Research graph
References from Cefazolin Versus Antistaphylococcal Penicillins in Methicillin-Susceptible Staphylococcus aureus Bone and Joint Infections: A Narrative Review. Local targets link to admitted publications; unresolved targets remain external evidence.
Staphylococcus aureus infections: Epidemiology, pathophysiology, clinical manifestations, and management
10.1128/cmr.00134-14 · 2015 · External reference
Prosthetic-joint infections
10.1056/nejmra040181 · 2004 · External reference
2015 IDSA guidelines for native vertebral osteomyelitis in adults
10.1093/cid/civ482 · 2015 · External reference
Diagnosis and management of prosthetic joint infection: IDSA guidelines
10.1093/cid/cis803 · 2013 · External reference
Antibiotic treatment for 6 weeks versus 12 weeks in patients with pyogenic vertebral osteomyelitis
10.1016/s0140-6736(14)61233-2 · 2015 · External reference
Oral versus intravenous antibiotics for bone and joint infection (OVIVA)
10.1056/nejmoa1710926 · 2019 · External reference
Cefazolin versus anti-staphylococcal penicillins for treatment of MSSA bacteremia: A narrative review
10.1016/j.cmi.2017.07.003 · 2018 · External reference
Treatment of osteomyelitis and septic arthritis with cefazolin
10.1128/aac.13.3.405 · 1978 · External reference
Continuous cefazolin infusion to treat bone and joint infections
10.1128/aac.00389-08 · 2009 · External reference
Comparative evaluation of the tolerability of cefazolin and nafcillin … in the outpatient setting
10.1093/cid/ciu301 · 2014 · External reference
Systematic review and meta-analysis of the safety of antistaphylococcal penicillins compared to cefazolin
10.1128/aac.01816-17 · 2018 · External reference
10.1186/s12879-018-3418-9
10.1186/s12879-018-3418-9 · External reference
Cefazolin versus anti-staphylococcal penicillins for MSSA infection: Meta-analysis with trial sequential analysis
10.1007/s40121-019-00259-4 · 2019 · External reference
Staphylococcus aureus Network Adaptive Platform MSSA/PSSA domain-specific working group. Cefazolin vs. antistaphylococcal penicillins for the treatment of methicillin-susceptible Staphylococcus aureus bacteremia: A systematic review and meta-analysis
10.1016/j.cmi.2025.04.045 · 2025 · External reference
CloCeBa Study Group Cloxacillin versus cefazolin for meticillin-susceptible Staphylococcus aureus bacteremia (CloCeBa): A prospective, open-label, multicentre, non-inferiority, randomised clinical trial
10.1016/s0140-6736(25)01624-1 · 2025 · External reference
Cefazolin versus cloxacillin or flucloxacillin for methicillin-susceptible Staphylococcus aureus bacteremia: A randomized clinical trial
10.1056/nejmoa2506905 · 2026 · External reference
A review of the randomized clinical trial results from the SNAP MSSA and PSSA domains and CloCeBa
10.1093/jac/dkag215 · 2026 · External reference
Unresolved reference
External reference
Antistaphylococcal penicillin vs cefazolin for the treatment of MSSA spinal epidural abscesses
10.1093/ofid/ofab071 · 2021 · External reference
Cefazolin versus cloxacillin as definitive antibiotic therapy for MSSA spinal epidural abscess: A retrospective cohort study
10.1016/j.ijantimicag.2021.106429 · 2021 · External reference
10.3390/antibiotics15080798
10.3390/antibiotics15080798 · External reference
Staphylococcus aureus Network Adaptive Platform (SNAP) Study Group the Staphylococcus aureus Network Adaptive Platform trial protocol: New tools for an old foe
10.1093/cid/ciac476 · 2022 · External reference
Unresolved reference
External reference
Comparison of cefazolin versus oxacillin for treatment of complicated bacteremia caused by MSSA
10.1128/aac.02800-14 · 2014 · External reference
Treatment outcomes with cefazolin versus oxacillin for deep-seated MSSA bloodstream infections
