Research graph
References from 2,4,5-trimethoxy-2′-trifluoromethylchalcone Attenuates Oxidative Stress and Inflammasome-Associated Inflammation in Experimental Models of Crystal-Induced Inflammation. Local targets link to admitted publications; unresolved targets remain external evidence.
Artritis Microcristalinas
10.1016/j.med.2017.02.003 · 2017 · External reference
Calcium Pyrophosphate Deposition Disease
10.1016/s2665-9913(24)00122-x · 2024 · External reference
Unresolved reference
External reference
Gout
10.7326/aitc201607050 · 2016 · External reference
Gout-Associated Uric Acid Crystals Activate the NALP3 Inflammasome
10.1038/nature04516 · 2006 · External reference
NF-κB Signaling in Inflammation
10.1038/sigtrans.2017.23 · 2017 · External reference
Gout
10.1016/s0140-6736(16)00346-9 · 2016 · External reference
10.3389/fimmu.2023.1137822
10.3389/fimmu.2023.1137822 · External reference
Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death
10.1016/j.tibs.2016.10.004 · 2017 · External reference
Update on Biology: Uric Acid and the Activation of Immune and Inflammatory Cells
10.1007/s11926-010-0092-3 · 2010 · External reference
The NLRP3 Inflammasome: Molecular Activation and Regulation to Therapeutics
10.1038/s41577-019-0165-0 · 2019 · External reference
NRF2 as a Guardian of Health: From an Ancient Survival Pathway to a Modern Therapeutic Target
10.1016/j.redox.2026.104217 · 2026 · External reference
The Emerging Role of Nrf2 in Mitochondrial Function
10.1016/j.freeradbiomed.2015.04.036 · 2015 · External reference
2016 Updated EULAR Evidence-Based Recommendations for the Management of Gout
10.1136/annrheumdis-2016-209707 · 2017 · External reference
2020 American College of Rheumatology Guideline for the Management of Gout
10.1002/acr.24180 · 2020 · External reference
Recent Advances in the Treatment of Gout with NLRP3 Inflammasome Inhibitors
10.1016/j.bmc.2024.117874 · 2024 · External reference
A Review of Anti-Infective and Anti-Inflammatory Chalcones
10.1016/j.ejmech.2006.09.019 · 2007 · External reference
Chalcone: A Potential Scaffold for NLRP3 Inflammasome Inhibitors
2023 · External reference
Synthesis and Anti-Inflammatory Activity of Chalcone Derivatives
10.1016/s0960-894x(98)00179-6 · 1998 · External reference
4-Dimethylamino-3′,4′-Dimethoxychalcone Downregulates INOS Expression and Exerts Anti-Inflammatory Effects
10.1016/s0891-5849(00)00443-3 · 2001 · External reference
1-(2,3,4-Trimethoxyphenyl)-3-(3-(2-Chloroquinolinyl))-2-Propen-1-One, a Chalcone Derivative with Analgesic, Anti-Inflammatory and Immunomodulatory Properties
10.1007/s00011-003-1164-x · 2003 · External reference
Structure–Activity Relationship Studies on Chalcone Derivatives
10.1016/s0968-0896(02)00312-7 · 2003 · External reference
Therapeutic Administration of 3,4,5-Trimethoxy-4′-Fluorochalcone, a Selective Inhibitor of INOS Expression, Attenuates the Development of Adjuvant-Induced Arthritis in Rats
10.1007/s00210-003-0780-x · 2003 · External reference
The Role of Chalcones in Suppression of NF-κB-Mediated Inflammation and Cancer
10.1016/j.intimp.2010.12.006 · 2011 · External reference
10.3390/molecules23071803
10.3390/molecules23071803 · External reference
10.3390/cancers16061092
10.3390/cancers16061092 · External reference
The Synthesis and Effect of Fluorinated Chalcone Derivatives on Nitric Oxide Production
10.1016/s0960-894x(02)00317-7 · 2002 · External reference
Rapid Chemosensitivity Assay with Human Normal and Tumor Cells in Vitro
10.1007/bf02624436 · 1990 · External reference
10.3390/ijms25052752
10.3390/ijms25052752 · External reference
Hesperidin Methylchalcone Suppresses Experimental Gout Arthritis in Mice by Inhibiting NF-κB Activation
10.1021/acs.jafc.8b00959 · 2018 · External reference
10.3389/fphar.2018.01123
10.3389/fphar.2018.01123 · External reference
Inflammation in Gout: Mechanisms and Therapeutic Targets
10.1038/nrrheum.2017.155 · 2017 · External reference
P2X7 Receptor and the NLRP3 Inflammasome: Partners in Crime
10.1016/j.bcp.2020.114385 · 2021 · External reference
P2X7R Mediates the Synergistic Effect of ATP and MSU Crystals to Induce Acute Gouty Arthritis
10.1155/2023/3317307 · 2023 · External reference
Activation of Nrf2 Antioxidant Signaling Alleviates Gout Arthritis Pain and Inflammation
10.1016/j.biopha.2023.115957 · 2024 · External reference
Nrf2 Signaling Pathway: Pivotal Roles in Inflammation
10.1016/j.bbadis.2016.11.005 · 2017 · External reference
Neutrophils and Extracellular Traps in Crystal-Associated Diseases
10.1016/j.molmed.2024.05.010 · 2024 · External reference
