Research graph
References from Effects of Dietary Supplementation with Conjugated Linoleic Acid on Redox Marker Profiles and Neuroaxonal Degeneration in Amyotrophic Lateral Sclerosis. Local targets link to admitted publications; unresolved targets remain external evidence.
Amyotrophic lateral sclerosis
10.1038/nrdp.2017.71 · 2017 · External reference
Amyotrophic lateral sclerosis
10.1056/nejmra1603471 · 2017 · External reference
Decoding ALS: From genes to mechanism
10.1038/nature20413 · 2016 · External reference
Emerging insights into the complex genetics and pathophysiology of amyotrophic lateral sclerosis
10.1016/s1474-4422(21)00414-2 · 2022 · External reference
Oxidative stress in ALS: Key role in motor neuron injury and therapeutic target
10.1016/j.freeradbiomed.2009.11.018 · 2010 · External reference
Pathways to mitochondrial dysfunction in ALS pathogenesis
10.1016/j.bbrc.2016.07.055 · 2017 · External reference
Clinical perspective on oxidative stress in ALS
10.1016/j.freeradbiomed.2013.06.029 · 2013 · External reference
Modelling ALS: Progress and possibilities
10.1242/dmm.029058 · 2017 · External reference
Immune dysregulation in ALS: Mechanisms and emerging therapies
10.1016/s1474-4422(18)30394-6 · 2019 · External reference
Panel of oxidative stress and inflammatory biomarkers in ALS: A pilot study
10.1017/cjn.2016.284 · 2017 · External reference
Glucose-6-phosphate dehydrogenase, NADPH, and cell survival
2012 · External reference
Transcription factor NRF2 as a therapeutic target for chronic diseases: A systems medicine approach
10.1124/pr.117.014753 · 2018 · External reference
Nuclear erythroid 2-related factor 2-antioxidative response element signaling pathway in motor cortex and spinal cord in amyotrophic lateral sclerosis
10.1097/nen.0b013e31818b4906 · 2008 · External reference
Nrf2 activation in astrocytes protects against neu-rodegeneration in mouse models of familial amyotrophic lateral sclerosis
10.1523/jneurosci.4099-08.2008 · 2008 · External reference
Mutant SOD1 alters the motor neuronal transcriptome: Implications for familial ALS
10.1093/brain/awh503 · 2005 · External reference
Deficiency in the transcription factor NRF2 worsens inflammatory parameters in a mouse model with combined tauopathy and amyloidopathy
10.1016/j.redox.2018.07.006 · 2018 · External reference
NRF2 as a therapeutic opportunity to impact in the molecular roadmap of ALS
10.1016/j.freeradbiomed.2021.07.022 · 2021 · External reference
The role of glutathione reductase and related enzymes in the cellular redox homeostasis network
10.1016/j.freeradbiomed.2016.02.028 · 2016 · External reference
Crosslinking of human plasma C-reactive protein to human serum albumin via disulfide bond oxidation
10.1016/j.redox.2021.101925 · 2021 · External reference
Oxidative stress in amyotrophic lateral sclerosis: Pathophysiology and opportunities for pharmacological intervention
2020 · External reference
The thiol pool in human plasma: The central contribution of albumin to redox processes
10.1016/j.freeradbiomed.2013.05.050 · 2013 · External reference
Neurofilament light chain in drug development for amyotrophic lateral sclerosis: A critical appraisal
10.1093/brain/awac394 · 2023 · External reference
The cerebrospinal fluid values of advanced oxidation protein products and total thiol content in patients with amyotrophic lateral sclerosis
10.1016/j.clineuro.2017.10.015 · 2017 · External reference
Oxidant-antioxidant imbalance in the erythrocytes of sporadic amyotrophic lateral sclerosis patients correlates with the progression of disease
10.1016/j.neuint.2008.01.009 · 2008 · External reference
Time course of oxidant markers and antioxidant defenses in subgroups of amyotrophic lateral sclerosis patients
10.1016/j.neuint.2010.02.004 · 2010 · External reference
Neurofilaments as biomarkers in neurological disorders
10.1038/s41582-018-0058-z · 2018 · External reference
Neurofilament light chain in serum for the diagnosis of amyotrophic lateral sclerosis
10.1136/jnnp-2018-318704 · 2019 · External reference
Validation of serum neurofilaments as prognostic and potential pharmacodynamic biomarkers for ALS
10.1212/wnl.0000000000009559 · 2020 · External reference
10.3390/ijms26199739
10.3390/ijms26199739 · External reference
The effect of conjugated linoleic acids on inflammation, oxidative stress, body composition and physical performance: A comprehensive review of putative molecular mechanisms