10.1128/aac.04677-14 · 2015 · External reference
Comparative effectiveness of cefazolin versus cloxacillin as definitive antibiotic therapy for MSSA bacteremia
10.1093/jac/dku560 · 2015 · External reference
Comparative Effectiveness of Cefazolin Versus Nafcillin or Oxacillin for Treatment of Methicillin-Susceptible Staphylococcus aureus Infections Complicated by Bacteremia: A Nationwide Cohort Study
10.1093/cid/cix287 · 2017 · External reference
A large retrospective cohort study of cefazolin compared with flucloxacillin for MSSA bacteremia
10.1016/j.ijantimicag.2018.02.013 · 2018 · External reference
ESPID bone and joint infection guidelines
10.1097/inf.0000000000001635 · 2017 · External reference
2021 PIDS/IDSA guideline on acute hematogenous osteomyelitis in pediatrics
10.1093/jpids/piab027 · 2021 · External reference
Cefazolin inoculum effect and MSSA osteoarticular infections in children
10.1128/aac.00703-20 · 2020 · External reference
Comparative effectiveness of cefazolin versus antistaphylococcal penicillins in MSSA infective endocarditis: SR
2025 · External reference
β-Lactam inoculum effect in methicillin-susceptible Staphylococcus aureus infective endocarditis
10.1001/jamanetworkopen.2024.51353 · 2024 · External reference
Inoculum effect with cefazolin among clinical isolates of methicillin-susceptible Staphylococcus aureus: Frequency and possible cause of cefazolin treatment failure
10.1128/aac.00317-09 · 2009 · External reference
In vivo effects of cefazolin, daptomycin, and nafcillin in experimental endocarditis with a methicillin-susceptible Staphylococcus aureus strain showing an inoculum effect against cefazolin
10.1128/aac.00856-13 · 2013 · External reference
Novel insights into the classification of staphylococcal β-lactamases in relation to the cefazolin inoculum effect
10.1128/aac.02511-19 · 2020 · External reference
The cefazolin inoculum effect: An underappreciated factor in MSSA treatment strategies
10.1007/s40121-025-01283-3 · 2026 · External reference
The cefazolin inoculum effect is associated with increased mortality in MSSA bacteremia
10.1093/ofid/ofy123 · 2018 · External reference
Clinical significance of cefazolin inoculum effect in serious MSSA infections: A systematic review
10.1093/jacamr/dlae069 · 2024 · External reference
Cefazolin inoculum effect and cefazolin microbiological treatment failure in serious methicillin-susceptible Staphylococcus aureus infections: A multicenter retrospective cohort study
10.1093/infdis/jiag199 · 2026 · External reference
Clinical features and medical–surgical management overweight the inoculum effect and genotypic characteristics of MSSA in infective endocarditis
10.1093/jac/dkaf115 · 2025 · External reference
Rationale for eliminating Staphylococcus breakpoints for β-lactam agents other than penicillin, oxacillin or cefoxitin, and ceftaroline
10.1093/cid/ciu043 · 2014 · External reference
Continued in vitro cefazolin susceptibility in methicillin-susceptible Staphylococcus aureus
10.1186/s12941-018-0257-x · 2018 · External reference
A test for the rapid detection of the cefazolin inoculum effect in methicillin-susceptible Staphylococcus aureus
10.1128/jcm.01938-20 · 2021 · External reference
Frequency of pharmacological target attainment with flucloxacillin and cefazolin in invasive MSSA infection: A prospective cohort study
10.1016/j.ijantimicag.2022.106695 · 2023 · External reference
Antibiotic penetration into bone and joints: An updated review
10.1016/j.ijid.2019.02.005 · 2019 · External reference
Population pharmacokinetics of flucloxacillin in bone and soft tissue—Standard dosing is not sufficient to achieve therapeutic concentrations
