897 · External reference
Impact of lipid nanoparticle size on mRNA vaccine immunogenicity
10.1016/j.jconrel.2021.05.021 · 2021 · External reference
Impact of ionizable lipid type on the pharmacokinetics and biodistribution of mRNA-lipid nanoparticles after intravenous and subcutaneous injection
10.1016/j.jconrel.2025.113945 · 2025 · External reference
On the mechanism of tissue-specific mRNA delivery by selective organ targeting nanoparticles
10.1073/pnas.2109256118 · 2021 · External reference
Selective organ targeting (SORT) nanoparticles for tissue-specific mRNA delivery and CRISPR–Cas gene editing
10.1038/s41565-020-0669-6 · 2020 · External reference
Unresolved reference
External reference
TransMA: An explainable multi-modal deep learning model for predicting properties of ionizable lipid nanoparticles in mRNA delivery
10.1093/bib/bbaf307 · 2025 · External reference
Preparation of selective organ-targeting (SORT) lipid nanoparticles (LNPs) using multiple technical methods for tissue-specific mRNA delivery
10.1038/s41596-022-00755-x · 2023 · External reference
On the Formation and Morphology of Lipid Nanoparticles Containing Ionizable Cationic Lipids and siRNA
10.1021/acsnano.8b01516 · 2018 · External reference
Enhancing RNA encapsulation quantification in lipid nanoparticles: Sustainable alternatives to Triton X-100 in the RiboGreen assay
10.1016/j.ejpb.2024.114571 · 2024 · External reference
A careful look at lipid nanoparticle characterization: Analysis of benchmark formulations for encapsulation of RNA cargo size gradient
10.1038/s41598-024-52685-1 · 2024 · External reference
Angle-dependent effects in DLS measurements of polydisperse particles
10.1088/1361-6501/ac42b2 · 2022 · External reference
Time-dependent particle size increase during lipid nanoparticle purification by cross-flow filtration
10.1016/j.jcis.2025.137663 · 2025 · External reference
Improved multidetector asymmetrical-flow field-flow fractionation method for particle sizing and concentration measurements of lipid-based nanocarriers for RNA delivery
10.1016/j.ejpb.2021.03.004 · 2021 · External reference
Exploring the impact of commonly used ionizable and pegylated lipids on mRNA-LNPs: A combined in vitro and preclinical perspective
10.1016/j.jconrel.2024.11.010 · 2025 · External reference
On the Influence of Fabrication Methods and Materials for mRNA-LNP Production: From Size and Morphology to Internal Structure and mRNA Delivery Performance In Vitro and In Vivo
10.1002/adhm.202401252 · 2024 · External reference
Capillary-Based Physicochemical Characterization of Lipid Nanoparticles
10.1002/elps.70032 · 2025 · External reference
Capillary electrophoretic separation of nanoparticles
10.1007/s00216-011-4650-y · 2011 · External reference
10.3390/vaccines12020169
10.3390/vaccines12020169 · External reference
10.3390/vaccines11071224
10.3390/vaccines11071224 · External reference
10.3390/ijms25115718
10.3390/ijms25115718 · External reference
pVAC-Seq: A genome-guided in silico approach to identifying tumor neoantigens
10.1186/s13073-016-0264-5 · 2016 · External reference
Unresolved reference
External reference
Unresolved reference
External reference
Unresolved reference
External reference
Unresolved reference
External reference
Unresolved reference
External reference
Multiple criteria decision analysis for health care decision making—An introduction: Report 1 of the ISPOR MCDA Emerging Good Practices Task Force
10.1016/j.jval.2015.12.003 · 2016 · External reference
Applications of machine learning in drug discovery and development
10.1038/s41573-019-0024-5 · 2019 · External reference
Multi-objective optimization methods in drug design
10.1016/j.ddtec.2013.02.001 · 2013 · External reference
Computer-aided multi-objective optimization in small molecule discovery
10.1016/j.patter.2023.100678 · 2023 · External reference
pVACview: An interactive visualization tool for efficient neoantigen prioritization and selection
10.1186/s13073-024-01384-7 · 2024 · External reference
Opportunities at the Intersection of Synthetic Biology, Machine Learning, and Automation
10.1021/acssynbio.8b00540 · 2019 · External reference
Engineering Cellular Metabolism
10.1016/j.cell.2016.02.004 · 2016 · External reference
Taking the human out of the loop: A review of Bayesian optimization
10.1109/jproc.2015.2494218 · 2016 · External reference