10.1186/s12986-023-00758-9 · 2023 · External reference
Implication of conjugated linoleic acid (CLA) in human health
10.1080/10408398.2010.501409 · 2012 · External reference
Mechanisms underlying the hormetic effect of conjugated linoleic acid: Focus on Nrf2, mitochondria and NADPH oxidases
10.1016/j.freeradbiomed.2021.03.015 · 2021 · External reference
Phase 2 enzyme induction by conjugated linoleic acid improves lupus-associated oxidative stress
10.1016/j.freeradbiomed.2007.03.023 · 2007 · External reference
Conjugated linoleic acid downregulates Alzheimer’s hallmarks in an aluminum mouse model through an NRF2-mediated adaptive response and increases brain glucose transporter levels
10.1016/j.freeradbiomed.2022.08.027 · 2022 · External reference
Supplementation withconjugated linoleic acid ameliorates the level of some Nrf2-activated systemic markers in patients with amyotrophic lateral sclerosis: A proof-of-principle study
10.1016/j.freeradbiomed.2026.03.067 · 2026 · External reference
PARALS Study Group. Phenotypic heterogeneity of amyotrophic lateral sclerosis: A population-based study
10.1136/jnnp.2010.235952 · 2011 · External reference
The ALSFRS-R: A revised ALS functional 507 rating scale that incorporates assessments of respiratory function. BDNF ALS Study Group (Phase III)
10.1016/s0022-510x(99)00210-5 · 1999 · External reference
Cerebrospinal fluid neurofilaments may discriminate upper motor neuron syndromes: A pilot study
10.1159/000493986 · 2018 · External reference
Population-based evidence for the use of serum neurofilaments as individual diagnostic and prognostic biomarkers in amyotrophic lateral sclerosis
10.1002/ana.27054 · 2024 · External reference
Quantification of blood glial fibrillary acidic protein using a second-generation microfluidic assay: Validation and comparative analysis with two established assays
10.1515/cclm-2023-1256 · 2024 · External reference
Moving past NfL? Multibiomarker models for ALS prognosis and stratification
2025 · External reference
Neurofilament light: A candidate biomarker of presymptomatic amyotrophic lateral sclerosis and phenoconversion
10.1002/ana.25276 · 2018 · External reference
Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases
10.1038/s41573-018-0008-x · 2019 · External reference
10.3390/molecules27051471
10.3390/molecules27051471 · External reference
Neurofilament light: A candidate biomarker of presymptomatic amyotrophic lateral sclerosis and phenoconversion
10.1002/ana.25276 · ExternalCitation · doi-reference
Population-based evidence for the use of serum neurofilaments as individual diagnostic and prognostic biomarkers in amyotrophic lateral sclerosis
10.1002/ana.27054 · ExternalCitation · doi-reference
Pathways to mitochondrial dysfunction in ALS pathogenesis
10.1016/j.bbrc.2016.07.055 · ExternalCitation · doi-reference
The cerebrospinal fluid values of advanced oxidation protein products and total thiol content in patients with amyotrophic lateral sclerosis
10.1016/j.clineuro.2017.10.015 · ExternalCitation · doi-reference
Phase 2 enzyme induction by conjugated linoleic acid improves lupus-associated oxidative stress
10.1016/j.freeradbiomed.2007.03.023 · ExternalCitation · doi-reference
Oxidative stress in ALS: Key role in motor neuron injury and therapeutic target
10.1016/j.freeradbiomed.2009.11.018 · ExternalCitation · doi-reference
The thiol pool in human plasma: The central contribution of albumin to redox processes
10.1016/j.freeradbiomed.2013.05.050 · ExternalCitation · doi-reference
Clinical perspective on oxidative stress in ALS
10.1016/j.freeradbiomed.2013.06.029 · ExternalCitation · doi-reference
The role of glutathione reductase and related enzymes in the cellular redox homeostasis network
10.1016/j.freeradbiomed.2016.02.028 · ExternalCitation · doi-reference
Mechanisms underlying the hormetic effect of conjugated linoleic acid: Focus on Nrf2, mitochondria and NADPH oxidases
10.1016/j.freeradbiomed.2021.03.015 · ExternalCitation · doi-reference
NRF2 as a therapeutic opportunity to impact in the molecular roadmap of ALS
10.1016/j.freeradbiomed.2021.07.022 · ExternalCitation · doi-reference
Conjugated linoleic acid downregulates Alzheimer’s hallmarks in an aluminum mouse model through an NRF2-mediated adaptive response and increases brain glucose transporter levels
10.1016/j.freeradbiomed.2022.08.027 · ExternalCitation · doi-reference