10.1007/s11095-022-03197-y · 2022 · External reference
A population pharmacokinetic analysis of continuous infusion of cloxacillin during S. aureus bone and joint infections
10.1128/aac.01562-20 · 2020 · External reference
10.3390/antibiotics13100928
10.3390/antibiotics13100928 · External reference
Consensus guidance for beta-lactam antibiotic dose individualization in acutely ill patients
10.1002/phar.70181 · 2026 · External reference
Pharmacokinetic evaluation of cefazolin in the cerebrospinal fluid of critically ill patients
10.1093/ofid/ofab649 · 2022 · External reference
HLA-B5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin
10.1038/ng.379 · 2009 · External reference
The risk of drug-induced liver injury associated with flucloxacillin: A nationwide, entropy-balanced cohort study
10.1016/j.cmi.2024.12.013 · 2025 · External reference
Quantification of the risk of liver injury associated with flucloxacillin: A UK population-based cohort study
10.1093/jac/dkx183 · 2017 · External reference
Higher occurrence of hepatotoxicity and rash in patients treated with oxacillin, compared with those treated with nafcillin
10.1086/338047 · 2002 · External reference
The safety and economic impact of cefazolin versus nafcillin for the treatment of MSSA bloodstream infections
10.1007/s40121-017-0148-z · 2017 · External reference
Time to acute kidney injury in β-lactam-induced acute interstitial nephritis
10.1016/j.ekir.2020.04.008 · 2020 · External reference
A review of β-lactam-associated neutropenia and implications for cross-reactivity
10.1177/1060028020975646 · 2021 · External reference
Intravenous flucloxacillin treatment is associated with a high incidence of hypokalaemia
10.1111/bcp.13969 · 2019 · External reference
Extravasation of noncytotoxic drugs: A review of the literature
10.1177/1060028014527820 · 2014 · External reference
Seizures associated with high-dose cefazolin in a patient with renal dysfunction: A case report
10.1177/08971900251326735 · 2025 · External reference
Cephalosporin allergy: R1 side-chain and penicillin cross-reactivity patterns in an Australian cohort
10.1016/j.jacig.2025.100583 · 2026 · External reference
Safety of cefazolin for perioperative prophylaxis in patients with penicillin allergy labels
10.1016/j.anai.2022.03.015 · 2022 · External reference
10.3390/antibiotics10091112
10.3390/antibiotics10091112 · External reference
10.3390/jcm14082722
10.3390/jcm14082722 · External reference
10.3390/jcm11061551
10.3390/jcm11061551 · External reference
BSAC Drug Stability Working Party. Assessment of the stability of citrate-buffered flucloxacillin for injection when stored in two commercially available ambulatory elastomeric devices
10.1136/ejhpharm-2018-001515 · 2020 · External reference
Updated good practice recommendations for OPAT in adults and children in the UK
10.1093/jacamr/dlz026 · 2019 · External reference
10.3390/antibiotics13020153
10.3390/antibiotics13020153 · External reference
A systematic review of antibiotic drug shortages and the strategies employed for managing these shortages
10.1016/j.cmi.2024.09.023 · 2025 · External reference
WHO’s essential medicines and AWaRe: Recommendations on first- and second-choice antibiotics for empiric treatment of clinical infections
10.1016/j.cmi.2024.02.003 · 2024 · External reference
Kalkulierte parenterale Initialtherapie bakterieller Infektionen: Knochen- und Gelenkinfektionen
2020 · External reference
Unresolved reference
External reference
Efficacy and safety of an early oral switch in low-risk S. aureus bloodstream infection (SABATO)
10.1016/s1473-3099(23)00756-9 · 2024 · External reference
Early oral antibiotic switch in Staphylococcus aureus bacteremia: The SNAP trial early oral switch protocol
