Research graph
References from Proteomic Landscape of Spermatozoa Under Inflammatory and Oxidative Injury: Molecular Mechanisms and Clinical Translation. Local targets link to admitted publications; unresolved targets remain external evidence.
10.3390/antiox9020111
10.3390/antiox9020111 · External reference
Reactive oxygen species impact on sperm DNA and its role in male infertility
10.1111/and.13012 · 2018 · External reference
Contemporary evidence on the physiological role of reactive oxygen species in human sperm function
10.1007/s10815-014-0425-7 · 2015 · External reference
Effect of oxidative stress on male reproduction
10.5534/wjmh.2014.32.1.1 · 2014 · External reference
10.3390/ijms221810043
10.3390/ijms221810043 · External reference
Oxidative stress and male infertility
10.1002/rmb2.12353 · 2021 · External reference
Reactive oxygen species and male reproductive hormones
10.1186/s12958-018-0406-2 · 2018 · External reference
10.3390/antiox9020134
10.3390/antiox9020134 · External reference
10.3390/antiox14060720
10.3390/antiox14060720 · External reference
10.3389/fendo.2025.1520835
10.3389/fendo.2025.1520835 · External reference
Role of oxidative stress in male infertility: An updated review
10.4103/jhrs.jhrs_150_18 · 2019 · External reference
The impact of oxidative stress on male reproductive function: Exploring the role of antioxidant supplementation
2023 · External reference
Sperm activation: Role of reactive oxygen species and kinases
10.1016/j.bbapap.2007.08.024 · 2008 · External reference
Oxidative stress impairs function and increases redox protein modifications in human spermatozoa
10.1530/rep-14-0240 · 2015 · External reference
Peroxiredoxin 6 is the primary antioxidant enzyme for the maintenance of viability and DNA integrity in human spermatozoa
10.1093/humrep/dey221 · 2018 · External reference
Human spermatozoa contain multiple targets for protein S-nitrosylation: An alternative mechanism of the modulation of sperm function by nitric oxide?
10.1002/pmic.200700254 · 2007 · External reference
10.3389/fmolb.2021.799294
10.3389/fmolb.2021.799294 · External reference
Oxidative stress and male infertility
10.1038/nrurol.2017.69 · 2017 · External reference
Ultrasound evaluation of patients with male accessory gland inflammation: A pictorial review
10.1111/andr.13011 · 2021 · External reference
10.3390/ijms27052498
10.3390/ijms27052498 · External reference
Male accessory gland inflammation, infertility, and sexual dysfunctions: A practical approach to diagnosis and therapy
10.1111/andr.12427 · 2017 · External reference
Therapeutic options in male genital tract inflammation
10.1111/and.13207 · 2019 · External reference
Ultrasound aspects of symptomatic versus asymptomatic forms of male accessory gland inflammation
10.1111/andr.13014 · 2021 · External reference
10.1111/andr.70349
10.1111/andr.70349 · External reference
Male accessory gland infection and sperm parameters: A review
10.1111/j.1365-2605.2011.01200.x · 2011 · External reference
10.3390/diagnostics16050722
10.3390/diagnostics16050722 · External reference
Implications of prostate inflammation on male fertility
10.1111/and.13093 · 2018 · External reference
Male accessory gland inflammation and male infertility: Pathophysiological and clinical considerations
2018 · External reference
Epidemiology of varicocele
10.4103/1008-682x.172640 · 2016 · External reference
10.1016/j.fertnstert.2014.10.007
10.1016/j.fertnstert.2014.10.007 · External reference
Unresolved reference
External reference
Insight into oxidative stress in varicocele-associated male infertility: Part 1
10.1038/nrurol.2012.197 · 2012 · External reference
Oxidative stress and varicocele-associated male infertility
10.1007/978-3-030-89340-8_10 · 2022 · External reference
Comprehensive diagnostic and therapeutic approach to male factor infertility aimed at natural fertility: A multicentric retrospective cohort study
10.1111/andr.70006 · 2025 · External reference
Metabolic syndrome and male fertility
10.5534/wjmh.180055 · 2019 · External reference
Obesity and male fertility disorders
10.1016/j.mam.2024.101273 · 2024 · External reference
Unresolved reference
External reference
Oxidative stress and male infertility—A clinical perspective
10.1093/humupd/dmn004 · 2008 · External reference
Environmental exposures, oxidative stress, and male reproductive health
2022 · External reference
Environmental contaminants and male reproductive toxicity: Mechanisms and biomarkers
2022 · External reference
10.3390/antiox11081617
10.3390/antiox11081617 · External reference
Unresolved reference