Supplementation withconjugated linoleic acid ameliorates the level of some Nrf2-activated systemic markers in patients with amyotrophic lateral sclerosis: A proof-of-principle study
10.1016/j.freeradbiomed.2026.03.067 · ExternalCitation · doi-reference
Oxidant-antioxidant imbalance in the erythrocytes of sporadic amyotrophic lateral sclerosis patients correlates with the progression of disease
10.1016/j.neuint.2008.01.009 · ExternalCitation · doi-reference
Time course of oxidant markers and antioxidant defenses in subgroups of amyotrophic lateral sclerosis patients
10.1016/j.neuint.2010.02.004 · ExternalCitation · doi-reference
Deficiency in the transcription factor NRF2 worsens inflammatory parameters in a mouse model with combined tauopathy and amyloidopathy
10.1016/j.redox.2018.07.006 · ExternalCitation · doi-reference
Crosslinking of human plasma C-reactive protein to human serum albumin via disulfide bond oxidation
10.1016/j.redox.2021.101925 · ExternalCitation · doi-reference
The ALSFRS-R: A revised ALS functional 507 rating scale that incorporates assessments of respiratory function. BDNF ALS Study Group (Phase III)
10.1016/s0022-510x(99)00210-5 · ExternalCitation · doi-reference
Immune dysregulation in ALS: Mechanisms and emerging therapies
10.1016/s1474-4422(18)30394-6 · ExternalCitation · doi-reference
Emerging insights into the complex genetics and pathophysiology of amyotrophic lateral sclerosis
10.1016/s1474-4422(21)00414-2 · ExternalCitation · doi-reference
Panel of oxidative stress and inflammatory biomarkers in ALS: A pilot study
10.1017/cjn.2016.284 · ExternalCitation · doi-reference
Decoding ALS: From genes to mechanism
10.1038/nature20413 · ExternalCitation · doi-reference
Amyotrophic lateral sclerosis
10.1038/nrdp.2017.71 · ExternalCitation · doi-reference
Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases
10.1038/s41573-018-0008-x · ExternalCitation · doi-reference
Neurofilaments as biomarkers in neurological disorders
10.1038/s41582-018-0058-z · ExternalCitation · doi-reference
Amyotrophic lateral sclerosis
10.1056/nejmra1603471 · ExternalCitation · doi-reference
Implication of conjugated linoleic acid (CLA) in human health
10.1080/10408398.2010.501409 · ExternalCitation · doi-reference
Neurofilament light chain in drug development for amyotrophic lateral sclerosis: A critical appraisal
10.1093/brain/awac394 · ExternalCitation · doi-reference
Mutant SOD1 alters the motor neuronal transcriptome: Implications for familial ALS
10.1093/brain/awh503 · ExternalCitation · doi-reference
Nuclear erythroid 2-related factor 2-antioxidative response element signaling pathway in motor cortex and spinal cord in amyotrophic lateral sclerosis
10.1097/nen.0b013e31818b4906 · ExternalCitation · doi-reference
Transcription factor NRF2 as a therapeutic target for chronic diseases: A systems medicine approach
10.1124/pr.117.014753 · ExternalCitation · doi-reference
Neurofilament light chain in serum for the diagnosis of amyotrophic lateral sclerosis
10.1136/jnnp-2018-318704 · ExternalCitation · doi-reference
PARALS Study Group. Phenotypic heterogeneity of amyotrophic lateral sclerosis: A population-based study
10.1136/jnnp.2010.235952 · ExternalCitation · doi-reference
Cerebrospinal fluid neurofilaments may discriminate upper motor neuron syndromes: A pilot study
10.1159/000493986 · ExternalCitation · doi-reference
The effect of conjugated linoleic acids on inflammation, oxidative stress, body composition and physical performance: A comprehensive review of putative molecular mechanisms
10.1186/s12986-023-00758-9 · ExternalCitation · doi-reference
Validation of serum neurofilaments as prognostic and potential pharmacodynamic biomarkers for ALS
10.1212/wnl.0000000000009559 · ExternalCitation · doi-reference
Modelling ALS: Progress and possibilities
10.1242/dmm.029058 · ExternalCitation · doi-reference
Quantification of blood glial fibrillary acidic protein using a second-generation microfluidic assay: Validation and comparative analysis with two established assays
10.1515/cclm-2023-1256 · ExternalCitation · doi-reference
Nrf2 activation in astrocytes protects against neu-rodegeneration in mouse models of familial amyotrophic lateral sclerosis
10.1523/jneurosci.4099-08.2008 · ExternalCitation · doi-reference
10.3390/ijms26199739
10.3390/ijms26199739 · ExternalCitation · doi-reference
10.3390/molecules27051471
10.3390/molecules27051471 · ExternalCitation · doi-reference