10.1093/cid/ciad666 · 2024 · External reference
β-Lactam inoculum effect in methicillin-susceptible Staphylococcus aureus infective endocarditis
10.1001/jamanetworkopen.2024.51353 · ExternalCitation · doi-reference
Consensus guidance for beta-lactam antibiotic dose individualization in acutely ill patients
10.1002/phar.70181 · ExternalCitation · doi-reference
Population pharmacokinetics of flucloxacillin in bone and soft tissue—Standard dosing is not sufficient to achieve therapeutic concentrations
10.1007/s11095-022-03197-y · ExternalCitation · doi-reference
The safety and economic impact of cefazolin versus nafcillin for the treatment of MSSA bloodstream infections
10.1007/s40121-017-0148-z · ExternalCitation · doi-reference
Cefazolin versus anti-staphylococcal penicillins for MSSA infection: Meta-analysis with trial sequential analysis
10.1007/s40121-019-00259-4 · ExternalCitation · doi-reference
The cefazolin inoculum effect: An underappreciated factor in MSSA treatment strategies
10.1007/s40121-025-01283-3 · ExternalCitation · doi-reference
Safety of cefazolin for perioperative prophylaxis in patients with penicillin allergy labels
10.1016/j.anai.2022.03.015 · ExternalCitation · doi-reference
Cefazolin versus anti-staphylococcal penicillins for treatment of MSSA bacteremia: A narrative review
10.1016/j.cmi.2017.07.003 · ExternalCitation · doi-reference
WHO’s essential medicines and AWaRe: Recommendations on first- and second-choice antibiotics for empiric treatment of clinical infections
10.1016/j.cmi.2024.02.003 · ExternalCitation · doi-reference
A systematic review of antibiotic drug shortages and the strategies employed for managing these shortages
10.1016/j.cmi.2024.09.023 · ExternalCitation · doi-reference
The risk of drug-induced liver injury associated with flucloxacillin: A nationwide, entropy-balanced cohort study
10.1016/j.cmi.2024.12.013 · ExternalCitation · doi-reference
Staphylococcus aureus Network Adaptive Platform MSSA/PSSA domain-specific working group. Cefazolin vs. antistaphylococcal penicillins for the treatment of methicillin-susceptible Staphylococcus aureus bacteremia: A systematic review and meta-analysis
10.1016/j.cmi.2025.04.045 · ExternalCitation · doi-reference
Time to acute kidney injury in β-lactam-induced acute interstitial nephritis
10.1016/j.ekir.2020.04.008 · ExternalCitation · doi-reference
A large retrospective cohort study of cefazolin compared with flucloxacillin for MSSA bacteremia
10.1016/j.ijantimicag.2018.02.013 · ExternalCitation · doi-reference
Cefazolin versus cloxacillin as definitive antibiotic therapy for MSSA spinal epidural abscess: A retrospective cohort study
10.1016/j.ijantimicag.2021.106429 · ExternalCitation · doi-reference
Frequency of pharmacological target attainment with flucloxacillin and cefazolin in invasive MSSA infection: A prospective cohort study
10.1016/j.ijantimicag.2022.106695 · ExternalCitation · doi-reference
Antibiotic penetration into bone and joints: An updated review
10.1016/j.ijid.2019.02.005 · ExternalCitation · doi-reference
Cephalosporin allergy: R1 side-chain and penicillin cross-reactivity patterns in an Australian cohort
10.1016/j.jacig.2025.100583 · ExternalCitation · doi-reference
Antibiotic treatment for 6 weeks versus 12 weeks in patients with pyogenic vertebral osteomyelitis
10.1016/s0140-6736(14)61233-2 · ExternalCitation · doi-reference
CloCeBa Study Group Cloxacillin versus cefazolin for meticillin-susceptible Staphylococcus aureus bacteremia (CloCeBa): A prospective, open-label, multicentre, non-inferiority, randomised clinical trial
10.1016/s0140-6736(25)01624-1 · ExternalCitation · doi-reference
Efficacy and safety of an early oral switch in low-risk S. aureus bloodstream infection (SABATO)