External reference
Oxidative stress affects sperm health and fertility—Time to apply clinically relevant measures
2024 · External reference
Effects of increased paternal age on sperm quality, reproductive outcome and associated epigenetic risks to offspring
10.1186/s12958-015-0028-x · 2015 · External reference
10.3390/cells14110813
10.3390/cells14110813 · External reference
10.3390/antiox14121470
10.3390/antiox14121470 · External reference
An update on clinical and surgical interventions to reduce sperm DNA fragmentation in infertile men
10.1111/andr.12724 · 2020 · External reference
Sperm DNA damage caused by oxidative stress: Modifiable clinical, lifestyle and nutritional factors in male infertility
10.1016/j.rbmo.2014.02.004 · 2014 · External reference
Male genital tract inflammation: The role of selected interleukins in regulation of pro-oxidant and antioxidant enzymatic substances in seminal plasma
10.1002/j.1939-4640.2003.tb02693.x · 2003 · External reference
Interleukin 8 and the male genital tract
10.1016/j.jri.2013.02.004 · 2013 · External reference
Cytokines in the male reproductive tract and their role in infertility disorders
10.1016/j.jri.2015.02.001 · 2015 · External reference
Seminal vesicles and male fertility: Much more than a mere accessory gland
2013 · External reference
suPAR as a biomarker of support in different clinical settings
10.1016/j.cca.2025.120303 · 2025 · External reference
Leukocytospermia, oxidative stress and male infertility: Current evidence and clinical implications
2024 · External reference
Proteomic characterization of the human sperm nucleus
10.1002/pmic.201000799 · 2011 · External reference
10.3390/ijms21051621
10.3390/ijms21051621 · External reference
Identification of gene products present in Triton X-100 soluble and insoluble fractions of human spermatozoa lysates using LC-MS/MS analysis
10.1002/prca.200601013 · 2007 · External reference
10.1017/cbo9780511729942
10.1017/cbo9780511729942 · External reference
The combined human sperm proteome: Cellular pathways and implications for basic and clinical science
10.1093/humupd/dmt046 · 2014 · External reference
Pre-analytical variables in human semen proteomics: Collection, processing, storage, and sample purity
2022 · External reference
Unresolved reference
External reference
Abstinence time and its impact on basic and advanced semen parameters
10.1016/j.urology.2016.03.059 · 2016 · External reference
The impact of ejaculatory abstinence on semen analysis parameters: A systematic review
10.1007/s10815-017-1086-0 · 2018 · External reference
Characterization of the sperm proteome and reproductive outcomes with a short ejaculatory abstinence interval
2019 · External reference
Comparative evaluation of swim-up and density-gradient centrifugation for sperm selection
2015 · External reference
Sperm purification and proteomic analysis: Methodological considerations
2023 · External reference
10.3390/antiox9040287
10.3390/antiox9040287 · External reference
Epididymosomes, prostasomes, and liposomes: Their roles in mammalian sperm maturation
10.1530/rep-13-0058 · 2013 · External reference
Prostasomes: Extracellular vesicles from the prostate
10.1530/rep-13-0358 · 2014 · External reference
Molecular Biology of Reproduction and Development Research Group. Semen proteomics and male infertility
10.1016/j.jprot.2016.08.018 · 2017 · External reference
Human sperm tail proteome suggests new endogenous metabolic pathways
10.1074/mcp.m112.020552 · 2013 · External reference
Sperm cell proteomics
10.1002/pmic.200800588 · 2009 · External reference
Proteomics of the spermatozoon
2013 · External reference
Universal sample preparation method for proteome analysis
10.1038/nmeth.1322 · 2009 · External reference
Sperm proteomic profiling after swim-up selection reveals proteins associated with motility and fertilization potential
2021 · External reference
Proteomic profiling of the human sperm flagellum
2015 · External reference
Comparative proteomic analysis of human spermatozoa using urea/thiourea/CHAPS extraction
2015 · External reference
Genomic and proteomic dissection and characterization of the human sperm chromatin
10.1093/molehr/gau079 · 2014 · External reference
S-Trap, an ultrafast sample-preparation approach for shotgun proteomics
10.1021/acs.jproteome.8b00505 · 2018 · External reference
Suspension trapping (S-Trap) sample preparation method for bottom-up proteomics analysis
10.1002/pmic.201300553 · 2014 · External reference
Ultrasensitive proteome analysis using paramagnetic bead technology