10.3390/cells14191541
10.3390/cells14191541 · External reference
2020 American College of Rheumatology Guideline for the Management of Gout
10.1002/acr.24180 · ExternalCitation · doi-reference
Rapid Chemosensitivity Assay with Human Normal and Tumor Cells in Vitro
10.1007/bf02624436 · ExternalCitation · doi-reference
1-(2,3,4-Trimethoxyphenyl)-3-(3-(2-Chloroquinolinyl))-2-Propen-1-One, a Chalcone Derivative with Analgesic, Anti-Inflammatory and Immunomodulatory Properties
10.1007/s00011-003-1164-x · ExternalCitation · doi-reference
Therapeutic Administration of 3,4,5-Trimethoxy-4′-Fluorochalcone, a Selective Inhibitor of INOS Expression, Attenuates the Development of Adjuvant-Induced Arthritis in Rats
10.1007/s00210-003-0780-x · ExternalCitation · doi-reference
Update on Biology: Uric Acid and the Activation of Immune and Inflammatory Cells
10.1007/s11926-010-0092-3 · ExternalCitation · doi-reference
Nrf2 Signaling Pathway: Pivotal Roles in Inflammation
10.1016/j.bbadis.2016.11.005 · ExternalCitation · doi-reference
P2X7 Receptor and the NLRP3 Inflammasome: Partners in Crime
10.1016/j.bcp.2020.114385 · ExternalCitation · doi-reference
Activation of Nrf2 Antioxidant Signaling Alleviates Gout Arthritis Pain and Inflammation
10.1016/j.biopha.2023.115957 · ExternalCitation · doi-reference
Recent Advances in the Treatment of Gout with NLRP3 Inflammasome Inhibitors
10.1016/j.bmc.2024.117874 · ExternalCitation · doi-reference
A Review of Anti-Infective and Anti-Inflammatory Chalcones
10.1016/j.ejmech.2006.09.019 · ExternalCitation · doi-reference
The Emerging Role of Nrf2 in Mitochondrial Function
10.1016/j.freeradbiomed.2015.04.036 · ExternalCitation · doi-reference
The Role of Chalcones in Suppression of NF-κB-Mediated Inflammation and Cancer
10.1016/j.intimp.2010.12.006 · ExternalCitation · doi-reference
Artritis Microcristalinas
10.1016/j.med.2017.02.003 · ExternalCitation · doi-reference
Neutrophils and Extracellular Traps in Crystal-Associated Diseases
10.1016/j.molmed.2024.05.010 · ExternalCitation · doi-reference
NRF2 as a Guardian of Health: From an Ancient Survival Pathway to a Modern Therapeutic Target
10.1016/j.redox.2026.104217 · ExternalCitation · doi-reference
Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death
10.1016/j.tibs.2016.10.004 · ExternalCitation · doi-reference
Gout
10.1016/s0140-6736(16)00346-9 · ExternalCitation · doi-reference
4-Dimethylamino-3′,4′-Dimethoxychalcone Downregulates INOS Expression and Exerts Anti-Inflammatory Effects
10.1016/s0891-5849(00)00443-3 · ExternalCitation · doi-reference
The Synthesis and Effect of Fluorinated Chalcone Derivatives on Nitric Oxide Production
10.1016/s0960-894x(02)00317-7 · ExternalCitation · doi-reference
Synthesis and Anti-Inflammatory Activity of Chalcone Derivatives
10.1016/s0960-894x(98)00179-6 · ExternalCitation · doi-reference
Structure–Activity Relationship Studies on Chalcone Derivatives
10.1016/s0968-0896(02)00312-7 · ExternalCitation · doi-reference
Calcium Pyrophosphate Deposition Disease
10.1016/s2665-9913(24)00122-x · ExternalCitation · doi-reference
Hesperidin Methylchalcone Suppresses Experimental Gout Arthritis in Mice by Inhibiting NF-κB Activation
10.1021/acs.jafc.8b00959 · ExternalCitation · doi-reference
Gout-Associated Uric Acid Crystals Activate the NALP3 Inflammasome
10.1038/nature04516 · ExternalCitation · doi-reference
Inflammation in Gout: Mechanisms and Therapeutic Targets
10.1038/nrrheum.2017.155 · ExternalCitation · doi-reference
The NLRP3 Inflammasome: Molecular Activation and Regulation to Therapeutics
10.1038/s41577-019-0165-0 · ExternalCitation · doi-reference
NF-κB Signaling in Inflammation
10.1038/sigtrans.2017.23 · ExternalCitation · doi-reference
2016 Updated EULAR Evidence-Based Recommendations for the Management of Gout
10.1136/annrheumdis-2016-209707 · ExternalCitation · doi-reference
P2X7R Mediates the Synergistic Effect of ATP and MSU Crystals to Induce Acute Gouty Arthritis
10.1155/2023/3317307 · ExternalCitation · doi-reference
10.3389/fimmu.2023.1137822
10.3389/fimmu.2023.1137822 · ExternalCitation · doi-reference
10.3389/fphar.2018.01123
10.3389/fphar.2018.01123 · ExternalCitation · doi-reference
10.3390/cancers16061092
10.3390/cancers16061092 · ExternalCitation · doi-reference
10.3390/cells14191541
10.3390/cells14191541 · ExternalCitation · doi-reference
10.3390/ijms25052752
10.3390/ijms25052752 · ExternalCitation · doi-reference
10.3390/molecules23071803
10.3390/molecules23071803 · ExternalCitation · doi-reference
Gout
10.7326/aitc201607050 · ExternalCitation · doi-reference