10.1016/s1473-3099(23)00756-9 · ExternalCitation · doi-reference
HLA-B5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin
10.1038/ng.379 · ExternalCitation · doi-reference
Oral versus intravenous antibiotics for bone and joint infection (OVIVA)
10.1056/nejmoa1710926 · ExternalCitation · doi-reference
Cefazolin versus cloxacillin or flucloxacillin for methicillin-susceptible Staphylococcus aureus bacteremia: A randomized clinical trial
10.1056/nejmoa2506905 · ExternalCitation · doi-reference
Prosthetic-joint infections
10.1056/nejmra040181 · ExternalCitation · doi-reference
Higher occurrence of hepatotoxicity and rash in patients treated with oxacillin, compared with those treated with nafcillin
10.1086/338047 · ExternalCitation · doi-reference
Staphylococcus aureus Network Adaptive Platform (SNAP) Study Group the Staphylococcus aureus Network Adaptive Platform trial protocol: New tools for an old foe
10.1093/cid/ciac476 · ExternalCitation · doi-reference
Early oral antibiotic switch in Staphylococcus aureus bacteremia: The SNAP trial early oral switch protocol
10.1093/cid/ciad666 · ExternalCitation · doi-reference
Diagnosis and management of prosthetic joint infection: IDSA guidelines
10.1093/cid/cis803 · ExternalCitation · doi-reference
Rationale for eliminating Staphylococcus breakpoints for β-lactam agents other than penicillin, oxacillin or cefoxitin, and ceftaroline
10.1093/cid/ciu043 · ExternalCitation · doi-reference
Comparative evaluation of the tolerability of cefazolin and nafcillin … in the outpatient setting
10.1093/cid/ciu301 · ExternalCitation · doi-reference
2015 IDSA guidelines for native vertebral osteomyelitis in adults
10.1093/cid/civ482 · ExternalCitation · doi-reference
Comparative Effectiveness of Cefazolin Versus Nafcillin or Oxacillin for Treatment of Methicillin-Susceptible Staphylococcus aureus Infections Complicated by Bacteremia: A Nationwide Cohort Study
10.1093/cid/cix287 · ExternalCitation · doi-reference
Cefazolin inoculum effect and cefazolin microbiological treatment failure in serious methicillin-susceptible Staphylococcus aureus infections: A multicenter retrospective cohort study
10.1093/infdis/jiag199 · ExternalCitation · doi-reference
Clinical features and medical–surgical management overweight the inoculum effect and genotypic characteristics of MSSA in infective endocarditis
10.1093/jac/dkaf115 · ExternalCitation · doi-reference
A review of the randomized clinical trial results from the SNAP MSSA and PSSA domains and CloCeBa
10.1093/jac/dkag215 · ExternalCitation · doi-reference
Comparative effectiveness of cefazolin versus cloxacillin as definitive antibiotic therapy for MSSA bacteremia
10.1093/jac/dku560 · ExternalCitation · doi-reference
Quantification of the risk of liver injury associated with flucloxacillin: A UK population-based cohort study
10.1093/jac/dkx183 · ExternalCitation · doi-reference
Clinical significance of cefazolin inoculum effect in serious MSSA infections: A systematic review
10.1093/jacamr/dlae069 · ExternalCitation · doi-reference
Updated good practice recommendations for OPAT in adults and children in the UK
10.1093/jacamr/dlz026 · ExternalCitation · doi-reference
2021 PIDS/IDSA guideline on acute hematogenous osteomyelitis in pediatrics
10.1093/jpids/piab027 · ExternalCitation · doi-reference
Antistaphylococcal penicillin vs cefazolin for the treatment of MSSA spinal epidural abscesses
10.1093/ofid/ofab071 · ExternalCitation · doi-reference
Pharmacokinetic evaluation of cefazolin in the cerebrospinal fluid of critically ill patients
10.1093/ofid/ofab649 · ExternalCitation · doi-reference
The cefazolin inoculum effect is associated with increased mortality in MSSA bacteremia