10.15252/msb.20145625 · 2014 · External reference
Testosterone-associated changes in the human sperm proteome
2022 · External reference
A systematic review identifying fertility biomarkers in semen: A clinical approach through omics to diagnose male infertility
10.1016/j.fertnstert.2022.04.028 · 2022 · External reference
Understanding seminal plasma in male infertility: Emerging markers and their implications
10.1111/andr.13563 · 2024 · External reference
10.3390/ijms21239113
10.3390/ijms21239113 · External reference
Molecular interactions associated with oxidative stress-mediated male infertility: Sperm and seminal plasma proteomics
10.1007/978-3-030-89340-8_4 · 2022 · External reference
Seminal plasma proteomics as putative biomarkers for male infertility diagnosis
10.1016/j.cca.2024.119757 · 2024 · External reference
Update on the proteomics of male infertility: A systematic review
10.1016/j.aju.2017.11.016 · 2018 · External reference
Acquisition and analysis of DIA-based proteomic data: A comprehensive survey in 2023
10.1016/j.mcpro.2024.100712 · 2024 · External reference
Parallel reaction monitoring for high resolution and high mass accuracy quantitative, targeted proteomics
10.1074/mcp.o112.020131 · 2012 · External reference
10.3389/fcell.2019.00295
10.3389/fcell.2019.00295 · External reference
Comparative analysis of mammalian sperm ultrastructure reveals relationships between sperm morphology, mitochondrial functions and motility
10.1186/s12958-019-0510-y · 2019 · External reference
Functional anatomy of the mammalian sperm flagellum
10.1002/cm.21338 · 2016 · External reference
Proteomics analysis of asthenozoospermia and identification of glucose-6-phosphate isomerase as an important enzyme for sperm motility
10.1016/j.jprot.2019.103478 · 2019 · External reference
Ca2+ signaling in mammalian spermatozoa
10.1016/j.mce.2020.110953 · 2020 · External reference
The regulation role of calcium channels in mammalian sperm function: A narrative review with a focus on humans and mice
10.7717/peerj.18429 · 2024 · External reference
CatSper: The complex main gate of calcium entry in mammalian spermatozoa
10.1016/j.mce.2020.110951 · 2020 · External reference
CatSper calcium channels: 20 years on
10.1152/physiol.00028.2022 · 2023 · External reference
Sperm mitochondrial dysfunction and oxidative stress as possible reasons for isolated asthenozoospermia
2018 · External reference
Nitric oxide-targeted protein phosphorylation during human sperm capacitation
10.1038/s41598-021-00494-1 · 2021 · External reference
HSPA2 emerges as a key biomarker: Insights from global lysine acetylproteomic profiling in idiopathic male infertility
10.1016/j.cstres.2025.100090 · 2025 · External reference
Evolutionarily conserved sperm factors, DCST1 and DCST2, are required for gamete fusion
10.7554/elife.66313 · 2021 · External reference
Oxidation-reduction potential as a new marker for oxidative stress: Correlation to male infertility
10.4111/icu.2017.58.6.385 · 2017 · External reference
The role of sperm oxidative stress in male infertility and the significance of oral antioxidant therapy
10.1093/humrep/der132 · 2011 · External reference
Antioxidants for male subfertility
2022 · External reference
10.3390/antiox10081283
10.3390/antiox10081283 · External reference
Global Andrology Forum clinical guidelines on antioxidant use in the treatment of male infertility
10.5534/wjmh.250290 · 2026 · External reference
Diagnosis and treatment of infertility in men: AUA/ASRM guideline part II
10.1097/ju.0000000000001520 · 2021 · External reference
The use of nutraceuticals in male sexual and reproductive disturbances: Position statement from the Italian Society of Andrology and Sexual Medicine (SIAMS)
10.1007/s40618-017-0699-6 · 2017 · External reference
Head and flagella subcompartmental proteomic analysis of human spermatozoa
10.1002/pmic.201200350 · 2013 · External reference
10.3390/genes10070522
10.3390/genes10070522 · External reference
10.3390/medicina60020279
10.3390/medicina60020279 · External reference
10.1007/978-3-031-12966-7_17
10.1007/978-3-031-12966-7_17 · External reference
Functional anatomy of the mammalian sperm flagellum
10.1002/cm.21338 · ExternalCitation · doi-reference
Male genital tract inflammation: The role of selected interleukins in regulation of pro-oxidant and antioxidant enzymatic substances in seminal plasma
10.1002/j.1939-4640.2003.tb02693.x · ExternalCitation · doi-reference
Human spermatozoa contain multiple targets for protein S-nitrosylation: An alternative mechanism of the modulation of sperm function by nitric oxide?
10.1002/pmic.200700254 · ExternalCitation · doi-reference
Sperm cell proteomics
10.1002/pmic.200800588 · ExternalCitation · doi-reference
Proteomic characterization of the human sperm nucleus
10.1002/pmic.201000799 · ExternalCitation · doi-reference
Head and flagella subcompartmental proteomic analysis of human spermatozoa
10.1002/pmic.201200350 · ExternalCitation · doi-reference
Suspension trapping (S-Trap) sample preparation method for bottom-up proteomics analysis
10.1002/pmic.201300553 · ExternalCitation · doi-reference
Identification of gene products present in Triton X-100 soluble and insoluble fractions of human spermatozoa lysates using LC-MS/MS analysis
10.1002/prca.200601013 · ExternalCitation · doi-reference
Oxidative stress and male infertility
10.1002/rmb2.12353 · ExternalCitation · doi-reference
Oxidative stress and varicocele-associated male infertility
10.1007/978-3-030-89340-8_10 · ExternalCitation · doi-reference
Molecular interactions associated with oxidative stress-mediated male infertility: Sperm and seminal plasma proteomics
10.1007/978-3-030-89340-8_4 · ExternalCitation · doi-reference
10.1007/978-3-031-12966-7_17
10.1007/978-3-031-12966-7_17 · ExternalCitation · doi-reference
Contemporary evidence on the physiological role of reactive oxygen species in human sperm function
10.1007/s10815-014-0425-7 · ExternalCitation · doi-reference
The impact of ejaculatory abstinence on semen analysis parameters: A systematic review
10.1007/s10815-017-1086-0 · ExternalCitation · doi-reference
The use of nutraceuticals in male sexual and reproductive disturbances: Position statement from the Italian Society of Andrology and Sexual Medicine (SIAMS)
10.1007/s40618-017-0699-6 · ExternalCitation · doi-reference
Update on the proteomics of male infertility: A systematic review
10.1016/j.aju.2017.11.016 · ExternalCitation · doi-reference
Sperm activation: Role of reactive oxygen species and kinases
10.1016/j.bbapap.2007.08.024 · ExternalCitation · doi-reference
Seminal plasma proteomics as putative biomarkers for male infertility diagnosis
10.1016/j.cca.2024.119757 · ExternalCitation · doi-reference
suPAR as a biomarker of support in different clinical settings
10.1016/j.cca.2025.120303 · ExternalCitation · doi-reference
HSPA2 emerges as a key biomarker: Insights from global lysine acetylproteomic profiling in idiopathic male infertility
10.1016/j.cstres.2025.100090 · ExternalCitation · doi-reference
10.1016/j.fertnstert.2014.10.007
10.1016/j.fertnstert.2014.10.007 · ExternalCitation · doi-reference
A systematic review identifying fertility biomarkers in semen: A clinical approach through omics to diagnose male infertility
10.1016/j.fertnstert.2022.04.028 · ExternalCitation · doi-reference
Molecular Biology of Reproduction and Development Research Group. Semen proteomics and male infertility
10.1016/j.jprot.2016.08.018 · ExternalCitation · doi-reference
Proteomics analysis of asthenozoospermia and identification of glucose-6-phosphate isomerase as an important enzyme for sperm motility
10.1016/j.jprot.2019.103478 · ExternalCitation · doi-reference
Interleukin 8 and the male genital tract
10.1016/j.jri.2013.02.004 · ExternalCitation · doi-reference
Cytokines in the male reproductive tract and their role in infertility disorders
10.1016/j.jri.2015.02.001 · ExternalCitation · doi-reference
Obesity and male fertility disorders
10.1016/j.mam.2024.101273 · ExternalCitation · doi-reference
CatSper: The complex main gate of calcium entry in mammalian spermatozoa
10.1016/j.mce.2020.110951 · ExternalCitation · doi-reference
Ca2+ signaling in mammalian spermatozoa