10.1093/ofid/ofy123 · ExternalCitation · doi-reference
ESPID bone and joint infection guidelines
10.1097/inf.0000000000001635 · ExternalCitation · doi-reference
Intravenous flucloxacillin treatment is associated with a high incidence of hypokalaemia
10.1111/bcp.13969 · ExternalCitation · doi-reference
Inoculum effect with cefazolin among clinical isolates of methicillin-susceptible Staphylococcus aureus: Frequency and possible cause of cefazolin treatment failure
10.1128/aac.00317-09 · ExternalCitation · doi-reference
Continuous cefazolin infusion to treat bone and joint infections
10.1128/aac.00389-08 · ExternalCitation · doi-reference
Cefazolin inoculum effect and MSSA osteoarticular infections in children
10.1128/aac.00703-20 · ExternalCitation · doi-reference
In vivo effects of cefazolin, daptomycin, and nafcillin in experimental endocarditis with a methicillin-susceptible Staphylococcus aureus strain showing an inoculum effect against cefazolin
10.1128/aac.00856-13 · ExternalCitation · doi-reference
A population pharmacokinetic analysis of continuous infusion of cloxacillin during S. aureus bone and joint infections
10.1128/aac.01562-20 · ExternalCitation · doi-reference
Systematic review and meta-analysis of the safety of antistaphylococcal penicillins compared to cefazolin
10.1128/aac.01816-17 · ExternalCitation · doi-reference
Novel insights into the classification of staphylococcal β-lactamases in relation to the cefazolin inoculum effect
10.1128/aac.02511-19 · ExternalCitation · doi-reference
Comparison of cefazolin versus oxacillin for treatment of complicated bacteremia caused by MSSA
10.1128/aac.02800-14 · ExternalCitation · doi-reference
Treatment outcomes with cefazolin versus oxacillin for deep-seated MSSA bloodstream infections
10.1128/aac.04677-14 · ExternalCitation · doi-reference
Treatment of osteomyelitis and septic arthritis with cefazolin
10.1128/aac.13.3.405 · ExternalCitation · doi-reference
Staphylococcus aureus infections: Epidemiology, pathophysiology, clinical manifestations, and management
10.1128/cmr.00134-14 · ExternalCitation · doi-reference
A test for the rapid detection of the cefazolin inoculum effect in methicillin-susceptible Staphylococcus aureus
10.1128/jcm.01938-20 · ExternalCitation · doi-reference
BSAC Drug Stability Working Party. Assessment of the stability of citrate-buffered flucloxacillin for injection when stored in two commercially available ambulatory elastomeric devices
10.1136/ejhpharm-2018-001515 · ExternalCitation · doi-reference
Seizures associated with high-dose cefazolin in a patient with renal dysfunction: A case report
10.1177/08971900251326735 · ExternalCitation · doi-reference
Extravasation of noncytotoxic drugs: A review of the literature
10.1177/1060028014527820 · ExternalCitation · doi-reference
A review of β-lactam-associated neutropenia and implications for cross-reactivity
10.1177/1060028020975646 · ExternalCitation · doi-reference
10.1186/s12879-018-3418-9
10.1186/s12879-018-3418-9 · ExternalCitation · doi-reference
Continued in vitro cefazolin susceptibility in methicillin-susceptible Staphylococcus aureus
10.1186/s12941-018-0257-x · ExternalCitation · doi-reference
10.3390/antibiotics10091112
10.3390/antibiotics10091112 · ExternalCitation · doi-reference
10.3390/antibiotics13020153
10.3390/antibiotics13020153 · ExternalCitation · doi-reference
10.3390/antibiotics13100928
10.3390/antibiotics13100928 · ExternalCitation · doi-reference
10.3390/antibiotics15080798
10.3390/antibiotics15080798 · ExternalCitation · doi-reference
10.3390/jcm11061551
10.3390/jcm11061551 · ExternalCitation · doi-reference
10.3390/jcm14082722
10.3390/jcm14082722 · ExternalCitation · doi-reference