10.1016/j.mce.2020.110953 · ExternalCitation · doi-reference
Acquisition and analysis of DIA-based proteomic data: A comprehensive survey in 2023
10.1016/j.mcpro.2024.100712 · ExternalCitation · doi-reference
Sperm DNA damage caused by oxidative stress: Modifiable clinical, lifestyle and nutritional factors in male infertility
10.1016/j.rbmo.2014.02.004 · ExternalCitation · doi-reference
Abstinence time and its impact on basic and advanced semen parameters
10.1016/j.urology.2016.03.059 · ExternalCitation · doi-reference
10.1017/cbo9780511729942
10.1017/cbo9780511729942 · ExternalCitation · doi-reference
S-Trap, an ultrafast sample-preparation approach for shotgun proteomics
10.1021/acs.jproteome.8b00505 · ExternalCitation · doi-reference
Universal sample preparation method for proteome analysis
10.1038/nmeth.1322 · ExternalCitation · doi-reference
Insight into oxidative stress in varicocele-associated male infertility: Part 1
10.1038/nrurol.2012.197 · ExternalCitation · doi-reference
Oxidative stress and male infertility
10.1038/nrurol.2017.69 · ExternalCitation · doi-reference
Nitric oxide-targeted protein phosphorylation during human sperm capacitation
10.1038/s41598-021-00494-1 · ExternalCitation · doi-reference
Human sperm tail proteome suggests new endogenous metabolic pathways
10.1074/mcp.m112.020552 · ExternalCitation · doi-reference
Parallel reaction monitoring for high resolution and high mass accuracy quantitative, targeted proteomics
10.1074/mcp.o112.020131 · ExternalCitation · doi-reference
The role of sperm oxidative stress in male infertility and the significance of oral antioxidant therapy
10.1093/humrep/der132 · ExternalCitation · doi-reference
Peroxiredoxin 6 is the primary antioxidant enzyme for the maintenance of viability and DNA integrity in human spermatozoa
10.1093/humrep/dey221 · ExternalCitation · doi-reference
Oxidative stress and male infertility—A clinical perspective
10.1093/humupd/dmn004 · ExternalCitation · doi-reference
The combined human sperm proteome: Cellular pathways and implications for basic and clinical science
10.1093/humupd/dmt046 · ExternalCitation · doi-reference
Genomic and proteomic dissection and characterization of the human sperm chromatin
10.1093/molehr/gau079 · ExternalCitation · doi-reference
Diagnosis and treatment of infertility in men: AUA/ASRM guideline part II
10.1097/ju.0000000000001520 · ExternalCitation · doi-reference
Reactive oxygen species impact on sperm DNA and its role in male infertility
10.1111/and.13012 · ExternalCitation · doi-reference
Implications of prostate inflammation on male fertility
10.1111/and.13093 · ExternalCitation · doi-reference
Therapeutic options in male genital tract inflammation
10.1111/and.13207 · ExternalCitation · doi-reference
Male accessory gland inflammation, infertility, and sexual dysfunctions: A practical approach to diagnosis and therapy
10.1111/andr.12427 · ExternalCitation · doi-reference
An update on clinical and surgical interventions to reduce sperm DNA fragmentation in infertile men
10.1111/andr.12724 · ExternalCitation · doi-reference
Ultrasound evaluation of patients with male accessory gland inflammation: A pictorial review
10.1111/andr.13011 · ExternalCitation · doi-reference
Ultrasound aspects of symptomatic versus asymptomatic forms of male accessory gland inflammation
10.1111/andr.13014 · ExternalCitation · doi-reference
Understanding seminal plasma in male infertility: Emerging markers and their implications
10.1111/andr.13563 · ExternalCitation · doi-reference
Comprehensive diagnostic and therapeutic approach to male factor infertility aimed at natural fertility: A multicentric retrospective cohort study
10.1111/andr.70006 · ExternalCitation · doi-reference
10.1111/andr.70349
10.1111/andr.70349 · ExternalCitation · doi-reference
Male accessory gland infection and sperm parameters: A review
10.1111/j.1365-2605.2011.01200.x · ExternalCitation · doi-reference
CatSper calcium channels: 20 years on
10.1152/physiol.00028.2022 · ExternalCitation · doi-reference
Effects of increased paternal age on sperm quality, reproductive outcome and associated epigenetic risks to offspring
10.1186/s12958-015-0028-x · ExternalCitation · doi-reference
Reactive oxygen species and male reproductive hormones
10.1186/s12958-018-0406-2 · ExternalCitation · doi-reference
Comparative analysis of mammalian sperm ultrastructure reveals relationships between sperm morphology, mitochondrial functions and motility
10.1186/s12958-019-0510-y · ExternalCitation · doi-reference
Ultrasensitive proteome analysis using paramagnetic bead technology
10.15252/msb.20145625 · ExternalCitation · doi-reference
Epididymosomes, prostasomes, and liposomes: Their roles in mammalian sperm maturation
10.1530/rep-13-0058 · ExternalCitation · doi-reference
Prostasomes: Extracellular vesicles from the prostate
10.1530/rep-13-0358 · ExternalCitation · doi-reference
Oxidative stress impairs function and increases redox protein modifications in human spermatozoa
10.1530/rep-14-0240 · ExternalCitation · doi-reference
10.3389/fcell.2019.00295
10.3389/fcell.2019.00295 · ExternalCitation · doi-reference
10.3389/fendo.2025.1520835
10.3389/fendo.2025.1520835 · ExternalCitation · doi-reference
10.3389/fmolb.2021.799294
10.3389/fmolb.2021.799294 · ExternalCitation · doi-reference
10.3390/antiox10081283
10.3390/antiox10081283 · ExternalCitation · doi-reference
10.3390/antiox11081617
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10.3390/antiox14060720
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10.3390/antiox14121470
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10.3390/antiox9020111
10.3390/antiox9020111 · ExternalCitation · doi-reference
10.3390/antiox9020134
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10.3390/antiox9040287
10.3390/antiox9040287 · ExternalCitation · doi-reference
10.3390/cells14110813
10.3390/cells14110813 · ExternalCitation · doi-reference
10.3390/diagnostics16050722
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10.3390/genes10070522
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10.3390/ijms27052498
10.3390/ijms27052498 · ExternalCitation · doi-reference
10.3390/medicina60020279
10.3390/medicina60020279 · ExternalCitation · doi-reference
Epidemiology of varicocele
10.4103/1008-682x.172640 · ExternalCitation · doi-reference
Role of oxidative stress in male infertility: An updated review
10.4103/jhrs.jhrs_150_18 · ExternalCitation · doi-reference
Oxidation-reduction potential as a new marker for oxidative stress: Correlation to male infertility
10.4111/icu.2017.58.6.385 · ExternalCitation · doi-reference
Metabolic syndrome and male fertility
10.5534/wjmh.180055 · ExternalCitation · doi-reference
Effect of oxidative stress on male reproduction
10.5534/wjmh.2014.32.1.1 · ExternalCitation · doi-reference
Global Andrology Forum clinical guidelines on antioxidant use in the treatment of male infertility
10.5534/wjmh.250290 · ExternalCitation · doi-reference
Evolutionarily conserved sperm factors, DCST1 and DCST2, are required for gamete fusion
10.7554/elife.66313 · ExternalCitation · doi-reference
The regulation role of calcium channels in mammalian sperm function: A narrative review with a focus on humans and mice
10.7717/peerj.18429 · ExternalCitation · doi-reference
